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  1. Article ; Online: Purkinje Re-Entry Associated With Reproducible ECG Morphology During Initiation of PVC-Triggered Ventricular Fibrillation.

    Arps, Kelly / Barnett, Adam S / Piccini, Jonathan P / Koontz, Jason I / Sun, Albert Y

    JACC. Clinical electrophysiology

    2024  

    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2024.102331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rethinking Regional Neurologic Care in the Coronavirus Disease 2019 Era.

    George, Benjamin P / Kelly, Adam G

    JAMA neurology

    2020  Volume 77, Issue 9, Page(s) 1061–1062

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Delivery of Health Care/methods ; Delivery of Health Care/trends ; Humans ; Nervous System Diseases/epidemiology ; Nervous System Diseases/therapy ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Telemedicine/methods ; Telemedicine/trends
    Keywords covid19
    Language English
    Publishing date 2020-06-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2020.1956
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  3. Article ; Online: Evaluation of the trajectory of recovery following surgically treated acetabular fractures.

    Tucker, Adam / Roffey, Darren M / Guy, Pierre / Potter, Jeffrey M / Broekhuyse, Henry M / Lefaivre, Kelly A

    The bone & joint journal

    2024  Volume 106-B, Issue 1, Page(s) 69–76

    Abstract: ... disability versus baseline, including final follow-up (p < 0.001). Elementary fractures had higher SF-36 PCS ... at six months (p = 0.023) and one year (p = 0.007) compared to associated fractures, but not at two years ... p = 0.135) or five years (p = 0.631). The MCID in SF-36 PCS was observed in 37.3% of patients (69 ...

    Abstract Aims: Acetabular fractures are associated with long-term morbidity. Our prospective cohort study sought to understand the recovery trajectory of this injury over five years.
    Methods: Eligible patients at a level I trauma centre were recruited into a longitudinal registry of surgical acetabular fractures between June 2004 and August 2019. Patient-reported outcome measures (PROMs), including the 36-Item Short Form Health Survey (SF-36) physical component summary (PCS), were recorded at baseline pre-injury recall and six months, one year, two years, and five years postoperatively. Comparative analyses were performed for elementary and associated fracture patterns. The proportion of patients achieving minimal clinically important difference (MCID) was determined. The rate of, and time to, conversion to total hip arthroplasty (THA) was also established.
    Results: We recruited 251 patients (253 fractures), with a 4:1 male to female ratio and mean age of 46.1 years (SD 16.4). Associated fracture patterns accounted for 56.5% of fractures (n = 143). Trajectory analysis showed all timepoints had significant disability versus baseline, including final follow-up (p < 0.001). Elementary fractures had higher SF-36 PCS at six months (p = 0.023) and one year (p = 0.007) compared to associated fractures, but not at two years (p = 0.135) or five years (p = 0.631). The MCID in SF-36 PCS was observed in 37.3% of patients (69/185) between six months and one year, 26.9% of patients (39/145) between one and two years, and 23.3% of patients (20/86) between two and five years, highlighting the long recovery potential of these injuries. A significant proportion of patients failed to attain the MCID after five years (38.1%; 40/105). Conversion to THA occurred in 13.1% of patients (11/110 elementary and 22/143 associated fractures). Approximately two-thirds of THAs (21/33 patients; 63.6%) were performed within two years of index surgery.
    Conclusion: Acetabular fractures significantly impact physical function. Recovery trajectory is often elongated beyond one year, with two-thirds of our patients displaying persistent clinically relevant long-term disability.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Prospective Studies ; Hip Fractures ; Arthroplasty, Replacement, Hip ; Spinal Fractures ; Patient Reported Outcome Measures ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2024-01-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.106B1.BJJ-2023-0499.R2
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  4. Article: Children's and adolescents' evaluations of wealth-related STEM inequality.

    McGuire, Luke / Marlow, Christina / Hoffman, Adam J / Joy, Angelina / Law, Fidelia / Hartstone-Rose, Adam / Rutland, Adam / Winterbottom, Mark / Balkwill, Frances / Burns, Karen P / Butler, Laurence / Fields, Grace / Mulvey, Kelly Lynn

    Social development (Oxford, England)

    2023  Volume 33, Issue 1, Page(s) e12710

    Abstract: The fields of science, technology, engineering, and mathematics (STEM) are rife with inequalities and under-representation that have their roots in childhood. While researchers have focused on gender and race/ethnicity as two key dimensions of inequality, ...

