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Article ; Online: Pharmacogenetic and pharmacogenomic treatment of rheumatoid arthritis: a review of Pharmacogenomics Knowledge Base scientific evidence.

Dorado, Pedro / M Peñas-Lledó, Eva

2024 Volume 25, Issue 2, Page(s) 55–58

Abstract: Tweetable abstract Update on the genetic variants with the highest level of Pharmacogenomics Knowledge Base evidence for their association with toxicity and efficacy in response to the most commonly used disease-modifying antirheumatic drugs for the ... ...

Abstract	Tweetable abstract Update on the genetic variants with the highest level of Pharmacogenomics Knowledge Base evidence for their association with toxicity and efficacy in response to the most commonly used disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis.
MeSH term(s)	Humans ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Knowledge Bases ; Pharmacogenetics
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Editorial
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2023-0230
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Article ; Online: Dataset of an actual life-risk insurance portfolio

Lledó, Josep / Pavía, Jose M.

Data in Brief. 2022 Dec., v. 45, p. 108655

2022 , Page(s) 108655

Abstract: The foundation of the insurance business is built on data, the latter being one of the most valuable assets of any insurer. In fact, the risk structure to which an insurance company is exposed can actually be deduced by reviewing its customer database. ... ...

Abstract	The foundation of the insurance business is built on data, the latter being one of the most valuable assets of any insurer. In fact, the risk structure to which an insurance company is exposed can actually be deduced by reviewing its customer database. It is not surprising, therefore, that access to real insurance datasets is very limited. This paper introduces and describes a dataset corresponding to a cross-section extraction of a real life-risk insurance portfolio. The dataset contains information on 76,102 policies and a total of 15 variables, including the capital at risk, the genders and dates of birth of the insured, and the effective and renewal dates of their policies. This dataset can be used both in teaching and in research. Combined with external life tables, the data available in the dataset can be used to build and compare pricing systems, to evaluate marketing strategies, in portfolio analysis, for calculations required by Solvency II regulations or for market benchmarking analysis. For example, the data from this dataset have been used in Pavía and Lledó to compare the classic pricing methodology based on annual life tables with a new pricing methodology based on life tables with less than annual periodicity Pavía and Lledó, specifically quarterly, and in Lledó et al. to demonstrate the impact that using a new methodology to manage catastrophic risks in life insurance would have in terms of solvency capital requirements.
Keywords	capital ; data collection ; databases ; life insurance ; markets ; periodicity ; risk ; Life-risk insurance ; Quarterly life tables ; Capital at risk ; Pricing ; Actuarial
Language	English
Dates of publication	2022-0929
Size	p. 108655
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108655
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Satisfaction assessment study in patients (and their partners) with/without Peyronie's disease and penile prosthesis implantation.

Lledó García, E / González García, F J / Jara Rascón, J / García Muñoz, J / Lledó Graell, E / Sánchez Ochoa, M A / Hernández Fernández, C

Actas urologicas espanolas

2024

Abstract: ... satisfied) (p > 0.05). However, when we evaluated the PD subgroup of patients with severe PD who require ... intercourse (p < 0.01) with predominance of moderately satisfied patients over very satisfied: 78% vs. 22 ... respectively (p < 0.01). Overall, 84% of Group 1 implants and 79% of Group 2 reported that they would undergo ...

