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  1. Book ; Conference proceedings: Neuro-Visionen

    Hossmann, Konstantin-Alexander

    Perspektiven in Nordrhein-Westfalen ; Symposium der Nordrhein-Westfälischen Akademie der Wissenschaften ; [Symposium am 1. Dezember 2003 in Düsseldorf]

    2004  

    Institution Nordrhein-Westfälische Akademie der Wissenschaften
    Author's details Hrsg.: Konstantin-A. Hossmann
    Keywords Hirnfunktion ; Hirnkrankheit ; Nervensystem ; Krankheit
    Subject Erkrankung ; Krankheitszustand ; Krankheiten ; Morbus ; Nosos ; Pathos ; Gehirnkrankheit ; Encephalopathie ; Encephalopathia ; Enzephalopathie ; Gehirn ; Hirnleistung ; Hirnaktivität ; Hirnphysiologie ; Gehirnphysiologie ; Gehirnaktivität ; Gehirnfunktion ; Systema nervosum ; NS
    Language German ; English
    Size 231 S. : Ill., graph. Darst.
    Publisher Schöningh
    Publishing place Paderborn u.a.
    Publishing country Germany
    Document type Book ; Conference proceedings
    Note Beitr. teilw. dt., teilw. engl.
    HBZ-ID HT014067682
    ISBN 3506713182 ; 9783506713186
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2004 A 3532 order for loan Magazin

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  2. Book: Der experimentelle Schlaganfall

    Hossmann, Konstantin-Alexander

    pathophysiologische Konzepte und therapeutische Perspektiven

    (Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften : N, Naturwissenschaften und Medizin ; 468)

    2005  

    Author's details Konstantin-Alexander Hossmann
    Series title Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften : N, Naturwissenschaften und Medizin ; 468
    Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften
    Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften ; N, Naturwissenschaften und Medizin
    Collection Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften
    Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften ; N, Naturwissenschaften und Medizin
    Keywords Cerebrovascular Accident ; Middle Cerebral Artery / physiopathology ; Models, Animal ; Schlaganfall ; Pathophysiologie ; Tiermodell
    Subject Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Apoplektischer Insult ; Apoplexia cerebri ; Apoplexie ; Gehirnschlag ; Hirnschlag ; Zerebrovaskulärer Insult ; ZVI ; Ischämischer Insult ; Stroke
    Language German
    Size 47 S. : zahlr. Ill., graph. Darst.
    Publisher Schöningh
    Publishing place Paderborn u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014354505
    ISBN 3-506-72896-2 ; 978-3-506-72896-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2007 A 105 order for loan Magazin

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  3. Article ; Online: Neutrophil-derived reactive agents induce a transient SpeB negative phenotype in Streptococcus pyogenes.

    Shumba, Patience / Sura, Thomas / Moll, Kirsten / Chakrakodi, Bhavya / Tölken, Lea A / Hoßmann, Jörn / Hoff, Katharina J / Hyldegaard, Ole / Nekludov, Michael / Svensson, Mattias / Arnell, Per / Skrede, Steinar / Norrby-Teglund, Anna / Siemens, Nikolai

    Journal of biomedical science

    2023  Volume 30, Issue 1, Page(s) 52

    Abstract: Background: Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/or phenotype to the ... ...

