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Article ; Online: Multifunctional Amine Modifiers for Selective Dehydration of Methyl Lactate to Acrylates.

Pang, Yutong / Lee, ChoongSze / Vlaisavljevich, Bess / Nicholas, Christopher P / Dauenhauer, Paul J

JACS Au

2023 Volume 3, Issue 2, Page(s) 368–377

Abstract: Dehydration of methyl lactate to acrylic acid and methyl acrylate was experimentally evaluated over a Na-FAU zeolite catalyst impregnated with multifunctional diamines. 1,2-Bis(4-pyridyl)ethane (12BPE) and 4,4'-trimethylenedipyridine (44TMDP), at a ... ...

Abstract	Dehydration of methyl lactate to acrylic acid and methyl acrylate was experimentally evaluated over a Na-FAU zeolite catalyst impregnated with multifunctional diamines. 1,2-Bis(4-pyridyl)ethane (12BPE) and 4,4'-trimethylenedipyridine (44TMDP), at a nominal loading of 40 wt % or two molecules per Na-FAU supercage, afforded a dehydration selectivity of 96 ± 3% over 2000 min time on stream. Although 12BPE and 44TMDP have van der Waals diameters approximately 90% of the Na-FAU window opening diameter, both flexible diamines interact with internal active sites of Na-FAU as characterized by infrared spectroscopy. During continuous reaction at 300 °C, the amine loadings in Na-FAU remained constant for 12BPE but decreased as much as 83% for 44TMDP. Tuning the weighted hourly space velocity (WHSV) from 0.9 to 0.2 h
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ISSN	2691-3704
ISSN (online)	2691-3704
DOI	10.1021/jacsau.2c00513
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Article ; Online: Does a consumer co-designed infographic increase knowledge of physical activity after total knee joint replacement? A randomised controlled trial.

Hawke, Lyndon J / Shields, Nora / Dowsey, Michelle M / Choong, Peter F M / Taylor, Nicholas F

Musculoskeletal care

2023 Volume 21, Issue 4, Page(s) 1497–1506

Abstract: Purpose: To determine if a consumer co-designed infographic increased knowledge of physical activity and self-efficacy for exercise after total knee joint replacement surgery.: Methods: Forty-four adults with primary knee joint replacement surgery ... ...

Abstract	Purpose: To determine if a consumer co-designed infographic increased knowledge of physical activity and self-efficacy for exercise after total knee joint replacement surgery. Methods: Forty-four adults with primary knee joint replacement surgery were recruited from a public and a private hospital in Melbourne, Australia. Participants were randomly allocated to an experimental or control group. The experimental group received a consumer co-designed infographic. All participants received usual care. Primary outcome measures were knowledge of physical activity and self-efficacy for exercise. Outcomes were administered at baseline, week 1 and week 6. Semi-structured interviews with experimental group participants explored the acceptability, implementation and efficacy of the infographic. Results: There were no between-group differences for knowledge of physical activity at week 1 (MD -0.02 units, 95% CI -0.9 to 0.9) or week 6 (MD 0.01 units, 95% CI -0.9 to 0.9). Self-efficacy for exercise increased at week 1 (MD 14.2 units, 95% CI 2.9-25.4) but was not sustained. Qualitative data showed that the infographic was embraced by some participants but not by others. Conclusions: A consumer co-designed infographic did not improve knowledge of physical activity but may have had a short-term positive effect on self-efficacy for exercise after knee joint replacement. Trial registration ACTRN12621000910808.
MeSH term(s)	Adult ; Humans ; Data Visualization ; Exercise Therapy ; Arthroplasty, Replacement, Knee ; Exercise ; Australia ; Osteoarthritis, Knee/surgery ; Knee Joint/surgery
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2171452-6
ISSN	1557-0681 ; 1478-2189
ISSN (online)	1557-0681
ISSN	1478-2189
DOI	10.1002/msc.1827
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Article ; Online: In the Dark About Physical Activity - Exploring Patient Perceptions of Physical Activity After Elective Total Knee Joint Replacement: A Qualitative Study.