Abstract	Introduction and objective: Among the many treatments for erectile dysfunction, implantation of a penile prosthesis has been associated with high patient satisfaction rates. However, patients with coexistent Peyronie's disease (PD) and refractory erectile dysfunction and/or severe deformities may show different results. The aim of our study was to assess and to compare the level of satisfaction, with an inflatable penile prosthesis (IPP), in men with/without coexistent PD. Material and methods: A survey study based on a five-item satisfaction questionnaire was submitted to all those live patients implanted in the period 1992-2022 at our center (n = 570) and their partners. Ninety-two percent of implants were inflatable devices. Surgeries were mainly performed by two surgeons. The main outcome measure used was the level of patient and partner satisfaction with sexual intercourse after IPP. Results: Of the 570 eligible patients, 479 (84%) completed the survey (393 Non-PD: GROUP 1; 70 non-complex PD-Group 2; 16 complex PD). Eighty-six per cent of patients in Group 1 reported satisfactory sexual intercourse (very or moderately satisfied). Non-complex PD implanted patients (Group 2) reported a global 81% satisfactory sexual intercourse (very or moderately satisfied) (p > 0.05). However, when we evaluated the PD subgroup of patients with severe PD who require incision/excision/grafting at the time of implant (Group 3: n = 20), only 61% reported satisfactory sexual intercourse (p < 0.01) with predominance of moderately satisfied patients over very satisfied: 78% vs. 22%). Additionally, 84% (Group 1), 80% (Group 2) and 54% (Group 3) of partners reported satisfactory intercourses, respectively (p < 0.01). Overall, 84% of Group 1 implants and 79% of Group 2 reported that they would undergo the procedure again if the IPP failed (p > 0.05; ns). Only 50% of Group 3 patients would do it again. With regard to cosmetic aspects, 48% of the Group 3 implant reported penile shortness or soft glans as the main causes of their dissatisfaction. Only 2.4% of total PP patients expressed difficulty in manipulating the device. Conclusion: The presence of PD alone may not impact PP patient and partner satisfaction, but patients with more severe baseline deformity who require incision/grafting may be less satisfied with outcomes including penile length and glans sensation.
Language	Spanish
Publishing date	2024-02-15
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5786
ISSN (online)	2173-5786
DOI	10.1016/j.acuroe.2024.02.003
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Article ; Online: Preoperative renal embolisation in patients with polycystic kidney disease requiring incisional hernia repair after renal transplantation.

Hurtado-Pardo, Luis / Bueno Lledó, Jose / Nieto-Sánchez, Marta / García-Pastor, Providencia

BMJ case reports

2023 Volume 16, Issue 9

Abstract: In the same way that renal transcatheter arterial embolisation (TAE) has demonstrated its effectiveness and safety compared with nephrectomy of the polycystic kidney at the time of transplantation, we propose that TAE can be a minimally invasive option ... ...

Abstract	In the same way that renal transcatheter arterial embolisation (TAE) has demonstrated its effectiveness and safety compared with nephrectomy of the polycystic kidney at the time of transplantation, we propose that TAE can be a minimally invasive option in the surgical preparation for incisional hernia repair in order to reduce the compressive effect of the polycystic kidney, creating space and ensuring safe hernia repair. The objective of this article is to describe the first case in which TAE is used in advance of incisional hernia secondary to renal transplantation in patients with autosomal dominant polycystic kidney disease.
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-256219
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Article ; Online: Assessment of Nutritional Quality of Products Sold in University Vending Machines According to the Front-of-Pack (FoP) Guide.

Lasala, Carmen / Durán, Antonio / Lledó, Daniel / Soriano, Jose M

Nutrients

2022 Volume 14, Issue 23

Abstract: ... science and humanities faculties, except for energy drinks (p < 0.05) and soft drinks (p < 0.05 ...

Abstract	The aim of this research was to assess the nutritional composition of 654 foods and beverages from vending machines on a University Campus. The guide called “Creating a front of pack nutrition label for pre-packed products sold through retail outlets” from the Department of Health (UK) was used to assess the nutritional composition and to compare values from food and beverage categories. A high proportion of food items had high−moderate content of nutrients related to chronic disease (93, 88, 74 and 49% had high−moderate content of fat, saturated fat, salt and sugar, respectively). On the other hand, a few beverages had high−moderate content of these nutrients, except for sugar (2% high to moderate in fat, 2% in saturated fat, 0% in salt and 39% in sugar). The most frequent food categories were chocolates and bars (10.6%) and breadsticks (8.4%), whereas the most available beverages were water (27.7%) and soft drinks (23.4%). There were no statistically significant differences in the proportion of categories between the health science and humanities faculties, except for energy drinks (p < 0.05) and soft drinks (p < 0.05). Vending machines contribute to an obesogenic environment and do not support healthy snacking. Recommendations in this article should be considered to develop official guidelines to ensure the wider availability of healthy dietary choices in vending machines in university settings.
MeSH term(s)	Humans ; Food Dispensers, Automatic ; Nutritive Value ; Universities ; Beverages ; Snacks ; Sugars
Chemical Substances	Sugars
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14235010
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Article ; Online: Risk factors and associated factors for calcaneal apophysitis (Sever's disease): a systematic review.

