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  1. Article ; Online: Reply to Cédric Annweiler, Pierre Bigot, and Spyridon N. Karras' Letter to the Editor re: Jennifer R. Rider, Kathryn M. Wilson, Jennifer A. Sinnott, Rachel S. Kelly, Lorelei A. Muccia, Edward L. Giovannucci. Ejaculation Frequency and Risk of Prostate Cancer: Updated Results with an Additional Decade of Follow-up. Eur Urol 2016;70:974-82.

    Rider, Jennifer R / Wilson, Kathryn M / Mucci, Lorelei A / Giovannucci, Edward L

    European urology

    2017  Volume 71, Issue 1, Page(s) e18

    Language English
    Publishing date 2017-01
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2016.05.052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1247: Show issues Location:
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  2. Article ; Online: Reply to Herney Andrés García-Perdomo and Ramiro Manzano Nunez's Letter to the Editor Re: Jennifer R. Rider, Kathryn M. Wilson, Jennifer M. Sinnott, Rachel S. Kelly, Lorelei A. Mucci, Edward L. Giovannucci. Ejaculation Frequency and Risk of Prostate Cancer: Updated Results with an Additional Decade of Follow-up. Eur Urol 2016;70:974-82: Looking Deeper: P-hacking and Some Other Bias.

    Rider, Jennifer R / Wilson, Kathryn M / Sinnott, Jennifer A / Kelly, Rachel S / Mucci, Lorelei A / Giovannucci, Edward L

    European urology

    2016  Volume 70, Issue 6, Page(s) e156–e157

    Language English
    Publishing date 2016-12
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2016.04.032
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  3. Article ; Online: The critical need for guidance in managing glycaemic control in patients with cancer.

    Giovannucci, Edward

    Diabetic medicine : a journal of the British Diabetic Association

    2021  Volume 39, Issue 1, Page(s) e14624

    MeSH term(s) Glycemic Control ; Humans ; Hyperglycemia ; Hypoglycemic Agents/therapeutic use ; Neoplasms/therapy
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2021-07-30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 605769-x
    ISSN 1464-5491 ; 0742-3071 ; 1466-5468
    ISSN (online) 1464-5491
    ISSN 0742-3071 ; 1466-5468
    DOI 10.1111/dme.14624
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    Zs.A 1954: Show issues Location:
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  4. Article ; Online: Molecular Biologic and Epidemiologic Insights for Preventability of Colorectal Cancer.

    Giovannucci, Edward

    Journal of the National Cancer Institute

    2021  Volume 114, Issue 5, Page(s) 645–650

    Abstract: The etiology of colorectal cancer (CRC) has been informed from both a molecular biology perspective, which concerns the study of the nature, timing, and consequences of mutations in driver genes, and epidemiology, which focuses on identifying risk ... ...

    Abstract The etiology of colorectal cancer (CRC) has been informed from both a molecular biology perspective, which concerns the study of the nature, timing, and consequences of mutations in driver genes, and epidemiology, which focuses on identifying risk factors for cancer. For the most part, these fields have developed independently, and it is thus important to consider them in a more integrated manner. The molecular mutational perspective has stressed the importance of mutations due to replication of adult stem cells, and the molecular fingerprint of most CRCs does not suggest the importance of direct carcinogens. Epidemiology has identified numerous modifiable risk factors that account for most CRCs, most of which are not direct mutagens. The distribution of CRCs across the large bowel is not uniform, which is possibly caused by regional differences in the microbiota. Some risk factors are likely to act through or interact with the microbiota. The mutational perspective informs when risk factors may begin to operate in life and when they may cease to operate. Evidence from the mutational model and epidemiology supports that CRC risk factors begin early in life and may contribute to the risk of early-onset CRC. Later in carcinogenesis, there may be a "point of no return" when sufficient mutations have accumulated, and some risk factors do not affect cancer risk. This period may be at least 5-15 years for some risk factors. A more precise knowledge of timing of risk factor to cancer is required to inform preventive efforts.
    MeSH term(s) Adult ; Biological Products ; Carcinogenesis/genetics ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/genetics ; Humans ; Mutation ; Risk Factors
    Chemical Substances Biological Products
    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djab229
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  5. Article ; Online: The Association between Dietary Inflammatory Potential and Urologic Cancers: True Association or Bias?

    Zhang, Yiwen / Giovannucci, Edward

    Advances in nutrition (Bethesda, Md.)

