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  1. Article ; Online: Epigenetic-based antioxidant effect of an ethanolic extract of

    Benassi, Barbara / Bacchetta, Loretta / Maccioni, Oliviero / Pacchierotti, Francesca

    Natural product research

    2023  Volume 37, Issue 24, Page(s) 4162–4168

    Abstract: The ethanolic extract ... ...

    Abstract The ethanolic extract of
    MeSH term(s) Humans ; Antioxidants/chemistry ; Corylus/chemistry ; Hydrogen Peroxide/pharmacology ; Plant Extracts/chemistry ; Ethanol ; Epigenesis, Genetic ; MicroRNAs
    Chemical Substances Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Plant Extracts ; Ethanol (3K9958V90M) ; MicroRNAs
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2174537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TLRs: Innate Immune Sentries against SARS-CoV-2 Infection.

    Mantovani, Stefania / Oliviero, Barbara / Varchetta, Stefania / Renieri, Alessandra / Mondelli, Mario U

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March 2020. Toll-like receptors (TLRs), crucial components in the initiation of innate ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been responsible for a devastating pandemic since March 2020. Toll-like receptors (TLRs), crucial components in the initiation of innate immune responses to different pathogens, trigger the downstream production of pro-inflammatory cytokines, interferons, and other mediators. It has been demonstrated that they contribute to the dysregulated immune response observed in patients with severe COVID-19. TLR2, TLR3, TLR4 and TLR7 have been associated with COVID-19 severity. Here, we review the role of TLRs in the etiology and pathogenesis of COVID-19, including TLR7 and TLR3 rare variants, the L412F polymorphism in TLR3 that negatively regulates anti-SARS-CoV-2 immune responses, the TLR3-related cellular senescence, the interaction of TLR2 and TLR4 with SARS-CoV-2 proteins and implication of TLR2 in NET formation by SARS-CoV-2. The activation of TLRs contributes to viral clearance and disease resolution. However, TLRs may represent a double-edged sword which may elicit dysregulated immune signaling, leading to the production of proinflammatory mediators, resulting in severe disease. TLR-dependent excessive inflammation and TLR-dependent antiviral response may tip the balance towards the former or the latter, altering the equilibrium that drives the severity of disease.
    MeSH term(s) Humans ; Toll-Like Receptor 2 ; COVID-19 ; Toll-Like Receptor 4 ; Toll-Like Receptor 3 ; Toll-Like Receptor 7 ; SARS-CoV-2 ; Toll-Like Receptors ; Cytokines ; Immunity, Innate
    Chemical Substances Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; Toll-Like Receptor 3 ; Toll-Like Receptor 7 ; Toll-Like Receptors ; Cytokines
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098065
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  3. Article ; Online: Early bird or night owl? Controlling the ultrafast photodynamics of triphenylamine substituted 2,2':6',2''-terpyridine.

    Maroń, Anna Maria / Cannelli, Oliviero / Socie, Etienne Christophe / Lodowski, Piotr / Oppermann, Malte / Machura, Barbara / Chergui, Majed

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 7, Page(s) 6265–6276

    Abstract: Controlling the ultrafast photodynamics of metal-free organic molecules has great potential for technological applications. In this work, we use solvent polarity and viscosity as "external knobs" to govern the photodynamics of an electron-donating ... ...

    Abstract Controlling the ultrafast photodynamics of metal-free organic molecules has great potential for technological applications. In this work, we use solvent polarity and viscosity as "external knobs" to govern the photodynamics of an electron-donating derivative of 2,2':6',2''-terpyridine (terpy), namely 4'-(4-(di(4-
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04492k
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  4. Article ; Online: Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in the Host's Immunity.

    Mondelli, Mario U / Ottolini, Sabrina / Oliviero, Barbara / Mantovani, Stefania / Cerino, Antonella / Mele, Dalila / Varchetta, Stefania

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe chronic liver disease and primary liver cancer. Chronic infection remains for life if not spontaneously eliminated and viral persistence profoundly impairs the ... ...

    Abstract Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe chronic liver disease and primary liver cancer. Chronic infection remains for life if not spontaneously eliminated and viral persistence profoundly impairs the efficiency of the host's immunity. Attempts have been made to develop an effective vaccine, but efficacy trials have met with failure. The availability of highly efficacious direct-acting antivirals (DAA) has created hope for the progressive elimination of chronic HCV infections; however, this approach requires a monumental global effort. HCV elicits a prompt innate immune response in the host, characterized by a robust production of interferon-α (IFN-α), although interference in IFN-α signaling by HCV proteins may curb this effect. The late appearance of largely ineffective neutralizing antibodies and the progressive exhaustion of T cells, particularly CD8 T cells, result in the inability to eradicate the virus in most infected patients. Moreover, an HCV cure resulting from DAA treatment does not completely restore the normal immunologic homeostasis. Here, we discuss the main immunological features of immune responses to HCV and the epigenetic scars that chronic viral persistence leaves behind.
    MeSH term(s) Humans ; Hepacivirus ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cicatrix ; Hepatitis C, Chronic/drug therapy ; Hepatitis C ; Interferon-alpha
    Chemical Substances Antiviral Agents ; Interferon-alpha
    Language English
    Publishing date 2023-12-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Long-term dynamics of natural killer cells in response to SARS-CoV-2 vaccination: Persistently enhanced activity postvaccination.