Nieto-Gil, Pilar / Marco-Lledó, Javier / García-Campos, Jonatan / Ruiz-Muñoz, María / Gijon-Nogueron, Gabriel / Ramos-Petersen, Laura

BMJ open

2023 Volume 13, Issue 6, Page(s) e064903

Abstract: Objectives: The aim of this review was to identify the potential intrinsic and extrinsic risk factors (RFs), associated factors (AFs) and consequences of developing calcaneal apophysitis (CA).: Design: Systematic review.: Data sources: Cochrane ... ...

Abstract	Objectives: The aim of this review was to identify the potential intrinsic and extrinsic risk factors (RFs), associated factors (AFs) and consequences of developing calcaneal apophysitis (CA). Design: Systematic review. Data sources: Cochrane Library, Embase, Medline Ovid, PubMed, Web of Science and Evidence, searched from inception to April 2021. Eligibility criteria: We included cohort, case-control and cross-sectional studies that were conducted in patients younger than 18 years who were exposed to RFs or who presented with factors associated with developing CA. Studies in languages other than English or Spanish were excluded. Data extraction and synthesis: Two reviewers worked independently to evaluate the risk of bias of included studies. The Newcastle-Ottawa Scale (adapted version) was used. Results: A total of 736 studies were identified and 11 observational studies fully met the inclusion criteria, including 1265 participants with a mean age of 10.72 years. Four studies identified extrinsic factors, 10 identified intrinsic factors and three identified both. The extrinsic and intrinsic RFs, AFs and consequences of CA include limitation of ankle dorsiflexion, foot alignment, stiffness and mobility of the midfoot, plantar pressures and ground reaction force, body mass index, age, gender, presence of other osteochondroses and practice of sport. The risk of bias varied, being either moderate or low. Conclusions: Regarding the factors and consequences associated with CA (Sever's disease), ankle dorsiflexion limitation is the most frequent intrinsic factor studied, followed by peak plantar pressures and foot malalignment. However, disagreements between the investigators of the included studies were found; in some cases, there is a lack of unanimity between different studies as to which factors are considered to be RFs, AFs and consequences. Prospero registration number: CRD42021246366.
MeSH term(s)	Humans ; Child ; Calcaneus ; Cross-Sectional Studies ; Foot ; Foot Diseases ; Risk Factors ; Osteitis
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-064903
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Article ; Online: Usefulness of high-frequency ultrasonography in the evaluation and monitoring of sclerosing dermatoses: a cohort study.

Marti-Marti, I / Morgado-Carrasco, D / Podlipnik, S / Rizo-Potau, D / Bosch-Amate, X / Lledó, G M / Suárez-Lledó, M / Espinosa, G / Martínez, C / Mascaró, J M / Giavedoni, P

Clinical and experimental dermatology

2021 Volume 47, Issue 2, Page(s) 351–358

Abstract: Background: Monitoring of disease activity in sclerosing dermatoses (SD) can be challenging and tools to support clinical decision-making are lacking.: Aim: To analyse the impact of high-frequency ultrasonography (HFUS) on the clinical management of ... ...

