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Article ; Online: Upsurge of dengue outbreaks in several WHO regions: Public awareness, vector control activities, and international collaborations are key to prevent spread.

Sarker, Rapty / Roknuzzaman, A S M / Haque, Md Aminul / Islam, Md Rabiul / Kabir, Eva Rahman

Health science reports

2024 Volume 7, Issue 4, Page(s) e2034

Abstract: Background: Dengue, the world's fastest-growing vector-borne disease, has skyrocketed in the 21st century. Dengue has harmed human health since its first known cases among Spanish soldiers in the Philippines to its 21st-century outbreaks in Southeast ... ...

Abstract	Background: Dengue, the world's fastest-growing vector-borne disease, has skyrocketed in the 21st century. Dengue has harmed human health since its first known cases among Spanish soldiers in the Philippines to its 21st-century outbreaks in Southeast Asia, the Pacific, and the Americas. In light of the current circumstances, it is imperative to investigate its origin and prevalence, enabling the implementation of effective interventions to curb the upsurge. Methods: Our study examines the history of dengue outbreaks, and evolving impact on public health, aiming to offer valuable insights for a more resilient public health response worldwide. In this comprehensive review, we incorporated data from renowned databases such as PubMed, Google Scholar, and Scopus to provide a thorough analysis of dengue outbreaks. Results: Recent dengue outbreaks are associated with rapid urbanization, international travel, climatic change, and socioeconomic factors. Rapid urbanization and poor urban design and sanitation have created mosquito breeding places for dengue vectors. Also, international travel and trade have spread the pathogen. Climate change in the past two decades has favored mosquito habitats and outbreaks. Socioeconomic differences have also amplified the impact of dengue outbreaks on vulnerable communities. Dengue mitigation requires vector control, community engagement, healthcare strengthening, and international cooperation. Conclusion: Climate change adaptation and urban planning are crucial. Although problems remain, a comprehensive vector control and community involvement plan may reduce dengue epidemics and improve public health in our interconnected world.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.2034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Design optimization and validation of UV-C illumination chamber for filtering facepiece respirators.

Mohsin, Abu S M / Jamiruddin, Mohd Raeed / Peyal, Md Mahmudul Kabir / Sharmin, Shahana / Ahmed, Ashfaq / Puspita, Afrin Hossain / Sharfuddin, A A M / Malik, Afrida / Hasib, Al / Suchona, Sanjida Akter / Chowdhury, Arshad M / Kabir, Eva Rahman

Heliyon

2024 Volume 10, Issue 5, Page(s) e26348

Abstract: In this study, we constructed an UV-C illumination chamber using commercially available germicidal lamps and other locally available low-cost components for general-purpose biological decontamination purposes. The illumination chamber provides uniform ... ...

Abstract	In this study, we constructed an UV-C illumination chamber using commercially available germicidal lamps and other locally available low-cost components for general-purpose biological decontamination purposes. The illumination chamber provides uniform illumination of around 1 J/cm
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26348
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Article: Exploring existing drugs: proposing potential compounds in the treatment of COVID-19.

Kabir, Eva Rahman / Mustafa, Nashrah / Nausheen, Nahid / Sharif Siam, Mohammad Kawsar / Syed, Easin Uddin

Heliyon

2021 Volume 7, Issue 2, Page(s) e06284

Abstract: The COVID-19 situation had escalated into an unprecedented global crisis in just a few weeks. On the ... ...

Abstract	The COVID-19 situation had escalated into an unprecedented global crisis in just a few weeks. On the 30
Language	English
Publishing date	2021-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e06284
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Article ; Online: Unveiling the Potential of Polyphenols as Anti-Amyloid Molecules in Alzheimer's Disease.

Kabir, Eva Rahman / Chowdhury, Namara Mariam / Yasmin, Hasina / Kabir, Md Tanvir / Akter, Rokeya / Perveen, Asma / Ashraf, Ghulam Md / Akter, Shamima / Rahman, Md Habibur / Sweilam, Sherouk Hussein

Current neuropharmacology

2022 Volume 21, Issue 4, Page(s) 787–807

Abstract: Alzheimer's disease (AD) is a devastating neurodegenerative disease that mostly affects the elderly population. Mechanisms underlying AD pathogenesis are yet to be fully revealed, but there are several hypotheses regarding AD. Even though free radicals ... ...

