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Article ; Conference proceedings: Replication Series of an Arsenic-stressed Lemna gibba L. Test-system Investigating Homeopathic Preparations in High Potency Levels

Ücker, Annekathrin / Baumgartner, Stephan / Martin, David / Jäger, Tim

2024 Volume 113, Issue 01

Event/congress	HRI London 2023—Cutting Edge Research in Homeopathy: Presentation Abstracts, London, 2023-06-16
Language	English
Publishing date	2024-01-30
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2073322-7
ISSN	1476-4245 ; 1475-4916
ISSN (online)	1476-4245
ISSN	1475-4916
DOI	10.1055/s-0044-1779813
Database	Thieme publisher's database

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Article: Critical Evaluation of Specific Efficacy of Preparations Produced According to European Pharmacopeia Monograph 2371.

Ücker, Annekathrin / Baumgartner, Stephan / Martin, David / Jäger, Tim

Biomedicines

2022 Volume 10, Issue 3

Abstract: European Pharmacopoeia monograph 2371 describes the production of homeopathic preparations. A specific efficacy of these preparations in high dilution levels is questionable in view of basic scientific principles. There is empirical evidence for such ... ...

Abstract	European Pharmacopoeia monograph 2371 describes the production of homeopathic preparations. A specific efficacy of these preparations in high dilution levels is questionable in view of basic scientific principles. There is empirical evidence for such effects, for example in a Lemna-intoxication bioassay published 2010. To test the replicability and robustness of this bioassay, we conducted two experimental series (five independent blinded and randomised experiments each). The specimen of Lemna gibba L., clone-number 9352, were stressed in arsenic solution for 48 h (158 mg/L AsNa2HO4 (250 mg/L in series 2)), then grew in either As2O3 preparations produced according to Eu. Pharm. Monogr. 2371 or control solution. Comparing the area-related relative growth rate of day 3−9 (rgr 3−9) between treatment and control groups for each series showed differences that were not significant in series 1 (p = 0.10), significant in series 2 (p = 0.04) and significant in the pooled data of both series (p < 0.01). The effect direction (rgr 3−9 increase) was comparable to experiments of 2010, but the effect size was smaller, likely due to a changed light cycle. These results are not compatible with the hypothesis that the application of European Pharmacopoeia monograph 2371 results in pharmaceutical preparations without specific effects. Further studies are needed to investigate a potential mode of action explaining these effects.
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10030552
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Conference proceedings: Standard Deviation as Outcome Parameter in Plant-based Test Systems Investigating Homeopathic Preparations in High Potency Levels

Ücker, Annekathrin / Reif, Marcus / Doesburg, Paul / Martin, David / Baumgartner, Stephan

Homeopathy

2024 Volume 113, Issue 01

Event/congress	HRI London 2023—Cutting Edge Research in Homeopathy: Presentation Abstracts, London, 2023-06-16
Language	English
Publishing date	2024-01-30
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2073322-7
ISSN	1476-4245 ; 1475-4916
ISSN (online)	1476-4245
ISSN	1475-4916
DOI	10.1055/s-0044-1779783
Database	Thieme publisher's database

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Article ; Online: Exploiting death: apoptotic immunity in microbial pathogenesis.

Ucker, D S

Cell death and differentiation

2016 Volume 23, Issue 6, Page(s) 990–996

Abstract: Innate immunity typically is responsible for initial host responses against infections. Independently, nucleated cells that die normally as part of the physiological process of homeostasis in mammals (including humans) suppress immunity. Specifically, ... ...

