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  1. Article: Period Poverty: An Added Poverty In Humanitarian Crisis.

    Thaver, Inayat / Ashraf, Mariam

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73, Issue 9, Page(s) 1926–1927

    Language English
    Publishing date 2023-09-25
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.8089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Combined Photoactivated Chromophore for Infectious Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) and Therapeutic Penetrating Keratoplasty for Resistant Bacterial Keratitis.

    Bor'i, Ashraf / El-Haig, Wael M

    Clinical ophthalmology (Auckland, N.Z.)

    2022  Volume 16, Page(s) 273–279

    Abstract: Purpose: To report the results of treating resistant bacterial keratitis by corneal collagen cross-linking followed by therapeutic penetrating keratoplasty and to compare with those of therapeutic penetrating keratoplasty alone.: Methods: ... ...

    Abstract Purpose: To report the results of treating resistant bacterial keratitis by corneal collagen cross-linking followed by therapeutic penetrating keratoplasty and to compare with those of therapeutic penetrating keratoplasty alone.
    Methods: Retrospective analysis of the medical records of 33 eyes of 33 patients diagnosed with resistant bacterial keratitis. Fourteen eyes (14 patients) were treated with photoactivated chromophore for infectious keratitis corneal collagen cross-linking (PACK-CXL) followed by therapeutic penetrating keratoplasty (TPK) (group I) and 19 eyes (19 patients) were treated by TPK alone (group II). The main outcome measures were graft clarity and the mean best corrected visual acuity at 1, 3, 6, 12 and 18 months after penetrating keratoplasty.
    Results: The mean age of the patients was 53.6 ± 1.9 years and 52.3 ± 1.8 years in group I and group II, respectively (p = 0.374), the mean ulcer size was 49.9 ± 16.2 mm
    Conclusion: In resistant bacterial keratitis, priming infected corneas with PACK-CXL before performing TPK improve the results in such cases.
    Language English
    Publishing date 2022-02-03
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S348835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Infected Takayasu's arteritis presenting with aortic perforation.

    Lone, Hafeez U / Ashraf, Shady / Carr, Cornelia S / Bossom, Issam / Alkhulaifi, Abdulaziz M

    JRSM open

    2024  Volume 15, Issue 2, Page(s) 20542704231222735

    Abstract: We want to remind Physicians that unusual conditions can present in unusual ways and to keep an open mind always. ...

    Abstract We want to remind Physicians that unusual conditions can present in unusual ways and to keep an open mind always.
    Language English
    Publishing date 2024-02-21
    Publishing country England
    Document type Case Reports
    ZDB-ID 2762955-7
    ISSN 2054-2704
    ISSN 2054-2704
    DOI 10.1177/20542704231222735
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  4. Article ; Online: Elucidating the EXOSC3-IRE1α interaction: a convergent study incorporating computational,

    Ashraf, Ariha / Majeed, Younis / Gul, Irfan / Banday, Mariam / Ramzan, Khalida / Fazili, Khalid Majid

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–11

    Abstract: The Unfolded protein response (UPR) is an adaptive signalling pathway which is triggered by accumulation of unfolded/misfolded protein in ER lumen. The UPR consist of three transmembrane proteins-IRE1α, PERK and ATF6 that sense ER stress which leads to ... ...

    Abstract The Unfolded protein response (UPR) is an adaptive signalling pathway which is triggered by accumulation of unfolded/misfolded protein in ER lumen. The UPR consist of three transmembrane proteins-IRE1α, PERK and ATF6 that sense ER stress which leads to activation and downstream signaling from ER lumen to cytosol to restore homeostasis. IRE1α is an evolutionary conserved arm of UPR and acts as an interaction platform for many potential proteins that become activated under ER stress conditions. We investigated potential partners of IRE1 α through MS studies and found EXOSC3 as one of the binding partner of IRE1α. Exosomal complex proteins have 3'5' exonuclease properties (EXOSC3) that play an important role in mRNA surveillance. This property of exosomal proteins coincides with IRE1α ribonuclease activities and its mechanism of action is similar to that of IRE1α-RIDD pathway which degrades any unstable mRNA that disrupts cellular homeostasis. At the same time, studies have shown that knockdown of EXOSC3 causes ER stress in human cells, so we speculated that there might be a functional crosstalk between IRE1α and EXOSC3 under ER stress conditions. Therefore, we employed computational tools to predict and explore the stability and dynamics of the IRE1α-EXOSC3 complex. The analysis indicates that IRE1α and EXOSC3 exhibit potential interaction with the involvement of ScanNet, predicting binding pockets between the two proteins. Further, the interaction was validated
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2320252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Synthesis and Analysis of Euphorbia cognata Boiss-Assisted Organic-Inorganic Complex: Photosynthesis and Stabilization of CoO Nanoparticles.

