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  1. Article ; Online: Expert Commentary on Bowel-Preserving Surgery for Diffuse Stricturing Crohn's Jejunoileitis.

    Michelassi, Fabrizio

    Diseases of the colon and rectum

    2022  Volume 65, Issue 10, Page(s) 1171–1172

    MeSH term(s) Constriction, Pathologic/surgery ; Crohn Disease/surgery ; Digestive System Surgical Procedures ; Humans
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002575
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  2. Article ; Online: Immune-Mediated Necrotizing Myopathies: Current Landscape.

    Koumas, Christoforos / Michelassi, Francesco

    Current neurology and neuroscience reports

    2024  Volume 24, Issue 5, Page(s) 141–150

    Abstract: Purpose of review: Immune-mediated necrotizing myopathy (IMNM), characterized by acute or subacute onset, severe weakness, and elevated creatine kinase levels, poses diagnostic and therapeutic challenges. This article provides a succinct overview of ... ...

    Abstract Purpose of review: Immune-mediated necrotizing myopathy (IMNM), characterized by acute or subacute onset, severe weakness, and elevated creatine kinase levels, poses diagnostic and therapeutic challenges. This article provides a succinct overview of IMNM, including clinical features, diagnostic strategies, and treatment approaches.
    Recent findings: Recent insights highlight the different clinical presentations and therapeutic options of IMNM stratified by autoantibody positivity and type. Additionally, recent findings call into question the reported link between statin use and IMNM. This review synthesizes current knowledge on IMNM, emphasizing its distinct clinical features and challenging management. The evolving understanding of IMNM underscores the need for a comprehensive diagnostic approach that utilizes a growing range of modalities. Early and aggressive immunomodulatory therapy remains pivotal. Ongoing research aims to refine diagnostic tools and therapeutic interventions for this challenging muscle disorder, underscoring the importance of advancing our understanding to enhance patient outcomes.
    MeSH term(s) Humans ; Muscle, Skeletal ; Necrosis/diagnosis ; Myositis/therapy ; Myositis/drug therapy ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/therapy ; Muscular Diseases/diagnosis ; Muscular Diseases/therapy ; Autoantibodies
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-024-01337-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Managing Stricturing Crohn's Disease: Resect? Strictureplasty? Dilate?

    Lowenfeld, Lea / Michelassi, Fabrizio

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2021  Volume 31, Issue 8, Page(s) 881–889

    Abstract: Crohn's disease (CD) is a pan-intestinal disease of the gastrointestinal tract characterized by inflammatory, penetrating, and fibrostenotic phenotypes. Fibrostenotic stricture formation, without inflammatory or penetrating disease, is a common ... ...

    Abstract Crohn's disease (CD) is a pan-intestinal disease of the gastrointestinal tract characterized by inflammatory, penetrating, and fibrostenotic phenotypes. Fibrostenotic stricture formation, without inflammatory or penetrating disease, is a common complication in CD, primarily affecting the small intestine and leading to small bowel obstruction. Because there is no medical therapy that prevents or reverses stricturing disease, endoscopic and surgical treatments are the mainstays of treatment, indicated to palliate symptoms and treat the complications. Endoscopic approaches include dilation, stricturotomy, and endoscopic stenting. Surgical options include resection, intestinal bypass, and various strictureplasty techniques. In this article, we will focus on the treatment of stricturing CD: specifically, the considerations important in choosing between different treatment options and technical tips to deal with complicated disease.
    MeSH term(s) Constriction, Pathologic/etiology ; Constriction, Pathologic/surgery ; Crohn Disease/complications ; Crohn Disease/surgery ; Dilatation ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intestine, Small ; Treatment Outcome
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2021.0099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long-term Results of Side-to-Side Isoperistaltic Strictureplasty for Crohn Disease.

    Michelassi, Fabrizio

    JAMA surgery

    2016  Volume 151, Issue 5, Page(s) 461

    Language English
    Publishing date 2016-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2015.4661
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  5. Article: Report of ACSPA/ACS activities, June 2016.

    Michelassi, Fabrizio

    Bulletin of the American College of Surgeons

    2016  Volume 101, Issue 9, Page(s) 78–85

    MeSH term(s) General Surgery ; Humans ; Organizational Objectives ; Policy Making ; Politics ; Quality Assurance, Health Care ; Societies, Medical/organization & administration ; United States
    Language English
    Publishing date 2016
    Publishing country United States
    Document type News
    ZDB-ID 390409-x
    ISSN 0002-8045
    ISSN 0002-8045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Society for Surgery of the Alimentary Tract Presidential Address: Advanced GI Surgery Training: Past and Future Role of the SSAT.

    Michelassi, Fabrizio

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2015  Volume 20, Issue 1, Page(s) 1–5

    Language English
    Publishing date 2015-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-015-3028-4
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  7. Article ; Online: Michelassi II Strictureplasty for Crohn's Disease: A New Side-to-Side Isoperistaltic Strictureplasty With Discontinuous Bowel Loops.

