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  1. Article ; Online: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases.

    Gomez-Pinedo, Ulises / Matias-Guiu, Jorge / Sanclemente-Alaman, Inmaculada / Moreno-Jimenez, Lidia / Montero-Escribano, Paloma / Matias-Guiu, Jordi A

    Movement disorders : official journal of the Movement Disorder Society

    2020  Volume 35, Issue 7, Page(s) 1104–1105

    MeSH term(s) Aging ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Neurodegenerative Diseases ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2555: Show issues Location:
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    Zs.MO 238: Show issues

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  2. Article ; Online: Is the brain a reservoir organ for SARS-CoV2?

    Gomez-Pinedo, Ulises / Matias-Guiu, Jorge / Sanclemente-Alaman, Inmaculada / Moreno-Jimenez, Lidia / Montero-Escribano, Paloma / Matias-Guiu, Jordi A

    Journal of medical virology

    2020  Volume 92, Issue 11, Page(s) 2354–2355

    MeSH term(s) Angiotensin-Converting Enzyme 2/metabolism ; Brain/metabolism ; Brain/virology ; COVID-19/virology ; Humans ; Receptors, Coronavirus/metabolism ; SARS-CoV-2/physiology ; Virus Internalization
    Chemical Substances Receptors, Coronavirus ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System.

    Gómez-Pinedo, Ulises / García-Ávila, Yolanda / Gallego-Villarejo, Lucía / Matías-Guiu, Jordi A / Benito-Martín, María Soledad / Esteban-García, Noelia / Sanclemente-Alamán, Inmaculada / Pytel, Vanesa / Moreno-Jiménez, Lidia / Sancho-Bielsa, Francisco / Vidorreta-Ballesteros, Lucía / Montero-Escribano, Paloma / Matías-Guiu, Jorge

    International journal of molecular sciences

    2021  Volume 22, Issue 10

    Abstract: Introduction: AQP4 (aquaporin-4)-immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination ...

    Abstract Introduction: AQP4 (aquaporin-4)-immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4-IgG in cell differentiation.
    Material and methods: We included three groups-a group of patients with AQP4-IgG-positive neuromyelitis optica, a healthy group, and a sham group. We analyzed differentiation capacity in cultures of neurospheres from the subventricular zone of mice by adding serum at two different times: early and advanced stages of differentiation. We also analyzed differentiation into different cell lines.
    Results and conclusions: The effect of sera from patients with NMOSD on precursor cells differs according to the degree of differentiation, and probably affects oligodendrocyte progenitor cells from NG2 cells to a lesser extent than cells from the subventricular zone; however, the resulting oligodendrocytes may be compromised in terms of maturation and possibly limited in their ability to generate myelin. Furthermore, these cells decrease in number with age. It is very unlikely that the use of drugs favoring the migration and differentiation of oligodendrocyte progenitor cells in multiple sclerosis would be effective in the context of neuromyelitis optica, but cell therapy with oligodendrocyte progenitor cells seems to be a potential alternative.
    MeSH term(s) Animals ; Aquaporin 4/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Case-Control Studies ; Cell Differentiation ; Central Nervous System/immunology ; Central Nervous System/pathology ; Cerebellum/immunology ; Cerebellum/pathology ; Female ; Humans ; Immunoglobulin G/immunology ; Male ; Mice, Inbred BALB C ; Middle Aged ; Neuromyelitis Optica/blood ; Neuromyelitis Optica/immunology ; Neuromyelitis Optica/pathology ; Oligodendrocyte Precursor Cells/immunology ; Oligodendrocyte Precursor Cells/pathology ; Mice
    Chemical Substances AQP4 protein, human ; Aquaporin 4 ; Autoantibodies ; Immunoglobulin G
    Language English
    Publishing date 2021-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22105192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: SARS-CoV2 as a potential trigger of neurodegenerative diseases

    Gomez-Pinedo, Ulises / Matias-Guiu, Jorge / Sanclemente-Alaman, Inmaculada / Moreno-Jimenez, Lidia / Montero-Escribano, Paloma

    Mov Disord

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #527162
    Database COVID19

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  5. Article ; Online: Intranasal Administration of Undifferentiated Oligodendrocyte Lineage Cells as a Potential Approach to Deliver Oligodendrocyte Precursor Cells into Brain.

    Gómez-Pinedo, Ulises / Matías-Guiu, Jordi A / Benito-Martín, María Soledad / Moreno-Jiménez, Lidia / Sanclemente-Alamán, Inmaculada / Selma-Calvo, Belen / Pérez-Suarez, Sara / Sancho-Bielsa, Francisco / Canales-Aguirre, Alejandro / Mateos-Díaz, Juan Carlos / Hernández-Sapiéns, Mercedes A / Reza-Zaldívar, Edwin E / Ojeda-Hernández, Doddy Denise / Vidorreta-Ballesteros, Lucía / Montero-Escribano, Paloma / Matías-Guiu, Jorge

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over ...

