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  1. Book: Alexander Fleming og penicillinet

    Hartmann-Petersen, P

    (Ideernes bagmænd)

    2006  

    Author's details af Preben Hartmann-Petersen
    Series title Ideernes bagmænd
    MeSH term(s) Bacteriology ; History, 20th Century ; Penicillins/history
    Language Danish
    Size 93 p. :, ill., ports.
    Edition 1. udg.
    Publisher Polyteknisk
    Publishing place Lyngby
    Document type Book
    ISBN 9788750209805 ; 8750209809
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Book ; Thesis: Langzeitüberleben nach einem erneuten Aortenklappenersatz

    Hartmann, Alexander

    2012  

    Author's details vorgelegt von Alexander Hartmann
    Language German
    Size [3], 82 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2012
    HBZ-ID HT017519139
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 E 48 order for loan Magazin

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  3. Book ; Thesis: Transkutan gemessener Kohlenstoffdioxidpartialdruck als Möglichkeit des Monitorings bei intensivpflichtigen Patienten im Prozess der Beatmungsentwöhnung

    Börner, Kai / Hartmann, Alexander

    2018  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Kai Börner ; 1. Gutachter: Prof. Dr. med. Alexander Hartmann
    Language German
    Size 108 Seiten, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2018
    HBZ-ID HT019844330
    Database Catalogue ZB MED Medicine, Health

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    2018 D 981 order for loan Magazin

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  4. Article: Novel mutations in exon 6 of the GFAP gene affect a highly conserved if motif in the rod domain 2B and are associated with early onset infantile Alexander disease.

    Hartmann, H / Herchenbach, J / Stephani, U / Ledaal, P / Donnerstag, F / Lücke, T / Das, A M / Christen, H J / Hagedorn, M / Meins, M

    Neuropediatrics

    2007  Volume 38, Issue 3, Page(s) 143–147

    Abstract: Alexander disease is a rare disorder of cerebral white matter due to a dysfunction of astrocytes ... encoding Glial Fibrillary Acidic Protein, have been recognized as the cause of Alexander ... Alexander disease with early onset and severe course, caused by DE NOVO mutations A364 V and Y366C. Both affected ...

    Abstract Alexander disease is a rare disorder of cerebral white matter due to a dysfunction of astrocytes. The most common infantile form presents as a megalencephalic leukodystrophy. Mutations of the GFAP gene, encoding Glial Fibrillary Acidic Protein, have been recognized as the cause of Alexander disease. Glial Fibrillary Acidic Protein is the major intermediate filament protein in astrocytes, its functional rod domain is conserved in sequence and structure among other intermediate filament proteins. We report here two cases of infantile Alexander disease with early onset and severe course, caused by DE NOVO mutations A364 V and Y366C. Both affected GFAP residues are part of a highly conserved coiled-coil trigger motif in the C-terminal end of segment 2B, probably required for the stability of intermediate filament molecules. Comparable effects are seen with mutations of the corresponding residues of the gene coding for keratin 14, another intermediate filament, this further supports the hypothesis that these positions of the trigger motif are generally critical for a normal function of intermediate filaments.
    MeSH term(s) Age of Onset ; Alanine/genetics ; Alexander Disease/genetics ; Alexander Disease/pathology ; Cysteine/genetics ; DNA Mutational Analysis/methods ; Exons/genetics ; Female ; Frontal Lobe/pathology ; Glial Fibrillary Acidic Protein/genetics ; Humans ; Infant ; Magnetic Resonance Imaging/methods ; Male ; Mutation/genetics ; Protein Structure, Tertiary/genetics ; Tyrosine/genetics ; Valine/genetics
    Chemical Substances Glial Fibrillary Acidic Protein ; Tyrosine (42HK56048U) ; Valine (HG18B9YRS7) ; Cysteine (K848JZ4886) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2007-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-2007-985902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 728: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Thesis: Ergebnisse der Frührehabilitation nach intrazerebraler Blutung

    Nikolos, Jacqueline / hartmann, Alexander

    2020  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Jacqueline Veronika Nikolos, geb. Jania ; 1. Gutachter: Prof. Dr. med. Alexander Hartmann
    Language German
    Size 103 Seiten, Illustrationen, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2020
    HBZ-ID HT020618476
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 D 127 order for loan Magazin

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  6. Book ; Online ; E-Book: Gesunde Führung

    Häfner, Alexander / Pinneker, Lydia / Hartmann-Pinneker, Julia

    Gesundheit, Motivation und Leistung fördern

    2019  

    Author's details Alexander Häfner, Lydia Pinneker, Julia Hartmann-Pinneker
    Language German
    Size 1 Online-Ressource (X, 303 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020123055
    ISBN 978-3-662-58751-5 ; 9783662587508 ; 3-662-58751-3 ; 3662587505
    DOI 10.1007/978-3-662-58751-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Optimized finite-time work protocols for the Higgs RNA model with external force.

