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  1. Article ; Online: In vitro insecticide resistance patterns in field strains of the sheep blowfly, Lucilia cuprina.

    Kotze, Andrew C / Bagnall, Neil H / George, Sarah D / Rolls, Nicholas M

    Veterinary parasitology

    2024  Volume 328, Page(s) 110178

    Abstract: The control of the sheep blowfly relies on the use of insecticides. There have been several reports of in vitro and in vivo resistance to the most widely-used flystrike control chemical, dicyclanil. A recent report also described in vitro resistance to ... ...

    Abstract The control of the sheep blowfly relies on the use of insecticides. There have been several reports of in vitro and in vivo resistance to the most widely-used flystrike control chemical, dicyclanil. A recent report also described in vitro resistance to imidacloprid in a strain collected from a single property over three consecutive seasons that also showed resistance to dicyclanil. The present study aimed to use in vitro assays to examine five field-collected blowfly strains to determine if this co-occurrence of resistance to dicyclanil and imidacloprid was present more widely in field strains and to also measure resistance patterns to the other currently-used flystrike control chemicals. Each of the strains showed significant levels of resistance to both dicyclanil and imidacloprid: resistance factors at the IC
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 196831-2
    ISSN 1873-2550 ; 0304-4017
    ISSN (online) 1873-2550
    ISSN 0304-4017
    DOI 10.1016/j.vetpar.2024.110178
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4380: Show issues Location:
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  2. Article ; Online: What's New in Periprosthetic Femur Fractures?

    Gausden, Elizabeth B / Bedard, Nicholas A / Gililland, Jeremy M / Haidukewych, George J

    The Journal of arthroplasty

    2024  

    Abstract: Periprosthetic femur fracture (PFF) is one of the most common indications for reoperation following total hip arthroplasty (THA). This article provides a review of a symposium on PFF that was presented at the American Association of Hip and Knee Surgeons ...

    Abstract Periprosthetic femur fracture (PFF) is one of the most common indications for reoperation following total hip arthroplasty (THA). This article provides a review of a symposium on PFF that was presented at the American Association of Hip and Knee Surgeons (AAHKS) 2023 annual meeting, including an overview of the Vancouver classification and its implications on treatment and subsequent complications, an updated approach to the management of intraoperative fractures, and finally, contemporary strategies for both osteosynthesis as well as revision arthroplasty for periprosthetic femur fractures.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2024.04.037
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2134: Show issues Location:
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  3. Article ; Online: Exploring the impact of therapeutic advances in HIV-related mortality in the United States.

    Prince, Monique A / Tan, Min-Choon / Tan, Min-Xuan / George, Haydy / Prince, E'ebony O / Nicholas, Rick M / Shaaban, Hamid / Slim, Jihad

    IJID regions

    2024  Volume 11, Page(s) 100347

    Abstract: Objectives: Mortality from HIV has significantly declined with the introduction of highly active antiretroviral therapy (HAART). This study sought to examine the longitudinal trends in mortality from HIV-related diseases by race, sex, geographical ... ...

    Abstract Objectives: Mortality from HIV has significantly declined with the introduction of highly active antiretroviral therapy (HAART). This study sought to examine the longitudinal trends in mortality from HIV-related diseases by race, sex, geographical region, and over time as HAART trends changed.
    Methods: We queried the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database and performed serial cross-sectional analyses of national death certificate data for all-cause mortality with comorbid HIV from 1999 to 2020. HIV diseases (International Classification of Diseases, Tenth Revision codes B20-B24, O98.7, R75) were listed as the contributing cause of death. We calculated the age-adjusted mortality ratio (AAMR) per 1,000,000 individuals and determined mortality trends using the Joinpoint Regression Program. Subgroup analyses were performed by sex, race, region, and organ system. The study period was further stratified into three groups when specific drug regimens were more prevalent.
    Results: In the 22-year study period, 251,759 all-cause mortalities with comorbid HIV were identified. The leading cause of death was infectious disease (84.0%, N = 211,438). Men recorded a higher AAMR than women (4.66 vs 1.65,
    Conclusions: More than 80% of deaths occurred because of infectious disease over the last 2 decades with a decreasing trend over time when stratified by race, sex, and geographical region. Despite advances in HAART, mortality disparities persist which emphasizes the need for targeted interventions in these populations.
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ISSN 2772-7076
    ISSN (online) 2772-7076
    DOI 10.1016/j.ijregi.2024.03.002
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  4. Article ; Online: Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus. Reply.

