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  1. Article ; Online: SARS-CoV-2 sensitivity limbo - How low can we go?

    Patriquin, Glenn / LeBlanc, Jason J

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 103, Page(s) 23–24

    Keywords covid19
    Language English
    Publishing date 2020-11-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.11.138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Canadian physicians' knowledge, attitudes, and beliefs about the risk of HTLV infection in solid organ transplantation.

    Patriquin, Glenn / Hatchette, Jill E / Hatchette, Todd F

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2020  Volume 5, Issue 3, Page(s) 124–126

    Language English
    Publishing date 2020-10-11
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi-2019-0017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Raisonnement clinique : Avortement septique à Neisseria meningitidis.

    Stairs, Jocelyn / Shabi, Yahya / Patriquin, Glenn / Offman, Saul / Pierce, Marianne

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

    2021  Volume 43, Issue 4, Page(s) 500–502

    Abstract: Le choc septique post-avortement est une cause mondiale importante de mortalité maternelle, mais on l'observe rarement dans les pays développés. Nous décrivons ici un cas d'avortement septique associé à un nouvel agent pathogène : Neisseria meningitidis.  ...

    Abstract Le choc septique post-avortement est une cause mondiale importante de mortalité maternelle, mais on l'observe rarement dans les pays développés. Nous décrivons ici un cas d'avortement septique associé à un nouvel agent pathogène : Neisseria meningitidis. Une femme multipare de 30 ans s'est trouvée en choc septique après un avortement spontané incomplet. Elle a reçu un traitement empirique par antibiotiques et vasopresseurs, a subi une dilatation-aspiration d'urgence et a été admise à l'unité de soins intensifs. L'hémoculture et l'analyse de tissus endométriaux se sont révélées positives à la bactérie N. meningitidis. L'antibiothérapie a été ajustée en fonction de la culture et la patiente s'est rétablie. Il importe de reconnaître le choc septique, d'administrer l'antibiothérapie et de neutraliser la source d'infection dans les plus brefs délais. Ici, nous décrivons un cas d'avortement septique associé à un agent pathogène inhabituel. Nous soulignons aussi l'importance d'utiliser une antibiothérapie empirique à large spectre suivie d'une antibiothérapie spécifique aux résultats de culture pour obtenir la meilleure couverture possible.
    Language English
    Publishing date 2021-03-25
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2171082-X
    ISSN 1701-2163
    ISSN 1701-2163
    DOI 10.1016/j.jogc.2021.02.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6445: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Clinical Conundrum: Neisseria meningitidis Septic Abortion.

    Stairs, Jocelyn / Shabi, Yahya / Patriquin, Glenn / Offman, Saul / Pierce, Marianne

    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

    2021  Volume 43, Issue 4, Page(s) 497–499

    Abstract: Septic shock after abortion is an important cause of global maternal mortality but is rarely encountered in developed countries. We describe a case of septic abortion with a novel associated pathogen: Neisseria meningitidis. A 30-year-old multiparous ... ...

    Abstract Septic shock after abortion is an important cause of global maternal mortality but is rarely encountered in developed countries. We describe a case of septic abortion with a novel associated pathogen: Neisseria meningitidis. A 30-year-old multiparous woman presented in septic shock after an incomplete spontaneous abortion. She received empiric antibiotics and vasopressors, underwent an urgent dilatation and curettage, and was admitted to the intensive care unit. Her blood cultures and endometrial tissue were positive for N. meningitidis. Antibiotics were adjusted based on culture, and the patient recovered. Septic shock requires prompt identification, antibiotic administration, and source control. Here, we identify an uncommon pathogen associated with septic abortion and highlight the importance of broad empiric and subsequent culture-guided antibiotic choice to ensure coverage.
    MeSH term(s) Abortion, Induced ; Abortion, Septic/diagnosis ; Abortion, Septic/microbiology ; Abortion, Septic/surgery ; Adult ; Dilatation and Curettage ; Female ; Humans ; Meningitis, Meningococcal/diagnosis ; Neisseria meningitidis/isolation & purification ; Pregnancy ; Pregnancy Complications, Infectious ; Shock, Septic/microbiology ; Shock, Septic/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-03-26
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2171082-X
    ISSN 1701-2163
    ISSN 1701-2163
    DOI 10.1016/j.jogc.2020.12.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6445: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Investigating the Sensitivity of Nasal or Throat Swabs: Combination of Both Swabs Increases the Sensitivity of SARS-CoV-2 Rapid Antigen Tests.

    Goodall, Barbara L / LeBlanc, Jason J / Hatchette, Todd F / Barrett, Lisa / Patriquin, Glenn

    Microbiology spectrum

    2022  Volume 10, Issue 4, Page(s) e0021722

    Abstract: The COVID-19 pandemic has been hallmarked by several waves of variants of concern (VoCs), each with novel challenges. Currently, the highly transmissible Omicron VoC is predominant worldwide, and sore throat is common, among other cold-like symptoms. ... ...

    Abstract The COVID-19 pandemic has been hallmarked by several waves of variants of concern (VoCs), each with novel challenges. Currently, the highly transmissible Omicron VoC is predominant worldwide, and sore throat is common, among other cold-like symptoms. Anecdotes on social media have suggested that sampling one's throat can increase the sensitivity for Omicron detection by antigen-based rapid testing devices (Ag-RDTs). This work aimed to improve the local testing strategy and determine whether the sensitivity of Ag-RDTs designed for nasal sampling is altered with the use of self-administered throat swabs in self-perceived asymptomatic individuals. This investigation used a common Ag-RDT (i.e., Abbott Panbio COVID-19 Ag rapid test device) to compare three sampling sites: nasal swab, throat swab, and combined nasal/throat. All Ag-RDT results were confirmed with molecular testing from residual test buffer. Compared to reverse transcriptase PCR (RT-PCR), samples from nasal or throat swabs each detected 64.5% of SARS-CoV-2 cases; however, combining the contributions of each swab increased the positive percent agreement (PPA) with RT-PCR to 88.7%. This trend was also evident with the Rapid Response Ag-RDT (BTNX), which uses more flexible swabs than does the Panbio. When nasal swab collection was compared to paired sampling of the nose/throat using a single swab with the Panbio Ag-RDT, the PPAs were 68.4% and 81.6%, respectively. No false-positive results were observed with nasal, throat, or combined nasal/throat sampling. Self-administered throat and nasal/throat swabs both had >90% acceptability. These findings support the use of self-collected combined nasal/throat sampling for Ag-RDT-based SARS-CoV-2 detection in self-perceived asymptomatic individuals.
    MeSH term(s) COVID-19/diagnosis ; Humans ; Pandemics ; Pharynx ; SARS-CoV-2 ; Sensitivity and Specificity
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00217-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A pseudo-outbreak of echinocandin-resistant

    Shabi, Yahya / Russell-Tattrie, Audra / Bharat, Amrita / Haldane, David / Patriquin, Glenn

    Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada

    2021  Volume 6, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2021-05-03
    Publishing country Canada
    Document type Journal Article
    ISSN 2371-0888
    ISSN (online) 2371-0888
    DOI 10.3138/jammi-2020-0023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Taqman PACMAN: a simple molecular approach for positive rapid antigen test confirmation during periods of low prevalence.

    McCracken, Gregory R / Patriquin, Glenn / Hatchette, Todd F / Davidson, Ross J / Goodall, Barbara / Barrett, Lisa / MacDonald, James / Heinstein, Charles / Pettipas, Janice / Ross, John / LeBlanc, Jason J

    Microbiology spectrum

    2024  , Page(s) e0407323

    Abstract: Antigen-based rapid diagnostic tests (Ag-RDTs) were widely deployed to enhance SARS-CoV-2 testing capacity during the COVID-19 pandemic. Consistent with national guidance for low prevalence settings, positive Ag-RDTs were confirmed using nucleic acid ... ...

