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  1. Article: Editorial: Dietary factors, epigenetics and their implications for human obesity - volume II.

    Ramos-Lopez, Omar

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1328944

    MeSH term(s) Humans ; Epigenesis, Genetic ; Obesity/genetics
    Language English
    Publishing date 2023-12-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1328944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epigenetic Biomarkers of Metabolic Responses to Lifestyle Interventions.

    Ramos-Lopez, Omar

    Nutrients

    2023  Volume 15, Issue 19

    Abstract: Studies have examined the possible utility of epigenetic phenomena (DNA methylation changes, covalent histone modifications, and miRNA expression patterns) in predicting individual responses to different lifestyle programs. Nonetheless, most available ... ...

    Abstract Studies have examined the possible utility of epigenetic phenomena (DNA methylation changes, covalent histone modifications, and miRNA expression patterns) in predicting individual responses to different lifestyle programs. Nonetheless, most available evidence is focused on identifying epigenetic marks eventually associated with body composition and adiposity outcomes, whereas their roles in metabolic endings remain less explored. This document comprehensively reviewed the evidence regarding the use of epigenetic signatures as putative biomarkers of metabolic outcomes (glycemic, lipid, blood pressure, and inflammatory/oxidative stress features) in response to different lifestyle interventions in humans. Although more investigation is still necessary in order to translate this knowledge in clinical practice, these scientific insights are contributing to the design of advanced strategies for the precise management of cardiometabolic risk, gaining understanding on metabolic heterogeneity, allowing for the prediction of metabolic outcomes, and facilitating the design of epigenome-based nutritional strategies for a more customized approach for metabolic alterations treatment under the scope of precision nutrition.
    MeSH term(s) Humans ; Epigenesis, Genetic ; DNA Methylation ; Biomarkers ; Obesity/genetics ; Life Style
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-10-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15194251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus.

    Ramos-Lopez, Omar

    World journal of diabetes

    2023  Volume 15, Issue 2, Page(s) 142–153

    Abstract: Globally, type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders. T2DM physiopathology is influenced by complex interrelationships between genetic, metabolic and lifestyle factors (including diet), which differ between populations ... ...

    Abstract Globally, type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders. T2DM physiopathology is influenced by complex interrelationships between genetic, metabolic and lifestyle factors (including diet), which differ between populations and geographic regions. In fact, excessive consumptions of high fat/high sugar foods generally increase the risk of developing T2DM, whereas habitual intakes of plant-based healthy diets usually exert a protective effect. Moreover, genomic studies have allowed the characterization of sequence DNA variants across the human genome, some of which may affect gene expression and protein functions relevant for glucose homeostasis. This comprehensive literature review covers the impact of gene-diet interactions on T2DM susceptibility and disease progression, some of which have demonstrated a value as biomarkers of personal responses to certain nutritional interventions. Also, novel genotype-based dietary strategies have been developed for improving T2DM control in comparison to general lifestyle recommendations. Furthermore, progresses in other omics areas (epigenomics, metagenomics, proteomics, and metabolomics) are improving current understanding of genetic insights in T2DM clinical outcomes. Although more investigation is still needed, the analysis of the genetic make-up may help to decipher new paradigms in the pathophysiology of T2DM as well as offer further opportunities to personalize the screening, prevention, diagnosis, management, and prognosis of T2DM through precision nutrition.
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v15.i2.142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease.

    Ramos-Lopez, Omar

    Genes

    2022  Volume 13, Issue 11

    Abstract: Currently, metabolic-associated fatty liver disease (MAFLD) is a leading global cause of chronic liver disease, and is expected to become one of the most common indications of liver transplantation. MAFLD is associated with obesity, involving multiple ... ...

