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Book: Gutachten zur gesamthessischen Situation des Bibers (Castor fiber L., 1758)

Denk, Martina / Jung, Jürgen / Lohse, Susanne

zur Vorbereitung des Monitorings im Rahmen der Berichtspflichten zu FFH-Anhang-II-Arten

(Natura 2000)

2004

Title variant	Die Situation des Bibers in Hessen
Author's details	[Projektleitung: Martina Denk ; Jürgen Jung ; Susanne Lohse. Unter Mitarb. von: Mark Harthun ; Rainer Loos. Hrsg.: Hessen, Hessisches Ministerium für Umwelt, Ländlichen Raum und Verbraucherschutz, Abteilung Forsten und Naturschutz. Projektleitung: Peter Haase. Auftr.-Geber: Hessisches Dienstleistungszentrum für Landwirtschaft, Gartenbau und Naturschutz. Auftr.-Nehmer: Senckenberg, Forschungsinstitut und Naturmuseum, Forschungsstation für Mittelgebirge. Hessisches Ministerium für Umwelt, Ländlichen Raum und Verbraucherschutz]
Series title	Natura 2000
Language	German
Size	Getr. Zählung, Ill., graph. Darst., Kt., 30 cm
Edition	Stand November 2003, erg. im Juni 2004
Publisher	Hessisches Ministerium für Umwelt, Ländlichen Raum und Verbraucherschutz, Abt. Forsten und Naturschutz
Publishing place	Wiesbaden
Publishing country	Germany
Document type	Book
Note	Literaturangaben
HBZ-ID	HT014591227
ISBN	3-89274-241-3 ; 978-3-89274-241-8
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Shelf mark	Loan status	Location
054/1137	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Divergent evolution in the genomes of closely related lacertids, Lacerta viridis and L. bilineata, and implications for speciation.

Kolora, Sree Rohit Raj / Weigert, Anne / Saffari, Amin / Kehr, Stephanie / Walter Costa, Maria Beatriz / Spröer, Cathrin / Indrischek, Henrike / Chintalapati, Manjusha / Lohse, Konrad / Doose, Gero / Overmann, Jörg / Bunk, Boyke / Bleidorn, Christoph / Grimm-Seyfarth, Annegret / Henle, Klaus / Nowick, Katja / Faria, Rui / Stadler, Peter F / Schlegel, Martin

GigaScience

2018 Volume 8, Issue 2

Abstract: ... eastern and western clades, respectively) that, until recently, were grouped together as the L. viridis ... which led to the delineation of two separate species within the L. viridis complex. The population history ... novo genome assemblies for both L. viridis and L. bilineata through Illumina and PacBio sequencing ...

Abstract	Background: Lacerta viridis and Lacerta bilineata are sister species of European green lizards (eastern and western clades, respectively) that, until recently, were grouped together as the L. viridis complex. Genetic incompatibilities were observed between lacertid populations through crossing experiments, which led to the delineation of two separate species within the L. viridis complex. The population history of these sister species and processes driving divergence are unknown. We constructed the first high-quality de novo genome assemblies for both L. viridis and L. bilineata through Illumina and PacBio sequencing, with annotation support provided from transcriptome sequencing of several tissues. To estimate gene flow between the two species and identify factors involved in reproductive isolation, we studied their evolutionary history, identified genomic rearrangements, detected signatures of selection on non-coding RNA, and on protein-coding genes. Findings: Here we show that gene flow was primarily unidirectional from L. bilineata to L. viridis after their split at least 1.15 million years ago. We detected positive selection of the non-coding repertoire; mutations in transcription factors; accumulation of divergence through inversions; selection on genes involved in neural development, reproduction, and behavior, as well as in ultraviolet-response, possibly driven by sexual selection, whose contribution to reproductive isolation between these lacertid species needs to be further evaluated. Conclusion: The combination of short and long sequence reads resulted in one of the most complete lizard genome assemblies. The characterization of a diverse array of genomic features provided valuable insights into the demographic history of divergence among European green lizards, as well as key species differences, some of which are candidates that could have played a role in speciation. In addition, our study generated valuable genomic resources that can be used to address conservation-related issues in lacertids.
MeSH term(s)	Animals ; Evolution, Molecular ; Female ; Genome ; Genomics ; Lizards/genetics ; Male ; Sequence Analysis, DNA ; Sequence Analysis, RNA
Language	English
Publishing date	2018-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2708999-X
ISSN	2047-217X ; 2047-217X
ISSN (online)	2047-217X
ISSN	2047-217X
DOI	10.1093/gigascience/giy160
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Divergent evolution in the genomes of closely related lacertids, Lacerta viridis and L. bilineata, and implications for speciation