Hawke, Lyndon J / Taylor, Nicholas F / Dowsey, Michelle M / Choong, Peter F M / Shields, Nora

Arthritis care & research

2022 Volume 74, Issue 6, Page(s) 965–974

Abstract: Objective: The study aimed to explore patient perceptions of and motivations for physical activity after total knee joint replacement.: Methods: Participants were purposively sampled after completing a public outpatient rehabilitation exercise group. ...

Abstract	Objective: The study aimed to explore patient perceptions of and motivations for physical activity after total knee joint replacement. Methods: Participants were purposively sampled after completing a public outpatient rehabilitation exercise group. Semistructured interviews were completed with 22 participants (mean age 70 years, 45% women) 6 to 12 months after total knee joint replacement. Interviews were audiotaped and transcribed verbatim. Themes were identified by an inductive and iterative process of data analysis. Results: The main theme to emerge was participants were in the dark about physical activity. Participants were typically not familiar with physical activity guidelines and had difficulty distinguishing between low- and moderate-intensity physical activity. Three subthemes were identified: 1) people prioritize participation in meaningful life situations after total knee joint replacement, 2) rehabilitation was perceived to not explicitly address moderate-intensity physical activity levels, and 3) other health and social reasons replaced knee osteoarthritis as barriers to physical activity. Conclusion: Limited understanding of physical activity recommendations, prioritization of participation in meaningful life situations, rehabilitation that was impairment focused, and other health and social reasons appeared to contribute to low levels of moderate-intensity physical activity in adults after knee joint replacement. Addressing being in the dark about physical activity may be an important first step to increase the effectiveness of behavioral interventions designed to promote physical activity after total knee joint replacement.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Knee/rehabilitation ; Exercise ; Exercise Therapy ; Female ; Humans ; Knee Prosthesis ; Male ; Osteoarthritis, Knee/rehabilitation ; Osteoarthritis, Knee/surgery ; Qualitative Research
Language	English
Publishing date	2022-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.24718
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Article ; Online: Broken Machines or Active Bodies? Part 1. Ways of Talking About Health and Why It Matters.

Bunzli, Samantha / Taylor, Nicholas F / O'Brien, Penny / Wallis, Jason A / Caneiro, J P / Woodward-Kron, Robyn / Hunter, David J / Choong, Peter F / Dowsey, Michelle M / Shields, Nora

The Journal of orthopaedic and sports physical therapy

2023 Volume 53, Issue 5, Page(s) 236–238

Abstract: SYNOPSIS: ...

Abstract	SYNOPSIS:
MeSH term(s)	Humans ; Osteoarthritis/therapy ; Health Knowledge, Attitudes, Practice ; Communication ; Health Promotion/methods
Language	English
Publishing date	2023-04-25
Publishing country	United States
Document type	Editorial
ZDB-ID	604640-x
ISSN	1938-1344 ; 0190-6011
ISSN (online)	1938-1344
ISSN	0190-6011
DOI	10.2519/jospt.2023.11879
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Article ; Online: Broken Machines or Active Bodies? Part 3. Five Recommendations to Shift the Way Clinicians Communicate With People Who Are Seeking Care for Osteoarthritis.

Bunzli, Samantha / Taylor, Nicholas F / O'Brien, Penny / Wallis, Jason A / Caneiro, J P / Woodward-Kron, Robyn / Hunter, David J / Choong, Peter F / Dowsey, Michelle M / Shields, Nora

The Journal of orthopaedic and sports physical therapy

2023 Volume 53, Issue 7, Page(s) 375–380

Abstract: SYNOPSIS: ...

Abstract	SYNOPSIS:
MeSH term(s)	Humans ; Osteoarthritis/therapy ; Exercise ; Healthy Lifestyle
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	604640-x
ISSN	1938-1344 ; 0190-6011
ISSN (online)	1938-1344
ISSN	0190-6011
DOI	10.2519/jospt.2023.11881
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Article ; Online: Zone 1 Aortic Arch Hybrid Endovascular Repair with Extra-anatomical Bypass: A Meta-analysis.

Bayfield, Nicholas Gr / Samuel, Miny / Bayfield, Anna-Louise E / Choong, Andrew Mtl

Annals of vascular surgery

2020 Volume 72, Page(s) 601–609

Abstract: Background: The aim of this meta-analysis is to determine the morbidity and mortality outcomes of adult patients with aortic arch disease managed with extra-anatomical bypass avoiding median sternotomy and cardiopulmonary bypass, with simultaneous or ... ...

