LIVIVO - Search results -

Search results

Result 1 - 10 of total 113

Search options

Article ; Online: Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury.

Chen, Mingjie / Lei, Shuyue / Zhou, Zihua / Wang, Meng / Feng, Chunlan / Gao, Xiaoling / Ding, Chunyong / Song, Zilan / Tang, Wei / Zhang, Ao

Journal of medicinal chemistry

2024 Volume 67, Issue 8, Page(s) 6268–6291

Abstract: Overactivation of cyclic GMP-AMP synthase (cGAS) is implicated in the occurrence of many inflammatory and autoimmune diseases, and inhibition of cGAS with a specific inhibitor has been proposed as a potential therapeutic strategy. However, only a few low- ...

Abstract	Overactivation of cyclic GMP-AMP synthase (cGAS) is implicated in the occurrence of many inflammatory and autoimmune diseases, and inhibition of cGAS with a specific inhibitor has been proposed as a potential therapeutic strategy. However, only a few low-potency cGAS inhibitors have been reported, and few are suitable for clinical investigation. As a continuation of our structural optimization on the reported cGAS inhibitor
MeSH term(s)	Acute Lung Injury/drug therapy ; Animals ; Mice ; Drug Design ; Male ; Humans ; Rats ; Carbazoles/chemical synthesis ; Carbazoles/pharmacology ; Carbazoles/chemistry ; Carbazoles/therapeutic use ; Carbazoles/pharmacokinetics ; Pyrrolidines/pharmacology ; Pyrrolidines/chemical synthesis ; Pyrrolidines/chemistry ; Pyrrolidines/therapeutic use ; Pyrrolidines/pharmacokinetics ; Nucleotidyltransferases/antagonists & inhibitors ; Nucleotidyltransferases/metabolism ; Lipopolysaccharides ; Rats, Sprague-Dawley ; Spiro Compounds/chemical synthesis ; Spiro Compounds/pharmacology ; Spiro Compounds/chemistry ; Spiro Compounds/therapeutic use ; Spiro Compounds/pharmacokinetics ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Enzyme Inhibitors/pharmacokinetics ; Enzyme Inhibitors/chemistry ; Structure-Activity Relationship ; Molecular Docking Simulation
Chemical Substances	Carbazoles ; Pyrrolidines ; Nucleotidyltransferases (EC 2.7.7.-) ; Lipopolysaccharides ; Spiro Compounds ; Enzyme Inhibitors ; cGAS protein, human (EC 2.7.7.-)
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c02229
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells.

Li, Yang / Zhu, Yuyuan / Shang, Fan-Fan / Xu, Lin / Jiang, Defang / Sun, Bin / Zhang, Lei / Luo, Cheng / Zhang, Ao / Zhang, Hao / Ding, Chunyong

Journal of medicinal chemistry

2024

Abstract: Peroxiredoxin (PRDX1) is a tumor-overexpressed antioxidant enzyme for eliminating excessive reactive oxygen species (ROS) to protect tumor cells from oxidative damage. Herein, a series of celastrol urea derivatives were developed based on its cocrystal ... ...

Abstract	Peroxiredoxin (PRDX1) is a tumor-overexpressed antioxidant enzyme for eliminating excessive reactive oxygen species (ROS) to protect tumor cells from oxidative damage. Herein, a series of celastrol urea derivatives were developed based on its cocrystal structure with PRDX1, with the aim of pursuing a PRDX1-specific inhibitor. Among them, derivative
Language	English
Publishing date	2024-04-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.4c00023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3-

Xiao, Xuanzheng / Feng, Juanjuan / Ma, Jing / Xia, Xinting / Liu, Xiaogu / Zhang, Jian / Ding, Chunyong / Pang, Xiufeng / Zhang, Ao

Journal of medicinal chemistry

2023 Volume 66, Issue 22, Page(s) 15524–15549

Abstract: The breakthrough in drug development of ... ...