Kolora, S.R.R. / Weigert, A. / Saffari, A. / Kehr, S. / Costa, M.B.W. / Spröer, C. / Indrischek, H. / Chintalapati, M. / Lohse, K. / Doose, G. / Overmann, J. / Bunk, B. / Bleidorn, C. / Grimm-Seyfarth, A. / Henle, K. / Nowick, K. / Faria, R. / Stadler, P.F. / Schlegel, M.

2019

Abstract: ... together as the L. viridis complex. Genetic incompatibilities were observed between lacertid populations ... through crossing experiments, which led to the delineation of two separate species within the L. viridis complex ... the first high-quality de novo genome assemblies for both L. viridis and L. bilineata through Illumina and ...

Abstract	Art. giy160, 15 S. Background: Lacerta viridis and Lacerta bilineata are sister species of European green lizards (eastern and western clades, respectively) that, until recently, were grouped together as the L. viridis complex. Genetic incompatibilities were observed between lacertid populations through crossing experiments, which led to the delineation of two separate species within the L. viridis complex. The population history of these sister species and processes driving divergence are unknown. We constructed the first high-quality de novo genome assemblies for both L. viridis and L. bilineata through Illumina and PacBio sequencing, with annotation support provided from transcriptome sequencing of several tissues. To estimate gene flow between the two species and identify factors involved in reproductive isolation, we studied their evolutionary history, identified genomic rearrangements, detected signatures of selection on non-coding RNA, and on protein-coding genes. Findings: Here we show that gene flow was primarily unidirectional from L. bilineata to L. viridis after their split at least 1.15 million years ago. We detected positive selection of the non-coding repertoire; mutations in transcription factors; accumulation of divergence through inversions; selection on genes involved in neural development, reproduction, and behavior, as well as in ultraviolet-response, possibly driven by sexual selection, whose contribution to reproductive isolation between these lacertid species needs to be further evaluated. Conclusion: The combination of short and long sequence reads resulted in one of the most complete lizard genome assemblies. The characterization of a diverse array of genomic features provided valuable insights into the demographic history of divergence among European green lizards, as well as key species differences, some of which are candidates that could have played a role in speciation. In addition, our study generated valuable genomic resources that can be used to address conservation-related ...
Keywords	610 ; 620
Subject code	590
Language	English
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Expositionstherapie in virtueller Realität bei Zwangsstörungen. Einsatz der virtuellen Realität bei der Behandlung von Wasch- und Kontrollzwängen

Lohse, Luzie

Psychotherapie Aktuell

2023 Volume 15, Issue 2, Page(s) 20–26

Abstract: Trotz eindeutiger Empfehlung in den Behandlungsleitlinien wird die kognitive Verhaltenstherapie mit Expositionstherapie mit Reaktionsmanagement (ERM) bei Patient*innen mit Zwangsstörungen (OCD) nicht in ausreichendem Maße angewandt, was zum Teil auf ... ...

Title translation	Virtual reality exposure therapy for obsessive-compulsive disorder. Use of virtual reality in the treatment of washing and control compulsions
Abstract	Trotz eindeutiger Empfehlung in den Behandlungsleitlinien wird die kognitive Verhaltenstherapie mit Expositionstherapie mit Reaktionsmanagement (ERM) bei Patientinnen mit Zwangsstörungen (OCD) nicht in ausreichendem Maße angewandt, was zum Teil auf verschiedene Behandlungsbarrieren zurückzuführen ist (zum Beispiel die Angst der Patientinnen vor der Exposition). Der Einsatz von virtueller Realität (VR) könnte diese Barrieren überwinden, indem sie eine weniger aversive Form von ERM darstellt. In einer randomisiert kontrollierten Studie (RCT) untersuchten wir die Wirksamkeit, die Akzeptanz und entscheidende Faktoren (zum Beispiel das Präsenzgefühl) von ERM in VR (VERM) bei Patient*innen mit Wasch- und Kontrollzwängen. Zwangshandlungen verbesserten sich in der Gruppe mit VERM signifikant stärker als in der Wartekontrollgruppe (T0 bis T1). Insgesamt wurde VERM akzeptiert, wobei vorrangig die subjektiv empfundene Wirksamkeit kritisiert wurde. Das Präsenzgefühl lag im unteren Bereich und wies auf die Notwendigkeit der technischen Überarbeitung hin.
Keywords	Cognitive Behavior Therapy ; Expositionstherapie ; Exposure Therapy ; Kognitive Verhaltenstherapie ; Obsessive Compulsive Disorder ; Therapieerfolgskontrolle ; Treatment Effectiveness Evaluation ; Virtual Reality ; Virtuelle Realität ; Zwangsstörung
Language	German
Document type	Article
ISSN	1869-0335
ISSN	1869-0335
Database	PSYNDEX

