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  1. Article: Extracellular vesicles: important players in immune homeostasis.

    Isola, Allison L / Chen, Suzie

    Annals of translational medicine

    2017  Volume 5, Issue Suppl 1, Page(s) S16

    Language English
    Publishing date 2017-05-17
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2017.03.76
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exosomes: The Messengers of Health and Disease.

    Isola, Allison L / Chen, Suzie

    Current neuropharmacology

    2016  Volume 15, Issue 1, Page(s) 157–165

    Abstract: Exosomes are small vesicles comprised of a lipid bilayer containing various proteins, RNAs and bioactive lipids. They act as intercellular messengers that give the ability to communicate between both cells of the same type and other cell types. They are ... ...

    Abstract Exosomes are small vesicles comprised of a lipid bilayer containing various proteins, RNAs and bioactive lipids. They act as intercellular messengers that give the ability to communicate between both cells of the same type and other cell types. They are released by healthy cells, both constitutively and upon cell activation and play an important role in immune system function. Exosomes are essential for healthy physiological conditions, however under pathological circumstances, they act to potentiate cellular stress and damage. This review explores the characteristics, biogenesis, role(s) in the pathogenesis of diseases and role(s) in progression of cancer of these nano-sized messages-in-a-vesicle: exosomes.
    MeSH term(s) Animals ; Biological Transport/physiology ; Cell Communication/physiology ; Disease Progression ; Exosomes/physiology ; Humans ; Neoplasms/pathology ; Neoplasms/physiopathology ; Organelle Biogenesis ; Secretory Vesicles
    Language English
    Publishing date 2016-08-17
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159x14666160825160421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Exosomes: The Link between GPCR Activation and Metastatic Potential?

    Isola, Allison L / Chen, Suzie

    Frontiers in genetics

    2016  Volume 7, Page(s) 56

    Abstract: The activation of G-Protein Coupled Receptors (GPCRs) by their respective ligands initiates a cascade of multiple signaling processes within the cell, regulating growth, metabolism and other essential cellular functions. Dysregulation and aberrant ... ...

    Abstract The activation of G-Protein Coupled Receptors (GPCRs) by their respective ligands initiates a cascade of multiple signaling processes within the cell, regulating growth, metabolism and other essential cellular functions. Dysregulation and aberrant expression of these GPCRs and their subsequent signaling cascades are associated with many different types of pathologies, including cancer. The main life threatening complication in patients diagnosed with cancer is the dissemination of cells from the primary tumor to distant vital organs within the body, metastasis. Communication between the primary tumor, immune system, and the site of future metastasis are some of the key events in the early stages of metastasis. It has been postulated that the communication is mediated by nanovesicles that, under non-pathological conditions, are released by normal cells to relay signals to other cells in the body. These nanovesicles are called exosomes, and are utilized by the tumor cell to influence changes within the recipient cell, such as bone marrow progenitor cells, and cells within the site of future metastatic growth, in order to prepare the site for colonization. Tumor cells have been shown to release an increased number of exosomes when compared to their normal cell counterpart. Exosome production and release are regulated by proteins involved in localization, degradation and size of the multivesicular body, whose function may be altered within cancer cells, resulting in the release of an increased number of these vesicles. This review investigates the possibility of GPCR signaling cascades acting as the upstream activator of proteins involved in exosome production and release, linking a commonly targeted trans-membrane protein class with cellular communication utilized by tumor cells in early stages of metastasis.
    Language English
    Publishing date 2016-04-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2016.00056
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  4. Article: Biology, Therapy and Implications of Tumor Exosomes in the Progression of Melanoma.

    Isola, Allison L / Eddy, Kevinn / Chen, Suzie

    Cancers

    2016  Volume 8, Issue 12

    Abstract: Cancer is the second leading cause of death in the United States, and about 6% of the estimated cancer diagnoses this year will be melanoma cases. Melanomas are derived from transformation of the pigment producing cells of the skin, melanocytes. Early ... ...

    Abstract Cancer is the second leading cause of death in the United States, and about 6% of the estimated cancer diagnoses this year will be melanoma cases. Melanomas are derived from transformation of the pigment producing cells of the skin, melanocytes. Early stage melanoma is usually curable by surgical resection, but late stage or subsequent secondary metastatic tumors are treated with some success with chemotherapies, radiation and/or immunotherapies. Most cancer patients die from metastatic disease, which is especially the case in melanoma. A better understanding of tumor metastasis will provide insights and guide rational therapeutic designs. Recently, the importance of melanoma-derived exosomes in the progression of that cancer has become more apparent, namely, their role in various stages of metastasis, including the induction of migration, invasion, primary niche manipulation, immune modulation and pre-metastatic niche formation. This review focuses on the critical roles that melanoma exosomes play in the progression of this deadly disease.
    Language English
    Publishing date 2016-12-09
    Publishing country Switzerland
    Document type Review ; Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers8120110
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  5. Article ; Online: Biology, Therapy and Implications of Tumor Exosomes in the Progression of Melanoma

    Allison L. Isola / Kevinn Eddy / Suzie Chen

    Cancers, Vol 8, Iss 12, p

    2016  Volume 110

    Abstract: Cancer is the second leading cause of death in the United States, and about 6% of the estimated cancer diagnoses this year will be melanoma cases. Melanomas are derived from transformation of the pigment producing cells of the skin, melanocytes. Early ... ...