    Abstract Background: Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/or phenotype to the surrounding environment. Hyper-virulent streptococcal pyrogenic exotoxin B (SpeB) negative variants caused by covRS mutations are enriched during infection. A key driving force for this process is the bacterial Sda1 DNase.
    Methods: Bacterial infiltration, immune cell influx, tissue necrosis and inflammation in patient´s biopsies were determined using immunohistochemistry. SpeB secretion and activity by GAS post infections or challenges with reactive agents were determined via Western blot or casein agar and proteolytic activity assays, respectively. Proteome of GAS single colonies and neutrophil secretome were profiled, using mass spectrometry.
    Results: Here, we identify another strategy resulting in SpeB-negative variants, namely reversible abrogation of SpeB secretion triggered by neutrophil effector molecules. Analysis of NSTI patient tissue biopsies revealed that tissue inflammation, neutrophil influx, and degranulation positively correlate with increasing frequency of SpeB-negative GAS clones. Using single colony proteomics, we show that GAS isolated directly from tissue express but do not secrete SpeB. Once the tissue pressure is lifted, GAS regain SpeB secreting function. Neutrophils were identified as the main immune cells responsible for the observed phenotype. Subsequent analyses identified hydrogen peroxide and hypochlorous acid as reactive agents driving this phenotypic GAS adaptation to the tissue environment. SpeB-negative GAS show improved survival within neutrophils and induce increased degranulation.
    Conclusions: Our findings provide new information about GAS fitness and heterogeneity in the soft tissue milieu and provide new potential targets for therapeutic intervention in NSTIs.
    MeSH term(s) Streptococcus pyogenes/genetics ; Neutrophils ; Bacterial Proteins ; Exotoxins/genetics
    Chemical Substances erythrogenic toxin ; Bacterial Proteins ; Exotoxins
    Language English
    Publishing date 2023-07-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193378-1
    ISSN 1423-0127 ; 1021-7770
    ISSN (online) 1423-0127
    ISSN 1021-7770
    DOI 10.1186/s12929-023-00947-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4037: Show issues Location:
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  4. Book ; Conference proceedings: Cerebrovascular transport mechanisms

    Hossmann, Konstantin-Alexander

    (ACTA NEUROPATHOLOGICA : SUPPLEMENTUM ; 8)

    1983  

    Event/congress International Congress of Neuropathology (9, 1982, Wien)
    Author's details Internat. Congress of Neuropathology, Vienna, Sept. 5-10, 1982. Ed. by Konstantin-Alexander Hossmann
    Series title ACTA NEUROPATHOLOGICA : SUPPLEMENTUM ; 8
    Acta neuropathologica
    ACTA NEUROPATHOLOGICA ; SUPPLEMENTUM
    Collection Acta neuropathologica
    ACTA NEUROPATHOLOGICA ; SUPPLEMENTUM
    Keywords BIOLOGICAL TRANSPORT ; BLOOD-BRAIN BARRIER ; Hirngefäß ; Stofftransport
    Subject Transport ; Biologischer Transport
    Language English
    Size 150 S.
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT002520883
    ISBN 3-540-12204-4 ; 978-3-540-12204-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ui II Zs 188 -Suppl.8- verfügbar in Königswinter Königswinter

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  5. Book: Mechanismen der ischämischen Hirnschädigung

    Hossmann, Konstantin-Alexander / Bolt, Hermann M.

    (Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften : N, Natur-, Ingenieur- und Wirtschaftswissenschaften ; 402)

    1993  

    Author's details Konstantin-Alexander Hossmann
    Series title Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften : N, Natur-, Ingenieur- und Wirtschaftswissenschaften ; 402
    Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften
    Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften ; N, Natur-, Ingenieur- und Wirtschaftswissenschaften
    Collection Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften
    Vorträge / Nordrhein-Westfälische Akademie der Wissenschaften ; N, Natur-, Ingenieur- und Wirtschaftswissenschaften
    Keywords Hirnkrankheit ; Ischämie ; Alkene ; Carcinogen
    Subject Cancerogen ; Karzinogen ; Kanzerogener Stoff ; Karzinogener Stoff ; Krebserregender Stoff ; Krebserzeugender Stoff ; Carcinogene ; Karzinogene ; Krebserregende Stoffe ; Olefine ; Alkylene ; Isoalkene ; n-Alkene ; Blutleere ; Anoxietoleranz ; Ischämietoleranz ; Gehirnkrankheit ; Encephalopathie ; Encephalopathia ; Enzephalopathie
    Language German
    Size 68 S. : Ill., graph. Darst.
    Publisher Westdt. Verl
    Publishing place Opladen
    Document type Book
    HBZ-ID HT006133168
    ISBN 3-531-08402-X ; 978-3-531-08402-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 10833 order for loan Magazin

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  6. Article: Genetically modified animals in molecular stroke research.