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Book ; Online: Optimierung des Selbst

Dalski, Loreen / Flöter, Kirsten / Keil, Lisa / Lohse, Kathrin / Sand, Lucas / Schülein, Annabelle

Konzepte, Darstellungen und Praktiken

(Edition Kulturwissenschaft)

2022

Series title	Edition Kulturwissenschaft
Keywords	Cultural studies ; Literary studies: general ; Sociology ; Selbstoptimierung ; Individualisierung ; Leistungssteigerung ; Selbstmanagement ; Verhaltensmodifikation ; Digitalisierung ; Neoliberalismus ; Autonomie ; Technik ; Technologie ; Kultur ; Literatur ; Körper ; Kulturtheorie ; Allgemeine Literaturwissenschaft ; Gender Studies ; Kulturwissenschaft ; Self-Optimiziation ; Individualization ; Self Management ; Behaviour Modification ; Digitalization ; Neoliberalism ; Autonomy ; Technology ; Culture ; Literature ; Body ; Cultural Theory ; Literary Studies ; Cultural Studies
Language	0\|d
Size	1 electronic resource (222 pages)
Publisher	transcript Verlag
Publishing place	Bielefeld
Document type	Book ; Online
Note	German ; Open Access
HBZ-ID	HT021620968
ISBN	9783837661347 ; 3837661342
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes.

Warrier, Sunita / Ramamurthy, Gopalakrishnan / Eckert, Richard L / Nikolaev, Viacheslav O / Lohse, Martin J / Harvey, Robert D

The Journal of physiology

2007 Volume 580, Issue Pt.3, Page(s) 765–776

Abstract: ... cAMP-dependent stimulation of the L-type Ca(2+) current in guinea pig ventricular myocytes. This is ... associated with betaAR regulation of L-type Ca(2+) channel function. ...

Abstract	Many different receptors can stimulate cAMP synthesis in the heart, but not all elicit the same functional responses. For example, it has been recognized for some time that prostaglandins such as PGE1 increase cAMP production and activate PKA, but they do not elicit responses like those produced by beta-adrenergic receptor (betaAR) agonists such as isoproterenol (isoprenaline), even though both stimulate the same signalling pathway. In the present study, we confirm that isoproterenol, but not PGE1, is able to produce cAMP-dependent stimulation of the L-type Ca(2+) current in guinea pig ventricular myocytes. This is despite finding evidence that these cells express EP(4) prostaglandin receptors, which are known to activate G(s)-dependent signalling pathways. Using fluorescence resonance energy transfer-based biosensors that are either freely diffusible or bound to A kinase anchoring proteins, we demonstrate that the difference is due to the ability of isoproterenol to stimulate cAMP production in cytosolic and caveolar compartments of intact cardiac myocytes, while PGE1 only stimulates cAMP production in the cytosolic compartment. Unlike other receptor-mediated responses, compartmentation of PGE1 responses was not due to concurrent activation of a G(i)-dependent signalling pathway or phosphodiesterase activity. Instead, compartmentation of the PGE1 response in cardiac myocytes appears to be due to transient stimulation of cAMP in a microdomain that can communicate directly with the bulk cytosolic compartment but not the caveolar compartment associated with betaAR regulation of L-type Ca(2+) channel function.
MeSH term(s)	Adrenergic beta-Agonists/pharmacology ; Alprostadil/pharmacology ; Animals ; Calcium Channels, L-Type/drug effects ; Calcium Channels, L-Type/metabolism ; Caveolae/metabolism ; Cells, Cultured ; Cyclic AMP/physiology ; Cytosol/metabolism ; GTP-Binding Protein alpha Subunits, Gi-Go/physiology ; Guinea Pigs ; Heart Ventricles ; Isoproterenol/pharmacology ; Myocytes, Cardiac/metabolism ; Phosphoric Diester Hydrolases/metabolism ; Protein Structure, Tertiary ; Receptors, Prostaglandin/metabolism ; Tissue Distribution/drug effects
Chemical Substances	Adrenergic beta-Agonists ; Calcium Channels, L-Type ; Receptors, Prostaglandin ; Cyclic AMP (E0399OZS9N) ; Phosphoric Diester Hydrolases (EC 3.1.4.-) ; GTP-Binding Protein alpha Subunits, Gi-Go (EC 3.6.5.1) ; Alprostadil (F5TD010360) ; Isoproterenol (L628TT009W)
Language	English
Publishing date	2007-05-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/jphysiol.2006.124891
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Conference proceedings: Strong in vivo antiviral efficacy of a new L-deoxycytidine derivate in hepatitis B virus infected chimeric uPA mice