Abstract	Background: Monitoring of disease activity in sclerosing dermatoses (SD) can be challenging and tools to support clinical decision-making are lacking. Aim: To analyse the impact of high-frequency ultrasonography (HFUS) on the clinical management of SD and to describe the US characteristics of disease activity. Methods: This was a cohort study of patients with various SD [morphoea, systemic sclerosis (SS) and chronic graft-versus-host disease (cGvHD)] who underwent HFUS between January 2017 and August 2019. HFUS criteria for diagnosing active SD were increased Doppler vascularity and/or meeting all B-mode greyscale US signs of activity. Discordance in SD activity between HFUS and clinical examination was evaluated at the time of the first US assessment. Changes in patient management were instituted after HFUS were recorded. Results: In total, 72 patients (31 with morphoea, 19 with SS and 22 with cGvHD), who underwent 163 HFUS sessions in total, were included. All HFUS-active morphoea lesions exhibited increased vascularity, and all HFUS-active SS exhibited dermal thickening and dermal hypoechogenicity. HFUS-active cGvHD displayed increased dermal thickness and loss of definition of the dermal-hypodermal junction, and there were signs of panniculitis in 80% of cases and of increased vascularity in 70%. Discordance in disease activity between clinical and HFUS evaluation was found in 17 (23.6%) patients. Changes in clinical management after HFUS were made for 14 (19.4%) patients: treatment discontinuation for 6 patients (42.9%), treatment initiation for 5 (35.7%), medication change for 2 (14.3%) and skin biopsy taken for 1 (7.1%). Conclusion: HFUS seems an efficacious support tool in the monitoring of SD activity with a notable impact on clinical management. Further studies are warranted to evaluate the impact of HFUS-supported management changes on SD outcomes.
MeSH term(s)	Adult ; Aged ; Cohort Studies ; Female ; Graft vs Host Disease/diagnostic imaging ; Humans ; Male ; Middle Aged ; Scleroderma, Localized/diagnostic imaging ; Scleroderma, Systemic/diagnostic imaging ; Skin/diagnostic imaging ; Skin/pathology ; Ultrasonography/methods
Language	English
Publishing date	2021-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.14903
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Article ; Online: Long-term results with biosynthetic absorbable P4HB mesh in ventral abdominal wall repair: a multicentre analysis.

Bueno-Lledó, J / Porrero-Guerrero, B / Ferreira, F / Peña-Soria, M J / Sanz-Sánchez, M / Mansilla-Roselló, A / Souto, R / Rejón-López, R / Pous-Serrano, S

Hernia : the journal of hernias and abdominal wall surgery

2024

Abstract: ... The multivariate analysis showed that the onlay location of the mesh (OR 1.07; CI 1.42-2.70, p = 0.004) was a significant ...

Abstract	Background: The aim of this multicentre study was to analyse the outcomes of biosynthetic absorbable poly-4-hydroxybutyrate (P4HB) prosthesis implantation in patients undergoing ventral hernia repair (VHR) in the context of different degrees of contamination. Methods: From May 2016 to December 2021, a multicentre retrospective analysis of patients who underwent elective or urgent hernia repair with P4HB prosthesis was performed in seven hospitals in Spain and Portugal. Patients with a postoperative follow-up of less than 20 months and those within the theoretical period of prosthesis resorption were excluded from the study. Regarding the degree of contamination, patients were assessed according to the modified Ventral Hernia Working Group (VHWG) classification. Epidemiological data, hernia characteristics, surgical and postoperative variables (Clavien-Dindo classification) of these patients were analyzed. Risk factors related to long-term recurrence were studied by a multivariate analysis. Results: In 236 cases of P4HB prosthesis implantation, repair in cases of Grade 3 was the most frequent (49.1%), followed by Grade 2 in 42.3% of cases and Grade 1 in 8.4%. The most frequent complications were Grade 1, with the majority occurring during the first year. The overall rate of surgical site occurrences (SSO) was 30%. The hernia recurrence rate was 14.4% (n = 34), with a mean postoperative follow-up time of 41 months (22-61). The multivariate analysis showed that the onlay location of the mesh (OR 1.07; CI 1.42-2.70, p = 0.004) was a significant independent risk factor for recurrence. Conclusions: The use of a P4HB bioresorbable mesh for the VHR with different degrees of contamination leads to favourable results overall, with an acceptable rate of hernia recurrence. The onlay location of the P4HB prosthesis is the main factor in recurrence in both elective and emergency settings.
Language	English
Publishing date	2024-03-13
Publishing country	France
Document type	Journal Article
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-024-02981-6
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Article ; Online: Respiratory syncytial virus: A new era.

Ruiz-Galiana, J / Cantón, R / De Lucas Ramos, P / García-Botella, A / García-Lledó, A / Hernández-Sampelayo, T / Gómez-Pavón, J / González Del Castillo, J / Martín-Delgado, M C / Martín Sánchez, F J / Martínez-Sellés, M / Molero García, J M / Moreno Guillén, S / Rodríguez-Artalejo, F J / Rodríguez Fernandez, R / Kestler, M / Bouza, E

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2024 Volume 37, Issue 2, Page(s) 134–148

Abstract: Respiratory syncytial virus (RSV) is a major public health problem that has undergone significant changes in recent years. First of all, it has become easier to diagnose with highly reliable and rapidly available confirmatory tests. This has led to a ... ...