Abstract	The breakthrough in drug development of KRAS
MeSH term(s)	Animals ; Humans ; Mice ; Mutation ; Proto-Oncogene Proteins p21(ras) ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use
Chemical Substances	KRAS protein, human ; KRASG12D inhibitor MRTX1133 ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Pyrimidines ; pyrido(4,3-d)pyrimidine
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c01724
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors.

Xie, Chenghu / Liu, Bo / Song, Zilan / Yang, Ye / Dai, Mengdi / Gao, Yinglei / Yao, Yujia / Ding, Chunyong / Ai, Jing / Zhang, Ao

Journal of medicinal chemistry

2023 Volume 66, Issue 23, Page(s) 16201–16221

Abstract: Hematopoietic progenitor kinase 1 (HPK1) is an important negative regulator in T-cell receptor signaling and as a promising key target for immunotherapy. Herein, based on the reported HPK1 ... ...

Abstract	Hematopoietic progenitor kinase 1 (HPK1) is an important negative regulator in T-cell receptor signaling and as a promising key target for immunotherapy. Herein, based on the reported HPK1 inhibitor
MeSH term(s)	Mice ; Rats ; Animals ; Signal Transduction ; T-Lymphocytes/metabolism ; Phosphorylation ; Protein Binding ; Receptors, Antigen, T-Cell
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c01571
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[

Zeng, Ruoqing / Fang, Meimiao / Shen, Ancheng / Chai, Xiaolei / Zhao, Yumiao / Liu, Mingyao / Zhu, Lingfeng / Rui, Weiwei / Feng, Bo / Hong, Liang / Ding, Chunyong / Song, Zilan / Lu, Weiqiang / Zhang, Ao

Journal of medicinal chemistry

2024 Volume 67, Issue 5, Page(s) 3520–3541

Abstract: Accumulating evidence has demonstrated a critical pathological role of oxysterol receptor GPR183 in various inflammatory and autoimmune diseases, including inflammatory bowel disease (IBD). However, the currently reported GPR183 antagonists are very ... ...

Abstract	Accumulating evidence has demonstrated a critical pathological role of oxysterol receptor GPR183 in various inflammatory and autoimmune diseases, including inflammatory bowel disease (IBD). However, the currently reported GPR183 antagonists are very limited and not qualified for
MeSH term(s)	Humans ; Oxysterols/adverse effects ; Thiazoles/adverse effects ; Inflammatory Bowel Diseases/drug therapy ; Colitis/chemically induced ; Colitis/drug therapy ; Dextran Sulfate ; Receptors, G-Protein-Coupled ; Receptors, Steroid
Chemical Substances	oxysterol binding protein ; Oxysterols ; Thiazoles ; Dextran Sulfate (9042-14-2) ; GPR183 protein, human ; Receptors, G-Protein-Coupled ; Receptors, Steroid
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c01905
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators.

Tang, Hairong / Zeng, Ruoqing / He, Ende / Zhang, Isabella / Ding, Chunyong / Zhang, Ao

Journal of medicinal chemistry

2022 Volume 65, Issue 9, Page(s) 6441–6453

Abstract: Piezo1 is a member of the mechanosensitive piezo ion channel family, which transduces various mechanical stimulations into electrochemical signals. Piezo1 is closely implicated in different physiological processes ranging from erythrocyte volume ... ...

Abstract	Piezo1 is a member of the mechanosensitive piezo ion channel family, which transduces various mechanical stimulations into electrochemical signals. Piezo1 is closely implicated in different physiological processes ranging from erythrocyte volume homeostasis to lymphatic vessel formation and bone homeostasis. Aberrant Piezo1 functions caused by gain-of-function or loss-of-function mutations are associated with various pathological conditions. Due to the significant contribution on the recognition of Piezo ion channels for sensing mechanical stress, Ardem Patapoutian received the 2021 Nobel Prize in Physiology or Medicine (jointly). Strategies of targeting and modulating Piezo1 have shown potential to produce significant therapeutic effects, thus validating Piezo1 as a promising drug target for diseases. In this Perspective, we review the cryo-EM structure, mechanogating mechanism, and physiological profiles of Piezo1, together with the latest advances in the development of its modulators. Limitations and challenges as well as future development of Piezo1 modulators are discussed as well.
MeSH term(s)	Homeostasis ; Ion Channels/metabolism ; Lymphangiogenesis ; Mechanotransduction, Cellular ; Mutation
Chemical Substances	Ion Channels
Language	English
Publishing date	2022-04-24
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c00085
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Activatable NIR-II Fluorescent Nanoprobe for Rapid Detection and Imaging of Methylglyoxal Facilitated by the Local Nonpolar Microenvironment.