    Abstract Currently, metabolic-associated fatty liver disease (MAFLD) is a leading global cause of chronic liver disease, and is expected to become one of the most common indications of liver transplantation. MAFLD is associated with obesity, involving multiple mechanisms such as alterations in lipid metabolism, insulin resistance, hyperinflammation, mitochondrial dysfunction, cell apoptosis, oxidative stress, and extracellular matrix formation. However, the onset and progression of MAFLD is variable among individuals, being influenced by intrinsic (personal) and external environmental factors. In this context, sequence structural variants across the human genome, epigenetic phenomena (i.e., DNA methylation, histone modifications, and long non-coding RNAs) affecting gene expression, gut microbiota dysbiosis, and metabolomics/lipidomic fingerprints may account for differences in MAFLD outcomes through interactions with nutritional features. This knowledge may contribute to gaining a deeper understanding of the molecular and physiological processes underlying MAFLD pathogenesis and phenotype heterogeneity, as well as facilitating the identification of biomarkers of disease progression and therapeutic targets for the implementation of tailored nutritional strategies. This comprehensive literature review highlights the potential of nutrigenetic, nutriepigenetic, nutrimetagenomic, nutritranscriptomics, and nutrimetabolomic approaches for the prevention and management of MAFLD in humans through the lens of precision nutrition.
    MeSH term(s) Humans ; Epigenesis, Genetic ; DNA Methylation/genetics ; Obesity/genetics ; Insulin Resistance/genetics ; Dysbiosis/complications
    Language English
    Publishing date 2022-11-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13112142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Low Dietary Betaine Intake Is Associated with Increased Blood Cholesterol in Mexican Subjects.

    Ramos-Lopez, Omar / Santuario-Loera, Alma

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 8

    Abstract: Background: Betaine, an osmolyte derivative of the metabolite choline and the amino acid glycine, acts as a methyl donor in the conversion of homocysteine to methionine and is involved in the maintenance of adequate lipid metabolism. There is growing ... ...

    Abstract Background: Betaine, an osmolyte derivative of the metabolite choline and the amino acid glycine, acts as a methyl donor in the conversion of homocysteine to methionine and is involved in the maintenance of adequate lipid metabolism. There is growing evidence for the role of betaine in the development of various lipid-related diseases, including dyslipidemia and cardiovascular risk. This study aimed to analyze associations between betaine intake and blood lipid profiles in Mexican subjects.
    Methods: A total of 212 adults were randomly recruited in the city of Tijuana, Baja California, Mexico. Betaine intake was estimated using Nutritionist Pro software. Body composition and metabolic measurements were obtained by conventional methods. In the total sample, the average intake of betaine was 14.32 mg/d. Individuals were categorized into three groups according to tertiles of betaine consumption: tertile/group 1 (<4.16 mg/d), tertile/group 2 (4.16-12.02 mg/d), and tertile/group 3 (>12.02 mg/d).
    Results: Compared to group 3, subjects within group 1 had higher serum levels of total cholesterol (
    Conclusions: Our results show that a low intake of betaine is associated with elevated blood cholesterol levels in Mexican subjects. On this basis, betaine consumption could be used as an additional dietary measure for cardiovascular care. However, additional studies are required to confirm our results in other Mexican regions as well as in other populations worldwide.
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12080819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Dietary Intake of Capsaicin and Its Association with Markers of Body Adiposity and Fatty Liver in a Mexican Adult Population of Tijuana.

    Martínez-Aceviz, Yesenia / Sobrevilla-Navarro, Ana Alondra / Ramos-Lopez, Omar

    Healthcare (Basel, Switzerland)

    2023  Volume 11, Issue 22

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11223001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prevalence of food addiction and its association with lifestyle factors in undergraduate students from Northwest Mexico.

    Rivera-Mateos, Melissa / Ramos-Lopez, Omar

    Journal of addictive diseases

    2022  Volume 41, Issue 4, Page(s) 308–316

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1077616-3
    ISSN 1545-0848 ; 1055-0887
    ISSN (online) 1545-0848
    ISSN 1055-0887
    DOI 10.1080/10550887.2022.2116252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: Genomic medicine in hepatology: Towards personalized medicine in obesity and chronic liver disease.

    Roman, Sonia / Ramos-Lopez, Omar / Panduro, Arturo

    Annals of hepatology

    2022  Volume 28, Issue 1, Page(s) 100875

    Language English
    Publishing date 2022-11-09
    Publishing country Mexico
    Document type Editorial
    ZDB-ID 2188733-0
    ISSN 1665-2681
    ISSN 1665-2681
    DOI 10.1016/j.aohep.2022.100875
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6221: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Application of Gut Bacterial Profiling Information in Precision Nutrition for Obesity and Weight Loss Management.

