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  1. Article ; Online: The boundary conditions of the liking bias in moral character judgments.

    Bocian, Konrad / Szarek, Katarzyna Myslinska / Miazek, Katarzyna / Baryla, Wieslaw / Wojciszke, Bogdan

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 17217

    Abstract: Recent research has shown that moral character judgments are prone to the liking bias-well-liked people are seen as morally superior to disliked or neutral ones. However, whether moral information about their past behavior would moderate the liking bias ... ...

    Abstract Recent research has shown that moral character judgments are prone to the liking bias-well-liked people are seen as morally superior to disliked or neutral ones. However, whether moral information about their past behavior would moderate the liking bias is still an open empirical question addressed in present studies. In Study 1 (N = 653), participants updated their biased moral character impressions when moral information about the target was introduced after the liking induction. In preregistered Study 2 (N = 601), when moral information about the target was presented before the liking induction, moral information had a stronger impact on moral character judgments than liking. Study 3 (N = 398) showed that moral character impression updating was three times greater when moral information was presented after (vs. before) the attitude induction. Further analyses of changes in participants' moral judgments certainty revealed that moral information reduced their uncertainty stronger than attitudes. In effect, the latter were more amenable to updating than information-based judgments. Thus, we present evidence that moral information updates moral character impressions biased by liking. Nevertheless, liking also, but to a lesser extent, updates moral character impressions initially grounded on moral information. We propose that certainty about others' moral character explains when and how moral information limits the impact of attitudinal influences on moral character judgments.
    MeSH term(s) Character ; Emotions ; Humans ; Judgment ; Morals
    Language English
    Publishing date 2022-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-22147-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The solution and solid-state degradation study followed by identification of tedizolid related compounds in medicinal product by high performance liquid chromatography with diode array and tandem mass spectrometry detection.

    Michalska, Katarzyna / Widyńska, Weronika / Bus, Katarzyna / Bocian, Wojciech / Tyski, Stefan

    Journal of pharmaceutical and biomedical analysis

    2020  Volume 194, Page(s) 113783

    Abstract: The aim of the study was to investigate the intrinsic stability and to identify potential degradation products of tedizolid disodium phosphate (TED- ... ...

    Abstract The aim of the study was to investigate the intrinsic stability and to identify potential degradation products of tedizolid disodium phosphate (TED-OPO
    MeSH term(s) Chromatography, High Pressure Liquid ; Drug Stability ; Oxazolidinones ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry ; Tetrazoles
    Chemical Substances Oxazolidinones ; Tetrazoles ; tedizolid (97HLQ82NGL)
    Language English
    Publishing date 2020-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2020.113783
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  3. Article ; Online: Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR.

    Bocian, Wojciech / Bednarek, Elżbieta / Michalska, Katarzyna

    International journal of molecular sciences

    2021  Volume 22, Issue 13

    Abstract: Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid. The mechanism of interaction of ... ...

    Abstract Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid. The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described. Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies. In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations. Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures. The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods. Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies. Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson-Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods. Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the cEKC study. By changing the dielectric constant in the MM/PBSA and MM/GBSA calculations, the effect of changing the solution to methanol/acetonitrile was investigated. A fairly successful attempt was made to predict the chiral separation of the oxazolidinones using the modified cyclodextrin by computational methods.
    MeSH term(s) Cyclodextrins/chemistry ; Electrophoresis, Capillary/methods ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Spectroscopy/methods ; Models, Molecular ; Oxazolidinones/chemistry ; Oxazolidinones/metabolism ; Stereoisomerism ; Tetrazoles/chemistry ; Tetrazoles/metabolism ; beta-Cyclodextrins/chemistry
    Chemical Substances Cyclodextrins ; Oxazolidinones ; Tetrazoles ; beta-Cyclodextrins ; heptakis(2,3-diacetyl-6-sulfo)-cyclodextrin ; radezolid (53PC6LO35W) ; tedizolid (97HLQ82NGL) ; betadex (JV039JZZ3A)
    Language English
    Publishing date 2021-07-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22137139
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  4. Article ; Online: Letter to the Editor Concerning: Adam S. et al. Improvements in Diabetic Neuropathy and Nephropathy After Bariatric Surgery a Prospective Cohort Study.