Abstract	Alzheimer's disease (AD) is a devastating neurodegenerative disease that mostly affects the elderly population. Mechanisms underlying AD pathogenesis are yet to be fully revealed, but there are several hypotheses regarding AD. Even though free radicals and inflammation are likely to be linked with AD pathogenesis, still amyloid-beta (Aβ) cascade is the dominant hypothesis. According to the Aβ hypothesis, a progressive buildup of extracellular and intracellular Aβ aggregates has a significant contribution to the AD-linked neurodegeneration process. Since Aβ plays an important role in the etiology of AD, therefore Aβ-linked pathways are mainly targeted in order to develop potential AD therapies. Accumulation of Aβ plaques in the brains of AD individuals is an important hallmark of AD. These plaques are mainly composed of Aβ (a peptide of 39-42 amino acids) aggregates produced via the proteolytic cleavage of the amyloid precursor protein. Numerous studies have demonstrated that various polyphenols (PPHs), including cyanidins, anthocyanins, curcumin, catechins and their gallate esters were found to markedly suppress Aβ aggregation and prevent the formation of Aβ oligomers and toxicity, which is further suggesting that these PPHs might be regarded as effective therapeutic agents for the AD treatment. This review summarizes the roles of Aβ in AD pathogenesis, the Aβ aggregation pathway, types of PPHs, and distribution of PPHs in dietary sources. Furthermore, we have predominantly focused on the potential of food-derived PPHs as putative anti-amyloid drugs.
MeSH term(s)	Aged ; Humans ; Alzheimer Disease/metabolism ; Anthocyanins/therapeutic use ; Neurodegenerative Diseases ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Amyloid/metabolism ; Plaque, Amyloid/metabolism
Chemical Substances	Anthocyanins ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Amyloid
Language	English
Publishing date	2022-10-12
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2192352-8
ISSN	1875-6190 ; 1570-159X
ISSN (online)	1875-6190
ISSN	1570-159X
DOI	10.2174/1570159X20666221010113812
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Article ; Online: A review on endocrine disruptors and their possible impacts on human health.

Kabir, Eva Rahman / Rahman, Monica Sharfin / Rahman, Imon

Environmental toxicology and pharmacology

2015 Volume 40, Issue 1, Page(s) 241–258

Abstract: Endocrine disruption is a named field of research which has been very active for over 10 years, although the effects of endocrine disruptors in wildlife have been studied mainly in vast since the 1940s. A large number of chemicals have been identified as ...

Abstract	Endocrine disruption is a named field of research which has been very active for over 10 years, although the effects of endocrine disruptors in wildlife have been studied mainly in vast since the 1940s. A large number of chemicals have been identified as endocrine disruptors and humans can be exposed to them either due to their occupations or through dietary and environmental exposure (water, soil and air). Endocrine disrupting chemicals are compounds that alter the normal functioning of the endocrine system of both humans and wildlife. In order to understand the vulnerability and risk factors of people due to endocrine disruptors as well as the remedies for these, methods need to be developed in order to predict effects on populations and communities from the knowledge of effects on individuals. For several years there have been a growing interest on the mechanism and effect of endocrine disruptors and their relation with environment and human health effect. This paper, based on extensive literature survey, briefly studies the progress mainly in human to provide information concerning causative substances, mechanism of action, ubiquity of effects and important issues related to endocrine disruptors. It also reviews the current knowledge of the potential impacts of endocrine disruptors on human health so that the effects can be known and remedies applied for the problem as soon as possible.
MeSH term(s)	Awareness ; Endocrine Disruptors/pharmacokinetics ; Endocrine Disruptors/toxicity ; Humans
Chemical Substances	Endocrine Disruptors
Language	English
Publishing date	2015-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2015938-9
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2015.06.009
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Article ; Online: Exploring existing drugs

Eva Rahman Kabir / Nashrah Mustafa / Nahid Nausheen / Mohammad Kawsar Sharif Siam / Easin Uddin Syed

Heliyon, Vol 7, Iss 2, Pp e06284- (2021)

proposing potential compounds in the treatment of COVID-19

2021

Abstract: The COVID-19 situation had escalated into an unprecedented global crisis in just a few weeks. On the 30th of January 2020, World Health Organization officially declared the COVID-19 epidemic as a public health emergency of international concern. The ... ...