    Hossmann, K A

    Acta neurochirurgica. Supplement

    2004  Volume 89, Page(s) 37–45

    MeSH term(s) Animals ; Animals, Genetically Modified/metabolism ; Apoptosis ; Brain Damage, Chronic/etiology ; Brain Damage, Chronic/metabolism ; Brain Damage, Chronic/pathology ; Disease Models, Animal ; Neurons/metabolism ; Neurons/pathology ; Signal Transduction ; Stroke/complications ; Stroke/metabolism ; Stroke/pathology
    Language English
    Publishing date 2004-07-21
    Publishing country Austria
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 0065-1419
    ISSN 0065-1419
    DOI 10.1007/978-3-7091-0603-7_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Non-invasive imaging methods for the characterization of the pathophysiology of brain ischemia.

    Hossmann, K A

    Acta neurochirurgica. Supplement

    2003  Volume 86, Page(s) 21–27

    Abstract: Non-invasive imaging methods are increasingly used to study the evolution and therapy of brain diseases under both clinical and experimental conditions. In the animal experiment, these methods can be supplemented by invasive tissue assays to allow ... ...

    Abstract Non-invasive imaging methods are increasingly used to study the evolution and therapy of brain diseases under both clinical and experimental conditions. In the animal experiment, these methods can be supplemented by invasive tissue assays to allow precise characterization of the underlying pathophysiology. Based on such an approach, this review evaluates the importance of in vivo nuclear magnetic resonance (NMR) and positron emission tomography (PET) for the understanding of the pathophysiology of brain ischemia.
    MeSH term(s) Animals ; Brain Ischemia/diagnosis ; Brain Ischemia/physiopathology ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Tomography, Emission-Computed
    Language English
    Publishing date 2003
    Publishing country Austria
    Document type Journal Article ; Review
    ISSN 0065-1419
    ISSN 0065-1419
    DOI 10.1007/978-3-7091-0651-8_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Die Glutamathypothese des Schlaganfalls.

    Hossmann, K-A

    Fortschritte der Neurologie-Psychiatrie

    2003  Volume 71 Suppl 1, Page(s) S10–5

    Abstract: Neuronal injury following focal cerebral ischemia is widely attributed to the excitatory effects of glutamate. However, critical analysis of published data on glutamate toxicity in vitro and the comparison of this data with in vivo release of glutamate ... ...

    Title translation Glutamate hypothesis of stroke.
    Abstract Neuronal injury following focal cerebral ischemia is widely attributed to the excitatory effects of glutamate. However, critical analysis of published data on glutamate toxicity in vitro and the comparison of this data with in vivo release of glutamate and the therapeutic effect of glutamate antagonists raises doubts about a neurotoxic mechanism. An alternative explanation for glutamate-mediated injury is energy failure due to peri-infarct spreading depression-like depolarizations. These depolarizations cause a sharp increase in metabolic activity and therefore produce a mismatch between blood flow and the oxygen requirements of the tissue. The generation of peri-infarct spreading depressions and the associated metabolic workload can be suppressed by glutamate antagonists. As a result, energy failure is also prevented, and the volume of ischemic infarct decreases. Interventions to improve ischemic resistance should therefore aim at improving the oxygen supply or reducing the metabolic workload, rather than interfering with the consequences of a putative excitotoxic injury cascade.
    MeSH term(s) Animals ; Brain Chemistry/physiology ; Cerebral Infarction/physiopathology ; Electroencephalography ; Energy Metabolism/physiology ; Excitatory Amino Acid Antagonists/pharmacology ; Glutamic Acid/metabolism ; Glutamic Acid/physiology ; Glutamic Acid/toxicity ; Humans ; Stroke/etiology ; Stroke/physiopathology
    Chemical Substances Excitatory Amino Acid Antagonists ; Glutamic Acid (3KX376GY7L)
    Language German
    Publishing date 2003-07
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 625328-3
    ISSN 1439-3522 ; 0720-4299
    ISSN (online) 1439-3522
    ISSN 0720-4299
    DOI 10.1055/s-2003-40500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.110: Show issues Location:
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  9. Article: Neuronale Apoptose. Ein neuer Weg zur Therapie der zerebralen Ischämie?