    Iram, Sadia / Ahmad, Khuram Shahzad / Shaheen, Irum / Aljuwayid, Ahmed M / Ashraf, Ghulam Abbas

    Applied biochemistry and biotechnology

    2024  

    Abstract: Synthesis of metal oxide nanomaterials using phytochemicals has now been regarded as mutually exclusive to chemical synthesis techniques. Here, we have extracted, isolated, and characterized the phytochemicals of Euphorbia cognata Boiss leaf hydro- ... ...

    Abstract Synthesis of metal oxide nanomaterials using phytochemicals has now been regarded as mutually exclusive to chemical synthesis techniques. Here, we have extracted, isolated, and characterized the phytochemicals of Euphorbia cognata Boiss leaf hydro-organic extract and utilized them as biofuel in the preparation of metal oxide nanoparticles (CoO NPs). To evaluate the chemical composition of bio templates, chromatographic techniques like high-performance liquid chromatography (HPLC) and gas chromatography-mass spectroscopy (GC-MS) were being utilized. The reducing properties of the organic fuel were investigated by efficiently synthesizing CoO NPs by treating aqueous plant extract with an aqueous complex of Co(NO
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-024-04939-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3053: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Synergistic antibacterial activity of carvacrol loaded chitosan nanoparticles with Topoisomerase inhibitors and genotoxicity evaluation.

    Akhlaq, Amina / Ashraf, Muhammad / Ovais Omer, Muhammad / Altaf, Imran

    Saudi journal of biological sciences

    2023  Volume 30, Issue 9, Page(s) 103765

    Abstract: The increasing prevalence of antibiotic resistant bacteria is a significant healthcare crisis with substantial socioeconomic impact on global community. The development of new antibiotics is both costly and time-consuming prompting the exploration of ... ...

    Abstract The increasing prevalence of antibiotic resistant bacteria is a significant healthcare crisis with substantial socioeconomic impact on global community. The development of new antibiotics is both costly and time-consuming prompting the exploration of alternative solutions such as nanotechnology which represents opportunities for targeted drug delivery and reduced MIC. However, concerns have arisen regarding genotoxic effects of nanoparticles on human health necessitating an evaluation of nanoparticle induced DNA damage. This study aimed to investigate the antibacterial potential of already prepared, characterized chitosan nanoparticles loaded with carvacrol and their potential synergism with Topoisomerase II inhibitors against
    Language English
    Publishing date 2023-08-06
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 2515206-3
    ISSN 2213-7106 ; 1319-562X
    ISSN (online) 2213-7106
    ISSN 1319-562X
    DOI 10.1016/j.sjbs.2023.103765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unravelling of the genetic diversity, population structure, and phylogenetic relationships of the indigenous horse breeds of Pakistan.

    Sohail Ashraf, Muhammad / Basheer, Atia / Iqbal, Farheena / Zahoor, Imran

    Gene

    2023  Volume 889, Page(s) 147736

    Abstract: The current study aimed to evaluate the genetic diversity, level of admixture, and phylogenetic relationship, of the Pakistani horse breeds, along with their morphological characterization. Data for the body measurements showed that Morna horses had the ... ...

    Abstract The current study aimed to evaluate the genetic diversity, level of admixture, and phylogenetic relationship, of the Pakistani horse breeds, along with their morphological characterization. Data for the body measurements showed that Morna horses had the highest values of body height, body length, chest girth, leg length, and head length, whereas the Baluchi horses had the lowest values for these traits. For the genetic diversity 64 animals, 15/breed except for Baluchi(14) and Topras(05), were genotyped by using the 17-plex equine genotyping kit. The AMOVA results showed that 13% of genetic diversity was explained by breed differences, whereas 27% and 60% came from among and within individuals respectively. The highest values of genetic diversity parameters including Na(7.29±0.29), Ne(5.73±0.28), Ho(0.74±0.05) and He(0.82±0.01) were observed for Morna, whereas their lowest values were found for Topras. However, the highest value of inbreeding coefficient (Fis) was found for Baluchi and the lowest for KB horses. Among the markers, CA425 was found as the most polymorphic and ASB23 as the least polymorphic and highly fixed marker. Results of structure analysis revealed that, except Topras, each local horse breed had very admixed genetic structure perhaps due to their continuous crossing with other breeds in the past. Moreover, the structure analysis also showed that Morna and Shiean breeds had mixing of each other which was also confirmed by the lowest value of their pairwise Fst values and likewise the phylogenetic analysis also showed their close genetic relationship with each other. The phylogenetic analysis also revealed that Shiean breed had close genetic relationship with Arabian horses. Collectively, our data showed that Morna is the largest and genetically most diverse horse breed of Pakistan, whereas Baluchi horses are the smallest in size and have the highest values of inbreeding coefficient. And the phylogeny analysis showed that Shiean breed had close genetic relationship with the Arabian.
    Language English
    Publishing date 2023-09-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2023.147736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Detection of Drowsiness among Drivers Using Novel Deep Convolutional Neural Network Model.