Volz, T / Allweiss, L / Lütgehetmann, M / Lohse, A / Matthes, E / Petersen, J / Dandri, M

Zeitschrift für Gastroenterologie

2011

Abstract: ... the outcome of chronic hepatitis B virus (HBV) infection. L-nucleoside analogues represent one of the most ... efficient groups of antiviral compounds. Previous studies showed that among these nucleosides, a novel L ... hydroxydeoxycytidine compound, the ß-L-2´,3´-didehydro-2´,3´-dideoxy-N4-hydroxy-5-fluorocytidine (L-Hyd4FC ...

Event/congress	27. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Regensburg, 2011
Abstract	Suppression of viral replication with nucleos(t)ide inhibitors has shown to greatly improve the outcome of chronic hepatitis B virus (HBV) infection. L-nucleoside analogues represent one of the most efficient groups of antiviral compounds. Previous studies showed that among these nucleosides, a novel L-hydroxydeoxycytidine compound, the ß-L-2´,3´-didehydro-2´,3´-dideoxy-N4-hydroxy-5-fluorocytidine (L-Hyd4FC) with an ED50=0.05µM displayed the highest selectivity for the HBV polymerase and lack of toxicity in vitro. Aim of this study was to determine the activity of L-Hyd4FC in vivo using uPA/SCID mice harbouring livers repopulated with primary human hepatocytes. After establishment of chronic HBV infection (median viremia 6×10E7 HBV-DNA copies/ml), 7 mice received daily injections of L-Hyd4FC (50mg/Kg). As controls, HBV-infected mice were treated either with lamivudine (N=2) or saline (N=4). Serological and intrahepatic viral changes were determined by real-time PCR, ELISA and immunohistochemistry. Results: After 4 weeks of treatment, L-Hyd4FC induced strong reduction of viremia levels (2-Log), while 1-log decrease was determined in lamivudine-treated mice. Intrahepatic measurements performed in animals receiving L-Hyd4FC revealed a 10-fold decline of viral activity (rcDNA copies/ cccDNA molecule). As expected, no significant changes in expression levels of pgRNA, preS/S RNA and HBsAg concentrations in serum were observed. Maintenance of human serum albumin concentrations in mouse serum throughout the study and occurrence of viral rebound after discontinuation of drug administration indicated that L-Hyd4FC was not toxic for the human hepatocytes. Conclusions: Administration of this new L-hydroxydeoxycytidine derivative in uPA/SCID mice harbouring HBV-chronically infected hepatocytes demonstrated the high antiviral potency of this drug in vivo. Such characteristics make L-Hyd4FC a good candidate for further investigations as potential HBV therapeutic agent.
Keywords	HBV ; HBcAg ; HBsAg ; polymerase inhibitors ; uPA/SCID mice
Language	English
Publishing date	2011-01-13
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	201387-3
ISSN	1439-7803 ; 0044-2771 ; 0172-8504
ISSN (online)	1439-7803
ISSN	0044-2771 ; 0172-8504
DOI	10.1055/s-0030-1269702
Database	Thieme publisher's database

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Article ; Online: Large-scale transcriptome analysis in chickpea (Cicer arietinum L.), an orphan legume crop of the semi-arid tropics of Asia and Africa.