Dang, Yijing / Lai, Yi / Chen, Fengping / Sun, Qian / Ding, Chunyong / Zhang, Wen / Xu, Zhiai

Analytical chemistry

2022 Volume 94, Issue 2, Page(s) 1076–1084

Abstract: Closely related to multiple chronic inflammation, especially type-2 diabetes (T2D), methylglyoxal (MGO) may be a potential key to visualize disease progression and treatment effects. On the other hand, lack of convenient and fast analytical methods ... ...

Abstract	Closely related to multiple chronic inflammation, especially type-2 diabetes (T2D), methylglyoxal (MGO) may be a potential key to visualize disease progression and treatment effects. On the other hand, lack of convenient and fast analytical methods cannot afford accurate MGO quantitative evaluation. In this work, an activatable second near-infrared region (NIR-II) fluorescent probe TDTCD was synthesized and its reaction mechanism with MGO was discussed. The desired NIR-II product preferred response solvents with small polarity. A novel activatable nanoprobe, MG-SLNP, for MGO was then constructed based on rational packaging to provide a local nonpolar microenvironment. The hydrophobic core of nanoparticles not only successfully improved the stability and water solubility but also greatly promoted the response rate while reacting with MGO. The comparison between NIR-II fluorescence and the traditional high-performance liquid chromatography method for T2D blood samples was discussed. A high-resolution viewing window, quick response, and good biocompatibility led to a satisfactory signal-to-noise ratio of MG-SLNP for real-time MGO bio-detection and imaging in vivo.
MeSH term(s)	Fluorescent Dyes/chemistry ; Nanoparticles/chemistry ; Optical Imaging/methods ; Pyruvaldehyde
Chemical Substances	Fluorescent Dyes ; Pyruvaldehyde (722KLD7415)
Language	English
Publishing date	2022-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c04076
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4033: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Discovery of 2

Cheng, Zhiyuan / Wang, Yijie / Zhang, Yao / Zhang, Chan / Wang, Mengru / Wang, Wei / He, Jiacheng / Wang, Yang / Zhang, Hankun / Zhang, Qiansen / Ding, Chunyong / Wu, Deyan / Yang, Linlin / Liu, Mingyao / Lu, Weiqiang

Journal of medicinal chemistry

2023 Volume 66, Issue 9, Page(s) 6218–6238

Abstract: Nowadays, small-molecule drugs have become an indispensable part of tumor immunotherapy. Accumulating evidence has indicated that specifically blocking ... ...

Abstract	Nowadays, small-molecule drugs have become an indispensable part of tumor immunotherapy. Accumulating evidence has indicated that specifically blocking PGE
MeSH term(s)	Humans ; Colonic Neoplasms/pathology ; Immunotherapy ; Prostaglandins ; Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors ; Signal Transduction ; Indazoles/chemistry ; Indazoles/pharmacology
Chemical Substances	Prostaglandins ; Receptors, Prostaglandin E, EP4 Subtype ; Indazoles
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c02058
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Medulloblastoma: Molecular understanding, treatment evolution, and new developments.

Liu, Xiaohua / Ding, Chunyong / Tan, Wenfu / Zhang, Ao

Pharmacology & therapeutics

2020 Volume 210, Page(s) 107516

Abstract: Medulloblastoma (MB) is the most common childhood malignant brain tumor, accounting for approximately 20% of all pediatric central nervous system tumors. Current standard treatments involving surgical interventions followed by craniospinal irradiation ... ...