    Abstract The fields of science, technology, engineering, and mathematics (STEM) are rife with inequalities and under-representation that have their roots in childhood. While researchers have focused on gender and race/ethnicity as two key dimensions of inequality, less attention has been paid to wealth. To this end, and drawing from the Social Reasoning Development approach, we examined children's and adolescents' perceptions of STEM ability and access to opportunities as a function of wealth, as well as their desire to rectify such inequalities. Participants (
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001609-8
    ISSN 1467-9507 ; 0961-205X
    ISSN (online) 1467-9507
    ISSN 0961-205X
    DOI 10.1111/sode.12710
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  5. Article ; Online: Clinical decision support to enhance venous thromboembolism pharmacoprophylaxis prescribing for pediatric inpatients with COVID-19.

    Yan, Adam Paul / Parsons, Chase / Caplan, Gregory / Kelly, Daniel P / Duzan, Julie / Drake, Emily / Kumar, Riten

    Pediatric blood & cancer

    2024  Volume 71, Issue 3, Page(s) e30843

    Abstract: ... of patients triggering a CDS alert occurred in the post-intervention period (44.3% vs. 6.9%, p < .001 ... however, no reciprocal increase in VTE prophylaxis prescribing was achieved (36.6% vs. 40.9%, p = .53 ...

    Abstract Objective: To design and evaluate a clinical decision support (CDS) module to improve guideline concordant venous thromboembolism (VTE) pharmacoprophylaxis prescribing for pediatric inpatients with COVID-19.
    Materials and methods: The proportion of patients who met our institutional clinical practice guideline's (CPG) criteria for VTE prophylaxis was compared to those who triggered a CDS alert, indicating the patient needed VTE prophylaxis, and to those who were prescribed prophylaxis pre and post the launch of a new VTE CDS module to support VTE pharmacoprophylaxis prescribing. The sensitivity, specificity, positive predictive value (PPV), negative predictive value, F1-score and accuracy of the tool were calculated for the pre- and post-intervention periods using the CPG recommendation as the gold standard. Accuracy was defined as the sum of the true positives and true negatives over the sum of the true positives, false positives, true negatives, and false negatives. Logistic regression was used to identify variables associated with correct thromboprophylaxis prescribing.
    Results: A significant increase in the proportion of patients triggering a CDS alert occurred in the post-intervention period (44.3% vs. 6.9%, p < .001); however, no reciprocal increase in VTE prophylaxis prescribing was achieved (36.6% vs. 40.9%, p = .53). The updated CDS module had an improved sensitivity (55.0% vs. 13.3%), NPV (44.9% vs. 36.3%), F1-score (66.7% vs. 23.5%), and accuracy (62.5% vs. 42.0%), but an inferior specificity (78.6% vs. 100%) and PPV (84.6% vs. 100%).
    Discussion: The updated CDS model had an improved accuracy and overall performance in correctly identifying patients requiring VTE prophylaxis. Despite an increase in correct patient identification by the CDS module, the proportion of patients receiving appropriate pharmacologic prophylaxis did not change.
    Conclusion: CDS tools to support correct VTE prophylaxis prescribing need ongoing refinement and validation to maximize clinical utility.
    MeSH term(s) Humans ; Child ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control ; Inpatients ; Decision Support Systems, Clinical ; Anticoagulants/therapeutic use ; COVID-19 ; Risk Factors
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.30843
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  6. Article ; Online: Reply to: Two ripples in a pond: The subtleties of mapping observations in localizing PVC sites.

    Arps, Kelly / Barnett, Adam S / Koontz, Jason I / Pokorney, Sean D / Jackson, Kevin P / Bahnson, Tristram D / Piccini, Jonathan P / Sun, Albert Y

    Journal of cardiovascular electrophysiology

    2023  Volume 34, Issue 8, Page(s) 1789–1790

    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.16004
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  7. Article ; Online: Effect of Vegetable Host Plant Type on Halyomorpha halys (Hemiptera: Pentatomidae) Nymphal Development.

    Formella, Adam / McIntyre, Kelly / Kuhar, Thomas P

    Journal of economic entomology

    2022  

    Abstract: The brown marmorated stink bug, Halyomorpha halys (Stål), is an invasive pest introduced to North America in the mid-1990's that has caused economic losses to a wide range of commodities. In vegetables, H. halys feeding damage has been well described, ... ...

    Abstract The brown marmorated stink bug, Halyomorpha halys (Stål), is an invasive pest introduced to North America in the mid-1990's that has caused economic losses to a wide range of commodities. In vegetables, H. halys feeding damage has been well described, but the effect of different vegetable hosts on H. halys fitness is less understood. We caged 2nd instar H. halys on different vegetable hosts (e.g., tomato, sweet corn, eggplant, bell pepper, and snap bean) and monitored their development until adulthood to compare the effects of vegetable host type on H. halys nymph survival and development time. Experiments were replicated nine times over a two-year period. Survival of 2nd instars from F1 generation (early-season) eggs was low (<30%) on all vegetables resulting in no significant treatment effect. However, H. halys nymphs collected from F2 generation (late-season) eggs had higher survivorship on all vegetables except tomato. The percentage of H. halys 2nd instars that reached adulthood was greatest on corn (53%) and pepper (45%), followed by snap bean (24%), and significantly lower on eggplant (9%) and tomato (2%). Total development time from 2nd instar to adult was fastest on corn and slowest on peppers, although tomatoes were not tested due to the low survival. Trends in development rate were not seasonally-dependent. Our study compares H. halys survivability on several vegetable commodities, and provides insights into H. halys developmental success and dependence on various host plants over the season.
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 3031-4
    ISSN 1938-291X ; 0022-0493
    ISSN (online) 1938-291X
    ISSN 0022-0493
    DOI 10.1093/jee/toac148
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  8. Article ; Online: An exploration of organizational climate in community-based opiate prescribing services; a mixed methods study.

