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  1. Article ; Online: Paisley: Preliminary validation of a novel app-based e-Screener for ASD in children 18-36 months.

    Honaker, Makayla G / Weitlauf, Amy S / Swanson, Amy R / Hooper, Madison / Sarkar, Nilanjan / Wade, Joshua / Warren, Zachary E

    Autism research : official journal of the International Society for Autism Research

    2023  Volume 16, Issue 10, Page(s) 1963–1975

    Abstract: The purpose of this study was to assess the validity of an autism e-screener, Paisley ...

    Abstract The purpose of this study was to assess the validity of an autism e-screener, Paisley, when utilized in a clinical research setting via a tablet application. The Paisley application used a series of play-based activities, all of which incorporated varying aspects of the ASD-PEDS. Participants included children (18-36 months; n = 198) referred for evaluation of autism spectrum disorder (ASD) and community providers (n = 66) with differing levels of familiarity with ASD. Community providers administered the Paisley application to children who then completed a comprehensive psychological evaluation. Based on comprehensive evaluation, 75% of children met diagnostic criteria for ASD. Paisley scores were significantly higher for children diagnosed with ASD (15.06) versus those not diagnosed (9.34). The newly determined cutoff ASD-PEDS cutoff score of 13 had significantly higher specificity and positive predictive value than the originally proposed cutoff of 11. Results support the use of Paisley by community providers to identify autism risk in toddlers. Limitations and strengths of the work, as well as opportunities for future clinical validation, are described.
    MeSH term(s) Humans ; Autism Spectrum Disorder/diagnosis ; Mobile Applications ; Predictive Value of Tests ; Autistic Disorder
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bilateral neuralgic amyotrophy in a patient with livestock-associated hepatitis E virus infection.

    Miller, Nicholas J / Hooper, Davyd R / Sharma, Aditya

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2022  Volume 194, Issue 13, Page(s) E495–E499

    MeSH term(s) Animals ; Brachial Plexus Neuritis/complications ; Brachial Plexus Neuritis/etiology ; Hepatitis E/complications ; Hepatitis E/diagnosis ; Hepatitis E virus/genetics ; Humans ; Livestock ; Phrenic Nerve
    Language English
    Publishing date 2022-03-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.211679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Transmission pathways for sporadic Shiga-toxin producing E. coli infections: A systematic review and meta-analysis.

    Kintz, Erica / Brainard, Julii / Hooper, Lee / Hunter, Paul

    International journal of hygiene and environmental health

    2017  Volume 220, Issue 1, Page(s) 57–67

    Abstract: Background: Shiga-toxin E. coli infections remain a public health concern because of the severity ...

    Abstract Background: Shiga-toxin E. coli infections remain a public health concern because of the severity of the gastrointestinal illness and associated complications. Transmission pathways are typically elucidated from outbreaks, with foodborne transmission the primary source. However, most STEC cases are sporadic. This systematic review aimed to identify the most common pathways for sporadic STEC transmission and quantify their importance.
    Methods: We systematically reviewed epidemiological studies of sporadic (non-outbreak) STEC cases that investigated potential risk factors. Searches were run in Medline, EMBASE, and Scopus. Included studies needed to confirm STEC infection and investigate ≥20 cases.
    Results: 31 studies were included, of which 25 were case-control or case-case studies. 62.5% found consumption of undercooked/raw meat associated with STEC infection while 70.4% found contact with animals or their environment a risk factor. Random-effects meta-analysis provided pooled odds ratios and population attributable fraction (PAF). The PAF was 19% for undercooked/raw meat, followed by person to person transmission at 15%. Contact with animals and visiting farm environments had PAFs of 14% and 12% respectively.
    Conclusions: Out of potential sources for STEC exposure, undercooked meat and contact with animals and their environment were the most frequently found transmission routes. Decreasing the chances of acquiring the bacteria by these methods would additionally cut down on the other major transmission route, person-to-person spread.
    MeSH term(s) Animals ; Animals, Domestic ; Cooking ; Dairy Products ; Drinking Water ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/transmission ; Food Contamination ; Humans ; Meat ; Shiga-Toxigenic Escherichia coli
    Chemical Substances Drinking Water
    Language English
    Publishing date 2017-01
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2009176-X
    ISSN 1618-131X ; 1438-4639
    ISSN (online) 1618-131X
    ISSN 1438-4639
    DOI 10.1016/j.ijheh.2016.10.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early Subjective Sensory Experiences with "Cigalike" E-cigarettes Among African American Menthol Smokers: A Qualitative Study.