    Abstract Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches in the adult CNS. However, age and disease reduce the pool of OPCs; as a result, the remyelination capacity of the CNS decreases over time. Several experimental studies have introduced OPCs to the brain via direct injection or intrathecal administration. In this study, we used the nose-to brain pathway to deliver oligodendrocyte lineage cells (human oligodendroglioma (HOG) cells), which behave similarly to OPCs in vitro. To this end, we administered GFP-labelled HOG cells intranasally to experimental animals, which were subsequently euthanised at 30 or 60 days. Our results show that the intranasal route is a viable route to the CNS and that HOG cells administered intranasally migrate preferentially to niches of OPCs (clusters created during embryonic development and adult life). Our study provides evidence, albeit limited, that HOG cells either form clusters or adhere to clusters of OPCs in the brains of experimental animals.
    MeSH term(s) Administration, Intranasal ; Animals ; Brain/cytology ; Brain/physiology ; Cell Differentiation ; Cells, Cultured ; Demyelinating Diseases/therapy ; Humans ; Oligodendrocyte Precursor Cells/cytology ; Oligodendroglioma/chemistry ; Remyelination ; Stem Cells/cytology
    Language English
    Publishing date 2021-10-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: SARS-CoV-2 as a Potential Trigger of Neurodegenerative Diseases

    Gomez-Pinedo, Ulises / Matias-Guiu, Jorge / Sanclemente-Alaman, Inmaculada / Moreno-Jimenez, Lidia / Montero-Escribano, Paloma / Matias-Guiu, Jordi A

    Mov Disord

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #659207
    Database COVID19

    Kategorien

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  7. Article: Is the brain a reservoir organ for SARS-CoV2?

    Gomez-Pinedo, Ulises / Matias-Guiu, Jorge / Sanclemente-Alaman, Inmaculada / Moreno-Jimenez, Lidia / Montero-Escribano, Paloma / Matias-Guiu, Jordi A

    J. med. virol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #327183
    Database COVID19

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  8. Article ; Online: Is the brain a reservoir organ for SARS‐CoV2?

    Gomez‐Pinedo, Ulises / Matias‐Guiu, Jorge / Sanclemente‐Alaman, Inmaculada / Moreno‐Jimenez, Lidia / Montero‐Escribano, Paloma / Matias‐Guiu, Jordi A.

    Journal of Medical Virology

    2020  Volume 92, Issue 11, Page(s) 2354–2355

    Keywords Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26046
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: SARS‐CoV‐2 as a Potential Trigger of Neurodegenerative Diseases

    Gomez‐Pinedo, Ulises / Matias‐Guiu, Jorge / Sanclemente‐Alaman, Inmaculada / Moreno‐Jimenez, Lidia / Montero‐Escribano, Paloma / Matias‐Guiu, Jordi A.

    Movement Disorders

    2020  Volume 35, Issue 7, Page(s) 1104–1105

    Keywords Neurology ; Clinical Neurology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1265024-9
    ISSN 0885-3185
    ISSN 0885-3185
    DOI 10.1002/mds.28179
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System

    Ulises Gómez-Pinedo / Yolanda García-Ávila / Lucía Gallego-Villarejo / Jordi A. Matías-Guiu / María Soledad Benito-Martín / Noelia Esteban-García / Inmaculada Sanclemente-Alamán / Vanesa Pytel / Lidia Moreno-Jiménez / Francisco Sancho-Bielsa / Lucía Vidorreta-Ballesteros / Paloma Montero-Escribano / Jorge Matías-Guiu

    International Journal of Molecular Sciences, Vol 22, Iss 5192, p

    2021  Volume 5192

    Abstract: Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination ... ...

    Abstract Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4–IgG in cell differentiation. Material and Methods: We included three groups—a group of patients with AQP4–IgG-positive neuromyelitis optica, a healthy group, and a sham group. We analyzed differentiation capacity in cultures of neurospheres from the subventricular zone of mice by adding serum at two different times: early and advanced stages of differentiation. We also analyzed differentiation into different cell lines. Results and Conclusions: The effect of sera from patients with NMOSD on precursor cells differs according to the degree of differentiation, and probably affects oligodendrocyte progenitor cells from NG2 cells to a lesser extent than cells from the subventricular zone; however, the resulting oligodendrocytes may be compromised in terms of maturation and possibly limited in their ability to generate myelin. Furthermore, these cells decrease in number with age. It is very unlikely that the use of drugs favoring the migration and differentiation of oligodendrocyte progenitor cells in multiple sclerosis would be effective in the context of neuromyelitis optica, but cell therapy with oligodendrocyte progenitor cells seems to be a potential alternative.
    Keywords AQP4–IgG ; neurogenesis ; neural stem cells ; neuromyelitis optica ; NMOSD ; precursor cells ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 571 ; 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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