    Mele, Dalila / Ottolini, Sabrina / Lombardi, Andrea / Conteianni, Daniela / Bandera, Alessandra / Oliviero, Barbara / Mantovani, Stefania / Cassaniti, Irene / Baldanti, Fausto / Gori, Andrea / Mondelli, Mario U / Varchetta, Stefania

    Journal of medical virology

    2024  Volume 96, Issue 4, Page(s) e29585

    Abstract: Natural Killer (NK) cells play a significant role in the early defense against virus infections and cancer. Recent studies have demonstrated the involvement of NK cells in both the induction and effector phases of vaccine-induced immunity in various ... ...

    Abstract Natural Killer (NK) cells play a significant role in the early defense against virus infections and cancer. Recent studies have demonstrated the involvement of NK cells in both the induction and effector phases of vaccine-induced immunity in various contexts. However, their role in shaping immune responses following SARS-CoV-2 vaccination remains poorly understood. To address this matter, we conducted a comprehensive analysis of NK cell phenotype and function in SARS-CoV-2 unexposed individuals who received the BNT162b2 vaccine. We employed a longitudinal study design and utilized a panel of 53 15-mer overlapping peptides covering the receptor binding domain (RBD) of the SARS-CoV-2 Spike protein to assess NK cell function at 0 and 20 days following the first vaccine, and 30 and 240 days following booster. Additionally, we evaluated the levels of total IgG anti-Spike antibodies and their potential neutralizing ability. Our findings revealed an increased NK cell activity upon re-exposure to RBD when combined with IL12 and IL18 several months after booster. Concurrently, we observed that the frequencies of NKG2A + NK cells declined over the course of the follow-up period, while NKG2C increased only in CMV positive subjects. The finding that NK cell functions are inducible 9 months after vaccination upon re-exposure to RBD and cytokines, sheds light on the role of NK cells in contributing to SARS-CoV-2 vaccine-induced immune protection and pave the way to further studies in the field.
    MeSH term(s) Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; BNT162 Vaccine ; Longitudinal Studies ; COVID-19/prevention & control ; Vaccination ; Killer Cells, Natural ; Antibodies, Viral ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus
    Chemical Substances spike protein, SARS-CoV-2 ; COVID-19 Vaccines ; BNT162 Vaccine ; Antibodies, Viral ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29585
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Ultrashort Cationic Peptide Fmoc-FFK as Hydrogel Building Block for Potential Biomedical Applications.

    Gallo, Enrico / Diaferia, Carlo / Giordano, Sabrina / Rosa, Elisabetta / Carrese, Barbara / Piccialli, Gennaro / Borbone, Nicola / Morelli, Giancarlo / Oliviero, Giorgia / Accardo, Antonella

    Gels (Basel, Switzerland)

    2023  Volume 10, Issue 1

    Abstract: Fmoc-diphenylalanine (Fmoc-FF) is a low-molecular-weight peptide hydrogelator. This simple all-aromatic peptide can generate self-supporting hydrogel materials, which have been proposed as novel materials for diagnostic and pharmaceutical applications. ... ...

    Abstract Fmoc-diphenylalanine (Fmoc-FF) is a low-molecular-weight peptide hydrogelator. This simple all-aromatic peptide can generate self-supporting hydrogel materials, which have been proposed as novel materials for diagnostic and pharmaceutical applications. Our knowledge of the molecular determinants of Fmoc-FF aggregation is used as a guide to design new peptide-based gelators, with features for the development of improved tools. Here, we enlarge the plethora of Fmoc-FF-based hydrogelated matrices by studying the properties of the Fmoc-FFK tripeptide, alone or in combination with Fmoc-FF. For multicomponent matrices, the relative weight ratios between Fmoc-FFK and Fmoc-FF (specifically, 1/1, 1/5, 1/10, and 1/20
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels10010012
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  7. Article ; Online: First description of Rhodococcus equi infection in common bottlenose dolphin (Tursiops truncatus).

    Oliviero, Maria / Iaccarino, Doriana / Esposito, Emanuele / Paduano, Gianluigi / Di Nocera, Fabio / Borriello, Giorgia / Paradiso, Rubina / Degli Uberti, Barbara / Dimatteo, Maria / Amoroso, Maria Grazia / Lucifora, Giuseppe / Fusco, Giovanna / De Carlo, Esterina

    Veterinary research communications

    2024  

    Abstract: Rhodococcus equi is a terrestrial bacterium and a common pathogen in foals (Equus caballus), in which causes pneumonia. This report describes for the first time the infection caused by R. equi in a common bottlenose dolphin (Tursiops truncatus) stranded ... ...