    2023  Volume 15, Issue 1, Page(s) 100132

    MeSH term(s) Humans ; Urologic Neoplasms/epidemiology ; Urologic Neoplasms/etiology ; Diet
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1016/j.advnut.2023.10.005
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  6. Article ; Online: Adiposity over the life course and prostate cancer: unraveling the complexities.

    Giovannucci, Edward

    Cancer causes & control : CCC

    2020  Volume 31, Issue 12, Page(s) 1051–1055

    Abstract: The association between obesity and prostate cancer has been extensively studied, but clear answers have evaded us. Most of the studies have been based on a single time-point measure, most commonly of body mass index (BMI) during adulthood. Emerging data ...

    Abstract The association between obesity and prostate cancer has been extensively studied, but clear answers have evaded us. Most of the studies have been based on a single time-point measure, most commonly of body mass index (BMI) during adulthood. Emerging data suggest a complex pattern that may be better understood through a life course approach. The data suggest that early life adiposity, possibly before or during puberty, as being associated with lower risk of advanced prostate cancer. In contrast, moderate weight gain in men who were initially lean during pre-adulthood or early adulthood may increase risk of advanced prostate cancer. This pattern suggests competing factors associated with overall adiposity, some protective and some adverse. Factors that may increase risk appear to show more strongly in men who maintain a relatively low BMI but have a high waist circumference or waist:hip ratio. Possibly, this pattern may be associated with relatively high levels of factors associated with insulin resistance and related metabolic abnormalities (mostly central adiposity) while avoiding the protective factors (mostly generalized or subcutaneous adiposity). Broad measures at one time-point, such as adult BMI, are not likely to contribute further to our understanding. Instead, direct measures of visceral fat might be useful. For feasibility, combined measures, such as examining waist:hip ratio among men with normal BMI in relation to risk, might be useful. It may be informative to better determine the precise point in early life when adiposity may be protective and through what mechanisms, such as delay in puberty.
    MeSH term(s) Adiposity ; Breast Neoplasms ; Female ; Humans ; Kallikreins/blood ; Male ; Obesity/blood ; Obesity/diagnosis ; Prostate-Specific Antigen/blood ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnosis ; Risk Factors
    Chemical Substances KLK3 protein, human (EC 3.4.21.-) ; Kallikreins (EC 3.4.21.-) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2020-10-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1064022-8
    ISSN 1573-7225 ; 0957-5243
    ISSN (online) 1573-7225
    ISSN 0957-5243
    DOI 10.1007/s10552-020-01353-6
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  7. Article ; Online: Response by Lee and Giovannucci to Letter Regarding Article, "Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults".

    Lee, Dong Hoon / Giovannucci, Edward L

    Circulation

    2023  Volume 147, Issue 9, Page(s) e627

    MeSH term(s) Humans ; Adult ; Cause of Death ; Prospective Studies ; Exercise ; Leisure Activities
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.063393
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    Ui IV Zs.60: Show issues Location:
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  8. Article ; Online: Comment on Zaccardi et al. Duration of Type 2 Diabetes and Incidence of Cancer: An Observational Study in England. Diabetes Care 2023;46:1923-1930.

    Zhang, Yin / Giovannucci, Edward L

    Diabetes care

    2023  Volume 47, Issue 1, Page(s) e6

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/epidemiology ; England/epidemiology ; Incidence ; Neoplasms ; Observational Studies as Topic
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc23-1707
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  9. Article ; Online: Response to Scherübl.

    Zhang, Yin / Giovannucci, Edward L

    The American journal of gastroenterology

    2022  Volume 117, Issue 12, Page(s) 2085–2088

    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000002005
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  10. Article ; Online: A growing link-what is the role of height in cancer risk?

    Giovannucci, Edward

    British journal of cancer

    2019  Volume 120, Issue 6, Page(s) 575–576

    Abstract: A recent study has examined adult height in relation to cancer risk in a cohort of 23 million Korean adults. Taller stature was associated with higher risk of every cancer studied, except for oesophageal cancer. This association contributes to our ... ...

    Abstract A recent study has examined adult height in relation to cancer risk in a cohort of 23 million Korean adults. Taller stature was associated with higher risk of every cancer studied, except for oesophageal cancer. This association contributes to our understanding of cancer and may help aid in cancer risk prediction.
    MeSH term(s) Body Height ; Female ; Humans ; Incidence ; Male ; Neoplasms/epidemiology ; Sex Factors
    Language English
    Publishing date 2019-02-19
    Publishing country England
    Document type Editorial
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-018-0370-9
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