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Article ; Online: Editorial Commentary: Is Medical Ozone Therapy Beneficial in the Treatment of Knee Osteoarthritis?

Manoto, Sello Lebohang

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

2019 Volume 36, Issue 1, Page(s) 287–288

Abstract: Osteoarthritis is a degenerative joint disease that is difficult to manage and a major cause of disability in the elderly population. The use of ozone for treatment of knee osteoarthritis (KOA) is controversial and of interest. Although the exact ... ...

Abstract	Osteoarthritis is a degenerative joint disease that is difficult to manage and a major cause of disability in the elderly population. The use of ozone for treatment of knee osteoarthritis (KOA) is controversial and of interest. Although the exact mechanism of ozone for the treatment of KOA is not fully understood, it has been shown that ozone administration may promote oxidative preconditioning or adaptation to oxidative stress, which in turn will result in the stimulation of antioxidant endogenous system which prevents tissue damage. A number of European studies show ozone injection for treatment of KOA results in pain relief, disappearance of edema, and improved mobility. Dosages and volume of injections vary among studies, risk of bias is generally high, and outcomes are inconsistent and not uniformly excellent. At present, there is insufficient evidence to support the effectiveness of ozone therapy for KOA.
MeSH term(s)	Aged ; Humans ; Osteoarthritis, Knee ; Oxygen ; Ozone ; Pain Management ; Randomized Controlled Trials as Topic
Chemical Substances	Ozone (66H7ZZK23N) ; Oxygen (S88TT14065)
Language	English
Publishing date	2019-12-21
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	632528-2
ISSN	1526-3231 ; 0749-8063
ISSN (online)	1526-3231
ISSN	0749-8063
DOI	10.1016/j.arthro.2019.09.036
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Article ; Online: Laser-enhanced drug delivery of antiretroviral drugs into human immunodeficiency virus-1 infected TZMbl cells.

Malabi, Rudzani / Lebohang Manoto, Sello / Ombinda-Lemboumba, Saturnin / Maaza, Malik / Mthunzi-Kufa, Patience

Journal of biophotonics

2019 Volume 12, Issue 10, Page(s) e201800424

Abstract: The introduction of highly active antiretroviral therapy (HAART) has significantly increased life expectancy and improved management of the human immunodeficiency virus-1 (HIV-1) disease globally. This well-established treatment regime has shown to ... ...

Abstract	The introduction of highly active antiretroviral therapy (HAART) has significantly increased life expectancy and improved management of the human immunodeficiency virus-1 (HIV-1) disease globally. This well-established treatment regime has shown to reduce viral capacity to undetectable limits when using traditional clinical assays. The establishment of viral reservoirs during the early stages of infection are the major contributors to failure of the current regimens to eradicate HIV-1 infection since the reservoirs are not affected by antiretroviral drugs (ARVs). Therefore, advanced modification of the present treatment and investigation of novel antiretroviral drug delivery system are needed. The aim of this study was to use femtosecond (fs) laser pulses to deliver ARVs into HIV-1 infected TZMbl cells. Different ARVs were translocated into TZMbl cells using fs pulsed laser (800 nm) with optimum power of 4 μW and 10 ms laser to cell exposure time. Changes in cellular processes were evaluated using cellular morphology, viability, cytotoxicity and luciferase activity assays. Cells treated with the laser in the presence of ARVs showed a significant reduction in viral infectivity, cell viability and an increase in cytotoxicity. This study demonstrated that fs laser pulses were highly effective in delivering ARVs into HIV-1 infected TZMbl cells, causing a significant reduction in HIV-1 infection.
MeSH term(s)	Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/pharmacology ; Drug Delivery Systems/methods ; HEK293 Cells ; HIV-1/drug effects ; Humans ; Lasers
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2019-07-15
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2390063-5
ISSN	1864-0648 ; 1864-063X
ISSN (online)	1864-0648
ISSN	1864-063X
DOI	10.1002/jbio.201800424
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Article ; Online: The combination of low level laser therapy and efavirenz drastically reduces HIV infection in TZM-bl cells.

