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  1. Book ; Online: Major Histocompatibility Complex (MHC) in Health and Disease

    Kulski, Jerzy K. / Shiina, Takashi / Dijkstra, Johannes M.

    2020  

    Abstract: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC ... ...

    Abstract The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on "MHC in Health and Disease" covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species
    Keywords Science (General) ; Biology (General)
    Size 1 electronic resource (375 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020480859
    ISBN 9783039280728 ; 9783039280735 ; 3039280724 ; 3039280732
    DOI 10.3390/books978-3-03928-073-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: A method for making alignments of related protein sequences that share very little similarity; shark interleukin 2 as an example.

    Dijkstra, Johannes M

    Immunogenetics

    2021  Volume 73, Issue 1, Page(s) 35–51

    Abstract: An optimized alignment of related protein sequences helps to see their important shared features and to deduce their phylogenetic relationships. At low levels of sequence similarity, there are no suitable computer programs for making the best possible ... ...

    Abstract An optimized alignment of related protein sequences helps to see their important shared features and to deduce their phylogenetic relationships. At low levels of sequence similarity, there are no suitable computer programs for making the best possible alignment. This review summarizes some guidelines for how in such instances, nevertheless, insightful alignments can be made. The method involves, basically, the understanding of molecular family features at both the protein and intron-exon level, and the collection of many related sequences so that gradual differences may be observed. The method is exemplified by identifying and aligning interleukin 2 (IL-2) and related sequences in Elasmobranchii (sharks/rays) and coelacanth, as other authors have expressed difficulty with their identification. From the point of general immunology, it is interesting that the unusual long "leader" sequence of IL-15, already known in other species, is even more impressively conserved in cartilaginous fish. Furthermore, sequence comparisons suggest that IL-2 in cartilaginous fish has lost its ability to bind an IL-2Rα/15Rα receptor chain, which would prohibit the existence of a mechanism for regulatory T cell regulation identical to mammals.
    MeSH term(s) Amino Acid Sequence ; Animals ; Evolution, Molecular ; Interleukin-15/chemistry ; Interleukin-15/genetics ; Interleukin-15/metabolism ; Interleukin-2/chemistry ; Interleukin-2/genetics ; Interleukin-2/metabolism ; Interleukins/chemistry ; Interleukins/metabolism ; Phylogeny ; Sequence Alignment/methods ; Sharks/classification ; Sharks/genetics ; Sharks/immunology ; Vertebrates/classification ; Vertebrates/genetics ; Vertebrates/immunology
    Chemical Substances Interleukin-15 ; Interleukin-2 ; Interleukins ; interleukin-21 (MKM3CA6LT1)
    Language English
    Publishing date 2021-01-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 186560-2
    ISSN 1432-1211 ; 0093-7711
    ISSN (online) 1432-1211
    ISSN 0093-7711
    DOI 10.1007/s00251-020-01191-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Life and Science of Professor Tsuneko Okazaki, and her time at Fujita Health University.

    Dijkstra, Johannes M / Nagatsu, Toshiharu

    Fujita medical journal

    2023  Volume 10, Issue 1, Page(s) 1–7

    Abstract: Distinguished Professor Emeritus Tsuneko Okazaki is a hero of science. Together with her late husband, Professor Reiji Okazaki, she discovered that DNA replication involves the discontinuous synthesis of the DNA lagging strand by intermediates of, what ... ...

    Abstract Distinguished Professor Emeritus Tsuneko Okazaki is a hero of science. Together with her late husband, Professor Reiji Okazaki, she discovered that DNA replication involves the discontinuous synthesis of the DNA lagging strand by intermediates of, what is now called, "Okazaki fragments." She has been a pioneer for women in science and, in 1983, became the first female full Professor at Nagoya University. From 1997 to 2012, she was a full Professor and later a Visiting Professor at Fujita Health University, and this review zooms in on that period. Besides a summary of her career, this article also includes personal memories of researchers who worked with Professor Okazaki.
    Language English
    Publishing date 2023-11-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 3011241-2
    ISSN 2189-7255 ; 2189-7247
    ISSN (online) 2189-7255
    ISSN 2189-7247
    DOI 10.20407/fmj.2023-014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Parkinson's Disease: Cells Succumbing to Lifelong Dopamine-Related Oxidative Stress and Other Bioenergetic Challenges.