    Varghese, George M / Mukaka, Mavuto / Day, Nicholas P J

    The New England journal of medicine

    2023  Volume 388, Issue 23, Page(s) 2204–2205

    MeSH term(s) Humans ; Doxycycline/therapeutic use ; Azithromycin/therapeutic use ; Scrub Typhus/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Administration, Intravenous
    Chemical Substances Doxycycline (N12000U13O) ; Azithromycin (83905-01-5) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2303757
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  5. Article ; Online: Increasing the Resolution of Field-Flow Fractionation with Increasing Crossflow Gradients.

    Larson, Nicholas R / Bou-Assaf, George M

    Analytical chemistry

    2023  Volume 95, Issue 44, Page(s) 16138–16143

    Abstract: The resolution of flow field-flow fractionation (flow FFF) depends primarily on the crossflow rate and its change over time. In this work, we demonstrate a method for modulation of the crossflow rate during separation that increases the peak-to-peak ... ...

    Abstract The resolution of flow field-flow fractionation (flow FFF) depends primarily on the crossflow rate and its change over time. In this work, we demonstrate a method for modulation of the crossflow rate during separation that increases the peak-to-peak resolution of the resulting fractograms. In classical FFF methods, the crossflow rate is either maintained constant or decreased during the separation of the different species. In this work, higher resolution between peaks was achieved by a novel gradient method in which the crossflow is increased briefly during separation to allow stronger retention of the later eluting peaks. We first outline the theoretical basis by which improved separation is achieved. We confirm our hypothesis by quantifying the impact of increasing crossflow on the resolution between a monoclonal antibody monomer and its high-molecular-weight aggregate. We then demonstrate that this method is applicable to two different FFF methods (AF4 and HF5) and various pharmaceutically relevant samples (monoclonal antibodies and adeno-associated viruses). Finally, we hypothesize that increasing the force perpendicular to the laminar flow as described here is broadly applicable to all FFF methods and improves the quality of FFF-based separations.
    MeSH term(s) Fractionation, Field Flow/methods ; Antibodies, Monoclonal ; Molecular Weight ; Gravitation
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c02570
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    Zs.A 4033: Show issues Location:
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  6. Article ; Online: Increasing the Resolution of Field-Flow Fractionation with Increasing Crossflow Gradients

    Larson, Nicholas R. / Bou-Assaf, George M.

    Analytical Chemistry. 2023 Oct. 24, v. 95, no. 44 p.16138-16143

    2023  

    Abstract: The resolution of flow field-flow fractionation (flow FFF) depends primarily on the crossflow rate and its change over time. In this work, we demonstrate a method for modulation of the crossflow rate during separation that increases the peak-to-peak ... ...

    Abstract The resolution of flow field-flow fractionation (flow FFF) depends primarily on the crossflow rate and its change over time. In this work, we demonstrate a method for modulation of the crossflow rate during separation that increases the peak-to-peak resolution of the resulting fractograms. In classical FFF methods, the crossflow rate is either maintained constant or decreased during the separation of the different species. In this work, higher resolution between peaks was achieved by a novel gradient method in which the crossflow is increased briefly during separation to allow stronger retention of the later eluting peaks. We first outline the theoretical basis by which improved separation is achieved. We confirm our hypothesis by quantifying the impact of increasing crossflow on the resolution between a monoclonal antibody monomer and its high-molecular-weight aggregate. We then demonstrate that this method is applicable to two different FFF methods (AF4 and HF5) and various pharmaceutically relevant samples (monoclonal antibodies and adeno-associated viruses). Finally, we hypothesize that increasing the force perpendicular to the laminar flow as described here is broadly applicable to all FFF methods and improves the quality of FFF-based separations.
    Keywords analytical chemistry ; fractionation ; laminar flow ; monoclonal antibodies
    Language English
    Dates of publication 2023-1024
    Size p. 16138-16143.
    Publishing place American Chemical Society
    Document type Article ; Online
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c02570
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  7. Article: Vitamin C deficiency presenting as pseudoscleroderma in a pediatric patient with food aversion.

    Appiah, Margaret M / Bohrer, Nicholas / Galati, Aidan / Vuong, Carrie / Tucker, Suzanne M / Hightower, George

    JAAD case reports

    2023  Volume 44, Page(s) 82–84

    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2023.12.008
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  8. Article ; Online: Promoting a health-centered approach to acute mental health crises on college campuses: The case for collegiate-based emergency medical services.