    Michalik, Maciej / Bocian, Agnes / Łęczycka, Katarzyna / Dowgiałło-Gornowicz, Natalia

    Obesity surgery

    2021  Volume 32, Issue 10, Page(s) 3458–3459

    MeSH term(s) Bariatric Surgery ; Diabetes Mellitus ; Diabetic Neuropathies/surgery ; Humans ; Kidney Diseases ; Obesity, Morbid/surgery ; Prospective Studies
    Language English
    Publishing date 2021-11-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1070827-3
    ISSN 1708-0428 ; 0960-8923
    ISSN (online) 1708-0428
    ISSN 0960-8923
    DOI 10.1007/s11695-021-05819-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The versatility of N,O-dialkylphosphoramidate stationary phase-separations in HILIC, highly aqueous RP LC conditions and purely aqueous mobile phase.

    Krzemińska, Katarzyna / Bocian, Szymon

    The Analyst

    2018  Volume 143, Issue 5, Page(s) 1217–1223

    Abstract: The chromatographic properties of N,O-dialkylphosphoramidate stationary phase with an octadecyl chain (Amino-P-C18) were studied. Based on the U-shape retention plots over the mobile phase composition for the particular tested compounds (nucleosides and ... ...

    Abstract The chromatographic properties of N,O-dialkylphosphoramidate stationary phase with an octadecyl chain (Amino-P-C18) were studied. Based on the U-shape retention plots over the mobile phase composition for the particular tested compounds (nucleosides and nucleic bases) and solvent excess adsorption isotherms, the separations of the tested compounds were performed in various chromatographic conditions. The separations were performed via hydrophilic interaction liquid chromatography, in highly aqueous mobile phase as well as using pure water as a mobile phase. The obtained results confirm that the specific structure of the amino-P-C18 stationary phase allows solvation over a whole range of mobile phase compositions. The ability of this material to undergo chromatographic separation in extreme mobile phase compositions (hydrophilic interaction chromatography and purely aqueous systems) was also confirmed. Successful separation of test mixtures using pure water as a mobile phase is in accordance with the rules of "green chemistry".
    Language English
    Publishing date 2018-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/c7an01634d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The separations using pure water as a mobile phase in liquid chromatography using polar-embedded stationary phases

    Szymon Bocian / Katarzyna Krzemińska

    Green Chemistry Letters and Reviews, Vol 12, Iss 1, Pp 69-

    2019  Volume 78

    Abstract: Following the idea of green chemistry, especially green analytical chemistry, a series of stationary phases was synthesized. The obtained materials connect polar and hydrophobic groups in the structure of bonded ligands. These specific surface properties ...

    Abstract Following the idea of green chemistry, especially green analytical chemistry, a series of stationary phases was synthesized. The obtained materials connect polar and hydrophobic groups in the structure of bonded ligands. These specific surface properties provide the stability of the stationary phase in pure water as a mobile phase. To confirm the solvation ability in purely aqueous mobile phases, excess isotherms of water and acetonitrile were determined. Further, the mixtures of nucleosides, nucleic bases and purine alkaloids were applied to test the separation selectivity of stationary phases in purely aqueous conditions at ambient temperature without any additives to the mobile phase. Among the four tested stationary phases, it is possible to find one for separation of each group of analytes that offers selective separation in reasonable time. The presented data confirms that it is possible to synthesize stationary phases for the separation of target mixtures in pure water conditions.
    Keywords liquid chromatography ; purely aqueous mobile phase ; stationary phase ; green chemistry ; Science ; Q ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Explanation of the Formation of Complexes between Representatives of Oxazolidinones and HDAS-β-CD Using Molecular Modeling as a Complementary Technique to cEKC and NMR

    Wojciech Bocian / Elżbieta Bednarek / Katarzyna Michalska

    International Journal of Molecular Sciences, Vol 22, Iss 7139, p

    2021  Volume 7139

    Abstract: Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid. The mechanism of interaction of ... ...