    Ramos-Lopez, Omar / Aranaz, Paula / Riezu-Boj, Jose I / Milagro, Fermin I

    Lifestyle genomics

    2024  Volume 17, Issue 1, Page(s) 22–30

    Abstract: Background: It has been suggested that the dysfunction of the gut microbiome can have deleterious effects on the regulation of body weight and adiposity by affecting energy metabolism. In this context, gut bacterial profiling studies have contributed to ...

    Abstract Background: It has been suggested that the dysfunction of the gut microbiome can have deleterious effects on the regulation of body weight and adiposity by affecting energy metabolism. In this context, gut bacterial profiling studies have contributed to characterize specific bacteria associated with obesity. This review covers the information driven by gut bacterial profiling analyses and emphasizes the potential application of this knowledge in precision nutrition strategies for obesity understanding and weight loss management.
    Summary: Gut bacterial profiling studies have identified bacterial families that are more abundant in obese than in nonobese individuals (i.e., Prevotellaeae, Ruminococcaceae, and Veillonellaceae) as well as other families that have been repeatedly found more abundant in nonobese people (i.e., Christensenellaceae and Coriobacteriaceae), suggesting that an increase in their relative amount could be an interesting target in weight-loss treatments. Also, some gut-derived metabolites have been related to the regulation of body weight, including short-chain fatty acids, trimethylamine-N-oxide, and branched-chain and aromatic amino acids. Moreover, gut microbiota profiles may play a role in determining weight loss responses to specific nutritional treatments for the precise management of obesity. Thus, incorporating gut microbiota features may improve the performance of integrative models to predict weight loss outcomes.
    Key messages: The application of gut bacterial profiling information is of great value for precision nutrition in metabolic diseases since it contributes to the understanding of the role of the gut microbiota in obesity onset and progression, facilitates the identification of potential microorganism targets, and allows the personalization of tailored weight loss diets as well as the prediction of adiposity outcomes based on the gut bacterial profiling of each individual. Integrating microbiota information with other omics knowledge (genetics, epigenetics, transcriptomics, proteomics, and metabolomics) may provide a more comprehensive understanding of the molecular and physiological events underlying obesity and adiposity outcomes for precision nutrition.
    MeSH term(s) Humans ; Gastrointestinal Microbiome/physiology ; Obesity/therapy ; Obesity/diet therapy ; Weight Loss ; Precision Medicine ; Bacteria/metabolism ; Bacteria/classification
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2946059-1
    ISSN 2504-3188 ; 2504-3161
    ISSN (online) 2504-3188
    ISSN 2504-3161
    DOI 10.1159/000536156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7783: Show issues

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  10. Article ; Online: Holistic Integration of Omics Tools for Precision Nutrition in Health and Disease.

    Ramos-Lopez, Omar / Martinez, J Alfredo / Milagro, Fermin I

    Nutrients

    2022  Volume 14, Issue 19

    Abstract: The combination of multiple omics approaches has emerged as an innovative holistic scope to provide a more comprehensive view of the molecular and physiological events underlying human diseases (including obesity, dyslipidemias, fatty liver, insulin ... ...

    Abstract The combination of multiple omics approaches has emerged as an innovative holistic scope to provide a more comprehensive view of the molecular and physiological events underlying human diseases (including obesity, dyslipidemias, fatty liver, insulin resistance, and inflammation), as well as for elucidating unique and specific metabolic phenotypes. These omics technologies include genomics (polymorphisms and other structural genetic variants), epigenomics (DNA methylation, histone modifications, long non-coding RNA, telomere length), metagenomics (gut microbiota composition, enterotypes), transcriptomics (RNA expression patterns), proteomics (protein quantities), and metabolomics (metabolite profiles), as well as interactions with dietary/nutritional factors. Although more evidence is still necessary, it is expected that the incorporation of integrative omics could be useful not only for risk prediction and early diagnosis but also for guiding tailored dietary treatments and prognosis schemes. Some challenges include ethical and regulatory issues, the lack of robust and reproducible results due to methodological aspects, the high cost of omics methodologies, and high-dimensional data analyses and interpretation. In this review, we provide examples of system biology studies using multi-omics methodologies to unravel novel insights into the mechanisms and pathways connecting the genotype to clinically relevant traits and therapy outcomes for precision nutrition applications in health and disease.
    MeSH term(s) Epigenomics/methods ; Genomics/methods ; Humans ; Metabolomics/methods ; Proteomics/methods ; RNA, Long Noncoding
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2022-09-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14194074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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