Article ; Online: Risk assessment of severe adult tetanus using the NLR and AST level and construction of a nomogram prediction model
Heliyon, Vol 10, Iss 1, Pp e23487- (2024)
1481
Abstract: Objective: We sought to examine high-risk factors for severe tetanus, construct a nomogram model, and predict the risk probability of severe tetanus in adult patients to provide a theoretical basis for clinical intervention. Methods: A retrospective ... ...
| Abstract | Objective: We sought to examine high-risk factors for severe tetanus, construct a nomogram model, and predict the risk probability of severe tetanus in adult patients to provide a theoretical basis for clinical intervention. Methods: A retrospective analysis was employed in this study, which enrolled 65 adult patients with tetanus diagnosed at the Second Affiliated Hospital of Hainan Medical University from January 2017 to September 2022. Study participants were divided into severe and mild groups based on the Ablett classification. The general data and laboratory markers of both groups were compared, and logistic regression analysis was used to screen for independent risk factors for severe tetanus. A nomogram prediction model was constructed, and receiver operating characteristic (ROC), calibration curve, and decision curve analysis (DCA) were constructed and used to assess discrimination, calibration, and net benefit. Results: Of the 65 adults patients with tetanus, 28 were placed in the severe group and 37 were placed in the mild group. Univariate logistic regression analysis showed that there were statistically significant differences in the incubation period, time from disease onset to treatment, white blood cell count (WBC), neutrophil count (NEU), lymphocyte count (LYM), platelet count (PLT), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lactate dehydrogenase level (LDH), myoglobin level (Mb), and aspartate aminotransferase (AST) level between the two groups (P < 0.05). while the differences in age; sex; and creatine kinase, creatine kinase isoenzyme, and alanine aminotransferase levels were not statistically significant (P > 0.05). Multivariate analysis showed that NLR (odds ratio [OR] = 4.998, 95 % confidence interval [CI] = 1.154–21.649, P = 0.031), AST (OR = 1.074, 95 % CI = 1.007–1.146, P = 0.031), PLT (OR = 1.055, 95 % CI = 1.006–1.106, P = 0.027), and incubation period (OR = 0.597, 95 % CI = 0.423–0.843, P = 0.003) are independent risk factor for severe tetanus. A ... |
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| Keywords | Severe tetanus ; NLR ; Myocardial enzymes ; Nomogram ; Prediction model ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99 |
| Subject code | 610 |
| Language | English |
| Publishing date | 2024-01-01T00:00:00Z |
| Publisher | Elsevier |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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