Lugongolo, Masixole Yvonne / Manoto, Sello Lebohang / Ombinda-Lemboumba, Saturnin / Maaza, Malik / Mthunzi-Kufa, Patience

Biomedical journal

2020 Volume 44, Issue 6 Suppl 1, Page(s) S37–S47

Abstract: Background: Human immunodeficiency virus (HIV) infection remains a global health challenge despite the use of antiretroviral therapy, which has led to a significant decline in the mortality rates. Owing to the unavailability of an effective treatment to ...

Abstract	Background: Human immunodeficiency virus (HIV) infection remains a global health challenge despite the use of antiretroviral therapy, which has led to a significant decline in the mortality rates. Owing to the unavailability of an effective treatment to completely eradicate the virus, researchers continue to explore new methods. Low level laser therapy (LLLT) has been widely used to treat different medical conditions and involves the exposure of cells or tissues to low levels of red and near infrared light. The study aimed to determine the effect of combining two unrelated therapies on HIV infection in TZM-bl cells. Methods: In the current study, LLLT was combined with efavirenz, an HIV reverse transcriptase inhibitor to establish their impact on HIV infection in TZM-bl cells. Both the HIV infected and uninfected cells were laser irradiated using a wavelength of 640 nm with fluencies of 2-10 J/cm Results: The impact of HIV, efavirenz and irradiation were determined 24 h post irradiation using biological assays. Luciferase assay results showed that the combination of LLLT and efavirenz significantly reduced HIV infection in cells, despite the undesirable effects observed in the cells as demonstrated by cell morphology, proliferation and cell integrity assay. Flow cytometry results demonstrated that cell death was mainly through necrosis while fluorescence microscopy showed the production of reactive oxygen species in HIV infected cells. Conclusion: Efavirenz and LLLT significantly reduced HIV infection in TZM-bl cells. Furthermore, the death of HIV infected cells was due to necrosis.
MeSH term(s)	Alkynes ; Benzoxazines/pharmacology ; Benzoxazines/therapeutic use ; Cyclopropanes ; HIV Infections/drug therapy ; Humans ; Low-Level Light Therapy ; Necrosis
Chemical Substances	Alkynes ; Benzoxazines ; Cyclopropanes ; efavirenz (JE6H2O27P8)
Language	English
Publishing date	2020-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698541-X
ISSN	2320-2890 ; 2320-2890
ISSN (online)	2320-2890
ISSN	2320-2890
DOI	10.1016/j.bj.2020.05.022
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Article: Medical ozone therapy as a potential treatment modality for regeneration of damaged articular cartilage in osteoarthritis.

Manoto, Sello Lebohang / Maepa, Makwese Johaness / Motaung, Shirley Keolebogile

Saudi journal of biological sciences

2016 Volume 25, Issue 4, Page(s) 672–679

Abstract: Osteoarthritis (OA) is the most common degenerative joint disease and a growing health problem affecting more than half of the population over the age of 65. It is characterized by inflammation in the cartilage and synovium, resulting in the loss of ... ...

Abstract	Osteoarthritis (OA) is the most common degenerative joint disease and a growing health problem affecting more than half of the population over the age of 65. It is characterized by inflammation in the cartilage and synovium, resulting in the loss of joint structure and progressive damage to the cartilage. Many pro-inflammatory mediators are elevated in OA, including reactive oxygen species (ROS) such as nitric oxide (NO) and hydrogen peroxide (H
Language	English
Publishing date	2016-02-09
Publishing country	Saudi Arabia
Document type	Journal Article ; Review
ZDB-ID	2515206-3
ISSN	2213-7106 ; 1319-562X
ISSN (online)	2213-7106
ISSN	1319-562X
DOI	10.1016/j.sjbs.2016.02.002
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Article ; Online: Point of Care Diagnostics for HIV in Resource Limited Settings: An Overview.