Abstract	Medulloblastoma (MB) is the most common childhood malignant brain tumor, accounting for approximately 20% of all pediatric central nervous system tumors. Current standard treatments involving surgical interventions followed by craniospinal irradiation and adjuvant chemotherapy have severe motor and cognitive defects. Therefore, individualized treatment regimens with reduced toxicity designed according to the presence of specific oncogenic 'driver' genes are urgently demanded. To this end, recent genetic and epigenetic findings have advanced the classification of MB into the international consensus of four distinct MB molecular subgroups (WNT, SHH, Group 3, and Group 4) based on their respective molecular and histopathological characteristics. More recent studies have indicated that up to seven molecular subgroups exist in childhood MB. Moreover, studies on the inter- and intra-tumoral features of the four subgroups revealed that each subgroup contains variant subtypes. These results have greatly helped risk stratification of MB patients at diagnosis and significantly improved clinical treatment options. Herein, we highlight the recent advances and challenges associated with MB classification, and the development of therapeutic treatments targeting novel subgroup-specific molecular and epigenetic factors, especially those in the SHH-driven MB tumors.
MeSH term(s)	Animals ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cerebellar Neoplasms/drug therapy ; Cerebellar Neoplasms/genetics ; Cerebellar Neoplasms/metabolism ; Clinical Decision-Making ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Genetic Heterogeneity ; Humans ; Medulloblastoma/drug therapy ; Medulloblastoma/genetics ; Medulloblastoma/metabolism ; Molecular Targeted Therapy ; Precision Medicine ; Signal Transduction ; Treatment Outcome
Chemical Substances	Antineoplastic Agents ; Biomarkers, Tumor
Language	English
Publishing date	2020-02-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2020.107516
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1183: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Novel nomograms for predicting survival for immediate breast reconstruction patients diagnosed with invasive breast cancer-a single-center 15-year experience.

He, Shanshan / Chen, Qingjinan / Li, Gang / Ding, Bowen / Wang, Shu / Han, Chunyong / Sun, Jingyan / Huang, Qingfeng / Yin, Jian

Frontiers in oncology

2023 Volume 13, Page(s) 1202650

Abstract: Background: Immediate breast reconstruction is widely accepted following oncologic mastectomy. This study aimed to build a novel nomogram predicting the survival outcome for Chinese patients undergoing immediate reconstruction following mastectomy for ... ...

Abstract	Background: Immediate breast reconstruction is widely accepted following oncologic mastectomy. This study aimed to build a novel nomogram predicting the survival outcome for Chinese patients undergoing immediate reconstruction following mastectomy for invasive breast cancer. Methods: A retrospective review of all patients undergoing immediate reconstruction following treatment for invasive breast cancer was performed from May 2001 to March 2016. Eligible patients were assigned to a training set or a validation set. Univariate and multivariate Cox proportional hazard regression models were used to select associate variables. Two nomograms were developed based on the training cohort for breast cancer-specific survival (BCSS) and disease-free survival (DFS). Internal and external validations were performed, and the C-index and calibration plots were generated to evaluate the performance (discrimination and accuracy) of the models. Results: The 10-year estimated BCSS and DFS were 90.80% (95% CI: 87.30%-94.40%) and 78.40% (95% CI: 72.50%-84.70%), respectively, in the training cohort. In the validation cohort, they were and 85.60% (95% CI, 75.90%-96.50%) and 84.10% (95% CI, 77.80%-90.90%), respectively. Ten independent factors were used to build a nomogram for prediction of 1-, 5- and 10-year BCSS, while nine were used for DFS. The C-index was 0.841 for BCSS and 0.737 for DFS in internal validation, and the C-index was 0.782 for BCSS and 0.700 for DFS in external validation. The calibration curve for both BCSS and DFS demonstrated acceptable agreement between the predicted and actual observation in the training and the validation cohorts. Conclusion: The nomograms provided valuable visualization of factors predicting BCSS and DFS in invasive breast cancer patients with immediate breast reconstruction. The nomograms may have tremendous potential in guiding individualized decision-making for physicians and patients in choosing the optimized treatment methods.
Language	English
Publishing date	2023-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1202650
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito