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  1. Article: RAD51 wrestles with SUMO.

    Kee, Younghoon / Lee, Jung-Hee / You, Ho Jin

    Molecular & cellular oncology

    2022  Volume 9, Issue 1, Page(s) 2054263

    Abstract: RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS ... ...

    Abstract RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2022.2054263
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  2. Article: Putting the brakes on transcription at damaged chromatin: Do Polycomb silencers do more than modify histones?

    Kee, Younghoon

    Molecular & cellular oncology

    2016  Volume 3, Issue 6, Page(s) e1244513

    Abstract: One of the cellular responses to DNA damage is to monitor and execute temporary arrest of RNA synthesis at chromatin lesions. The Polycomb silencer BMI1 is a well-known contributor to this process. We recently described a new mode of BMI1-mediated ... ...

    Abstract One of the cellular responses to DNA damage is to monitor and execute temporary arrest of RNA synthesis at chromatin lesions. The Polycomb silencer BMI1 is a well-known contributor to this process. We recently described a new mode of BMI1-mediated transcription arrest at lesions that involves UBR5 E3 ligase and FACT histone chaperon.
    Language English
    Publishing date 2016-10-14
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2016.1244513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unveiling the Chemical Diversity of the Deep-Sea Sponge

    Afoullouss, Sam / Sanchez, Anthony R / Jennings, Laurence K / Kee, Younghoon / Allcock, A Louise / Thomas, Olivier P

    Marine drugs

    2022  Volume 20, Issue 1

    Abstract: Sponges are at the forefront of marine natural product research. In the deep sea, extreme conditions have driven secondary metabolite pathway evolution such that we might expect deep-sea sponges to yield a broad range of unique natural products. Here, we ...

    Abstract Sponges are at the forefront of marine natural product research. In the deep sea, extreme conditions have driven secondary metabolite pathway evolution such that we might expect deep-sea sponges to yield a broad range of unique natural products. Here, we investigate the chemodiversity of a deep-sea tetractinellid sponge,
    MeSH term(s) Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Aquatic Organisms ; Female ; HeLa Cells/drug effects ; Humans ; Porifera ; Uterine Cervical Neoplasms/pathology ; Vitamin B 12/chemistry ; Vitamin B 12/pharmacology ; Vitamin B 12/therapeutic use
    Chemical Substances Antineoplastic Agents ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2022-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20010052
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  4. Article ; Online: OTUD5 limits replication fork instability by organizing chromatin remodelers.

    de Vivo, Angelo / Song, Hongseon / Lee, Yujin / Tirado-Class, Neysha / Sanchez, Anthony / Westerheide, Sandy / Dungrawala, Huzefa / Kee, Younghoon

    Nucleic acids research

    2023  Volume 51, Issue 19, Page(s) 10467–10483

    Abstract: Proper regulation of replication fork progression is important for genomic maintenance. Subverting the transcription-induced conflicts is crucial in preserving the integrity of replication forks. Various chromatin remodelers, such as histone chaperone ... ...

    Abstract Proper regulation of replication fork progression is important for genomic maintenance. Subverting the transcription-induced conflicts is crucial in preserving the integrity of replication forks. Various chromatin remodelers, such as histone chaperone and histone deacetylases are known to modulate replication stress, but how these factors are organized or collaborate are not well understood. Here we found a new role of the OTUD5 deubiquitinase in limiting replication stress. We found that OTUD5 is recruited to replication forks, and its depletion causes replication fork stress. Through its C-terminal disordered tail, OTUD5 assembles a complex containing FACT, HDAC1 and HDAC2 at replication forks. A cell line engineered to specifically uncouple FACT interaction with OTUD5 exhibits increases in FACT loading onto chromatin, R-loop formation, and replication fork stress. OTUD5 mediates these processes by recruiting and stabilizing HDAC1 and HDAC2, which decreases H4K16 acetylation and FACT recruitment. Finally, proteomic analysis revealed that the cells with deficient OTUD5-FACT interaction activates the Fanconi Anemia pathway for survival. Altogether, this study identified a new interaction network among OTUD5-FACT-HDAC1/2 that limits transcription-induced replication stress.
    MeSH term(s) Humans ; Cell Line ; Chromatin/genetics ; DNA Replication ; Genomic Instability ; Proteomics
    Chemical Substances Chromatin ; OTUD5 protein, human (EC 3.4.-)
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Splicing factor SRSF3 represses translation of p21

    Kim, Jeeho / Park, Ra Young / Kee, Younghoon / Jeong, Sunjoo / Ohn, Takbum

    Cell death & disease

    2022  Volume 13, Issue 11, Page(s) 933

    Abstract: Serine/arginine-rich splicing factor 3 (SRSF3) is an RNA binding protein that most often regulates gene expression at the splicing level. Although the role of SRSF3 in mRNA splicing in the nucleus is well known, its splicing-independent role outside of ... ...

