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  1. Article: Comparison of changes in the nasal cavity, pharyngeal airway, and maxillary sinus volumes after expansion and maxillary protraction with two protocols: Rapid palatal expansion versus alternate rapid maxillary expansion and constriction.

    Liu, Weitao / Zhou, Shaonan / Yen, Edwin / Zou, Bingshuang

    Korean journal of orthodontics

    2023  Volume 53, Issue 3, Page(s) 175–184

    Abstract: Objective: To evaluate and compare a series of volume changes in the nasal cavity (NC), nasopharynx, oropharynx, and maxillary sinuses (MS) in growing Class III patients after either rapid palatal expansion (RPE) or alternate rapid maxillary expansion ... ...

    Abstract Objective: To evaluate and compare a series of volume changes in the nasal cavity (NC), nasopharynx, oropharynx, and maxillary sinuses (MS) in growing Class III patients after either rapid palatal expansion (RPE) or alternate rapid maxillary expansion and constriction (Alt-RAMEC) followed by facemask (FM) therapy, by using conebeam computed tomography (CBCT).
    Methods: Forty growing Class III patients were retrospectively selected and divided into two matched groups: RPE/FM (14 females, 6 males; mean age, 9.66 ± 1.23 years) and Alt-RAMEC/FM groups (14 females, 6 males; mean age, 10.28 ± 1.45 years). The anteroposterior and vertical displacements of Point A, the volumes of the NC, nasopharyngeal, oropharyngeal, and MS were measured at different time points: pretreatment (T1), postexpansion (T2), and postprotraction (T3).
    Results: Both groups demonstrated significant maxilla advancement (by 1.3 mm) during expansion, with a statistically significant intergroup difference during protraction (RPE/FM, 1.1 mm; Alt-RAMEC/FM, 2.4 mm;
    Conclusions: There was no significant difference in airway volume changes, including NC, nasopharyngeal, oropharyngeal airway, and MS, between RPE/FM and Alt-RAMEC/FM groups at different time points. Although there was significantly more forward movement after protraction in the Alt-RAMEC/FM group, the difference was deemed too small to be clinically relevant.
    Language English
    Publishing date 2023-05-08
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2888152-7
    ISSN 2234-7518 ; 2234-7518 ; 1225-5610
    ISSN (online) 2234-7518
    ISSN 2234-7518 ; 1225-5610
    DOI 10.4041/kjod22.075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Population level screening for celiac disease: is now the time?

    Shuler, Brianne / Liu, Edwin / Stahl, Marisa G

    Current opinion in gastroenterology

    2023  Volume 39, Issue 6, Page(s) 455–462

    Abstract: Purpose of review: As incidence and prevalence of celiac disease is increasing, subclinical and asymptomatic presentations are more commonly identified through celiac disease screening. However, the United States Preventive Services Task Force released ... ...

    Abstract Purpose of review: As incidence and prevalence of celiac disease is increasing, subclinical and asymptomatic presentations are more commonly identified through celiac disease screening. However, the United States Preventive Services Task Force released a statement in 2017 maintaining that there is insufficient evidence to recommend general population screening for celiac disease for asymptomatic individuals. This review summarizes the current available evidence on celiac disease screening.
    Recent findings: Literature demonstrates that by limiting screening to individuals with recognized symptoms, celiac disease diagnosis is frequently delayed or missed entirely. Most individuals with screening-identified celiac disease have previously unrecognized symptoms that improve through treatment with a gluten-free diet. Screening-identified individuals also demonstrate signs of impaired nutrition, growth, bone health, and quality of life which improve with treatment. Overall, celiac disease screening is viewed favorably by those identified through celiac disease screening programs.
    Summary: Individuals with screening-identified celiac disease may still incur complications from untreated disease and receive benefit from treatment with a gluten-free diet. More data is needed to determine the cost effectiveness of different mass screening approaches that incorporate the societal perspective towards screening.
    MeSH term(s) Humans ; United States ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Celiac Disease/complications ; Quality of Life ; Diet, Gluten-Free ; Mass Screening ; Prevalence
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632571-3
    ISSN 1531-7056 ; 0267-1379
    ISSN (online) 1531-7056
    ISSN 0267-1379
    DOI 10.1097/MOG.0000000000000969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Influence of Community Determinants on Barriers and Facilitators to COVID-19 Vaccine Uptake: Regional Stakeholders' Perspectives.

    Russ, Savanah / Bennett, Nancy / van Wijngaarden, Edwin / Hill, Elaine / Liu, Yu

    Vaccine

    2024  Volume 42, Issue 5, Page(s) 1160–1167

    Abstract: Our study objective was to explore possible pathways by which neighborhood-level characteristics drive COVID-19 vaccination among communities experiencing health inequity and disparities. To do so, we conducted semi-structured qualitative interviews with ...