Manoto, Sello Lebohang / Lugongolo, Masixole / Govender, Ureshnie / Mthunzi-Kufa, Patience

Medicina (Kaunas, Lithuania)

2018 Volume 54, Issue 1

Abstract: Human immunodeficiency virus (HIV) is a global health problem. Early diagnosis, rapid antiretroviral therapy (ART) initiation and monitoring of viral load are the key strategies for effective HIV management. Many people in resource limited settings where ...

Abstract	Human immunodeficiency virus (HIV) is a global health problem. Early diagnosis, rapid antiretroviral therapy (ART) initiation and monitoring of viral load are the key strategies for effective HIV management. Many people in resource limited settings where timely access to medical care is a challenge and healthcare infrastructure is poor have no access to laboratory facilities and diagnosis is dependent on the presence of point of care (POC) devices. POC instruments have shown to be easy to operate, maintain and transport and can easily be operated by less skilled health workers. Additionally, POC tests do not require laboratory technicians to operate. POC devices have resulted in a growing number of people testing for HIV and thereby receiving treatment early. In recent years, there has been great improvement in the development of POC technologies for early HIV diagnosis, HIV viral load and cluster of differentiation 4 (CD4) measurement. This review discusses POC technologies that are currently available and in the pipeline for diagnosing and monitoring HIV. We also give an overview of the technical and commercialization challenges in POC diagnostics for HIV.
MeSH term(s)	Biomedical Technology/trends ; HIV Infections/diagnosis ; Health Resources ; Health Services Accessibility ; Humans ; Point-of-Care Systems/trends
Language	English
Publishing date	2018-03-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina54010003
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Article ; Online: Medical ozone therapy as a potential treatment modality for regeneration of damaged articular cartilage in osteoarthritis

Sello Lebohang Manoto / Makwese Johaness Maepa / Shirley Keolebogile Motaung

Saudi Journal of Biological Sciences, Vol 25, Iss 4, Pp 672-

2018 Volume 679

Abstract	Osteoarthritis (OA) is the most common degenerative joint disease and a growing health problem affecting more than half of the population over the age of 65. It is characterized by inflammation in the cartilage and synovium, resulting in the loss of joint structure and progressive damage to the cartilage. Many pro-inflammatory mediators are elevated in OA, including reactive oxygen species (ROS) such as nitric oxide (NO) and hydrogen peroxide (H2O2). Damaged articular cartilage remains a challenge to treat due to the limited self-healing capacity of the tissue and unsuccessful biological interventions. This highlights the need for better therapeutic strategies to heal damaged articular cartilage. Ozone (O3) therapy has been shown to have positive results in the treatment of OA; however the use of O3 therapy as a therapeutic agent is controversial. There is a perception that O3 is always toxic, whereas evidence indicates that when it is applied following a specified method, O3 can be effective in the treatment of degenerative diseases. The mechanism of action of O3 therapy in OA is not fully understood and this review summarizes the use of O3 therapy in the treatment of damaged articular cartilage in OA. Keywords: Osteoarthritis (OA), Articular cartilage, Ozone (O3) therapy, Reactive oxygen species (ROS)
Keywords	Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Resistance of lung cancer cells grown as multicellular tumour spheroids to zinc sulfophthalocyanine photosensitization.

Manoto, Sello Lebohang / Houreld, Nicolette Nadene / Abrahamse, Heidi

International journal of molecular sciences

2015 Volume 16, Issue 5, Page(s) 10185–10200

Abstract: Photodynamic therapy (PDT) is phototherapeutic modality used in the treatment of neoplastic and non-neoplastic diseases. The photochemical interaction of light, photosensitizer (PS) and molecular oxygen produces singlet oxygen which induces cell death. ... ...