    Smiley, Sabrina L / DeAtley, Teresa / Rubin, Leslie F / Harvey, Emily / Kierstead, Elexis C / Webb Hooper, Monica / Niaura, Raymond S / Abrams, David B / Pearson, Jennifer L

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2017  Volume 20, Issue 9, Page(s) 1069–1075

    Abstract: Introduction: Despite smoker interest in e-cigarettes as a harm reduction or cessation aid ... interested in trying e-cigarettes were recruited in Washington, DC. Participants were followed for 3 weeks ... and provided menthol cigalike e-cigarettes after Week 1. Participants completed three interviews ...

    Abstract Introduction: Despite smoker interest in e-cigarettes as a harm reduction or cessation aid, many smokers prematurely discontinue vaping after trying a product. This study explored the role of early subjective sensory experiences in vaping persistence and desistance.
    Methods: African American menthol cigarette smokers aged ≥18 years (N = 15; M = 54.1 years; SD = 8.2), motivated to quit smoking, and interested in trying e-cigarettes were recruited in Washington, DC. Participants were followed for 3 weeks and provided menthol cigalike e-cigarettes after Week 1. Participants completed three interviews about their vaping experiences. Thematic analysis of responses was designed to understand the sensory aspects of vaping.
    Results: During the first 2 weeks of vaping, four participants reported a positive vaping experience while 11 reported decreased satisfaction. Salient sensory attributes of dissatisfaction included poor taste, insufficient throat hit, difficulty pulling, and a lack of "whole body" satisfaction compared to their preferred cigarette brand.
    Conclusions: The sensory experiences with a specific cigalike e-cigarette were related to vaping persistence and desistence. Although this was a small volunteer sample of African American menthol smokers motivated to quit smoking, 27% (N = 4) of participants with a positive vaping experience continued using the product, while 73% (N = 11) of participants' vaping experience was unsatisfactory across several experiential categories. In future research of e-cigarettes' efficacy as a smoking cessation or reduction aid, both device characteristics and smokers' expectations for these devices should be considered, so vapers do not expect the same taste sensations, throat sensations, and "whole body" satisfaction as they experienced with their menthol cigarettes.
    Implications: The subjective sensory experiences associated with initial e-cigarette product use are associated with use patterns. Subjective sensory experiences may also help understand the differences in the appeal, satisfaction, and harm-reduction potential of the rapidly evolving diverse types of products emerging in the marketplace. How products meet the sensory needs of smokers wanting to switch or quit smoking may influence adherence and success rates.
    MeSH term(s) Adult ; African Americans/psychology ; Aged ; Electronic Nicotine Delivery Systems/methods ; Female ; Health Behavior ; Humans ; Male ; Menthol/administration & dosage ; Middle Aged ; Qualitative Research ; Smokers/psychology ; Smoking Cessation/methods ; Smoking Cessation/psychology ; Surveys and Questionnaires ; Tobacco Products ; Tobacco Smoking/epidemiology ; Tobacco Smoking/psychology ; Tobacco Smoking/therapy ; Vaping/epidemiology ; Vaping/psychology ; Vaping/therapy
    Chemical Substances Menthol (1490-04-6)
    Language English
    Publishing date 2017-05-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntx102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Comparison of E-Cigarette Use among Menthol and Non-Menthol Smokers: Findings from a Community Based Sample.

    Webb Hooper, Monica / Smiley, Sabrina L

    Ethnicity & disease

    2018  Volume 28, Issue 3, Page(s) 153–160

    Abstract: Objective: E-cigarette use is increasing among adult cigarette smokers. With the availability and ... variety of appealing characteristics, including menthol flavor, e-cigarette use patterns may differ ... among menthol and non-menthol cigarette smokers. This study compared e-cigarette knowledge and use between ...