Abstract	Innate immunity typically is responsible for initial host responses against infections. Independently, nucleated cells that die normally as part of the physiological process of homeostasis in mammals (including humans) suppress immunity. Specifically, the physiological process of cell death (apoptosis) generates cells that are recognized specifically by viable cells of all types and elicit a profound transient suppression of host immunity (termed 'innate apoptotic immunity' (IAI)). IAI appears to be important normally for the maintenance of self-tolerance and for the resolution of inflammation. In addition, pathogens are able to take advantage of IAI through a variety of distinct mechanisms, to enable their proliferation within the host and enhance pathogenicity. For example, the protist pathogen Leishmania amazonensis, at its infective stage, mimics apoptotic cells by expressing apoptotic-like protein determinants on the cell surface, triggering immunosuppression directly. In contrast, the pathogenic bacterium Listeria monocytogenes triggers cell death in host lymphocytes, relying on those apoptotic cells to suppress host immune control and facilitate bacterial expansion. Finally, although the inhibition of apoptotic cell death is a common attribute of many viruses which facilitates their extended replication, it is clear that adenoviruses also reprogram the non-apoptotic dead cells that arise subsequently to manifest apoptotic-like immunosuppressive properties. These three instances represent diverse strategies used by microbial pathogens to exploit IAI, focusing attention on the potency of this facet of host immune control. Further examination of these cases will be revealing both of varied mechanisms of pathogenesis and the processes involved in IAI control.
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/cdd.2016.17
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Zs.A 4230: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Multi-Photonic behavior of Nb2O5 and its correlation with synthetic methods

Ücker, Cátia L / Goetzke, Vitor / Riemke, Fábio C / Vitale, Marcelo L / de Andrade, Lucas R.Q / Ücker, Maicon D / Moreira, Eduardo C / Moreira, Mário L / Raubach, Cristiane W / Cava, Sérgio S

Journal of materials science. 2021 May, v. 56, no. 13

2021

Abstract: The performance of niobium pentoxide (Nb₂O₅) as photoanodes in dye-sensitized solar cells (DSSCs) and as catalysts in the photocatalytic degradation of Rhodamine B (RhB) was investigated. Four samples of Nb₂O₅ (Nb₂O₅_SG, Nb₂O₅_CR, Nb₂O₅_PP, and Nb₂O₅_MA) ...

Abstract	The performance of niobium pentoxide (Nb₂O₅) as photoanodes in dye-sensitized solar cells (DSSCs) and as catalysts in the photocatalytic degradation of Rhodamine B (RhB) was investigated. Four samples of Nb₂O₅ (Nb₂O₅_SG, Nb₂O₅_CR, Nb₂O₅_PP, and Nb₂O₅_MA) were synthesized by four different methods, respectively, entailing the sol-gel, combustion, polymeric precursors, and a microwave-assisted hydrothermal reaction. In all these samples, the orthorhombic phase of Nb₂O₅ was obtained, which resulted in different shapes and assemblies, which is very relevant because the surface area, shape, and size distribution of the nanoparticles significantly contribute to the optical process. The bandgap remained constant at 3.0 eV for all the samples, even for the sample prepared by the combustion method. An additional phase, which is related to local distortions, was revealed by Raman spectroscopy within the vibration range of 688–260 cm⁻¹. DSSCs using photoanodes with smaller and more dispersed Nb₂O₅ particles showed better results than those with inhomogeneities. For comparison, DSSCs were assembled using two different counter electrodes, platinum and graphite. The DSSC with platinum showed better photovoltaic results, mainly with photocurrents from 1.17 mA.cm⁻² for Nb₂O₅_CR to 1.64 mA.cm⁻² for Nb₂O₅_SG. The same trend was observed for the photocatalytic degradation of RhB, where the smaller and dispersed particles of Nb₂O₅_CR and Nb₂O₅_SG exhibited the best performance and, respectively, degraded approximately 75% and 61% of the RhB dye over 180 min. Therefore, the results of this study established a correlation between the synthesis methods and photonic behavior.
Keywords	Raman spectroscopy ; combustion ; dyes ; electric current ; graphene ; microwave treatment ; niobium ; photocatalysis ; photons ; platinum ; polymers ; rhodamines ; surface area ; vibration
Language	English
Dates of publication	2021-05
Size	p. 7889-7905.
Publishing place	Springer US
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2015305-3
ISSN	1573-4803 ; 0022-2461
ISSN (online)	1573-4803
ISSN	0022-2461
DOI	10.1007/s10853-021-05770-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Phosphatidylserine externalization by apoptotic cells is dispensable for specific recognition leading to innate apoptotic immune responses.

Gomes, Marta T / Palasiewicz, Karol / Gadiyar, Varsha / Lahey, Kevin / Calianese, David / Birge, Raymond B / Ucker, David S

The Journal of biological chemistry

2022 Volume 298, Issue 7, Page(s) 102034

Abstract: Surface determinants newly expressed by apoptotic cells that are involved in triggering potent immunosuppressive responses, referred to as "innate apoptotic immunity (IAI)" have not been characterized fully. It is widely assumed, often implicitly, that ... ...