Abstract	Background: The aim of this meta-analysis is to determine the morbidity and mortality outcomes of adult patients with aortic arch disease managed with extra-anatomical bypass avoiding median sternotomy and cardiopulmonary bypass, with simultaneous or staged hybrid zone 1 endovascular aortic repair. Methods: Systematic literature searches of the MEDLINE, EMBASE, and Cochrane databases were carried out to identify relevant studies on zone 1 hybrid arch repair. Extracted data were analyzed by random effects models. Primary outcomes included 30-day or in-hospital mortality. Longitudinal survival was analyzed up to 7 years from date of operation. Secondary outcomes included in-hospital morbidity, as well as late endoleak and reintervention. Results: Twenty studies incorporating 348 patients were included. In-hospital or 30-day mortality was 10.1% (95% confidence interval, 6.7-14.9%). Overall operative technical success was 89.8% (83.7-93.8%). Early type 1 endoleak rate was 14.0% (7.4-24.7%). Stroke prevalence was 9.5% (6.1-14.3%). Spinal cord paraplegia prevalence was 3.8% (1.9-7.6%). Retrograde aortic dissection prevalence was 4.1% (1.5-10.6%). Survival at 1 year postoperatively was 77.2% (66.1-85.4%). Survival at 3 years postoperatively was 73.7% (59.2-84.4%). Survival beyond 4 years postoperatively (range 58-80 months) was 65.9% (53.6-76.4%). Late type 1 endoleak prevalence was 11.8% (5.5-23.7%). Overall rate of reintervention was 11.6% (6.4-20.1%). Conclusions: Zone 1 hybrid repair has evidence for satisfactory short- and long-term morbidity/mortality outcomes and may be considered as an alternative approach to aortic arch disease.
Language	English
Publishing date	2020-11-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2020.10.010
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Zs.A 2882: Show issues

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Article: The Impact of Enhanced Recovery After Surgery on Total Joint Arthroplasty: Protocol for a Systematic Review and Meta-analysis.

Rele, Siddharth / Shadbolt, Cade / Schilling, Chris / Taylor, Nicholas F / Dowsey, Michelle M / Choong, Peter F M

JMIR research protocols

2021 Volume 10, Issue 3, Page(s) e25581

Abstract: Background: The number of total joint arthroplasties (TJAs) being performed is increasing worldwide. To match this increasing demand, there has been focus on hastening patients' recovery of function. This effort has culminated in the formulation of ... ...

Abstract	Background: The number of total joint arthroplasties (TJAs) being performed is increasing worldwide. To match this increasing demand, there has been focus on hastening patients' recovery of function. This effort has culminated in the formulation of enhanced recovery after surgery (ERAS) strategies. However, with evolving ERAS programs and new recommendations, a review of current evidence is required to provide clinicians with up-to-date information about its effect on outcomes for TJA. Objective: The objective of this study is to assess the utility of ERAS programs on patient, health service, and economic outcomes for primary, elective total hip arthroplasty (THA) and total knee arthroplasty (TKA). Methods: A systematic search will be conducted in Medline (Ovid), EMCARE (Ovid), EMBASE (Ovid), Web of Science, CINAHL, National Health Service Economic Evaluations Database, and the Cochrane Library. Analytical, observational, and experimental designs will be included in this systematic review. Only studies including patients undergoing primary TKA and THA comparing ERAS programs with conventional surgery and postoperative care will be included. Data related to patient outcomes, health service outcomes, safety, and economic evaluation will be extracted. Results: The search terms and primary database searches have been finalized. Findings will be reported in narrative and tabular form. Where appropriate, random effects meta-analyses will be conducted for each outcome, and heterogeneity quantified with Cochran Q test and I2 statistic. Measures of effect or mean differences will be reported with 95% confidence intervals. The results of this systematic review will be disseminated in a peer-reviewed journal. Conclusions: This protocol will guide a systematic review assessing outcomes associated with ERAS surgery in primary THA and TKA. Trial registration: Open Science Framework osf.io/y4bhs; https://osf.io/y4bhs. International registered report identifier (irrid): PRR1-10.2196/25581.
Language	English
Publishing date	2021-03-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2719222-2
ISSN	1929-0748
ISSN	1929-0748
DOI	10.2196/25581
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Article ; Online: Nordic Walking in Patients with Peripheral Artery Disease.