Plant biotechnology journal

2011 Volume 9, Issue 8, Page(s) 922–931

Abstract: Chickpea (Cicer arietinum L.) is an important legume crop in the semi-arid regions of Asia and ...

Abstract	Chickpea (Cicer arietinum L.) is an important legume crop in the semi-arid regions of Asia and Africa. Gains in crop productivity have been low however, particularly because of biotic and abiotic stresses. To help enhance crop productivity using molecular breeding techniques, next generation sequencing technologies such as Roche/454 and Illumina/Solexa were used to determine the sequence of most gene transcripts and to identify drought-responsive genes and gene-based molecular markers. A total of 103,215 tentative unique sequences (TUSs) have been produced from 435,018 Roche/454 reads and 21,491 Sanger expressed sequence tags (ESTs). Putative functions were determined for 49,437 (47.8%) of the TUSs, and gene ontology assignments were determined for 20,634 (41.7%) of the TUSs. Comparison of the chickpea TUSs with the Medicago truncatula genome assembly (Mt 3.5.1 build) resulted in 42,141 aligned TUSs with putative gene structures (including 39,281 predicted intron/splice junctions). Alignment of ∼37 million Illumina/Solexa tags generated from drought-challenged root tissues of two chickpea genotypes against the TUSs identified 44,639 differentially expressed TUSs. The TUSs were also used to identify a diverse set of markers, including 728 simple sequence repeats (SSRs), 495 single nucleotide polymorphisms (SNPs), 387 conserved orthologous sequence (COS) markers, and 2088 intron-spanning region (ISR) markers. This resource will be useful for basic and applied research for genome analysis and crop improvement in chickpea.
MeSH term(s)	Africa ; Asia ; Chromosome Mapping/methods ; Cicer/genetics ; Cicer/metabolism ; Cicer/physiology ; Droughts ; Energy Metabolism ; Expressed Sequence Tags ; Gene Expression Profiling/methods ; Gene Expression Regulation, Plant ; Gene Library ; Genetic Markers ; Genome, Plant ; Genotype ; Introns ; Medicago truncatula/genetics ; Microsatellite Repeats ; Plant Roots/genetics ; Polymorphism, Single Nucleotide ; Sequence Alignment/methods ; Stress, Physiological ; Transcription Factors/genetics
Chemical Substances	Genetic Markers ; Transcription Factors
Language	English
Publishing date	2011-05-25
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7644
ISSN (online)	1467-7652
ISSN	1467-7644
DOI	10.1111/j.1467-7652.2011.00625.x
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Article ; Conference proceedings: Hohe antivirale Wirksamkeit von einem neuen L-Desoxycytidinderivat in Hepatitis B Virus infizierten humanen Hepatozyten in uPA/SCID Mäusen

Matthes, E / Volz, T / Lütgehetmann, M / Lohse, AW / Allweiss, LF / Petersen, J / Dandri, M

Zeitschrift für Gastroenterologie

2010

Abstract: ... haben den Verlauf der chronischen Hepatitis-B-Virus (HBV)-Infektion erheblich verbessert. L-Nukleosidanaloga ... insbesondere L-Desoxycytidinderivate, gehören zu den wirksamsten antiviralen Substanzen. Innerhalb der Gruppe ... dieser L-Hydroxydesoxycytidin-Verbindungen weist β-L-2′,3′-didehydro-2′,3′-didesoxy-N 4 -hydroxy-5 ...