    Abstract Serine/arginine-rich splicing factor 3 (SRSF3) is an RNA binding protein that most often regulates gene expression at the splicing level. Although the role of SRSF3 in mRNA splicing in the nucleus is well known, its splicing-independent role outside of the nucleus is poorly understood. Here, we found that SRSF3 exerts a translational control of p21 mRNA. Depletion of SRSF3 induces cellular senescence and increases the expression of p21 independent of p53. Consistent with the expression patterns of SRSF3 and p21 mRNA in the TCGA database, SRSF3 knockdown increases the p21 mRNA level and its translation efficiency as well. SRSF3 physically associates with the 3'UTR region of p21 mRNA and the translational initiation factor, eIF4A1. Our study proposes a model in which SRSF3 regulates translation by interacting with eIF4A1 at the 3'UTR region of p21 mRNA. We also found that SRSF3 localizes to the cytoplasmic RNA granule along with eIF4A1, which may assist in translational repression therein. Thus, our results provide a new mode of regulation for p21 expression, a crucial regulator of the cell cycle and senescence, which occurs at the translational level and involves SRSF3.
    MeSH term(s) RNA, Messenger/genetics ; RNA, Messenger/metabolism ; 3' Untranslated Regions/genetics ; RNA Splicing Factors/metabolism ; Serine-Arginine Splicing Factors/genetics ; Serine-Arginine Splicing Factors/metabolism ; RNA-Binding Proteins/metabolism ; RNA Splicing
    Chemical Substances RNA, Messenger ; 3' Untranslated Regions ; RNA Splicing Factors ; Serine-Arginine Splicing Factors (170974-22-8) ; RNA-Binding Proteins
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-022-05371-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer.

    Rockfield, Stephanie / Kee, Younghoon / Nanjundan, Meera

    Oncogenesis

    2019  Volume 8, Issue 9, Page(s) 46

    Abstract: Mechanisms underlying the pathogenesis of high-grade serous epithelial ovarian cancers (HGSOC) are not yet well defined although key precursor cells have been identified (including fimbriated fallopian tube epithelium, FTSECs). Since iron is elevated in ... ...

    Abstract Mechanisms underlying the pathogenesis of high-grade serous epithelial ovarian cancers (HGSOC) are not yet well defined although key precursor cells have been identified (including fimbriated fallopian tube epithelium, FTSECs). Since iron is elevated in endometriotic cysts and the pelvic cavity, it is suggested that this source of redox-active iron may contribute to ovarian cancer pathogenesis. Specifically, sources of nontransferrin-bound iron (NTBI) within the pelvic cavity could arise from ovulation, retrograde menstruation, follicular fluid, or iron overload conditions (i.e., hemochromatosis). Herein, we investigated the cellular response of p53-inactivated and telomerase-expressing (immortalized) FTSECs (Pax8
    Language English
    Publishing date 2019-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2674437-5
    ISSN 2157-9024
    ISSN 2157-9024
    DOI 10.1038/s41389-019-0154-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unveiling the Chemical Diversity of the Deep-Sea Sponge Characella pachastrelloides

    Sam Afoullouss / Anthony R. Sanchez / Laurence K. Jennings / Younghoon Kee / A. Louise Allcock / Olivier P. Thomas

    Marine Drugs, Vol 20, Iss 52, p

    2022  Volume 52

    Abstract: Sponges are at the forefront of marine natural product research. In the deep sea, extreme conditions have driven secondary metabolite pathway evolution such that we might expect deep-sea sponges to yield a broad range of unique natural products. Here, we ...

