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  1. Article ; Online: Foreword.

    Suzuki, Takayoshi

    Chemical & pharmaceutical bulletin

    2024  Volume 72, Issue 2, Page(s) 135

    Language English
    Publishing date 2024-02-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c24-ctf7202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: General Synthesis of

    Zhao, Runze / Ismiyarto / Zhou, Da-Yang / Asano, Kaori / Suzuki, Takayoshi / Sasai, Hiroaki / Suzuki, Takeyuki

    ACS omega

    2024  Volume 9, Issue 16, Page(s) 17945–17955

    Abstract: A practical synthesis ... ...

    Abstract A practical synthesis of
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c09381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Special Issue: (Bio)Chemical Aspects of Epigenetics.

    Suzuki, Takayoshi

    Chemical record (New York, N.Y.)

    2019  Volume 18, Issue 12, Page(s) 1659

    MeSH term(s) Acetylation ; DNA/genetics ; DNA Methylation ; Epigenesis, Genetic ; Histone Code ; Humans
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 2044646-9
    ISSN 1528-0691 ; 1527-8999
    ISSN (online) 1528-0691
    ISSN 1527-8999
    DOI 10.1002/tcr.201800179
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  4. Article: Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR.

    Furihata, Chie / Suzuki, Takayoshi

    Genes and environment : the official journal of the Japanese Environmental Mutagen Society

    2023  Volume 45, Issue 1, Page(s) 7

    Abstract: Next-generation RNA sequencing (RNA-Seq) has identified more differentially expressed protein-coding genes (DEGs) and provided a wider quantitative range of expression level changes than conventional DNA microarrays. JEMS·MMS·Toxicogenomics group studied ...

    Abstract Next-generation RNA sequencing (RNA-Seq) has identified more differentially expressed protein-coding genes (DEGs) and provided a wider quantitative range of expression level changes than conventional DNA microarrays. JEMS·MMS·Toxicogenomics group studied DEGs with targeted RNA-Seq on freshly frozen rat liver tissues and on formalin-fixed paraffin-embedded (FFPE) rat liver tissues after 28 days of treatment with chemicals and quantitative real-time PCR (qPCR) on rat and mouse liver tissues after 4 to 48 h treatment with chemicals and analyzed by principal component analysis (PCA) as statics. Analysis of rat public DNA microarray data (Open TG-GATEs) was also performed. In total, 35 chemicals were analyzed [15 genotoxic hepatocarcinogens (GTHCs), 9 non-genotoxic hepatocarcinogens (NGTHCs), and 11 non-genotoxic non-hepatocarcinogens (NGTNHCs)]. As a result, 12 marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2, and Tubb4b) were proposed to discriminate GTHCs from NGTHCs and NGTNHCs. U.S. Environmental Protection Agency studied DEGs induced by 4 known GTHCs in rat liver using DNA microarray and proposed 7 biomarker genes, Bax, Bcmp1, Btg2, Ccng1, Cdkn1a, Cgr19, and Mgmt for GTHCs. Studies involving the use of whole-transcriptome RNA-Seq upon exposure to chemical carcinogens in vivo have also been performed in rodent liver, kidney, lung, colon, and other organs, although discrimination of GTHCs from NGTHCs was not examined. Candidate genes published using RNA-Seq, qPCR, and DNA microarray will be useful for the future development of short-term in vivo studies of environmental carcinogens using RNA-Seq.
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2269162-5
    ISSN 1880-7062 ; 1880-7046
    ISSN (online) 1880-7062
    ISSN 1880-7046
    DOI 10.1186/s41021-023-00262-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR

    Chie Furihata / Takayoshi Suzuki

    Genes and Environment, Vol 45, Iss 1, Pp 1-

    2023  Volume 16

    Abstract: Abstract Next-generation RNA sequencing (RNA-Seq) has identified more differentially expressed protein-coding genes (DEGs) and provided a wider quantitative range of expression level changes than conventional DNA microarrays. JEMS·MMS·Toxicogenomics ... ...

