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  1. Article: Experimental models of human bladder carcinogenesis.

    Crallan, R A / Georgopoulos, N T / Southgate, J

    Carcinogenesis

    2006  Volume 27, Issue 3, Page(s) 374–381

    Abstract: Bladder cancer is the fifth most common cancer in the UK, yet human bladder carcinogenesis remains poorly understood and the response of bladder tumours to radio- and chemo-therapy is unpredictable. The aims of this article are to review human bladder ... ...

    Abstract Bladder cancer is the fifth most common cancer in the UK, yet human bladder carcinogenesis remains poorly understood and the response of bladder tumours to radio- and chemo-therapy is unpredictable. The aims of this article are to review human bladder carcinogenesis and appraise the different in vitro and in vivo approaches that have been developed to study the process. The review considers how in vitro models based on normal human urothelial (NHU) cells can be applied to human bladder cancer research. We conclude that recent advances in NHU cell culture offer novel approaches for defining urothelial tissue-specific responses to genotoxic and non-genotoxic carcinogens and elucidating the role of specific genes involved in the mechanisms of bladder carcinogenesis and malignant progression.
    MeSH term(s) Animals ; Carcinogens/toxicity ; Cell Transformation, Neoplastic ; Disease Models, Animal ; Disease Progression ; Humans ; Models, Theoretical ; Rodentia ; Urinary Bladder Neoplasms/physiopathology ; Urothelium/cytology
    Chemical Substances Carcinogens
    Language English
    Publishing date 2006-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgi266
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1558: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Inter-individual variation in urothelial DNA repair gene expression in vitro.

    Crallan, R A / Lord, P G / Rees, R W / Southgate, J

    Toxicology in vitro : an international journal published in association with BIBRA

    2002  Volume 16, Issue 4, Page(s) 383–387

    Abstract: DNA repair efficiency may play a significant role in individual susceptibility to bladder cancer, the third most common cancer in Europe. Bladder cancer arises from the urothelial cell layer which lines the urinary tract. As DNA repair gene expression ... ...

    Abstract DNA repair efficiency may play a significant role in individual susceptibility to bladder cancer, the third most common cancer in Europe. Bladder cancer arises from the urothelial cell layer which lines the urinary tract. As DNA repair gene expression levels should reflect DNA repair capacity, we investigated the expression of genes from the base excision, nucleotide excision and mismatch repair pathways in normal human urothelial (NHU) cells in vitro. RNA was extracted from six independent NHU cell lines and expression of 26 DNA repair genes was determined by ribonuclease protection assay. The results show that all the genes analysed were detected in NHU cells in vitro with a similar expression pattern in most cell lines. However, there was some variation between cell lines, with one expressing base excision repair genes very strongly, but another having weak expression of mismatch repair genes. These results suggest that DNA repair genes are constitutively expressed by NHU cells and that there is some inter-individual variation. Prospective studies are required to determine whether these differences in gene expression may play a role in susceptibility to bladder cancer.
    MeSH term(s) Cell Line ; DNA Damage ; DNA Ligases/biosynthesis ; DNA Repair/genetics ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Ribonucleases/pharmacology ; Urinary Bladder Neoplasms/etiology ; Urinary Bladder Neoplasms/genetics ; Urothelium/physiology
    Chemical Substances Ribonucleases (EC 3.1.-) ; DNA Ligases (EC 6.5.1.-)
    Language English
    Publishing date 2002-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639064-x
    ISSN 1879-3177 ; 0887-2333
    ISSN (online) 1879-3177
    ISSN 0887-2333
    DOI 10.1016/s0887-2333(02)00034-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2223: Show issues Location:
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  3. Article: Letter: Serum immunoglobulins in herpes virus infections.

    De Silva, L M / Mortimer, P R / Casemore, D P / Crallan, J E

    British medical journal

    1975  Volume 2, Issue 5963, Page(s) 138–139

    MeSH term(s) Adolescent ; Adult ; Aged ; Antibodies, Viral ; Child, Preschool ; Female ; Herpesviridae Infections/immunology ; Humans ; Immunoglobulin A/analysis ; Immunoglobulin G/analysis ; Immunoglobulin M/analysis ; Male
    Chemical Substances Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 1975-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 80088-0
    ISSN 0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
    ISSN 0007-1447 ; 0267-0623 ; 0959-8138 ; 0959-8146
    DOI 10.1136/bmj.2.5963.138-c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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