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  1. Article ; Online: Timing of administration of indocyanine green for fluorescence-guided surgery in pancreatic cancer: response to Shirakawa et al.

    Labib, Peter L

    BMC surgery

    2020  Volume 20, Issue 1, Page(s) 225

    MeSH term(s) Fluorescence ; Humans ; Indocyanine Green ; Laparoscopy ; Optical Imaging ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/surgery ; Prospective Studies
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-020-00881-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Expanding the definition of covid-19 deaths will show the true effect of the pandemic.

    Labib, Peter L / Aroori, Somaiah

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m2153

    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
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  3. Article ; Online: Intraoperative ultrasound versus fluorescence and X-ray cholangiography for the identification of bile duct stones, biliary anatomy and bile duct injury during laparoscopic cholecystectomy: Time for a randomized controlled trial?

    Labib, Peter L / Aroori, Somaiah

    The British journal of surgery

    2020  Volume 107, Issue 11, Page(s) e563

    MeSH term(s) Bile Ducts/diagnostic imaging ; Bile Ducts/injuries ; Cholangiography/methods ; Cholecystectomy, Laparoscopic/methods ; Cholelithiasis/diagnostic imaging ; Cholelithiasis/surgery ; Humans ; Optical Imaging ; Randomized Controlled Trials as Topic ; Ultrasonography, Interventional/methods
    Language English
    Publishing date 2020-08-25
    Publishing country England
    Document type Letter
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.66: Show issues Location:
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  4. Article ; Online: Serious complications of pancreatoduodenectomy correlate with lower rates of adjuvant chemotherapy: Would high-risk patients benefit from neoadjuvant therapy?

    Russell, Thomas B / Labib, Peter L / Bowles, Matthew / Aroori, Somaiah

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2022  Volume 49, Issue 1, Page(s) 142–149

    Abstract: Introduction: Patients who suffer a serious complication of pancreatoduodenectomy (PD) may have their adjuvant chemotherapy (AC) delayed or omitted as a result. We aimed to investigate whether PD complications affected AC rates.: Materials and methods! ...

    Abstract Introduction: Patients who suffer a serious complication of pancreatoduodenectomy (PD) may have their adjuvant chemotherapy (AC) delayed or omitted as a result. We aimed to investigate whether PD complications affected AC rates.
    Materials and methods: A retrospective analysis of all PD patients with histologically-confirmed pancreatic ductal adenocarcinoma (2006-2015) was performed; 90-day mortality patients were excluded. Patients who commenced AC were compared to those who did not (morbidity rates and survival) and patients who developed selected postoperative complications were compared to those who did not (AC rates and survival).
    Results: 157 patients were included and 90-day mortality was 3.8%. Of the remaining patients, 102 (68.5%) received AC (AC data unavailable for two patients). Survival was longer in the AC group (p = 0.004). AC patients had less frequently experienced a postoperative chest infection (8.82% vs 34.0%, p = 0.0003) or a postoperative complication which was Clavien-Dindo (CD) grade ≥ II (29.4% vs 57.4%, p = 0.0019) or ≥ III (6.86% vs 21.3%, p = 0.023). Patients who experienced a postoperative chest infection (36.0% vs 75.0%, p = 0.0003) or a postoperative complication which was CD grade ≥ II (48.9% vs 73.1%, p = 0.0099) or ≥ III (29.4% vs 70.3%, p = 0.0018) less frequently commenced AC.
    Conclusion: Patients who received AC had less frequently experienced a serious postoperative complication. Efforts should be made to preoperatively identify those who are high-risk for a serious complication as this cohort may benefit from neoadjuvant therapy.
    MeSH term(s) Humans ; Pancreaticoduodenectomy/adverse effects ; Neoadjuvant Therapy/adverse effects ; Retrospective Studies ; Survival Rate ; Pancreatic Neoplasms/pathology ; Chemotherapy, Adjuvant ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology
    Language English
    Publishing date 2022-08-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2022.08.032
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1149: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 549: Show issues

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  6. Book ; Online: Expanding the definition of covid-19 deaths will show the true effect of the pandemic

    Labib, Peter L / Aroori, Somaiah

    2020  

    Keywords LETTERS ; covid19
    Language English
    Publishing date 2020-05-29 05:11:14.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Expanding the definition of covid-19 deaths will show the true effect of the pandemic

    Labib, Peter L / Aroori, Somaiah

    BMJ

    2020  , Page(s) m2153

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2153
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Chlamydia (lymphogranuloma venereum) peritonitis in a male patient.

    Antonik, Magdalena / Ovens, Katie J / Labib, Peter L / Briggs, Christopher D

    BMJ case reports

    2021  Volume 14, Issue 4

    Abstract: A 49-year-old man presented with a 1-week history of abdominal pain, distension, diarrhoea and fatigue. CT of the abdomen and pelvis revealed peritonitis with no identifiable cause. Diagnostic laparoscopy was performed, which excluded gastrointestinal ... ...