    Abstract Antigen-based rapid diagnostic tests (Ag-RDTs) were widely deployed to enhance SARS-CoV-2 testing capacity during the COVID-19 pandemic. Consistent with national guidance for low prevalence settings, positive Ag-RDTs were confirmed using nucleic acid amplification tests (NAATs) to avoid false positive results. However, increasing demands for positive Ag-RDT confirmation competed with other testing priorities in clinical laboratories. This work hypothesized that real-time RT-PCR without nucleic acid extraction (NAE) would be sufficiently sensitive to support positive Ag-RDT confirmation. Ag-RDT and NAAT results from community-based asymptomatic testing sites prior to the omicron variant wave were compared to calculate the weekly false positive rate (FPR) and false detection rate (FDR). Real-time RT-PCR was compared with and without NAE using 752 specimens previously tested positive for SARS-CoV-2 using commercial NAATs and 344 specimens from Ag-RDT-positive individuals. The impact of SARS-CoV-2 prevalence on laboratory resources required to sustain Ag-RDT confirmation was modeled for the RT-PCR with and without NAE. Overall, FPR was low [0.07% (222/330,763)] in asymptomatic testing sites, but FDR was high [30.7% (222/724)]. When RT-PCR was compared with and without NAE, 100% concordance was obtained with NAAT-positive specimens, including those from Ag-RDT-positive individuals. NAE-free RT-PCR significantly reduced time to results, human resources, and overall costs. A 30.7% FDR reaffirms the need for NAAT-based confirmation of positive Ag-RDT results during low SARS-CoV-2 prevalence. NAE-free RT-PCR was shown to be a simple and cost-sparing NAAT-based solution for positive Ag-RDT confirmation, and its implementation supported data-driven broader Ag-RDT deployment into communities, workplaces, and households.
    Importance: Rapid antigen testing for SARS-CoV-2 was widely deployed during the COVID-19 pandemic. In settings of low prevalence, national guidance recommends that positive antigen test results be confirmed with molecular testing. Given the high testing burden on clinical laboratories during the COVID-19 pandemic, the high volume of positive antigen tests submitted for confirmatory testing posed challenges for laboratory workflow. This study demonstrated that a simple PCR method without prior nucleic acid purification is an accurate and cost-effective solution for positive rapid antigen test confirmation. Implementing this method allowed molecular confirmatory testing for positive antigen tests to be sustained as antigen testing was expanded into large populations such as workplaces, schools, and households.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.04073-23
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  9. Article ; Online: Cystic neutrophilic granulomatous mastitis - a review of 12 consecutive cases.

    Maung, Magdalene H / Bethune, Gillian C / Patriquin, Glenn / Barnes, Penny J

    Histopathology

    2020  Volume 77, Issue 5, Page(s) 781–787

    Abstract: Aims: Cystic neutrophilic granulomatous mastitis (CNGM) is an uncommon but increasingly recognised cause of mastitis, often associated with Corynebacterium ssp. infection. We studied the histopathological and clinical features of CNGM in a Canadian ... ...

    Abstract Aims: Cystic neutrophilic granulomatous mastitis (CNGM) is an uncommon but increasingly recognised cause of mastitis, often associated with Corynebacterium ssp. infection. We studied the histopathological and clinical features of CNGM in a Canadian setting, and the work-up required to identify pathogenic microorganisms.
    Methods and results: A retrospective search for breast specimens with abscess, acute, chronic and/or granulomatous inflammation from 1998 to 2018 was performed. Haematoxylin and eosin slides were reviewed for typical histological features of CNGM. Histochemically stained slides for microorganisms were also reviewed. Repeat Gram stains were performed if initially negative. Electronic medical records were abstracted for microbiology results and relevant clinical data. Twelve cases were identified. All were female, aged 25-57 years, mainly Caucasian, with one Venezuelan and two of Chinese ethnicity. Most were parous (10 of 12); five of 12 had an endocrinopathy. Bacteria were identified in one or more specimens from eight of 12 patients; additional Gram stains revealed organisms in four of 12 cases. Of four bacterial cultures, one grew Corynebacterium kroppenstedtii. 16S polymerase chain reaction for three samples was negative. Two patients had multiple breast biopsies, showing early palisaded granulomas followed by classic features of CNGM. The patients had various management approaches, including surgery and antimicrobials.
    Conclusions: CNGM may present as palisaded granulomatous inflammation, without the expected 'cystic' pattern, suggesting that there is an evolution of histomorphology with this infection. Most patients with CNGM are parous, and there may be an association with endocrinopathies. Application of multiple Gram stains increases the yield of microorganism identification. Recognition of CNGM in breast biopsies and collaborative communications are essential to direct appropriate therapy.
    MeSH term(s) Adult ; Bacterial Infections/complications ; Female ; Granulomatous Mastitis/microbiology ; Granulomatous Mastitis/pathology ; Humans ; Middle Aged ; Nova Scotia ; Retrospective Studies
    Language English
    Publishing date 2020-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14187
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1328: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: SARS-CoV-2 sensitivity limbo – how low can we go?

    Patriquin, Glenn / LeBlanc, Jason J.

    International Journal of Infectious Diseases ; ISSN 1201-9712

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.ijid.2020.11.138
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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