    Kelly, Peter / Searby, Adam / Goodwin, John

    Journal of substance use and addiction treatment

    2024  Volume 162, Page(s) 209362

    Abstract: Introduction: Assessing the internal dynamics of organizations has been shown to provide information that can help planners and policymakers improve service delivery. A good organizational climate, which in this study incorporates mission clarity, team ... ...

    Abstract Introduction: Assessing the internal dynamics of organizations has been shown to provide information that can help planners and policymakers improve service delivery. A good organizational climate, which in this study incorporates mission clarity, team cohesion, staff autonomy, communication, levels of stress, and openness to change has been shown to be of particular importance. Still, there is a dearth of evidence in this area, and while relationships between organizational factors have been identified, little is known about the mechanisms that might underpin these relationships, and there is little understanding of how to address deficits once they are identified. The objective of this study was to identify relationships between program factors that influence organizational climate and to explore which mechanisms might underpin these relationships.
    Methods: This paper reports on a cross-sectional, concurrent, mixed-methods study design, across twelve discrete community-based prescribing service providers (organizations) in Ireland. Data was obtained using a staff survey [n = 132] which utilized measurements of organizational readiness to change and one-to-one interviews [n = 12]. Quantitative data was analyzed using multivariate linear regression modeling which assessed relationships between variables, while interviews were analyzed using an abductive approach, both types of data were synthesized at the interpretation stage.
    Results: A range of interdependent factors were considered to affect the climate of organizations. Surveys identified that specific types of resources, such as physical infrastructure, training, and staffing resources were important for supporting a good organizational climate, while programs with greater needs had a poorer climate. Opportunities for professional growth, the skill sets of staff, and having access to e-communication were also significant. Interviewees reported that rigid organizational hierarchies and bureaucracy, philosophical views of addiction, stress, and staff turnover were influenced by the provision of fewer resources. Interdependent factors such as leadership, supervision, staff relationships, and collective training, also thought to be influenced by resources, were considered to positively influence programs. Resources were not the only challenge identified, and practices within programs and how existing resources are used were also thought to contribute both positively and negatively to the internal dynamics of services.
    Conclusion: Key findings in this study identified that the organization of effective services is influenced by a range of specific factors, some of which can be addressed without additional resources. Overall, staff views of organizations can provide us with valuable information to support service improvement. Using a mixed methods approach can not only identify where relationships between organizational variables exist but can also help us to understand the mechanisms that underpin these relationships and, importantly, how to address deficits once they are identified. In order to improve how substance misuse services work, the need for a long-term systemic approach to program development, which incorporates some of the findings from this study, is required.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ISSN 2949-8759
    ISSN (online) 2949-8759
    DOI 10.1016/j.josat.2024.209362
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  9. Article ; Online: Interest, Mindsets and Engagement: Longitudinal Relations in Science Orientations for Adolescents in Informal Science Programs.

    Joy, Angelina / Mathews, Channing J / Zhao, Mengya / Law, Fidelia / McGuire, Luke / Hoffman, Adam J / Balkwill, Frances / Burns, Karen P / Butler, Laurence / Drews, Marc / Fields, Grace / Smith, Hannah / Ozturk, Emine / Winterbottom, Mark / Rutland, Adam / Hartstone-Rose, Adam / Mulvey, Kelly Lynn

    Journal of youth and adolescence

    2023  Volume 52, Issue 5, Page(s) 1088–1099

    Abstract: Little is known about the factors that influence engagement for adolescents participating in informal youth science programs. This study examined longitudinal reciprocal associations between adolescents' science engagement, interest, and growth mindset. ... ...

    Abstract Little is known about the factors that influence engagement for adolescents participating in informal youth science programs. This study examined longitudinal reciprocal associations between adolescents' science engagement, interest, and growth mindset. Participants were adolescents (M
    MeSH term(s) Adolescent ; Female ; Humans ; Male ; Science/education ; Motivation
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 186743-x
    ISSN 1573-6601 ; 0047-2891
    ISSN (online) 1573-6601
    ISSN 0047-2891
    DOI 10.1007/s10964-023-01734-5
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