    Abstract A 49-year-old man presented with a 1-week history of abdominal pain, distension, diarrhoea and fatigue. CT of the abdomen and pelvis revealed peritonitis with no identifiable cause. Diagnostic laparoscopy was performed, which excluded gastrointestinal perforation. Peritoneal fluid tested positive for
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Chlamydia trachomatis ; Homosexuality, Male ; Humans ; Lymphogranuloma Venereum/complications ; Lymphogranuloma Venereum/diagnosis ; Lymphogranuloma Venereum/drug therapy ; Male ; Middle Aged ; Peritonitis/diagnosis ; Peritonitis/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-04-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Molecular Pathogenesis of Cholangiocarcinoma.

    Labib, Peter L / Goodchild, George / Pereira, Stephen P

    BMC cancer

    2019  Volume 19, Issue 1, Page(s) 185

    Abstract: Background: Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based studies have identified a number of ... ...

    Abstract Background: Cholangiocarcinomas are a heterogeneous group of malignancies arising from a number of cells of origin along the biliary tree. Although most cases in Western countries are sporadic, large population-based studies have identified a number of risk factors. This review summarises the evidence behind reported risk factors and current understanding of the molecular pathogenesis of cholangiocarcinoma, with a focus on inflammation and cholestasis as the driving forces in cholangiocarcinoma development.
    Risk factors for cholangiocarcinogenesis: Cholestatic liver diseases (e.g. primary sclerosing cholangitis and fibropolycystic liver diseases), liver cirrhosis, and biliary stone disease all increase the risk of cholangiocarcinoma. Certain bacterial, viral or parasitic infections such as hepatitis B and C and liver flukes also increase cholangiocarcinoma risk. Other risk factors include inflammatory disorders (such as inflammatory bowel disease and chronic pancreatitis), toxins (e.g. alcohol and tobacco), metabolic conditions (diabetes, obesity and non-alcoholic fatty liver disease) and a number of genetic disorders.
    Molecular pathogenesis of cholangiocarcinoma: Regardless of aetiology, most risk factors cause chronic inflammation or cholestasis. Chronic inflammation leads to increased exposure of cholangiocytes to the inflammatory mediators interleukin-6, Tumour Necrosis Factor-ɑ, Cyclo-oxygenase-2 and Wnt, resulting in progressive mutations in tumour suppressor genes, proto-oncogenes and DNA mismatch-repair genes. Accumulating bile acids from cholestasis lead to reduced pH, increased apoptosis and activation of ERK1/2, Akt and NF-κB pathways that encourage cell proliferation, migration and survival. Other mediators upregulated in cholangiocarcinoma include Transforming Growth Factor-β, Vascular Endothelial Growth Factor, Hepatocyte Growth Factor and several microRNAs. Increased expression of the cell surface receptor c-Met, the glucose transporter GLUT-1 and the sodium iodide symporter lead to tumour growth, angiogenesis and cell migration. Stromal changes are also observed, resulting in alterations to the extracellular matrix composition and recruitment of fibroblasts and macrophages that create a microenvironment promoting cell survival, invasion and metastasis.
    Conclusion: Regardless of aetiology, most risk factors for cholangiocarcinoma cause chronic inflammation and/or cholestasis, leading to the activation of common intracellular pathways that result in reactive cell proliferation, genetic/epigenetic mutations and cholangiocarcinogenesis. An understanding of the molecular pathogenesis of cholangiocarcinoma is vital when developing new diagnostic biomarkers and targeted therapies for this disease.
    MeSH term(s) Animals ; Bile Duct Neoplasms/etiology ; Bile Duct Neoplasms/metabolism ; Bile Duct Neoplasms/pathology ; Biomarkers ; Cholangiocarcinoma/etiology ; Cholangiocarcinoma/metabolism ; Cholangiocarcinoma/pathology ; Disease Susceptibility ; Gene Expression Regulation, Neoplastic ; Humans ; Risk Factors ; Signal Transduction
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-02-28
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1471-2407
    ISSN (online) 1471-2407
    DOI 10.1186/s12885-019-5391-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Proteomic Alterations and Novel Markers of Neurotoxic Reactive Astrocytes in Human Induced Pluripotent Stem Cell Models.

    Labib, David / Wang, Zhen / Prakash, Priya / Zimmer, Matthew / Smith, Matthew D / Frazel, Paul W / Barbar, Lilianne / Sapar, Maria L / Calabresi, Peter A / Peng, Junmin / Liddelow, Shane A / Fossati, Valentina

    Frontiers in molecular neuroscience

    2022  Volume 15, Page(s) 870085

    Abstract: Astrocytes respond to injury, infection, and inflammation in the central nervous system by acquiring reactive states in which they may become dysfunctional and contribute to disease pathology. A sub-state of reactive astrocytes induced by proinflammatory ...

    Abstract Astrocytes respond to injury, infection, and inflammation in the central nervous system by acquiring reactive states in which they may become dysfunctional and contribute to disease pathology. A sub-state of reactive astrocytes induced by proinflammatory factors TNF, IL-1α, and C1q ("TIC") has been implicated in many neurodegenerative diseases as a source of neurotoxicity. Here, we used an established human induced pluripotent stem cell (hiPSC) model to investigate the surface marker profile and proteome of TIC-induced reactive astrocytes. We propose VCAM1, BST2, ICOSL, HLA-E, PD-L1, and PDPN as putative, novel markers of this reactive sub-state. We found that several of these markers colocalize with GFAP
    Language English
    Publishing date 2022-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2022.870085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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