    Friedman, Nicholas M G / Bartho, Murray J / Koenig, George J

    Journal of American college health : J of ACH

    2022  , Page(s) 1–3

    Abstract: As college and university campuses re-open during the COVID-19 pandemic, there is increased concern for mental health crises. Current trends in campus mental health care emphasize providing quality care in a safe, non-judgmental, and non-punitive manner. ...

    Abstract As college and university campuses re-open during the COVID-19 pandemic, there is increased concern for mental health crises. Current trends in campus mental health care emphasize providing quality care in a safe, non-judgmental, and non-punitive manner. Collegiate-based emergency medical services organizations are well-positioned to respond to acute mental health crises on college campuses. Campus health professionals and administrators seeking to promote a health-centered approach toward mental health crises should support the growth and development of collegiate-based emergency medical services organizations.
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2022.2104616
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 427: Show issues Location:
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  9. Article: Niche partitioning and the storage effect facilitate coexistence in an amphibian community.

    Brooks, George C / Caruso, Nicholas M / Chandler, Houston C / Haas, Carola A

    Ecology and evolution

    2023  Volume 13, Issue 10, Page(s) e10629

    Abstract: Virtually all natural community assemblages are dominated by a handful of common species. Dominant species can exert negative impacts on biodiversity through competitive exclusion, and thus there is a strong incentive to understand imbalances in ... ...

    Abstract Virtually all natural community assemblages are dominated by a handful of common species. Dominant species can exert negative impacts on biodiversity through competitive exclusion, and thus there is a strong incentive to understand imbalances in community composition, changes in dominance hierarchies through time, and mechanisms of coexistence. Pond-breeding amphibians that utilize ephemeral wetlands provide an excellent opportunity to evaluate theoretical predictions of community composition in stochastic environments. One of the most striking features of pond-breeding amphibians is the marked stochastic fluctuations in abundance across years. Given strong theoretical and empirical links between evenness and biomass, one would expect community evenness to change from year to year. Moreover, if different species exhibit different boom-and-bust reproductive cycles, then a storage effect may help to explain why one species does not outcompete all others. Here, we explore the interplay between biotic and abiotic conditions in shaping amphibian communities at two ephemeral wetlands on Eglin Air Force Base, Florida. We document consistent community composition over 6 years of monitoring, resulting from a lack of species turnover and similar responses of all community members to environmental conditions. The similar dynamics of species argues against a storage effect as the sole mechanism for coexistence and instead points to niche partitioning as a more important factor. In support of this conclusion, we show that the degree of synchrony in breeding migrations only correlates with environmental conditions within species, not between species. The lack of pattern seen between species implies that individuals are somewhat constrained in the timing of breeding migrations, perhaps owing in part to competition with other community members. We hope that our work reinvigorates interest in amphibian communities and highlights ephemeral wetlands as model systems to study community dynamics in stochastic environments.
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10629
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  10. Article ; Online: Pericardial Tamponade in a Patient With a History of Pneumonectomy.

    George, Nicholas / Chin, Brian / Mistry, Jamshid / Borger, Rodney / Dong, Fanglong / Neeki, Michael M

    Journal of medical cases

    2023  Volume 14, Issue 2, Page(s) 45–49

    Abstract: Shock is the clinical presentation of circulatory failure with impaired perfusion that results in inadequate cellular oxygen utilization. Treatment requires properly identifying the type of shock that is impacting the patient (obstructive, distributive, ... ...

    Abstract Shock is the clinical presentation of circulatory failure with impaired perfusion that results in inadequate cellular oxygen utilization. Treatment requires properly identifying the type of shock that is impacting the patient (obstructive, distributive, cardiogenic, and/or hypovolemic). Complex cases may involve numerous contributors to each type of shock and/or multiple types of shock which can present interesting diagnostic and management challenges to the clinician. In this case report, we present a 54-year-old male with a remote history of a right lung pneumonectomy presenting with multifactorial shock including cardiac tamponade, with initial compression of the expanding pericardial effusion by the postoperative fluid accumulation within the right hemithorax. While in the emergency department, the patient gradually became hypotensive with worsening tachycardia and dyspnea. A bedside echocardiogram revealed an increase in size of the pericardial effusion. An emergent ultrasound-guided pericardial drain was inserted with gradual improvement of his hemodynamics followed by placement of thoracostomy tube. This unique case highlights the importance of utilizing point-of-care ultrasound along with emergent intervention in critical resuscitation.
    Language English
    Publishing date 2023-02-25
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2586383-6
    ISSN 1923-4163 ; 1923-4163
    ISSN (online) 1923-4163
    ISSN 1923-4163
    DOI 10.14740/jmc4033
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