    Abstract Our study objective was to explore possible pathways by which neighborhood-level characteristics drive COVID-19 vaccination among communities experiencing health inequity and disparities. To do so, we conducted semi-structured qualitative interviews with stakeholders in the Finger Lakes region of New York between November 2022 through January 2023. Using a pre-developed interview guide informed by the Health Belief Model, we elicited county health commissioner, medical professional and community-health partner's perspectives regarding the impact community determinants have on shaping barriers to and facilitators of COVID-19 vaccine uptake, as well as recommended solutions for ensuring health equity in future vaccination efforts. Fifteen stakeholders were interviewed, of which 40% were county health commissioners, 27% hospital executives and 33% community-health organization partners. We identified diverse perceived and logistical barriers to COVID-19 vaccination that emerged as sub-themes including perceived risks outweighing the benefits of vaccination, concerns of vaccine safety, distrust stemming from changing scientific knowledge surrounding the vaccines, mistrust of the medical system, and challenges with transportation to and registering for vaccine appointments. Stakeholders reported these barriers were linked to the racial diversity, poverty, political conservatism, and availability of health care of the communities where they reported these were experienced. Notable solutions for improving equitable vaccination included facilitating structural access to vaccination and engaging community trusted messengers. Perceived and experienced barriers to COVID-19 vaccination may differ based upon the social, racial and economic composition of neighboring communities. Strategies for ensuring health equity in future vaccination campaigns should specifically target prevalent barriers based upon the community composition.
    MeSH term(s) Humans ; COVID-19 Vaccines ; COVID-19/prevention & control ; Vaccination ; Health Equity ; Health Facilities
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.01.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ganoderma lucidum

    Okoro, Nkwachukwu Oziamara / Odiba, Arome Solomon / Han, Junjie / Osadebe, Patience Ogoamaka / Omeje, Edwin Ogechukwu / Liao, Guiyan / Liu, Yichen / Jin, Cheng / Fang, Wenxia / Liu, Hongwei / Wang, Bin

    Food & function

    2024  Volume 15, Issue 2, Page(s) 530–542

    Abstract: Methyl Ganoderate E (MGE) is a triterpenoid derived ... ...

    Abstract Methyl Ganoderate E (MGE) is a triterpenoid derived from
    MeSH term(s) Mice ; Animals ; Reishi ; Longevity ; Caenorhabditis elegans/genetics ; Aging ; Triterpenes/pharmacology ; Ganoderma
    Chemical Substances Triterpenes
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo04166b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Detection of interactions between genetic marker sets and environment in a genome-wide study of hypertension.

    Shen, Linchuan / Amei, Amei / Liu, Bowen / Liu, Yunqing / Xu, Gang / Oh, Edwin C / Wang, Zuoheng

    bioRxiv : the preprint server for biology

    2023  

    Abstract: As human complex diseases are influenced by the interplay of genes and environment, detecting gene-environment ... ...

    Abstract As human complex diseases are influenced by the interplay of genes and environment, detecting gene-environment interactions
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.28.542666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: High SNR full brain relaxometry at 7T by accelerated MR-STAT.

    Versteeg, Edwin / Liu, Hongyan / van der Heide, Oscar / Fuderer, Miha / van den Berg, Cornelis A T / Sbrizzi, Alessandro

    Magnetic resonance in medicine

    2024  Volume 92, Issue 1, Page(s) 226–235

    Abstract: Purpose: To demonstrate the feasibility and robustness of the Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) framework for fast, high SNR relaxometry at 7T.: Methods: To deploy MR-STAT on 7T-systems, we designed optimized flip-angles ... ...

    Abstract Purpose: To demonstrate the feasibility and robustness of the Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) framework for fast, high SNR relaxometry at 7T.
    Methods: To deploy MR-STAT on 7T-systems, we designed optimized flip-angles using the BLAKJac-framework that incorporates the SAR-constraints. Transmit RF-inhomogeneities were mitigated by including a measured
    Results: The higher SNR at 7T enabled two-fold acceleration with respect to current 2D MR-STAT protocols at lower field strengths. The resulting scan had whole-brain coverage, with 1 x 1 x 3 mm
    Conclusion: We presented an accelerated version of MR-STAT tailored to high field (7T) MRI using a low-SAR flip-angle train and showed high quality parameter maps with an increased SNR-efficiency compared to MR-STAT at 3T.
    MeSH term(s) Humans ; Phantoms, Imaging ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Signal-To-Noise Ratio ; Algorithms ; Image Processing, Computer-Assisted/methods ; Adult ; Male ; Female
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.30052
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  7. Article ; Online: Coeliac disease: what can we learn from prospective studies about disease risk?

    Stahl, Marisa / Koletzko, Sibylle / Andrén Aronsson, Carin / Lindfors, Katri / Liu, Edwin / Agardh, Daniel

    The Lancet. Child & adolescent health

    2023  Volume 8, Issue 1, Page(s) 63–74

    Abstract: Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric ... ...

    Abstract Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.
    MeSH term(s) Child ; Humans ; Celiac Disease/epidemiology ; Celiac Disease/genetics ; Prospective Studies ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-11-14
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(23)00232-8
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  8. Article ; Online: Salt with a sweet tooth: galactan synthesis impacts salt tolerance in Arabidopsis.