    Watanabe, Hirohisa / Dijkstra, Johannes M / Nagatsu, Toshiharu

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: The core pathological event in Parkinson's disease (PD) is the specific dying of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). The reasons why SNc DA neurons are especially vulnerable and why idiopathic PD has only been found in ... ...

    Abstract The core pathological event in Parkinson's disease (PD) is the specific dying of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). The reasons why SNc DA neurons are especially vulnerable and why idiopathic PD has only been found in humans are still puzzling. The two main underlying factors of SNc DA neuron vulnerability appear related to high DA production, namely (i) the toxic effects of cytoplasmic DA metabolism and (ii) continuous cytosolic Ca
    MeSH term(s) Humans ; Parkinson Disease/metabolism ; Dopamine/metabolism ; Substantia Nigra/metabolism ; Dopaminergic Neurons/metabolism ; Oxidative Stress/physiology ; Energy Metabolism
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Comprehensive Sequence Analysis of Parvalbumins in Fish and Their Comparison with Parvalbumins in Tetrapod Species.

    Dijkstra, Johannes M / Kondo, Yasuto

    Biology

    2022  Volume 11, Issue 12

    Abstract: Parvalbumins are small molecules with important functions in ... ...

    Abstract Parvalbumins are small molecules with important functions in Ca
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11121713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immunogenetics special issue 2021: Fish Immunology.

    Dijkstra, Johannes M / Dixon, Brian

    Immunogenetics

    2021  Volume 73, Issue 1, Page(s) 1–3

    MeSH term(s) Animals ; Fishes/genetics ; Fishes/immunology ; Immunogenetics
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 186560-2
    ISSN 1432-1211 ; 0093-7711
    ISSN (online) 1432-1211
    ISSN 0093-7711
    DOI 10.1007/s00251-020-01198-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Comprehensive Sequence Analysis of Parvalbumins in Fish and Their Comparison with Parvalbumins in Tetrapod Species

    Dijkstra, Johannes M. / Kondo, Yasuto

    Biology (Basel). 2022 Nov. 25, v. 11, no. 12

    2022  

    Abstract: Parvalbumins are small molecules with important functions in Ca²⁺ signaling, but their sequence comparisons to date, especially in fish, have been relatively poor. We here, characterize sequence motifs that distinguish parvalbumin subfamilies across ... ...

    Abstract Parvalbumins are small molecules with important functions in Ca²⁺ signaling, but their sequence comparisons to date, especially in fish, have been relatively poor. We here, characterize sequence motifs that distinguish parvalbumin subfamilies across vertebrate species, as well as those that distinguish individual parvalbumins (orthologues) in fish, and map them to known parvalbumin structures. As already observed by others, all classes of jawed vertebrates possess parvalbumins of both the α-parvalbumin and oncomodulin subfamilies. However, we could not find convincing phylogenetic support for the common habit of classifying all non-α-parvalbumins together as “β-parvalbumins.” In teleost (modern bony) fish, we here distinguish parvalbumins 1-to-10, of which the gene copy number can differ between species. The genes for α-parvalbumins (pvalb6 and pvalb7) and oncomodulins (pvalb8 and pvalb9) are well conserved between teleost species, but considerable variation is observed in their copy numbers of the non-α/non-oncomodulin genes pvalb1-to-5 and pvalb10. Teleost parvalbumins 1-to-4 are hardly distinguishable from each other and are highly expressed in muscle, and described allergens belong to this subfamily. However, in some fish species α-parvalbumin expression is also high in muscle. Pvalb5 and pvalb10 molecules form distinct lineages, the latter even predating the origin of teleosts, but have been lost in some teleost species. The present study aspires to be a frame of reference for future studies trying to compare different parvalbumins.
    Keywords calcium ; fish ; gene dosage ; muscles ; phylogeny ; sequence analysis
    Language English
    Dates of publication 2022-1125
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology11121713
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Eumelanin Detection in Melanized Focal Changes but Not in Red Focal Changes on Atlantic Salmon (

    Wakamatsu, Kazumasa / Dijkstra, Johannes M / Mørkøre, Turid / Ito, Shosuke

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: Superficial discolored spots on Atlantic salmon ( ...