Abstract	Surface determinants newly expressed by apoptotic cells that are involved in triggering potent immunosuppressive responses, referred to as "innate apoptotic immunity (IAI)" have not been characterized fully. It is widely assumed, often implicitly, that phosphatidylserine, a phospholipid normally cloistered in the inner leaflet of cells and externalized specifically during apoptosis, is involved in triggering IAI, just as it plays an essential role in the phagocytic recognition of apoptotic cells. It is notable, however, that the triggering of IAI in responder cells is not dependent on the engulfment of apoptotic cells by those responders. Contact between the responder and the apoptotic target, on the other hand, is necessary to elicit IAI. Previously, we demonstrated that exposure of protease-sensitive determinants on the apoptotic cell surface are essential for initiating IAI responses; exposed glycolytic enzyme molecules were implicated in particular. Here, we report our analysis of the involvement of externalized phosphatidylserine in triggering IAI. To analyze the role of phosphatidylserine, we employed a panel of target cells that either externalized phosphatidylserine constitutively, independently of apoptosis, or did not, as well as their WT parental cells that externalized the phospholipid in an apoptosis-dependent manner. We found that the externalization of phosphatidylserine, which can be fully uncoupled from apoptosis, is neither sufficient nor necessary to trigger the profound immunomodulatory effects of IAI. These results reinforce the view that apoptotic immunomodulation and phagocytosis are dissociable and further underscore the significance of protein determinants localized to the cell surface during apoptosis in triggering innate apoptotic immunity.
MeSH term(s)	Animals ; Apoptosis/physiology ; Cell Line ; Humans ; Immunity, Innate ; Immunomodulation ; Mice ; Phagocytosis/physiology ; Phosphatidylserines/metabolism
Chemical Substances	Phosphatidylserines
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2022.102034
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Article: Innate apoptotic immunity: the calming touch of death.

Birge, R B / Ucker, D S

Cell death and differentiation

2008 Volume 15, Issue 7, Page(s) 1096–1102

Abstract: Apoptotic cell death is an essential and highly ordered process that contributes to both the development and the homeostasis of multicellular organisms. It is associated with dramatic biochemical and cell biological events within the dying cell, ... ...

Abstract	Apoptotic cell death is an essential and highly ordered process that contributes to both the development and the homeostasis of multicellular organisms. It is associated with dramatic biochemical and cell biological events within the dying cell, including fragmentation of the nucleus and the redistribution of intracellular proteins and membrane lipids. It has long been apparent that phagocytic clearance of the cell corpse is an integral part of the apoptotic process; apoptotic clearance also may be essential in tissue homeostasis. During the cell death process, apoptotic cells acquire new cell surface determinants for specific recognition by responder phagocytes and suppression of immune responsiveness. Recent studies indicate that these determinants are well conserved throughout metazoan evolution; remarkably, their recognition shows no species-specific restriction. Professional and non-professional phagocytes recognize and respond to apoptotic cells similarly, notably with the immediate-early transcriptional repression of a variety of specific genes including those encoding inflammatory cytokines. Secondary responses following engulfment of the apoptotic corpse, utilizing several distinct mechanisms, enhance and sustain this apoptotic suppression. In this review, we highlight the central role of apoptotic cells in innate homeostatic regulation of immunity.
MeSH term(s)	Animals ; Apoptosis/genetics ; Apoptosis/immunology ; Cytokines/immunology ; Humans ; Immune Tolerance/genetics ; Immunity, Innate/genetics ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Phagocytes/immunology ; Phagocytosis ; Phosphatidylserines/immunology ; Repressor Proteins/immunology ; Transcription, Genetic/immunology
Chemical Substances	Cytokines ; Phosphatidylserines ; Repressor Proteins
Language	English
Publishing date	2008-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1225672-9
ISSN	1350-9047
ISSN	1350-9047
DOI	10.1038/cdd.2008.58
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4230: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Death and dying in the immune system.

Ucker, D S

Advances in pharmacology (San Diego, Calif.)