    Abstract Molecular modeling (MM) results for tedizolid and radezolid with heptakis-(2,3-diacetyl-6-sulfo)-β-cyclodextrin (HDAS-β-CD) are presented and compared with the results previously obtained for linezolid and sutezolid. The mechanism of interaction of chiral oxazolidinone ligands belonging to a new class of antibacterial agents, such as linezolid, tedizolid, radezolid, and sutezolid, with HDAS-β-CD based on capillary electrokinetic chromatography (cEKC), nuclear magnetic resonance (NMR) spectroscopy, and MM methods was described. Principles of chiral separation of oxazolidinone analogues using charged single isomer derivatives of cyclodextrin by the cEKC method were presented, including the selection of the optimal chiral selector and separation conditions, complex stoichiometry, and binding constants, which provided a comprehensive basis for MM studies. In turn, NMR provided, where possible, direct information on the geometry of the inclusion complexes and also provided the necessary structural information to validate the MM calculations. Consequently, MM contributed to the understanding of the structure of diastereomeric complexes, the thermodynamics of complexation, and the visualization of their structures. The most probable mean geometries of the studied supramolecular complexes and their dynamics (geometry changes over time) were determined by molecular dynamics methods. Oxazolidinone ligands have been shown to complex mainly the inner part of cyclodextrin, while the external binding is less privileged, which is consistent with the conclusions of the NMR studies. Enthalpy values of binding of complexes were calculated using long-term molecular dynamics in explicit water as well as using molecular mechanics, the Poisson–Boltzmann or generalized Born, and surface area continuum solvation (MM/PBSA and MM/GBSA) methods. Computational methods predicted the effect of changes in pH and composition of the solution on the strength and complexation process, and it adapted the conditions selected as optimal during the ...
    Keywords chiral cEKC ; molecular modeling ; non-covalent interactions ; NMR ; oxazolidinone ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Surface properties of stationary phases with embedded polar group based on secondary interaction, zeta potential measurement and linear solvatation energy relationship studies.

    Krzemińska, Katarzyna / Bocian, Szymon / Pluskota, Robert / Buszewski, Bogusław

    Journal of chromatography. A

    2020  Volume 1637, Page(s) 461853

    Abstract: The chromatographic properties of six non-commercially available stationary phases with ester or phosphodiester functional groups embedded into alkyl chain were studied. Zeta potential values of stationary phases suspended in water, organic solvent and ... ...

    Abstract The chromatographic properties of six non-commercially available stationary phases with ester or phosphodiester functional groups embedded into alkyl chain were studied. Zeta potential values of stationary phases suspended in water, organic solvent and their mixtures were measured. Moreover, the selectivity coefficients were calculated on the basis of the retention factor for the test solutes. Separations were performed under hydrophilic interaction liquid chromatographic conditions. Hydrophobic and polar properties of the investigated columns were compared. Based on the chromatographic properties, polar embedded packing materials were classified. Also two phases with different spacer but the same embedded polar group and alkyl chain (Amino-P-C18 and Diol-P-C18) were used for comparison with homemade materials. Amino-P-C18 stationary phase exhibits positive values of zeta potential which is in accordance with the observed anion exchange properties. The highest negative values of zeta potential were observed for Diol-P-C18, together with cation exchange properties. The highest methylene selectivity, polar selectivity and configurational selectivity were observed for the stationary phase with an ester bond and a phenyl group.
    MeSH term(s) Anions ; Cations ; Chromatography, Ion Exchange ; Chromatography, Liquid/methods ; Hydrogen-Ion Concentration ; Hydrophobic and Hydrophilic Interactions ; Isomerism ; Solvents/chemistry ; Static Electricity ; Surface Properties ; Thermodynamics ; Water/chemistry
    Chemical Substances Anions ; Cations ; Solvents ; Water (059QF0KO0R)
    Language English
    Publishing date 2020-12-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2020.461853
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  9. Article ; Online: The Comparison of Honey Enriched with Laboratory Fermented Pollen vs. Natural Bee Bread in Terms of Nutritional and Antioxidant Properties, Protein In Vitro Bioaccessibility, and Its Genoprotective Effect in Yeast Cells.