    Abstract Superficial discolored spots on Atlantic salmon (
    MeSH term(s) Animals ; Melanins/metabolism ; Salmo salar/metabolism ; Dihydroxyphenylalanine ; Pigmentation
    Chemical Substances eumelanin (12627-86-0) ; Melanins ; Dihydroxyphenylalanine (63-84-3)
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cognitive behavioral therapy (CBT), acceptance and commitment therapy (ACT), and Morita therapy (MT); comparison of three established psychotherapies and possible common neural mechanisms of psychotherapies.

    Dijkstra, Johannes M / Nagatsu, Toshiharu

    Journal of neural transmission (Vienna, Austria : 1996)

    2021  Volume 129, Issue 5-6, Page(s) 805–828

    Abstract: Psychotherapies aim to relieve patients from mental distress by guiding them toward healthier attitudes and behaviors. Psychotherapies can differ substantially in concepts and approaches. In this review article, we compare the methods and science of ... ...

    Abstract Psychotherapies aim to relieve patients from mental distress by guiding them toward healthier attitudes and behaviors. Psychotherapies can differ substantially in concepts and approaches. In this review article, we compare the methods and science of three established psychotherapies: Morita Therapy (MT), which is a 100-year-old method established in Japan; Cognitive Behavioral Therapy (CBT), which-worldwide-has become the major psychotherapy; and Acceptance and Commitment Therapy (ACT), which is a relatively young psychotherapy that shares some characteristics with MT. The neuroscience of psychotherapy as a system is only beginning to be understood, but relatively solid scientific information is available about some of its important aspects such as learning, physical health, and social interactions. On average, psychotherapies work best if combined with pharmacotherapies. This synergy may rely on the drugs helping to "kickstart" the use of neural pathways (behaviors) to which a patient otherwise has poor access. Improved behavior, guided by psychotherapy, can then consolidate these pathways by their continued usage throughout a patient's life.
    MeSH term(s) Acceptance and Commitment Therapy ; Aged, 80 and over ; Cognitive Behavioral Therapy/methods ; Humans ; Learning ; Neural Pathways ; Psychotherapy/methods
    Language English
    Publishing date 2021-12-10
    Publishing country Austria
    Document type Journal Article ; Review
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-021-02450-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.150: Show issues Location:
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  10. Article ; Online: Expected immune recognition of COVID-19 virus by memory from earlier infections with common coronaviruses in a large part of the world population.

    Dijkstra, Johannes M / Hashimoto, Keiichiro

    F1000Research

    2020  Volume 9, Page(s) 285

    Abstract: SARS-CoV-2 is the coronavirus agent of the COVID-19 pandemic causing high mortalities. In contrast, the widely spread human coronaviruses OC43, HKU1, 229E, and NL63 tend to cause only mild symptoms. The present study shows, ... ...

    Abstract SARS-CoV-2 is the coronavirus agent of the COVID-19 pandemic causing high mortalities. In contrast, the widely spread human coronaviruses OC43, HKU1, 229E, and NL63 tend to cause only mild symptoms. The present study shows, by
    MeSH term(s) Humans ; Antigens, Viral/immunology ; Betacoronavirus ; Coronavirus/classification ; Coronavirus Infections/immunology ; COVID-19 ; Epitopes/immunology ; Immunologic Memory ; Pandemics ; Pneumonia, Viral/immunology ; SARS-CoV-2
    Chemical Substances Antigens, Viral ; Epitopes
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.23458.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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