    Abstract Objective: E-cigarette use is increasing among adult cigarette smokers. With the availability and variety of appealing characteristics, including menthol flavor, e-cigarette use patterns may differ among menthol and non-menthol cigarette smokers. This study compared e-cigarette knowledge and use between current menthol and non-menthol smokers aged ≥18 years.
    Design: Current adult cigarette smokers (N=223; M=42.1 years; SD=12.2; 68% menthol smokers) recruited in South Florida completed an interviewer-administered survey via telephone during June to November 2014.
    Main outcome measures: E-cigarette use (ever-use, past 30-day use, past 30-day flavored e-cigarette use, and past 30-day mentholated e-cigarette use), consideration of e-cigarette use for quitting/reduction of cigarettes, and knowledge assessments. Bivariate and multivariate analyses tested associations with menthol smoking.
    Results: Menthol smokers were more likely to be African American or Hispanic (P<.001) and report lower income (P=.02) and education (P<.001) than non-menthol smokers. Adjusted analyses found no association between menthol cigarette use and e-cigarette ever-use. However, menthol smokers demonstrated less e-cigarette knowledge (P<.01) and were more likely to consider using e-cigarettes to quit/reduce smoking (AOR=3.89, CI:1.55-9.78). Among ever-users, there was no association between menthol cigarette use and past 30-day e-cigarette use, yet menthol smokers were more likely to use menthol flavored e-cigarettes (AOR=6.65, CI: 1.94-12.78).
    Conclusions: Our findings suggest that, compared with current non-menthol smokers, current menthol smokers are more likely to consider using e-cigarettes to help quit/reduce smoking, and are more likely to use menthol flavored e-cigarettes. Further research is needed to better examine low e-cigarette knowledge among menthol smokers, which may represent an important intervention target.
    MeSH term(s) Adult ; African Americans/statistics & numerical data ; Cigarette Smoking ; Electronic Nicotine Delivery Systems/statistics & numerical data ; European Continental Ancestry Group/statistics & numerical data ; Female ; Florida ; Health Knowledge, Attitudes, Practice ; Hispanic Americans/statistics & numerical data ; Humans ; Male ; Menthol ; Middle Aged ; Smokers/statistics & numerical data ; Smoking Cessation/methods ; Smoking Cessation/statistics & numerical data ; Surveys and Questionnaires
    Chemical Substances Menthol (1490-04-6)
    Language English
    Publishing date 2018-07-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1274267-3
    ISSN 1945-0826 ; 1049-510X
    ISSN (online) 1945-0826
    ISSN 1049-510X
    DOI 10.18865/ed.28.3.153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Vitamin E and oxidative stress in abetalipoproteinemia and familial hypobetalipoproteinemia.

    Burnett, John R / Hooper, Amanda J

    Free radical biology & medicine

    2015  Volume 88, Issue Pt A, Page(s) 59–62

    Abstract: ... ophthalmopathy and neuropathy as a result of deficiency of the fat-soluble vitamins A and E. Heterozygous FHBL ... recommendations are the same: dietary fat restriction to prevent steatorrhea, and long-term high-dose vitamin E ... retinal degenerative disease. Despite their low plasma vitamin E levels, individuals with heterozygous FHBL do not ...

    Abstract Abetalipoproteinemia (ABL) and familial hypobetalipoproteinemia (FHBL) are genetic diseases characterized by low density lipoprotein deficiency. ABL presents early in life with the gastroenterological manifestations of fat malabsorption, steatorrhea, and failure to thrive, and later in life, with progressive ophthalmopathy and neuropathy as a result of deficiency of the fat-soluble vitamins A and E. Heterozygous FHBL subjects are usually asymptomatic, but may develop fatty liver disease. In homozygous (compound heterozygous) FHBL, the clinical and biochemical features are indistinguishable from those of ABL and treatment recommendations are the same: dietary fat restriction to prevent steatorrhea, and long-term high-dose vitamin E and A supplementation to prevent or at least slow the progression of neuromuscular and retinal degenerative disease. Despite their low plasma vitamin E levels, individuals with heterozygous FHBL do not require vitamin E supplementation. There are conflicting reports on whether increased oxidative stress is seen in ABL; these differences may relate to the small size of patient groups as well as differences in patient age and dose of vitamin E supplementation, or the contribution from dietary sources of vitamin E. High density lipoproteins in ABL appear to be severely oxidized yet able to inhibit platelet aggregation by binding to scavenger receptor B1. We review the role of vitamin E and oxidative stress in ABL and FHBL.
    MeSH term(s) Abetalipoproteinemia/drug therapy ; Abetalipoproteinemia/physiopathology ; Heterozygote ; Homozygote ; Humans ; Hypobetalipoproteinemias/drug therapy ; Hypobetalipoproteinemias/genetics ; Hypobetalipoproteinemias/physiopathology ; Oxidative Stress ; Vitamin E/blood ; Vitamin E/therapeutic use
    Chemical Substances Vitamin E (1406-18-4)
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2015.05.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin.