    Abstract Cancer is the second leading cause of death in the United States, and about 6% of the estimated cancer diagnoses this year will be melanoma cases. Melanomas are derived from transformation of the pigment producing cells of the skin, melanocytes. Early stage melanoma is usually curable by surgical resection, but late stage or subsequent secondary metastatic tumors are treated with some success with chemotherapies, radiation and/or immunotherapies. Most cancer patients die from metastatic disease, which is especially the case in melanoma. A better understanding of tumor metastasis will provide insights and guide rational therapeutic designs. Recently, the importance of melanoma-derived exosomes in the progression of that cancer has become more apparent, namely, their role in various stages of metastasis, including the induction of migration, invasion, primary niche manipulation, immune modulation and pre-metastatic niche formation. This review focuses on the critical roles that melanoma exosomes play in the progression of this deadly disease.
    Keywords cancer ; melanoma ; metastasis ; exosomes ; melanoma exosomes ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2016-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A Spontaneous Melanoma Mouse Model Applicable for a Longitudinal Chemotherapy and Immunotherapy Study.

    Eddy, Kevinn / Gupta, Kajal / Pelletier, Jeffrey C / Isola, Allison L / Marinaro, Christina / Rasheed, Maryam Abdur / Campagnolo, Joseph / Eddin, Mohamad Naser / Rossi, Marco / Fateeva, Anna / Reuhl, Kenneth / Shah, Raj / Robinson, Ann K / Chaly, Anna / Freeman, Katie B / Chen, Wenjin / Diaz, Jesus / Furmanski, Philip / Silk, Ann W /
    Reitz, Allen B / Zloza, Andrew / Chen, Suzie

    The Journal of investigative dermatology

    2023  Volume 143, Issue 10, Page(s) 2007–2018.e6

    Abstract: Mouse models that reflect human disorders provide invaluable tools for the translation of basic science discoveries to clinical therapies. However, many of these in vivo therapeutic studies are short term and do not accurately mimic patient conditions. ... ...

    Abstract Mouse models that reflect human disorders provide invaluable tools for the translation of basic science discoveries to clinical therapies. However, many of these in vivo therapeutic studies are short term and do not accurately mimic patient conditions. In this study, we used a fully immunocompetent, transgenic mouse model, TGS, in which the spontaneous development of metastatic melanoma is driven by the ectopic expression of a normal neuronal receptor, mGluR1, as a model to assess longitudinal treatment response (up to 8 months) with an inhibitor of glutamatergic signaling, troriluzole, which is a prodrug of riluzole, plus an antibody against PD-1, an immune checkpoint inhibitor. Our results reveal a sex-biased treatment response that led to improved survival in troriluzole and/or anti-PD-1-treated male mice that correlated with differential CD8
    MeSH term(s) Male ; Humans ; Mice ; Animals ; CD8-Positive T-Lymphocytes ; Melanoma/pathology ; Immunotherapy/methods
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2023.03.1664
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Exosomes released by metabotropic glutamate receptor 1 (GRM1) expressing melanoma cells increase cell migration and invasiveness.

    Isola, Allison L / Eddy, Kevinn / Zembrzuski, Krzysztof / Goydos, James S / Chen, Suzie

    Oncotarget

    2017  Volume 9, Issue 1, Page(s) 1187–1199

    Abstract: Exosomes are naturally occurring membrane-bound nanovesicles generated constitutively and released by various cell types, and often in higher quantities by tumor cells. Exosomes may facilitate communication between the primary tumor and its local ... ...

    Abstract Exosomes are naturally occurring membrane-bound nanovesicles generated constitutively and released by various cell types, and often in higher quantities by tumor cells. Exosomes may facilitate communication between the primary tumor and its local microenvironment, supporting cell invasion and other early events in metastasis. A neuronal receptor, metabotropic glutamate receptor 1 (GRM1), when ectopically expressed in melanocytes, induces
    Language English
    Publishing date 2017-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.23455
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  8. Article ; Online: Comparison of PAC and MOAH for understanding the carcinogenic and developmental toxicity potential of mineral oils.