Abstract	Respiratory syncytial virus (RSV) is a major public health problem that has undergone significant changes in recent years. First of all, it has become easier to diagnose with highly reliable and rapidly available confirmatory tests. This has led to a better understanding of its epidemiology and RSV has gone from being a disease of the pediatric age group, severe only in infants and immunosuppressed children, to being a common disease in people of all ages, particularly important in patients of advanced age or with immunosuppressive diseases. Recent therapeutic and prophylactic advances, both with long-lasting monoclonal antibodies and vaccines, are another reason for satisfaction. For these reasons, the COVID and Emerging Pathogens Committee of the Illustrious Official College of Physicians of Madrid (ICOMEM) has considered it pertinent to review this subject in the light of new knowledge and new resources for dealing with this infection. We have formulated a series of questions that we believe will be of interest not only to members of the College but also to any non-expert in this subject, with a particular focus on the situation of RSV infection in Spain.
MeSH term(s)	Infant ; Humans ; Child ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Antibodies, Monoclonal/therapeutic use ; Spain/epidemiology
Chemical Substances	Antibodies, Monoclonal
Language	English
Publishing date	2024-01-11
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
DOI	10.37201/req/147.2023
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Zs.A 2833: Show issues

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Article: O-RADS MRI scoring system: key points for correct application in inexperienced hands.

Cabedo, Lledó / Sebastià, Carmen / Munmany, Meritxell / Fusté, Pere / Gaba, Lydia / Saco, Adela / Rodriguez, Adela / Paño, Blanca / Nicolau, Carlos

Insights into imaging

2024 Volume 15, Issue 1, Page(s) 107

Abstract: Objectives: To evaluate the efficacy of the O-RADS MRI criteria in the stratification of risk of malignancy of solid or sonographically indeterminate ovarian masses and assess the interobserver agreement of this classification between experienced and ... ...

Abstract	Objectives: To evaluate the efficacy of the O-RADS MRI criteria in the stratification of risk of malignancy of solid or sonographically indeterminate ovarian masses and assess the interobserver agreement of this classification between experienced and inexperienced radiologists. Methods: This single-centre retrospective study included patients from 2019 to 2022 with sonographically indeterminate or solid ovarian masses who underwent MRI with a specific protocol for characterisation according to O-RADS MRI specifications. Each study was evaluated using O-RADS lexicon by two radiologists, one with 17 years of experience in gynaecological radiology and another with 4 years of experience in general radiology. Findings were classified as benign, borderline, or malignant according to histology or stability over time. Diagnostic performance and interobserver agreement were assessed. Results: A total of 183 patients with US indeterminate or solid adnexal masses were included. Fifty-seven (31%) did not have ovarian masses, classified as O-RADS 1. The diagnostic performance for scores 2-5 was excellent with a sensitivity, specificity, PPV, and NPV of 97.4%, 100%, 96.2%, and 100%, respectively by the experienced radiologist and 96.1%, 92.0%, 93.9%, and 94.8% by the inexperienced radiologist. Interobserver concordance was very high (Kappa index 0.92). Almost all the misclassified cases were due to misinterpretation of the classification similar to reports in the literature. Conclusion: The diagnostic performance of O-RADS MRI determined by either experienced or inexperienced radiologists is excellent, facilitating decision-making with high diagnostic accuracy and high reproducibility. Knowledge of this classification and use of assessment tools could avoid frequent errors due to misinterpretation. Critical relevance statement: Up to 31% of ovarian masses are considered indeterminate by transvaginal US and 32% of solid lesions considered malignant by transvaginal US are benign. The O-RADs MRI accurately classifies these masses, even when used by inexperienced radiologists, thereby avoiding incorrect surgical approaches. Key points: • O-RADS MRI accurately classifies indeterminate and solid ovarian masses by ultrasound. • There is excellent interobserver agreement between experienced and non-experienced radiologists. • O-RADS MRI is a helpful tool to assess clinical decision-making in ovarian tumours.
Language	English
Publishing date	2024-04-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-024-01670-3
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