    Abstract Abstract Next-generation RNA sequencing (RNA-Seq) has identified more differentially expressed protein-coding genes (DEGs) and provided a wider quantitative range of expression level changes than conventional DNA microarrays. JEMS·MMS·Toxicogenomics group studied DEGs with targeted RNA-Seq on freshly frozen rat liver tissues and on formalin-fixed paraffin-embedded (FFPE) rat liver tissues after 28 days of treatment with chemicals and quantitative real-time PCR (qPCR) on rat and mouse liver tissues after 4 to 48 h treatment with chemicals and analyzed by principal component analysis (PCA) as statics. Analysis of rat public DNA microarray data (Open TG-GATEs) was also performed. In total, 35 chemicals were analyzed [15 genotoxic hepatocarcinogens (GTHCs), 9 non-genotoxic hepatocarcinogens (NGTHCs), and 11 non-genotoxic non-hepatocarcinogens (NGTNHCs)]. As a result, 12 marker genes (Aen, Bax, Btg2, Ccnf, Ccng1, Cdkn1a, Gdf15, Lrp1, Mbd1, Phlda3, Plk2, and Tubb4b) were proposed to discriminate GTHCs from NGTHCs and NGTNHCs. U.S. Environmental Protection Agency studied DEGs induced by 4 known GTHCs in rat liver using DNA microarray and proposed 7 biomarker genes, Bax, Bcmp1, Btg2, Ccng1, Cdkn1a, Cgr19, and Mgmt for GTHCs. Studies involving the use of whole-transcriptome RNA-Seq upon exposure to chemical carcinogens in vivo have also been performed in rodent liver, kidney, lung, colon, and other organs, although discrimination of GTHCs from NGTHCs was not examined. Candidate genes published using RNA-Seq, qPCR, and DNA microarray will be useful for the future development of short-term in vivo studies of environmental carcinogens using RNA-Seq.
    Keywords RNA-Seq ; DNA microarray ; qPCR ; Rodent short-term in vivo test ; Genotoxic carcinogen ; Non-genotoxic carcinogen ; Ecology ; QH540-549.5 ; Genetics ; QH426-470
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos.

    Shao, Ruiqi / Suzuki, Takayoshi / Suyama, Mikita / Tsukada, Yuichi

    BMC genomics

    2024  Volume 25, Issue 1, Page(s) 143

    Abstract: Background: Histone acetylation, which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a crucial role in the control of gene expression. HDAC inhibitors (HDACi) have shown potential in cancer therapy; however, ... ...

    Abstract Background: Histone acetylation, which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a crucial role in the control of gene expression. HDAC inhibitors (HDACi) have shown potential in cancer therapy; however, the specific roles of HDACs in early embryos remain unclear. Moreover, although some pan-HDACi have been used to maintain cellular undifferentiated states in early embryos, the specific mechanisms underlying their effects remain unknown. Thus, there remains a significant knowledge gap regarding the application of selective HDACi in early embryos.
    Results: To address this gap, we treated early embryos with two selective HDACi (MGCD0103 and T247). Subsequently, we collected and analyzed their transcriptome data at different developmental stages. Our findings unveiled a significant effect of HDACi treatment during the crucial 2-cell stage of zygotes, leading to a delay in embryonic development after T247 and an arrest at 2-cell stage after MGCD0103 administration. Furthermore, we elucidated the regulatory targets underlying this arrested embryonic development, which pinpointed the G2/M phase as the potential period of embryonic development arrest caused by MGCD0103. Moreover, our investigation provided a comprehensive profile of the biological processes that are affected by HDACi, with their main effects being predominantly localized in four aspects of zygotic gene activation (ZGA): RNA splicing, cell cycle regulation, autophagy, and transcription factor regulation. By exploring the transcriptional regulation and epigenetic features of the genes affected by HDACi, we made inferences regarding the potential main pathways via which HDACs affect gene expression in early embryos. Notably, Hdac7 exhibited a distinct response, highlighting its potential as a key player in early embryonic development.
    Conclusions: Our study conducted a comprehensive analysis of the effects of HDACi on early embryonic development at the transcriptional level. The results demonstrated that HDACi significantly affected ZGA in embryos, elucidated the distinct actions of various selective HDACi, and identified specific biological pathways and mechanisms via which these inhibitors modulated early embryonic development.
    MeSH term(s) Pregnancy ; Female ; Mice ; Animals ; Histone Deacetylase Inhibitors/pharmacology ; Transcriptome ; Benzamides/pharmacology ; Pyrimidines/pharmacology
    Chemical Substances Histone Deacetylase Inhibitors ; mocetinostat (A6GWB8T96J) ; Benzamides ; Pyrimidines
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-024-10029-3
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  7. Article ; Online: Role of plant homeodomain finger protein 8 in P19 embryonic carcinoma cells revealed by genome editing and specific inhibitor.