    Abstract Rhodococcus equi is a terrestrial bacterium and a common pathogen in foals (Equus caballus), in which causes pneumonia. This report describes for the first time the infection caused by R. equi in a common bottlenose dolphin (Tursiops truncatus) stranded in the Calabrian coast, Italy. The post mortem examination of the animal revealed lesions in lung and colon. The animal was also positive to dolphin morbillivirus. The histological study showed lesions attributable to R. equi infection, such as pyogranulomatous bacterial pneumonia and chronic granulomatous colitis. Whole genome sequencing of the isolated strain confirmed its identification as R. equi.
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 406735-6
    ISSN 1573-7446 ; 0165-7380
    ISSN (online) 1573-7446
    ISSN 0165-7380
    DOI 10.1007/s11259-024-10352-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3453: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Hepatitis C Virus and the Host

    Mario U. Mondelli / Sabrina Ottolini / Barbara Oliviero / Stefania Mantovani / Antonella Cerino / Dalila Mele / Stefania Varchetta

    International Journal of Molecular Sciences, Vol 25, Iss 1, p

    A Mutual Endurance Leaving Indelible Scars in the Host’s Immunity

    2023  Volume 268

    Abstract: Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe chronic liver disease and primary liver cancer. Chronic infection remains for life if not spontaneously eliminated and viral persistence profoundly impairs the ... ...

    Abstract Hepatitis C virus (HCV) has spread worldwide, and it is responsible for potentially severe chronic liver disease and primary liver cancer. Chronic infection remains for life if not spontaneously eliminated and viral persistence profoundly impairs the efficiency of the host’s immunity. Attempts have been made to develop an effective vaccine, but efficacy trials have met with failure. The availability of highly efficacious direct-acting antivirals (DAA) has created hope for the progressive elimination of chronic HCV infections; however, this approach requires a monumental global effort. HCV elicits a prompt innate immune response in the host, characterized by a robust production of interferon-α (IFN-α), although interference in IFN-α signaling by HCV proteins may curb this effect. The late appearance of largely ineffective neutralizing antibodies and the progressive exhaustion of T cells, particularly CD8 T cells, result in the inability to eradicate the virus in most infected patients. Moreover, an HCV cure resulting from DAA treatment does not completely restore the normal immunologic homeostasis. Here, we discuss the main immunological features of immune responses to HCV and the epigenetic scars that chronic viral persistence leaves behind.
    Keywords HCV ; innate immunity ; adaptive immunity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Push-Pull Effect of Terpyridine Substituted by Triphenylamine Motive-Impact of Viscosity, Polarity and Protonation on Molecular Optical Properties.

    Maroń, Anna Maria / Cannelli, Oliviero / Socie, Etienne Christophe / Lodowski, Piotr / Machura, Barbara

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 20

    Abstract: The introduction of an electron-donating triphenylamine motive into a 2,2',6',2''-terpyridine (terpy) moiety, a cornerstone molecular unit in coordination chemistry, opens new ways for a rational design of photophysical properties of organic and ... ...

    Abstract The introduction of an electron-donating triphenylamine motive into a 2,2',6',2''-terpyridine (terpy) moiety, a cornerstone molecular unit in coordination chemistry, opens new ways for a rational design of photophysical properties of organic and inorganic compounds. A push-pull compound, 4'-(4-(di(4-tert-butylphenyl)amine)phenyl)-2,2',6',2''-terpyridine (tBuTPAterpy), was thoroughly investigated with the use of steady-state and time-resolved spectroscopies and Density Functional Theory (DFT) calculations. Our results demonstrate that solvent parameters have an enormous influence on the optical properties of this molecule, acting as knobs for external control of its photophysics. The Intramolecular Charge Transfer (ICT) process introduces a remarkable solvent polarity effect on the emission spectra without affecting the lowest absorption band, as confirmed by DFT simulations, including solvation effects. The calculations ascribe the lowest absorption transitions to two singlet ICT excited states, S
    MeSH term(s) Viscosity ; Electrons ; Solvents/chemistry ; Amines
    Chemical Substances Solvents ; Amines
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27207071
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  10. Article ; Online: Glugea plecoglossi (Strickland, 1911) infection in wild Sardinella aurita (Valenciennes, 1847) along the Campania coasts, in southern Italy.

    Oliviero, Maria / Iaccarino, Doriana / Esposito, Emanuele / Paduano, Gianluigi / D'Alessio, Nicola / Sgroi, Giovanni / Lucibelli, Maria Gabriella / Auriemma, Clementina / Uberti, Barbara Degli / D'Amore, Marianna / Dimatteo, Maria / Fusco, Giovanna / De Carlo, Esterina / Di Nocera, Fabio

    Journal of fish diseases

    2024  , Page(s) e13956

    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 432109-1
    ISSN 1365-2761 ; 0140-7775
    ISSN (online) 1365-2761
    ISSN 0140-7775
    DOI 10.1111/jfd.13956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4276: Show issues

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