    He, Yaowu / Davies, Claire M / Harrington, Brittney S / Hellmers, Linh / Sheng, Yonghua / Broomfield, Amy / McGann, Thomas / Bastick, Kate / Zhong, Laurie / Wu, Andy / Maresh, Grace / McChesney, Shannon / Yau Wong, Kuan / Adams, Mark N / Sullivan, Ryan C / Palmer, James S / Burke, Lez J / Ewing, Adam D / Zhang, Xin /
    Margolin, David / Li, Li / Lourie, Rohan / Matsika, Admire / Srinivasan, Bhuvana / McGuckin, Michael A / Lumley, John W / Hooper, John D

    Oncogene

    2019  Volume 39, Issue 1, Page(s) 219–233

    Abstract: ... catenin, and E-cadherin, to the nucleus. Of functional importance, disruption of CDCP1 reduces nuclear ... localized, chromatin-associated β-catenin and nuclear localized E-cadherin, increases sequestration ... of CDCP1 perturbs pro-cancerous Wnt signaling including nuclear localization of β-catenin and E-cadherin. ...

    Abstract Elevated CUB-domain containing protein 1 (CDCP1) is predictive of colorectal cancer (CRC) recurrence and poor patient survival. While CDCP1 expression identifies stem cell populations that mediate lung metastasis, mechanisms underlying the role of this cell surface receptor in CRC have not been defined. We sought to identify CDCP1 regulated processes in CRC using stem cell populations, enriched from primary cells and cell lines, in extensive in vitro and in vivo assays. These experiments, demonstrating that CDCP1 is functionally important in CRC tumor initiation, growth and metastasis, identified CDCP1 as a positive regulator of Wnt signaling. Detailed cell fractionation, immunoprecipitation, microscopy, and immunohistochemical analyses demonstrated that CDCP1 promotes translocation of the key regulators of Wnt signaling, β-catenin, and E-cadherin, to the nucleus. Of functional importance, disruption of CDCP1 reduces nuclear localized, chromatin-associated β-catenin and nuclear localized E-cadherin, increases sequestration of these proteins in cell membranes, disrupts regulation of CRC promoting genes, and reduces CRC tumor burden. Thus, disruption of CDCP1 perturbs pro-cancerous Wnt signaling including nuclear localization of β-catenin and E-cadherin.
    MeSH term(s) Active Transport, Cell Nucleus/genetics ; Antigens, Neoplasm/genetics ; Cadherins/genetics ; Carcinogenesis/genetics ; Cell Adhesion Molecules/genetics ; Cell Proliferation/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic/genetics ; HCT116 Cells ; Humans ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology ; Wnt Signaling Pathway/genetics ; beta Catenin/genetics
    Chemical Substances Antigens, Neoplasm ; CDCP1 protein, human ; CTNNB1 protein, human ; Cadherins ; Cell Adhesion Molecules ; beta Catenin
    Language English
    Publishing date 2019-08-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-019-0983-3
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  8. Article ; Online: Serological and molecular evidence of a plausible transmission of hepatitis E virus through pooled plasma.

    Andonov, A / Rock, G / Lin, L / Borlang, J / Hooper, J / Grudeski, E / Wu, J

    Vox sanguinis

    2014  Volume 107, Issue 3, Page(s) 213–219

    Abstract: Background and objectives: Recently, hepatitis E virus has been recognized as a new transfusion ...