    Majeed, Fiaz / Shafique, Umair / Safran, Mejdl / Alfarhood, Sultan / Ashraf, Imran

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 21

    Abstract: Detecting drowsiness among drivers is critical for ensuring road safety and preventing accidents caused by drowsy or fatigued driving. Research on yawn detection among drivers has great significance in improving traffic safety. Although various studies ... ...

    Abstract Detecting drowsiness among drivers is critical for ensuring road safety and preventing accidents caused by drowsy or fatigued driving. Research on yawn detection among drivers has great significance in improving traffic safety. Although various studies have taken place where deep learning-based approaches are being proposed, there is still room for improvement to develop better and more accurate drowsiness detection systems using behavioral features such as mouth and eye movement. This study proposes a deep neural network architecture for drowsiness detection employing a convolutional neural network (CNN) for driver drowsiness detection. Experiments involve using the DLIB library to locate key facial points to calculate the mouth aspect ratio (MAR). To compensate for the small dataset, data augmentation is performed for the 'yawning' and 'no_yawning' classes. Models are trained and tested involving the original and augmented dataset to analyze the impact on model performance. Experimental results demonstrate that the proposed CNN model achieves an average accuracy of 96.69%. Performance comparison with existing state-of-the-art approaches shows better performance of the proposed model.
    MeSH term(s) Automobile Driving ; Neural Networks, Computer ; Wakefulness ; Accidents, Traffic/prevention & control ; Eye Movements
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23218741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells.

    Akhlaq, Amina / Ashraf, Muhammad / Omer, Muhammad Ovais / Altaf, Imran

    ACS omega

    2023  Volume 8, Issue 35, Page(s) 31826–31838

    Abstract: Breast and cervical cancers are the most common heterogeneous malignancies in women. Chemotherapy with conventional drug delivery systems having several limitations along with development of multidrug resistance compelled us to seek out targeted ... ...

    Abstract Breast and cervical cancers are the most common heterogeneous malignancies in women. Chemotherapy with conventional drug delivery systems having several limitations along with development of multidrug resistance compelled us to seek out targeted therapeutics. Nanoparticles are suitable substitutes to circumvent multidrug resistance for the targeted treatment of cancer. The current study was aimed to investigate the anticancer effect of carvacrol-loaded chitosan nanoparticles with topoisomerase inhibitors. The average size of carvacrol-loaded chitosan nanoparticles was found to be 80 nm with 24.7 mV ζ-potential, and maximum absorbance was observed at 275 nm. Among all drug combinations, the carvacrol nanoparticles with the doxorubicin combination group exerted greater dose-dependent growth inhibition of both MCF-7 and HeLa cells as compared to single carvacrol nanoparticles and doxorubicin. Combination index values of carvacrol nanoparticles and the doxorubicin combination group showed a strong synergistic effect as they were found to be between 0.2 and 0.4, 0.31 for MCF-7 and 0.34 for HeLa cells. The carvacrol nanoparticles in combination with doxorubicin on MCF-7 cells reduced the dose 16.32-fold for carvacrol nanoparticles and 4.09-fold for doxorubicin at 6.23 μg/mL IC
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c03337
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A machine learning-based Biding price optimization algorithm approach.

    Ahmad, Saleem / Salem, Sultan / Khan, Yousaf Ali / Ashraf, I M

    Heliyon

    2023  Volume 9, Issue 10, Page(s) e20583

    Abstract: Trading companies of used product market are struggling to gain customers attentaion and to sell the products. The aim of this research is to develop a mechanism that can maximize the sale of products while considering profit implications. The literature ...

    Abstract Trading companies of used product market are struggling to gain customers attentaion and to sell the products. The aim of this research is to develop a mechanism that can maximize the sale of products while considering profit implications. The literature review classifies the procurement mechanism. Given the limited-supply nature, that also includes unpredictable quality levels and a procurement mechanism that perceives the company offering prices to suppliers on a single-item basis. The academic literature has not covered such a mechanism. Techniques like those that improve the required bidding strategy are reviewed and considered fit to be included in the support tool as the procedures intention to maximize an objective function depending on the bidding price and contain the probability of winning the auction and the profit made from the proceeding, the motivation laid on the approach that predicts the probability. It is determined that this assembles a Response to Reverse Request for Quotation that meets the assumptions of a First-Price Sealed-Bid(FPSD) auction that potentially includes a hidden reservation price.
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e20583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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