1997 Volume 41, Page(s) 179–218

MeSH term(s)	Animals ; Cell Death/physiology ; Immune System/physiology ; Signal Transduction/physiology
Language	English
Publishing date	1997
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1054-3589
ISSN	1054-3589
DOI	10.1016/s1054-3589(08)61059-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phosphatidylserine-Targeting Monoclonal Antibodies Exhibit Distinct Biochemical and Cellular Effects on Anti-CD3/CD28-Stimulated T Cell IFN-γ and TNF-α Production.

Calianese, David / Kreiss, Tamara / Kasikara, Canan / Davra, Viralkumar / Lahey, Kevin C / Gadiyar, Varsha / Geng, Ke / Singh, Sukhwinder / Honnen, William / Jaijyan, Dabbu Kumar / Reichman, Charles / Siekierka, John / Gennaro, Maria Laura / Kotenko, Sergei V / Ucker, David S / Brekken, Rolf A / Pinter, Abraham / Birge, Raymond B / Choudhary, Alok

Journal of immunology (Baltimore, Md. : 1950)

2021 Volume 207, Issue 2, Page(s) 436–448

Abstract: Phosphatidylserine (PS)-targeting monoclonal Abs (mAbs) that directly target PS and target PS via β2-gp1 (β2GP1) have been in preclinical and clinical development for over 10 y for the treatment of infectious diseases and cancer. Although the intended ... ...

Abstract	Phosphatidylserine (PS)-targeting monoclonal Abs (mAbs) that directly target PS and target PS via β2-gp1 (β2GP1) have been in preclinical and clinical development for over 10 y for the treatment of infectious diseases and cancer. Although the intended targets of PS-binding mAbs have traditionally included pathogens as well as stressed tumor cells and its associated vasculature in oncology, the effects of PS-targeting mAbs on activated immune cells, notably T cells, which externalize PS upon Ag stimulation, is not well understood. Using human T cells from healthy donor PBMCs activated with an anti-CD3 + anti-CD28 Ab mixture (anti-CD3/CD28) as a model for TCR-mediated PS externalization and T cell stimulation, we investigated effects of two different PS-targeting mAbs, 11.31 and bavituximab (Bavi), on TCR activation and TCR-mediated cytokine production in an ex vivo paradigm. Although 11.31 and Bavi bind selectivity to anti-CD3/28 activated T cells in a PS-dependent manner, surprisingly, they display distinct functional activities in their effect on IFN-γ and TNF-ɑ production, whereby 11.31, but not Bavi, suppressed cytokine production. This inhibitory effect on anti-CD3/28 activated T cells was observed on both CD4
MeSH term(s)	Antibodies, Monoclonal/immunology ; CD28 Antigens/immunology ; CD3 Complex/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Cell Line ; HEK293 Cells ; Humans ; Interferon-gamma/immunology ; Leukocytes, Mononuclear/immunology ; Lymphocyte Activation/immunology ; Muromonab-CD3/immunology ; Phosphatidylserines/immunology ; Tumor Necrosis Factor-alpha/immunology
Chemical Substances	Antibodies, Monoclonal ; CD28 Antigens ; CD3 Complex ; Muromonab-CD3 ; Phosphatidylserines ; Tumor Necrosis Factor-alpha ; Interferon-gamma (82115-62-6) ; bavituximab (Q16CT95N25)
Language	English
Publishing date	2021-07-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2000763
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

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Article: T-cell regulation. Tails of phosphorylation and T-cell activation.

Ucker, D S

Current biology : CB

1994 Volume 4, Issue 10, Page(s) 947–949

Abstract: How do quantitative differences in T-cell signal transduction lead to qualitatively different responses? Recent work demonstrates that even well-established regulatory paradigms are open to question. ...

Abstract	How do quantitative differences in T-cell signal transduction lead to qualitatively different responses? Recent work demonstrates that even well-established regulatory paradigms are open to question.
MeSH term(s)	Animals ; Humans ; Leukocyte Common Antigens/physiology ; Lymphocyte Activation ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) ; Phosphorylation ; Protein-Tyrosine Kinases/physiology ; Signal Transduction ; T-Lymphocytes/physiology
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (EC 2.7.10.2) ; Leukocyte Common Antigens (EC 3.1.3.48)
Language	English
Publishing date	1994-10-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/s0960-9822(00)00215-3
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