    Doi, Shusuke / Suzuki, Takayoshi / Soeda, Shuhei / Miyata, Naoki / Inazu, Tetsuya

    Biochemistry and biophysics reports

    2024  Volume 38, Page(s) 101670

    Abstract: Plant homeodomain finger protein 8 (PHF8) is a histone demethylase that regulates the expression of various genes. PHF8 targets repressor histone markers and activates gene expression. Although PHF8 has been involved in X-linked mental retardation and ... ...

    Abstract Plant homeodomain finger protein 8 (PHF8) is a histone demethylase that regulates the expression of various genes. PHF8 targets repressor histone markers and activates gene expression. Although PHF8 has been involved in X-linked mental retardation and certain types of cancers, the role of PHF8 remains largely unknown, and its relevance to the pathogenesis of these diseases is also uncertain. In the present study, we aimed to clarify the cellular function of PHF8 in P19 cells using
    Language English
    Publishing date 2024-03-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2024.101670
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  8. Article ; Online: Intermolecular Catalytic Asymmetric Iodoetherification of Unfunctionalized Alkenes.

    Suzuki, Takumi K / Yamanaka, Masahiro / Arai, Takayoshi

    Organic letters

    2022  Volume 24, Issue 21, Page(s) 3872–3877

    Abstract: A newly prepared trinuclear ... ...

    Abstract A newly prepared trinuclear Zn
    MeSH term(s) Alkenes/chemistry ; Catalysis ; Stereoisomerism
    Chemical Substances Alkenes
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c01490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: [Abnormal movements "Motare" in Kyudo have the characteristics of task-specific focal dystonia].

    Ogiso, Taichi / Ono, Yoya / Suzuki, Saiki / Shimohata, Takayoshi

    Rinsho shinkeigaku = Clinical neurology

    2023  Volume 63, Issue 8, Page(s) 532–535

    Abstract: Among the abnormal kyudo movements ("yips"), "motare" is the inability to release the arrow at the intended timing if aiming the target. We hypothesized that "motare" is a task-specific focal dystonia (TSFD). We interviewed three participants with " ... ...

    Abstract Among the abnormal kyudo movements ("yips"), "motare" is the inability to release the arrow at the intended timing if aiming the target. We hypothesized that "motare" is a task-specific focal dystonia (TSFD). We interviewed three participants with "motare," three participants with "hayake", and three controls without "motare" nor "hayake". Moreover, we conducted a surface electromyography (sEMG) examination and found that "motare" was characterized by stereotypy, sensory tricks, and morning benefit; however, these findings were not observed in "hayake". Abnormal co-contraction of the upper extremity antagonist muscles was observed in one of the three "motare" participants. Overall, these findings suggest that "motare" have the characteristics of TSFD not previously reported.
    MeSH term(s) Humans ; Dystonic Disorders/diagnosis ; Dystonia ; Dyskinesias ; Electromyography
    Language Japanese
    Publishing date 2023-07-29
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.cn-001844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms.

    Mukherjee, Anirban / Zamani, Farzad / Suzuki, Takayoshi

    Journal of medicinal chemistry

    2023  Volume 66, Issue 17, Page(s) 11672–11700

    Abstract: Because the overexpression of histone deacetylase enzymes (HDACs) has been linked to numerous diseases, including various cancers and neurodegenerative disorders, HDAC inhibitors have emerged as promising therapeutic agents. However, most HDAC inhibitors ...

    Abstract Because the overexpression of histone deacetylase enzymes (HDACs) has been linked to numerous diseases, including various cancers and neurodegenerative disorders, HDAC inhibitors have emerged as promising therapeutic agents. However, most HDAC inhibitors lack both subclass and isoform selectivity, which leads to potential toxicity. Unlike classical hydroxamate HDAC inhibitors, slow-binding HDAC inhibitors form tight and prolonged bonds with HDAC enzymes. This distinct mechanism of action improves both selectivity and toxicity profiles, which makes slow-binding HDAC inhibitors a promising class of therapeutic agents for various diseases. Therefore, the development of slow-binding HDAC inhibitors that can effectively target a wide range of HDAC isoforms is crucial. This Perspective provides valuable insights into the potential and progress of slow-binding HDAC inhibitors as promising drug candidates for the treatment of various diseases.
    MeSH term(s) Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylases ; Hydroxamic Acids ; Protein Isoforms
    Chemical Substances Histone Deacetylase Inhibitors ; Histone Deacetylases (EC 3.5.1.98) ; Hydroxamic Acids ; Protein Isoforms
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01160
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