    Carrillo, Juan-Carlos / Kamelia, Lenny / Romanuka, Julija / Kral, Olaf / Isola, Allison / Niemelä, Helena / Steneholm, Anna

    Regulatory toxicology and pharmacology : RTP

    2022  Volume 132, Page(s) 105193

    Abstract: The carcinogenicity and developmental toxicity of unrefined mineral oil is related to its 3-7 ring polycyclic aromatic compounds (PAC) content. Therefore, refining operations focus on the targeted removal PAC from mineral oil that may contain aromatics ... ...

    Abstract The carcinogenicity and developmental toxicity of unrefined mineral oil is related to its 3-7 ring polycyclic aromatic compounds (PAC) content. Therefore, refining operations focus on the targeted removal PAC from mineral oil that may contain aromatics of low toxicological concern. There are thus, two types of aromatic substances in mineral oil: hazardous and non-hazardous. The first type consists of 3-7 ring PAC which may be naked (unsubstituted) or lowly alkylated. The second type or non-hazardous consists of 1-7 ring aromatics with high degree of alkylation or lack of bay or fjord regions. Although these are toxicologically different, they may both elute in the same fraction when using chromatography. To understand how these two aromatic types are related we have assessed the entire mineral oil refinement process by measuring total mineral oil aromatic hydrocarbons (MOAH) content by chromatography next to regulatory hazard tests which focus on 3-7 ring PAC. MOAH content is positively correlated to its molecular weight resulting in aromatic content bias for high viscosity substances. Hazard to 3-7 ring PAC is best controlled by the validated IP346 or modified Ames test. We explain the concept of high vs low alkylation by shortly reviewing new data on alkylated PAC.
    MeSH term(s) Carcinogenesis ; Carcinogens/toxicity ; Humans ; Hydrocarbons, Aromatic/analysis ; Mineral Oil/chemistry ; Mineral Oil/toxicity ; Minerals ; Oils ; Polycyclic Compounds
    Chemical Substances Carcinogens ; Hydrocarbons, Aromatic ; Minerals ; Oils ; Polycyclic Compounds ; Mineral Oil (8020-83-5)
    Language English
    Publishing date 2022-05-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2022.105193
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Methylation of histone H3 on lysine 4 by the lysine methyltransferase SET1 protein is needed for normal clock gene expression.

    Raduwan, Hamidah / Isola, Allison L / Belden, William J

    The Journal of biological chemistry

    2013  Volume 288, Issue 12, Page(s) 8380–8390

    Abstract: The circadian oscillator controls time-of-day gene expression by a network of interconnected feedback loops and is reset by light. The requisite for chromatin regulation in eukaryotic transcription necessitates temporal regulation of histone-modifying ... ...

    Abstract The circadian oscillator controls time-of-day gene expression by a network of interconnected feedback loops and is reset by light. The requisite for chromatin regulation in eukaryotic transcription necessitates temporal regulation of histone-modifying and chromatin-remodeling enzymes for proper clock function. CHD1 is known to bind H3K4me3 in mammalian cells, and Neurospora CHD1 is required for proper regulation of the frequency (frq) gene. Based on this, we examined a strain lacking SET1 to determine the role of H3K4 methylation in clock- and light-mediated frq regulation. Expression of frq was altered in strains lacking set1 under both circadian- and light-regulated gene expression. There is a delay in the phasing of H3K4me3 relative to the peak in frq expression. White Collar 2 (WC-2) association with the frq promoter persists longer in Δset1, suggesting a more permissible chromatin state. Surprisingly, SET1 is required for DNA methylation in the frq promoter, indicating a dependence on H3K4me for DNA methylation. The data support a model where SET1 is needed for proper regulation by modulating chromatin at frq.
    MeSH term(s) Circadian Rhythm ; DNA Methylation ; DNA-Binding Proteins/metabolism ; Epigenesis, Genetic ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Fungal Proteins/physiology ; Gene Expression Regulation, Fungal/radiation effects ; Gene Knockout Techniques ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Histone-Lysine N-Methyltransferase/physiology ; Histones/metabolism ; Light ; Methylation ; Neurospora crassa/enzymology ; Neurospora crassa/genetics ; Neurospora crassa/physiology ; Neurospora crassa/radiation effects ; Protein Processing, Post-Translational ; Spores, Fungal/enzymology ; Spores, Fungal/genetics ; Spores, Fungal/physiology ; Spores, Fungal/radiation effects ; Transcription Factors/metabolism
    Chemical Substances DNA-Binding Proteins ; FRQ protein, Neurospora crassa ; Fungal Proteins ; Histones ; Transcription Factors ; white collar 2 protein, Neurospora ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
    Language English
    Publishing date 2013-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M112.359935
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