Abstract	Photodynamic therapy (PDT) is phototherapeutic modality used in the treatment of neoplastic and non-neoplastic diseases. The photochemical interaction of light, photosensitizer (PS) and molecular oxygen produces singlet oxygen which induces cell death. Zinc sulfophthalocyanine (ZnPcSmix) has been shown to be effective in A549 monolayers, multicellular tumor spheroids (MCTSs) (250 µm) and not on MCTSs with a size of 500 µm. A549 cells used in this study were grown as MCTSs to a size of 500 µm in order to determine their susceptibility to PDT. ZnPcSmix distribution in MCTSs and nuclear morphology was determined using a fluorescent microscope. Changes in cellular responses were evaluated using cell morphology, viability, proliferation, cytotoxicity, cell death analysis and mitochondrial membrane potential. Untreated MCTSs, showed no changes in cellular morphology, proliferation, cytotoxicity and nuclear morphology. Photoactivated ZnPcSmix also showed no changes in cellular morphology and nuclear morphology. However, photoactivated ZnPcSmix resulted in a significant dose dependant decrease in viability and proliferation as well as an increase in cell membrane damage in MCTSs over time. ZnPcSmix photosensitization induces apoptotic cell death in MCTSs with a size of 500 µm and more resistantance when compared to monolayer cells and MCTSs with a size of 250 µm.
MeSH term(s)	Apoptosis ; Cell Line, Tumor ; Cell Membrane/drug effects ; Cell Nucleus/drug effects ; Cell Proliferation ; Cell Survival ; Humans ; Indoles/pharmacology ; Indoles/radiation effects ; Lasers ; Lung Neoplasms/metabolism ; Membrane Potential, Mitochondrial ; Organometallic Compounds/pharmacology ; Organometallic Compounds/radiation effects ; Radiation-Sensitizing Agents/pharmacology ; Radiation-Sensitizing Agents/radiation effects ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/radiation effects
Chemical Substances	Indoles ; Organometallic Compounds ; Radiation-Sensitizing Agents ; zinc(II) phthalocyanine trisulfonic acid (61569-02-6)
Language	English
Publishing date	2015-05-05
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms160510185
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Article ; Online: Resistance of Lung Cancer Cells Grown as Multicellular Tumour Spheroids to Zinc Sulfophthalocyanine Photosensitization

Sello Lebohang Manoto / Nicolette Nadene Houreld / Heidi Abrahamse

International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 10185-

2015 Volume 10200

Abstract	Photodynamic therapy (PDT) is phototherapeutic modality used in the treatment of neoplastic and non-neoplastic diseases. The photochemical interaction of light, photosensitizer (PS) and molecular oxygen produces singlet oxygen which induces cell death. Zinc sulfophthalocyanine (ZnPcSmix) has been shown to be effective in A549 monolayers, multicellular tumor spheroids (MCTSs) (250 µm) and not on MCTSs with a size of 500 µm. A549 cells used in this study were grown as MCTSs to a size of 500 µm in order to determine their susceptibility to PDT. ZnPcSmix distribution in MCTSs and nuclear morphology was determined using a fluorescent microscope. Changes in cellular responses were evaluated using cell morphology, viability, proliferation, cytotoxicity, cell death analysis and mitochondrial membrane potential. Untreated MCTSs, showed no changes in cellular morphology, proliferation, cytotoxicity and nuclear morphology. Photoactivated ZnPcSmix also showed no changes in cellular morphology and nuclear morphology. However, photoactivated ZnPcSmix resulted in a significant dose dependant decrease in viability and proliferation as well as an increase in cell membrane damage in MCTSs over time. ZnPcSmix photosensitization induces apoptotic cell death in MCTSs with a size of 500 µm and more resistantance when compared to monolayer cells and MCTSs with a size of 250 µm.
Keywords	apoptosis ; resistance ; cytotoxicity ; spheroids ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2015-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of a newly synthesized Zn sulfophthalocyanine derivative on cell morphology, viability, proliferation, and cytotoxicity in a human lung cancer cell line (A549).