    Abstract Sponges are at the forefront of marine natural product research. In the deep sea, extreme conditions have driven secondary metabolite pathway evolution such that we might expect deep-sea sponges to yield a broad range of unique natural products. Here, we investigate the chemodiversity of a deep-sea tetractinellid sponge, Characella pachastrelloides , collected from ~800 m depth in Irish waters. First, we analyzed the MS/MS data obtained from fractions of this sponge on the GNPS public online platform to guide our exploration of its chemodiversity. Novel glycolipopeptides named characellides were previously isolated from the sponge and herein cyanocobalamin, a manufactured form of vitamin B 12 , not previously found in nature, was isolated in a large amount. We also identified several poecillastrins from the molecular network, a class of polyketide known to exhibit cytotoxicity. Light sensitivity prevented the isolation and characterization of these polyketides, but their presence was confirmed by characteristic NMR and MS signals. Finally, we isolated the new betaine 6-methylhercynine, which contains a unique methylation at C-2 of the imidazole ring. This compound showed potent cytotoxicity towards against HeLa (cervical cancer) cells.
    Keywords deep-sea ; sponge ; cyanocobalamin ; molecular networking ; poecillastrins ; hercynine ; Biology (General) ; QH301-705.5
    Subject code 551
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Role of Deubiquitinating Enzymes in DNA Repair

    Kee, Younghoon / Huang, Tony T

    Molecular and Cellular Biology. 2016 Feb. 1, v. 36, no. 4 p.524-544

    2016  

    Abstract: Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of ...

    Abstract Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling.
    Keywords DNA damage ; DNA repair ; cell biology ; genome ; humans ; proteolysis ; ubiquitination
    Language English
    Dates of publication 2016-0201
    Size p. 524-544.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00847-15
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1666: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Unveiling the Chemical Diversity of the Deep-Sea Sponge Characella pachastrelloides

    Afoullouss, Sam / Sanchez, Anthony R. / Jennings, Laurence K. / Kee, Younghoon / Allcock, A. Louise / Thomas, Olivier P.

    Marine drugs. 2022 Jan. 05, v. 20, no. 1

    2022  

    Abstract: Sponges are at the forefront of marine natural product research. In the deep sea, extreme conditions have driven secondary metabolite pathway evolution such that we might expect deep-sea sponges to yield a broad range of unique natural products. Here, we ...

    Abstract Sponges are at the forefront of marine natural product research. In the deep sea, extreme conditions have driven secondary metabolite pathway evolution such that we might expect deep-sea sponges to yield a broad range of unique natural products. Here, we investigate the chemodiversity of a deep-sea tetractinellid sponge, Characella pachastrelloides, collected from ~800 m depth in Irish waters. First, we analyzed the MS/MS data obtained from fractions of this sponge on the GNPS public online platform to guide our exploration of its chemodiversity. Novel glycolipopeptides named characellides were previously isolated from the sponge and herein cyanocobalamin, a manufactured form of vitamin B₁₂, not previously found in nature, was isolated in a large amount. We also identified several poecillastrins from the molecular network, a class of polyketide known to exhibit cytotoxicity. Light sensitivity prevented the isolation and characterization of these polyketides, but their presence was confirmed by characteristic NMR and MS signals. Finally, we isolated the new betaine 6-methylhercynine, which contains a unique methylation at C-2 of the imidazole ring. This compound showed potent cytotoxicity towards against HeLa (cervical cancer) cells.
    Keywords betaine ; cytotoxicity ; evolution ; imidazole ; methylation ; polyketides ; secondary metabolites ; uterine cervical neoplasms ; vitamin B12
    Language English
    Dates of publication 2022-0105
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20010052
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Bathyptilones: Terpenoids from an Antarctic Sea Pen,

    Thomas, Santana A L / Sanchez, Anthony / Kee, Younghoon / Wilson, Nerida G / Baker, Bill J

    Marine drugs

    2019  Volume 17, Issue 9

    Abstract: ...

    Abstract :
    MeSH term(s) Animals ; Antarctic Regions ; Anthozoa/chemistry ; Crystallography, X-Ray/methods ; Diterpenes/chemistry ; HeLa Cells ; Humans ; Magnetic Resonance Spectroscopy/methods ; Mass Spectrometry/methods ; Terpenes/chemistry
    Chemical Substances Diterpenes ; Terpenes
    Language English
    Publishing date 2019-09-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md17090513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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