    Werner, Peter / Hartmann, Alexander K

    Physical review. E

    2024  Volume 109, Issue 4-1, Page(s) 44127

    Abstract: The Higgs RNA model with an added term for a coupling to an external force is studied in regard to finite-time force-driving protocols with a minimal-work requirement. In this paper, RNA sequences which at low temperature exhibit hairpins are considered, ...

    Abstract The Higgs RNA model with an added term for a coupling to an external force is studied in regard to finite-time force-driving protocols with a minimal-work requirement. In this paper, RNA sequences which at low temperature exhibit hairpins are considered, which are often cited as typical template systems in stochastic thermodynamics. The optimized work protocols for this glassy many-particle system are determined numerically using the parallel tempering method. The protocols show distinct jumps at the beginning and end, which have been observed for single-particle systems and are proven to be optimal in the fast protocol limit generally. Optimality seems to be achieved by staying close to the equilibrium unfolding transition point, in agreement with experimental and theoretical observations. The change of work distributions, compared to those resulting from a naive linear driving protocol, are discussed generally and in terms of free energy estimation as well as the effect of optimized protocols on rare work process starting conditions.
    Language English
    Publishing date 2024-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.109.044127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Novel Mutations in Exon 6 of the GFAP Gene Affect a Highly Conserved IF Motif in the Rod Domain 2B and are Associated with Early Onset Infantile Alexander Disease

    Hartmann, H. / Herchenbach, J. / Stephani, U. / Ledaal, P. / Donnerstag, F. / Lücke, T. / Das, A. M. / Christen, H. J. / Hagedorn, M. / Meins, M.

    Neuropediatrics

    2007  Volume 38, Issue 03, Page(s) 143–147

    Abstract: Alexander disease is a rare disorder of cerebral white matter due to a dysfunction of astrocytes ... encoding Glial Fibrillary Acidic Protein, have been recognized as the cause of Alexander ... Alexander disease with early onset and severe course, caused by DE NOVO mutations A364 V and Y366C. Both affected ...

    Abstract Alexander disease is a rare disorder of cerebral white matter due to a dysfunction of astrocytes. The most common infantile form presents as a megalencephalic leukodystrophy. Mutations of the GFAP gene, encoding Glial Fibrillary Acidic Protein, have been recognized as the cause of Alexander disease. Glial Fibrillary Acidic Protein is the major intermediate filament protein in astrocytes, its functional rod domain is conserved in sequence and structure among other intermediate filament proteins. We report here two cases of infantile Alexander disease with early onset and severe course, caused by DE NOVO mutations A364 V and Y366C. Both affected GFAP residues are part of a highly conserved coiled-coil trigger motif in the C-terminal end of segment 2B, probably required for the stability of intermediate filament molecules. Comparable effects are seen with mutations of the corresponding residues of the gene coding for keratin 14, another intermediate filament, this further supports the hypothesis that these positions of the trigger motif are generally critical for a normal function of intermediate filaments.
    Keywords Alexander disease ; glial fibrillary acidic protein ; intermediate filament ; leukodystrophy ; epilepsy
    Language English
    Publishing date 2007-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 573291-8
    ISSN 1439-1899 ; 0174-304X
    ISSN (online) 1439-1899
    ISSN 0174-304X
    DOI 10.1055/s-2007-985902
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 728: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Acyclovir-resistant HSV-2 induced genital ulcerations.

    Kälber, Katharina Anna / Enk, Alexander / Hartmann, Martin

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2024  

    Language English
    Publishing date 2024-04-28
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15397
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 6148: Show issues Location:
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  10. Article ; Online: Large-deviations of disease spreading dynamics with vaccination.

    Feld, Yannick / Hartmann, Alexander K

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0287932

    Abstract: We numerically simulated the spread of disease for a Susceptible-Infected-Recovered (SIR) model on contact networks drawn from a small-world ensemble. We investigated the impact of two types of vaccination strategies, namely random vaccination and high- ... ...

    Abstract We numerically simulated the spread of disease for a Susceptible-Infected-Recovered (SIR) model on contact networks drawn from a small-world ensemble. We investigated the impact of two types of vaccination strategies, namely random vaccination and high-degree heuristics, on the probability density function (pdf) of the cumulative number C of infected people over a large range of its support. To obtain the pdf even in the range of probabilities as small as 10-80, we applied a large-deviation approach, in particular the 1/t Wang-Landau algorithm. To study the size-dependence of the pdfs within the framework of large-deviation theory, we analyzed the empirical rate function. To find out how typical as well as extreme mild or extreme severe infection courses arise, we investigated the structures of the time series conditioned to the observed values of C.
    MeSH term(s) Humans ; Epidemics ; Models, Biological ; Disease Susceptibility/epidemiology ; Vaccination ; Likelihood Functions
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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