    Abstract Background and objectives: Recently, hepatitis E virus has been recognized as a new transfusion-associated risk; however, its efficiency of transmission through blood products requires further investigation. Asymptomatic viremia of short duration has been observed in blood donors from several European countries to the rate of <1:10,000 and HEV transmission in recipients of blood products has been documented in Japan and Europe. Although HEV RNA was detected in large plasma fractionation pools used for manufacturing of plasma derived products, HEV transmission has not been demonstrated so far. In this study, we investigated the possibility of HEV transmission in patients with thrombotic thrombocytopenic purpura whose treatment included up to 40 l of plasma exchange.
    Materials and methods: Thirty-six TTP patients received either solvent-detergent-treated plasma prepared by pooling of 2500 single-donor or cryosupernatant plasma. Three samples were collected from TTP patients at time 0, 1 and 6 months post-treatment and tested for anti-HEV antibodies. Patients with HEV seroconversion were also tested for viremia by PCR.
    Results: Two of seventeen TTP patients treated with SDP showed serological evidence of HEV infection. The 1-month samples from these patients were also positive for HEV RNA. A distinct rise of anti-HEV IgG level was detected in two other TTP patients with weak pre-existing immunity to HEV; this observation is indicative of a possible immune response boost due to a breakthrough infection.
    Conclusion: This work provides, for the first time, indirect evidence of HEV transmission by pooled plasma and warrants further studies.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Base Sequence ; DNA Primers ; Female ; Hepatitis Antibodies/blood ; Hepatitis E/blood ; Hepatitis E/transmission ; Hepatitis E virus/genetics ; Hepatitis E virus/isolation & purification ; Humans ; Male ; Middle Aged ; Plasma/virology ; Plasma Exchange/adverse effects ; Polymerase Chain Reaction ; Purpura, Thrombotic Thrombocytopenic/therapy ; RNA, Viral/blood ; Young Adult
    Chemical Substances DNA Primers ; Hepatitis Antibodies ; RNA, Viral
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Isolated brachydactyly type E and idiopathic pancreatitis in a patient presenting to a lipid disorders clinic.

    Page, Michael M / Hooper, Amanda J / Glendenning, Paul / Burnett, John R

    BMJ case reports

    2017  Volume 2017

    Abstract: ... involving the metacarpals, classified as brachydactyly type E, can be isolated or occur as part ...

    Abstract An 18-year-old female tertiary student was referred to a lipid clinic with hypertriglyceridaemia discovered after presentation with acute pancreatitis. The patient's only medication was l-thyroxine for treatment of hypothyroidism. She was overweight, normotensive, with unremarkable facies. However, she had hypermobile hand joints and brachydactyly resulting in loss of left 3-5 and right 4 and 5 knuckle definitions. Radiography revealed shortening of metacarpals 3-5 on the left and 4 and 5 on the right. Her mother had similar skeletal changes, consistent with a dominant mode of inheritance. Abnormally short digits involving the metacarpals, classified as brachydactyly type E, can be isolated or occur as part of a syndrome. Turner syndrome, Albright hereditary osteodystrophy, hypertension with brachydactyly, chromosome 2q37 microdeletion and
    MeSH term(s) Brachydactyly/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Hypertriglyceridemia/etiology ; Pancreatitis/etiology ; Young Adult
    Language English
    Publishing date 2017-04-06
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2016-218825
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  10. Article: Vitamin E and atherosclerosis.

    Hooper, Philip L / Hooper, Joanna J

    Preventive cardiology

    2004  Volume 7, Issue 3, Page(s) 144

    MeSH term(s) Clinical Trials as Topic ; Coronary Artery Disease/prevention & control ; Dietary Supplements ; Humans ; Vitamin E/therapeutic use
    Chemical Substances Vitamin E (1406-18-4)
    Language English
    Publishing date 2004-08-23
    Publishing country United States
    Document type Letter
    ZDB-ID 2008427-4
    ISSN 1751-7141 ; 1520-037X
    ISSN (online) 1751-7141
    ISSN 1520-037X
    DOI 10.1111/j.1520-037x.2004.3520.x
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