    Hossmann, K A

    Der Anaesthesist

    2002  Volume 50, Issue 12, Page(s) 903–904

    Title translation Neuronal apoptosis. A new means of treatment for cerebral ischemia?.
    MeSH term(s) Apoptosis/physiology ; Brain Ischemia/pathology ; Brain Ischemia/therapy ; Humans ; Ischemic Attack, Transient/pathology ; Neurons/pathology
    Language German
    Publishing date 2002-01-09
    Publishing country Germany
    Document type Editorial
    ZDB-ID 260-4
    ISSN 1432-055X ; 0003-2417
    ISSN (online) 1432-055X
    ISSN 0003-2417
    DOI 10.1007/s00101-001-0236-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: sHIV-1 drug resistance in people on dolutegravir-based ART: Collaborative analysis of cohort studies.

    Loosli, Tom / Hossmann, Stefanie / Ingle, Suzanne M / Okhai, Hajra / Kusejko, Katharina / Mouton, Johannes / Bellecave, Pantxika / van Sighem, Ard / Stecher, Melanie / d'Arminio Monforte, Antonella / Gill, M John / Sabin, Caroline A / Maartens, Gary / Günthard, Huldrych F / Sterne, Jonathan A C / Lessells, Richard / Egger, Matthias / Kouyos, Roger

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Background: The widespread use of the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG) in first- and second-line antiretroviral therapy (ART) may facilitate emerging resistance. We combined data from HIV cohorts to examine patterns of drug ...

    Abstract Background: The widespread use of the integrase strand transfer inhibitor (INSTI) dolutegravir (DTG) in first- and second-line antiretroviral therapy (ART) may facilitate emerging resistance. We combined data from HIV cohorts to examine patterns of drug resistance mutations (DRMs) and identify risk factors for DTG resistance.
    Methods: Eight cohorts from Canada, Europe, and South Africa contributed data on individuals with genotypic resistance testing on DTG-based ART. Resistance levels were categorised using the Stanford algorithm. We identified risk factors for resistance using mixed-effects ordinal logistic regression models.
    Results: We included 750 people with genotypic resistance testing on DTG-based ART between 2013 and 2022. Most had HIV subtype B (N=444, 59·2%) and were treatment-experienced; 134 (17.9%) were on DTG dual and 19 (2.5%) on DTG monotherapy. INSTI DRMs were detected in 100 (13·3%) individuals; 21 (2·8%) had more than one mutation. Most (N=713, 95·1%) were susceptible to DTG, 8 (1·1%) had potential-low, 5 (0·7%) low, 18 (2·4%) intermediate and 6 (0·8%) high-level DTG resistance. The risk of DTG resistance was higher on DTG monotherapy (adjusted odds ratio (aOR) 37·25, 95% CI 11·17 to 124·2) and DTG lamivudine dual therapy (aOR 6·59, 95% CI 1·70 to 25·55) compared to combination ART, and higher in the presence of potential-low/low (aOR 4.62, 95% CI 1.24 to 17.2) or intermediate/high-level (aOR 7·01, 95% CI 2·52 to 19·48) nucleoside reverse transcriptase inhibitors (NRTI) resistance. Viral load on DTG showed a trend towards increased DTG resistance (aOR 1·42, 95% CI 0·92 to 2·19 per standard deviation of log
    Interpretation: Among people experiencing virological failure on DTG-based ART, INSTI DRMs were uncommon, and DTG resistance was rare. DTG monotherapy and NRTI resistance substantially increased the risk for DTG resistance, which is of concern, notably in resource-limited settings.
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.05.23288183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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