    Miłek, Michał / Mołoń, Mateusz / Kielar, Patrycja / Sidor, Ewelina / Bocian, Aleksandra / Marciniak-Lukasiak, Katarzyna / Pasternakiewicz, Anna / Dżugan, Małgorzata

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 15

    Abstract: The aim of the study was to compare the nutritional value and bioactivity of honey enriched with a 10% addition of natural bee bread and its substitutes obtained as a result of laboratory fermentation of bee pollen. Physicochemical parameters, ... ...

    Abstract The aim of the study was to compare the nutritional value and bioactivity of honey enriched with a 10% addition of natural bee bread and its substitutes obtained as a result of laboratory fermentation of bee pollen. Physicochemical parameters, antioxidant properties, as well as the bioaccessibility of proteins using an in vitro static digestion model were analyzed. The bioactivity of the obtained enriched honeys was tested using the yeast model. The research indicates the similarity of honeys with the addition of "artificial bee bread" to honey with natural ones. During in vitro digestion, good bioaccessibility of the protein from the tested products was demonstrated. The ability of the products to protect yeast cells against hydrogen superoxide-induced oxidative stress was demonstrated using a qualitative spot test, which was stronger in the case of enriched honey than in pure rapeseed control honey. Significant inhibition of the growth of both strains of yeast exposed to bee pollen-enriched honeys was also demonstrated. Furthermore, all tested samples showed significant genoprotective activity against the genotoxic effect of zeocin and the reduction of the number of DNA double-strand breaks by a minimum of 70% was observed.
    MeSH term(s) Bees ; Honey/analysis ; Propolis/chemistry ; Antioxidants/pharmacology ; Antioxidants/analysis ; Saccharomyces cerevisiae ; Pollen/chemistry
    Chemical Substances Propolis (9009-62-5) ; Antioxidants
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28155851
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  10. Article ; Online: Engineering of the Dsb (disulfide bond) proteins - contribution towards understanding their mechanism of action and their applications in biotechnology and medicine.

    Banaś, Anna Marta / Bocian-Ostrzycka, Katarzyna Marta / Jagusztyn-Krynicka, Elżbieta Katarzyna

    Critical reviews in microbiology

    2019  Volume 45, Issue 4, Page(s) 433–450

    Abstract: The Dsb protein family in prokaryotes catalyzes the generation of disulfide bonds between thiol groups of cysteine residues in nascent proteins, ensuring their proper three-dimensional structure; these bonds are crucial for protein stability and function. ...

    Abstract The Dsb protein family in prokaryotes catalyzes the generation of disulfide bonds between thiol groups of cysteine residues in nascent proteins, ensuring their proper three-dimensional structure; these bonds are crucial for protein stability and function. The first Dsb protein,
    MeSH term(s) Biotechnology/methods ; Disulfides/metabolism ; Protein Disulfide-Isomerases/genetics ; Protein Disulfide-Isomerases/metabolism ; Protein Engineering/methods ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
    Chemical Substances Disulfides ; Recombinant Proteins ; Protein Disulfide-Isomerases (EC 5.3.4.1)
    Language English
    Publishing date 2019-06-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1053620-6
    ISSN 1549-7828 ; 1040-841X
    ISSN (online) 1549-7828
    ISSN 1040-841X
    DOI 10.1080/1040841X.2019.1622509
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