    Mege, Diane / Michelassi, Fabrizio

    Annals of surgery

    2020  Volume 271, Issue 1, Page(s) e1–e2

    Abstract: Objective: We report on a new side-to-side isoperistaltic strictureplasty (SSIS), the Michelassi ... Summary background data: The SSIS Michelassi strictureplasty was described a quarter of a century ago ... of the SSIS.: Conclusions: The Michelassi II, or the end-to-side-to-side-to-end strictureplasty, is ...

    Abstract Objective: We report on a new side-to-side isoperistaltic strictureplasty (SSIS), the Michelassi II or end-to-side-to-side-to-end strictureplasty, performed with discontinuous bowel loops.
    Summary background data: The SSIS Michelassi strictureplasty was described a quarter of a century ago to avoid massive bowel resections in patients with extensive fibrostenosing Crohn's jejuno-ileitis.
    Methods: The end-to-side-to-side-to-end strictureplasty is performed in patients presenting with 3 severely fibrotic and deformed bowel loops separated by 2 diseased segments with sequential strictures. After the resection of the 3 severely diseased segments, the remaining 2 discontinuous segments are used to perform a SSIS, according to the original description. The 2 ends of the SSIS are then anastomosed with the proximal and the distal bowel, respectively. In the presence of discrepancy in length between the 2 discontinuous segments, the proximal small bowel is recruited to equalize the length and aid in the performance of the SSIS.
    Conclusions: The Michelassi II, or the end-to-side-to-side-to-end strictureplasty, is a variant of the original SSIS technique to address severe and extensive small bowel Crohn's disease presenting with 3 severely fibrotic and deformed bowel loops separated by 2 diseased segments with sequential strictures.
    MeSH term(s) Adult ; Anastomosis, Surgical/methods ; Crohn Disease/complications ; Crohn Disease/surgery ; Digestive System Surgical Procedures/methods ; Humans ; Ileum/surgery ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Jejunum/surgery ; Male ; Reconstructive Surgical Procedures/methods
    Language English
    Publishing date 2020-01-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000003430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Crohn's recurrence after intestinal resection and anastomosis.

    Michelassi, Fabrizio

    Digestive diseases and sciences

    2014  Volume 59, Issue 7, Page(s) 1352–1353

    MeSH term(s) Colectomy ; Colon/surgery ; Crohn Disease/surgery ; Humans ; Ileum/surgery ; Suture Techniques
    Language English
    Publishing date 2014-03-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-014-3096-4
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  9. Article ; Online: Update on the American Board of Surgery subspecialty certificate in Complex General Surgical Oncology.

    Michelassi, Fabrizio

    Annals of surgical oncology

    2013  Volume 20, Issue 7, Page(s) 2103–2105

    MeSH term(s) Certification/organization & administration ; General Surgery ; Humans ; Medical Oncology ; Specialization
    Language English
    Publishing date 2013-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-013-3007-5
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  10. Article ; Online: Laparoscopy in Crohn Disease: Learning Curve and Current Practice.

    Mege, Diane / Michelassi, Fabrizio

    Annals of surgery

    2018  Volume 271, Issue 2, Page(s) 317–324

    Abstract: ... eight procedures were performed in 427 patients [F:M 1:1; median age = 41 (12-95) yrs ...

    Abstract Objective: To identify preoperative characteristics to help in selecting laparoscopy or laparotomy in Crohn disease (CD).
    Summary background: Laparoscopy in CD is associated with high rates of conversion.
    Methods: All patients undergoing abdominal surgery for CD in 2004 to 2016 by the senior author. Patients operated by laparoscopy, laparotomy, and converted to open were compared.
    Results: Four hundred fifty-eight procedures were performed in 427 patients [F:M 1:1; median age = 41 (12-95) yrs], through laparotomy (n = 157, 34%) or laparoscopy (n = 301, 66%). Laparotomy rates decreased over time. Concomitant surgical procedures requiring laparotomy continued to dictate an open approach throughout the study. Sixty-five cases (21.6%) required conversion to laparotomy which occurred within 15' from start of case in 77%. Most common reasons for conversion included dense adhesions (34%), pelvic sepsis with fistulizing disease (26%), large inflammatory mass (18%), and thickened mesentery (9%). After multivariate analysis, predictive factors for conversion included recurrent disease after previous small bowel resection, thickened mesentery, large inflammatory mass, and extensive disease.
    Conclusion: Despite the increasing experience with laparoscopy in CD, one-fifth of selected cases still need conversion. Recurrent disease with dense adhesions, pelvic sepsis with fistulizing disease, large inflammatory mass, and thickened mesentery are all conditions predisposing to a conversion. When the severity of these conditions is known preoperatively or a simultaneous procedure requires a laparotomy, an open approach should be considered; if laparoscopy is selected, conversion to laparotomy can be decided early in the performance of the case.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Conversion to Open Surgery/statistics & numerical data ; Crohn Disease/surgery ; Decision Making ; Female ; Humans ; Laparoscopy/education ; Laparoscopy/statistics & numerical data ; Laparotomy/statistics & numerical data ; Learning Curve ; Male ; Middle Aged
    Language English
    Publishing date 2018-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000002995
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