Wee, Ian J Y / Syn, Nicholas / Choong, Andrew M T L

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2018 Volume 57, Issue 3, Page(s) 465

MeSH term(s)	Exercise ; Exercise Therapy ; Humans ; Peripheral Arterial Disease ; Walking
Language	English
Publishing date	2018-12-01
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2018.10.019
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Re: "Open vs Endovascular Repair of Descending Thoracic Aortic Aneurysm Disease: A Systematic Review and Meta-analysis".

Yan Wee, Ian Jun / Syn, Nicholas / Choong, Andrew M T L

Annals of vascular surgery

2018 Volume 56, Page(s) 358–359

Language	English
Publishing date	2018-11-23
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2018.10.009
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Article ; Online: A systematic review and meta-analysis of surgical versus endovascular thrombectomy of thrombosed arteriovenous grafts in hemodialysis patients.

Chan, Nicholas / Wee, Ian / Soong, Tse Kiat / Syn, Nicholas / Choong, Andrew M T L

Journal of vascular surgery

2019 Volume 69, Issue 6, Page(s) 1976–1988.e7

Abstract: Background: The major pitfall of arteriovenous grafts (AVGs) for hemodialysis patients is thrombosis and occlusion. Prompt intervention with either surgical or endovascular therapy to salvage the vascular access is crucial in maintaining effective ... ...

Abstract	Background: The major pitfall of arteriovenous grafts (AVGs) for hemodialysis patients is thrombosis and occlusion. Prompt intervention with either surgical or endovascular therapy to salvage the vascular access is crucial in maintaining effective hemodialysis. The purpose of this systematic review and meta-analysis was to assess and compare the efficacy of open surgical vs wholly endovascular therapy for the treatment of thrombosed AVGs. Methods: This review was conducted according to the PRISMA guidelines. Relative risks (RRs) and pooled proportions for both primary and secondary outcomes were calculated. Results: A total of eight randomized, controlled trials and two retrospective cohort studies were included, comprising 806 (63%) and 466 (37%) participants in the surgical and wholly endovascular treatment arms respectively. There were no significant differences between endovascular and surgical therapy in the 30-, 60-, and 90-day primary nonpatency rates. However, endovascular therapy reported a significantly higher 1-year primary nonpatency rate (rate ratio [RR], 1.22; 95% confidence interval [CI], 1.13-1.33; P < .01) and the 2-year primary nonpatency rate (RR, 1.26; 95% CI, 1.10-1.45; P < .01) as compared with surgical therapy. Similarly, the endovascular arm had a higher pooled proportion of primary nonpatency of 87.7% (95% CI, 81.5%-92.9%; P = .297), as compared with the surgical arm (72.1%; 95% CI, 66.4%-77.4%; P = .289). In terms of secondary nonpatency rates, there were no significant differences between endovascular and surgical procedures at 30, 60, and 90 days. Endovascular procedures reported a significantly higher technical failure rate as compared with surgical thrombectomy (RR, 1.58; 95% CI, 1.06-2.37; P = .03). There was no significant difference in terms of minor and major complications. Conclusions:** Our data suggest that, for thrombectomy of AVGs, wholly endovascular therapy seems to be inferior to open surgery plus adjuncts based on the long-term patency and technical failure rates. However, further research in the form of a well-conducted randomized trial is warranted to establish a firmer conclusion.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Arteriovenous Shunt, Surgical/adverse effects ; Arteriovenous Shunt, Surgical/instrumentation ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/instrumentation ; Endovascular Procedures/adverse effects ; Endovascular Procedures/methods ; Graft Occlusion, Vascular/etiology ; Graft Occlusion, Vascular/physiopathology ; Graft Occlusion, Vascular/surgery ; Humans ; Middle Aged ; Renal Dialysis ; Risk Factors ; Thrombectomy/adverse effects ; Thrombectomy/methods ; Thrombolytic Therapy/adverse effects ; Thrombolytic Therapy/methods ; Treatment Outcome ; Vascular Patency ; Young Adult
Language	English
Publishing date	2019-05-28
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2018.10.102
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