Event/congress	65. Jahrestagung der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten - 4. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV - Viszeralmedizin 2010, Stuttgart, 2010
Abstract	Hintergrund: Die starke Suppression der viralen Replikation mit Nukleos(t)idanaloga haben den Verlauf der chronischen Hepatitis-B-Virus (HBV)-Infektion erheblich verbessert. L-Nukleosidanaloga, insbesondere L-Desoxycytidinderivate, gehören zu den wirksamsten antiviralen Substanzen. Innerhalb der Gruppe dieser L-Hydroxydesoxycytidin-Verbindungen weist β-L-2′,3′-didehydro-2′,3′-didesoxy-N 4 -hydroxy-5-fluorocytidin (L-Hyd4FC) mit einer ED 50 von 0,05µM die höchste Selektivität für die HBV-Polymerase auf und gleichzeitig eine geringe Toxizitätin vitro. Ziel: Die Bestimmung der Aktivität von L-Hyd4FC in vivo mithilfe eines chimären Mausmodells, in dem Mauslebern mit humanen Hepatozyten repopuliert und mit HBV infiziert werden. Methoden: Chimäre UPA/SCID Mäuse wurden 2×10 7 HBV-Genomäquivalente injiziert. Nach Zustandekommen einer chronischen HBV-Infektion (Median 7×10 7 HBV-DNA/ml) wurden die Mäuse täglich mit 0,5mg L-Hyd4FC behandelt. Als Kontrolle dienten sowohl unbehandelte als auch mit Lamivudin behandelte Mäuse, die vergleichbare Virustiter und Repopulationsraten humaner Hepatozyten zeigten. Die Veränderung viraler Messwerte wurde mittels quantitativer PCR bestimmt. Ergebnisse: Eine zweiwöchige Behandlung mit L-Hyd4FC führte zu einer Verringerung der Virämie um zwei Log-Stufen. Im Gegensatz dazu zeigten Lamivudin behandelte Kontrollmäuse eine Verringerung um eine Log-Stufe. Intrahepatische Messungen in L-Hyd4FC-behandelten Mäusen legten eine 50-fache Abnahme der viralen Aktivität (rcDNA-Kopien pro cccDNA-Molekül) offen. Wie zu erwarten wurde keine signifikante Änderung der HBsAg-Konzentration im Serum oder des Expressionsniveaus von pgRNA und preS/S-RNA pro humaner GAPDH festgestellt. Nach Ende der Behandlung kehrten die Serumwerte auf ihr Ausgangsniveau zurück, während die Repopulationsrate der Mauslebern konstant blieb. Schlussfolgerung: Durch die Behandlung von uPA/SCID-Mäusen mit chronischer Hepatitis B stellte dieses neue L-Desoxycytidinderivat seine starke antivirale Wirksamkeit unter Beweis, ohne dabei eine toxische Wirkung auf humane Hepatozyten auszuüben. Dank dieser Eigenschaften sollte L-Hyd4FC für weitere Untersuchungen als potenzielles HBV-Therapeutikum in Betracht gezogen werden.
Language	German
Publishing date	2010-08-03
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	201387-3
ISSN	1439-7803 ; 0044-2771 ; 0172-8504
ISSN (online)	1439-7803
ISSN	0044-2771 ; 0172-8504
DOI	10.1055/s-0030-1264038
Database	Thieme publisher's database

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Article ; Online: Introducing an Evidence-Based Approach to Wait-And-Scan Management of Sporadic Vestibular Schwannoma: Size Threshold Surveillance.

Marinelli, John P / Lohse, Christine M / Carlson, Matthew L

Otolaryngologic clinics of North America

2023 Volume 56, Issue 3, Page(s) 445–457

Abstract: The advent of MRI has led to more sporadic vestibular schwannomas diagnosed today than ever before. Despite the average patient being diagnosed in their sixth decade of life with a small tumor and minimal symptoms, population-based data demonstrate that ... ...

Abstract	The advent of MRI has led to more sporadic vestibular schwannomas diagnosed today than ever before. Despite the average patient being diagnosed in their sixth decade of life with a small tumor and minimal symptoms, population-based data demonstrate that more tumors per capita are treated today than ever before. Emerging natural history data justify either an upfront treatment approach or the "Size Threshold Surveillance" approach. Specifically, if the patient elects to pursue observation, then existing data support the tolerance of some growth during observation in appropriately selected patients up until a specific size threshold range (about 15 mm of CPA extension). The current article discusses the rationale behind a shift in the existing observation management approach, where initial detection of growth typically begets treatment, and outlines the application of a more flexible and nuanced approach based on existing evidence.
MeSH term(s)	Humans ; Neuroma, Acoustic/diagnostic imaging ; Neuroma, Acoustic/therapy ; Treatment Outcome ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417489-6
ISSN	1557-8259 ; 0030-6665
ISSN (online)	1557-8259
ISSN	0030-6665
DOI	10.1016/j.otc.2023.02.006
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