    Wang, Liu / Lampugnani, Edwin R / Persson, Staffan

    Molecular plant

    2021  Volume 14, Issue 3, Page(s) 361–363

    MeSH term(s) Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cell Wall/metabolism ; Galactans ; Gene Expression Regulation, Plant ; Hypertension ; Salt Tolerance
    Chemical Substances Arabidopsis Proteins ; Galactans
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2393618-6
    ISSN 1752-9867 ; 1674-2052
    ISSN (online) 1752-9867
    ISSN 1674-2052
    DOI 10.1016/j.molp.2021.01.011
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  9. Article: RETROSPECTIVE VARYING COEFFICIENT ASSOCIATION ANALYSIS OF LONGITUDINAL BINARY TRAITS: APPLICATION TO THE IDENTIFICATION OF GENETIC LOCI ASSOCIATED WITH HYPERTENSION.

    Xu, Gang / Amei, Amei / Wu, Weimiao / Liu, Yunqing / Shen, Linchuan / Oh, Edwin C / Wang, Zuoheng

    The annals of applied statistics

    2024  Volume 18, Issue 1, Page(s) 487–505

    Abstract: Many genetic studies contain rich information on longitudinal phenotypes that require powerful analytical tools for optimal analysis. Genetic analysis of longitudinal data that incorporates temporal variation is important for understanding the genetic ... ...

    Abstract Many genetic studies contain rich information on longitudinal phenotypes that require powerful analytical tools for optimal analysis. Genetic analysis of longitudinal data that incorporates temporal variation is important for understanding the genetic architecture and biological variation of complex diseases. Most of the existing methods assume that the contribution of genetic variants is constant over time and fail to capture the dynamic pattern of disease progression. However, the relative influence of genetic variants on complex traits fluctuates over time. In this study, we propose a retrospective varying coefficient mixed model association test, RVMMAT, to detect time-varying genetic effect on longitudinal binary traits. We model dynamic genetic effect using smoothing splines, estimate model parameters by maximizing a double penalized quasi-likelihood function, design a joint test using a Cauchy combination method, and evaluate statistical significance via a retrospective approach to achieve robustness to model misspecification. Through simulations we illustrated that the retrospective varying-coefficient test was robust to model misspecification under different ascertainment schemes and gained power over the association methods assuming constant genetic effect. We applied RVMMAT to a genome-wide association analysis of longitudinal measure of hypertension in the Multi-Ethnic Study of Atherosclerosis. Pathway analysis identified two important pathways related to G-protein signaling and DNA damage. Our results demonstrated that RVMMAT could detect biologically relevant loci and pathways in a genome scan and provided insight into the genetic architecture of hypertension.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2376910-5
    ISSN 1941-7330 ; 1932-6157
    ISSN (online) 1941-7330
    ISSN 1932-6157
    DOI 10.1214/23-aoas1798
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  10. Article ; Online: A Qualitative Study of Emergency Physicians' and Nurses' Experiences Caring for Patients With Psychiatric Conditions and/or Substance Use Disorders.

    Isbell, Linda M / Chimowitz, Hannah / Huff, Nathan R / Liu, Guanyu / Kimball, Ezekiel / Boudreaux, Edwin

    Annals of emergency medicine

    2023  Volume 81, Issue 6, Page(s) 715–727

    Abstract: Study objective: Patients with psychiatric conditions and/or substance use disorders (SUDs) frequently seek care in emergency departments (EDs), where providing care for these populations can involve considerable challenges. This study aimed to develop ... ...

    Abstract Study objective: Patients with psychiatric conditions and/or substance use disorders (SUDs) frequently seek care in emergency departments (EDs), where providing care for these populations can involve considerable challenges. This study aimed to develop a comprehensive data-driven model of the complex challenges and unique dynamics associated with caring for these populations in the ED, as well as the effect on patient care quality.
    Methods: We conducted a preplanned topical analysis of grounded theory data obtained from semistructured interviews with 86 ED physicians and nurses from 8 hospitals in the Northeastern USA. Participants provided detailed descriptions of their experiences and challenges in caring for patients with psychiatric conditions and/or SUDs. We identified themes inductively using constant comparative analysis and developed a grounded model of physicians' and nurses' perceptions of challenges, biases, and effects on patient care.
    Results: Emergency physicians and nurses described emotional, diagnostic, and logistical challenges that patients with psychiatric conditions and/or SUDs present. These challenges are magnified by existing health care system issues and social structures, which fuel and reinforce negative attitudes, expectations, and biases. In combination, these processes create negative health care experiences for patients, physicians, and nurses and can adversely affect patient care quality and ED staff well-being.
    Conclusion: Our findings uncover a cyclical process whereby challenges and biases associated with patients with psychiatric conditions and/or SUDs can reciprocally threaten patient care quality. Systemic changes and localized interventions are urgently needed to mitigate challenges, reduce bias, improve patient care, and improve physicians' and nurses' experiences in the ED.
    MeSH term(s) Humans ; Attitude of Health Personnel ; Qualitative Research ; Substance-Related Disorders/therapy ; Emergency Service, Hospital ; Physicians/psychology ; Nurses
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2022.10.014
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