Manoto, Sello Lebohang / Abrahamse, Heidi

Lasers in medical science

2011 Volume 26, Issue 4, Page(s) 523–530

Abstract: Photodynamic therapy (PDT) is a photochemotherapeutic process that is used for the treatment of cancer. Photofrin is the most widely used photosensitizer, however, the chemical composition of Photofrin is unclear and it has a low absorption in the ... ...

Abstract	Photodynamic therapy (PDT) is a photochemotherapeutic process that is used for the treatment of cancer. Photofrin is the most widely used photosensitizer, however, the chemical composition of Photofrin is unclear and it has a low absorption in the therapeutic wavelength (600-900 nm). This factor has stimulated research in synthesis and testing of new photosensitizers. This in vitro study evaluated the effectiveness of a Zn sulfophthalocyanine (ZnPcS(mix)) as a potential photosensitizer in the treatment of human lung cancer. Lung cancer cells (A549) were divided into four groups: group 1 was control cells receiving neither light nor drug; group 2 was light control for cells exposed to laser irradiation at a fluence of 4.98 J/cm(2); group 3 was drug control for cells incubated with 15.8 μM photosensitizer and not exposed to laser irradiation, while group 4 was cells receiving the experimental treatment with 15.8 μM photosensitizer and irradiation with 4.98 J/cm(2). Laser irradiations were performed using a 636-nm diode laser with an output power of 110 mW at 4.98 J/cm(2). Changes in cellular responses were evaluated by cell morphology, viability, proliferation, and cytotoxicity. While control groups 1, 2, and 3 showed no changes in cell morphology, viability, proliferation, or cytotoxicity, group 4 receiving both photosensitizer and irradiation showed changes in cell morphology, a decrease in cell viability and proliferation, and an increase in cytotoxicity, cell death, and cell membrane damage. Irradiation or photosensitizer alone had no effect on the lung cancer cells since the cells remained viable and showed no evidence of damage. However, irradiation in the presence of a photosensitizer induced cell death.
MeSH term(s)	Adenocarcinoma ; Adenocarcinoma of Lung ; Analysis of Variance ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured/drug effects ; Hematoporphyrin Derivative ; Humans ; Indoles ; Low-Level Light Therapy/instrumentation ; Low-Level Light Therapy/methods ; Lung Neoplasms ; Organometallic Compounds ; Photochemotherapy/instrumentation ; Photochemotherapy/methods ; Photosensitizing Agents/administration & dosage ; Photosensitizing Agents/pharmacology
Chemical Substances	Indoles ; Organometallic Compounds ; Photosensitizing Agents ; zinc(II) phthalocyanine trisulfonic acid (61569-02-6) ; Hematoporphyrin Derivative (68335-15-9)
Language	English
Publishing date	2011-01-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-011-0887-0
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Article ; Online: The effects of low level laser therapy on both HIV-1 infected and uninfected TZM-bl cells.

Lugongolo, Masixole Yvonne / Manoto, Sello Lebohang / Ombinda-Lemboumba, Saturnin / Maaza, Malik / Mthunzi-Kufa, Patience

Journal of biophotonics

2017 Volume 10, Issue 10, Page(s) 1335–1344

Abstract: Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine and treatment that ...

Abstract	Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine and treatment that would completely eradicate the virus in infected individuals, the quest for new therapies continues. Low level laser therapy (LLLT) involves the exposure of cells to low levels of red or infrared light. LLLT has been widely used in different medical conditions, but not in HIV-1 infection. This study aimed to determine the effects of LLLT on HIV-1 infected and uninfected TZM-bl cells. Both infected and uninfected cells were irradiated at a wavelength of 660 nm with different fluences from 2 J/cm
Language	English
Publishing date	2017-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2390063-5
ISSN	1864-0648 ; 1864-063X
ISSN (online)	1864-0648
ISSN	1864-063X
DOI	10.1002/jbio.201600217
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