Abstract	The COVID-19 situation had escalated into an unprecedented global crisis in just a few weeks. On the 30th of January 2020, World Health Organization officially declared the COVID-19 epidemic as a public health emergency of international concern. The confirmed cases were reported to exceed 105,856,046 globally, with the death toll of above 2,311,048, according to the dashboard from Johns Hopkins University on the 7th of February, 2021, though the actual figures may be much higher. Conserved regions of the South Asian strains were used to construct a phylogenetic tree to find evolutionary relationships among the novel virus. Off target similarities were searched with other microorganisms that have been previously reported using Basic Local Alignment Search Tool (BLAST). The conserved regions did not match with any previously reported microorganisms or viruses, which confirmed the novelty of SARS-CoV-2. Currently there is no approved drug for the prevention and treatment of COVID-19, but researchers globally are attempting to come up with one or more soon. Therapeutic strategies need to be addressed urgently to combat COVID-19. Successful drug repurposing is a tool that uses old and safe drugs, is time effective and requires lower development costs, and was thus considered for the study. Molecular docking was used for repurposing drugs from our own comprehensive database of approximately 300 highly characterized, existing drugs with known safety profile, to identify compounds that will inhibit the chosen molecular targets - SARS-CoV-2, ACE2, and TMPRSS2. The study has identified and proposed twenty seven candidates for further in vitro and in vivo studies for the treatment of SARS-CoV-2 infection.
Keywords	SARS-CoV-2 ; COVID-19 ; Drug repurposing ; Molecular modeling ; ACE2 ; TMPRSS2 ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	360
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Breakthrough of Biosimilars: A Twist in the Narrative of Biological Therapy.

Kabir, Eva Rahman / Moreino, Shannon Sherwin / Sharif Siam, Mohammad Kawsar

Biomolecules

2019 Volume 9, Issue 9

Abstract: The coming wave of patent expiries of first generation commercialized biotherapeutical drugs has seen the global market open its doors to close copies of these products. These near perfect substitutes, which are termed as "biosimilars", do not need to ... ...

Abstract	The coming wave of patent expiries of first generation commercialized biotherapeutical drugs has seen the global market open its doors to close copies of these products. These near perfect substitutes, which are termed as "biosimilars", do not need to undergo intense clinical trials for their approval. However, they are mandated to produce identical similarity from their reference biologics in terms of clinical safety and efficacy. As such, these biosimilar products promise to foster unprecedented access to a wide range of life-saving biologics. However, seeing this promise be fulfilled requires the development of biosimilars to be augmented with product trust, predictable regulatory frameworks, and sustainable policies. It is vital for healthcare and marketing professionals to understand the critical challenges surrounding biosimilar use and implement informed clinical and commercial decisions. A proper framework of pharmacovigilance, education, and scientific exchange for biologics and biosimilars would ensure a dramatic rise in healthcare access and market sustainability. This paper seeks to collate and review all relevant published intelligence of the health and business potential of biosimilars. In doing so, it provides a visualization of the essential steps that are required to be taken for global biosimilar acceptance.
MeSH term(s)	Biological Products/chemistry ; Biological Products/metabolism ; Biological Products/pharmacokinetics ; Biosimilar Pharmaceuticals/economics ; Biosimilar Pharmaceuticals/metabolism ; Biosimilar Pharmaceuticals/pharmacokinetics ; Clinical Trials as Topic ; Drug Approval ; Government Regulation ; Guidelines as Topic ; Humans
Chemical Substances	Biological Products ; Biosimilar Pharmaceuticals
Language	English
Publishing date	2019-08-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom9090410
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Article ; Online: Different approaches in the treatment of obstructive pulmonary diseases.

Kabir, Eva Rahman / Morshed, Nabila

European journal of pharmacology

2015 Volume 764, Page(s) 306–317

Abstract: Advances in drug formulation, inhalation device design and disease management are generating new opportunities for patients suffering from obstructive pulmonary diseases. This article provides a comprehensive review of the different promising pulmonary ... ...

Abstract	Advances in drug formulation, inhalation device design and disease management are generating new opportunities for patients suffering from obstructive pulmonary diseases. This article provides a comprehensive review of the different promising pulmonary drug delivery technologies in the treatment of obstructive pulmonary diseases, particularly with regard to the treatment of asthma and chronic pulmonary diseases (COPD), which are increasing day by day due to increasing environmental pollution and its harmful and toxic contaminants. In the recent years, a better knowledge has been gained regarding the mechanism of action of glucocorticoids and how they suppress the chronic inflammation. New etiology has been brought into light regarding the inactivity of glucocorticoids in some patients having asthma and COPDs even though the inflammatory genes are triggered by similar molecules in both the diseases. This new knowledge has given a new platform to improve glucocorticoids and their resistance also how other combination therapy can be used for these diseases. It has also led to the quest for improving and developing other alternatives such as anti-leukotriene agents, muscarinic inhibitors, combination therapy, as well as biologic immune-modulators in the treatment of the different pulmonary diseases. Several new combinations of glucocorticoids are available in the global market for the use in pulmonary diseases especially asthma although their availability fluctuates between continents. There has been several studies done regarding the variation of effectiveness of the different inhaled glucocorticoids and hence it is important to take into consideration the different delivery systems and the methods which are used to treat the patients.
MeSH term(s)	Anti-Inflammatory Agents/adverse effects ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Glucocorticoids/adverse effects ; Glucocorticoids/pharmacokinetics ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Humans ; Lung Diseases, Obstructive/drug therapy ; Lung Diseases, Obstructive/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Glucocorticoids
Language	English
Publishing date	2015-07-11
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2015.07.030
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Article: Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion: development and characterization.

Halder, Shimul / Ahmed, Fairuza / Shuma, Madhabi Lata / Azad, M A K / Kabir, Eva Rahman

Heliyon

2020 Volume 6, Issue 9, Page(s) e05026

Abstract: Purpose: The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques.: Methods: SRSD- ... ...

Abstract	Purpose: The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques. Methods: SRSD-CAR containing different ratios of polymers were prepared and physicochemically characterized. Dissolution study was carried out in both sink and supersaturated conditions to identify the possible enhancement in dissolution behavior. Results: Based on the solubility study, Kolliphor® P188 and Eudragit® RSPO (50:25, % w/w) ratio exhibited the highest solubility among the samples and was chosen as the optimal composition of SRSD-CAR for further characterization. The crystallinity assessments of the optimized formulation indicated amorphization of CAR in the formulation, bring about improved solubility of CAR. The infrared spectroscopic study revealed minor transitions; demonstrating the absence of significant interactions between drug and carrier. Furthermore, the SRSD-CAR exhibited immediate formation of nano particles when dispersed in water. Dissolution study revealed significant improvement in dissolution behavior, with a release of CAR in a gradual manner compared to crystalline CAR. From the dissolution kinetics analysis, the Korsmeyer Peppas model fit the best and diffusion was predominant in release of CAR. The drug release pattern showed insignificant differences between the SRSD-CAR formulations prepared by rotary vacuum drying and freeze drying. Conclusion: From these experimental findings, SRSD approach might be a favorable dosage option for CAR, offering improved biopharmaceutical properties.
Language	English
Publishing date	2020-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e05026
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Article ; Online: Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion

Shimul Halder / Fairuza Ahmed / Madhabi Lata Shuma / M.A.K. Azad / Eva Rahman Kabir

Heliyon, Vol 6, Iss 9, Pp e05026- (2020)

development and characterization

2020

Abstract	Purpose: The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques. Methods: SRSD-CAR containing different ratios of polymers were prepared and physicochemically characterized. Dissolution study was carried out in both sink and supersaturated conditions to identify the possible enhancement in dissolution behavior. Results: Based on the solubility study, Kolliphor® P188 and Eudragit® RSPO (50:25, % w/w) ratio exhibited the highest solubility among the samples and was chosen as the optimal composition of SRSD-CAR for further characterization. The crystallinity assessments of the optimized formulation indicated amorphization of CAR in the formulation, bring about improved solubility of CAR. The infrared spectroscopic study revealed minor transitions; demonstrating the absence of significant interactions between drug and carrier. Furthermore, the SRSD-CAR exhibited immediate formation of nano particles when dispersed in water. Dissolution study revealed significant improvement in dissolution behavior, with a release of CAR in a gradual manner compared to crystalline CAR. From the dissolution kinetics analysis, the Korsmeyer Peppas model fit the best and diffusion was predominant in release of CAR. The drug release pattern showed insignificant differences between the SRSD-CAR formulations prepared by rotary vacuum drying and freeze drying. Conclusion: From these experimental findings, SRSD approach might be a favorable dosage option for CAR, offering improved biopharmaceutical properties.
Keywords	Biopharmaceutical ; Carvedilol ; Drying ; Solubility ; Sustained release solid dispersion ; Pharmaceutical engineering ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	660
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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