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  1. Article: Hepatoprotective effects of bioactive compounds from traditional herb Tulsi (

    Kamel, Fatemah O / Karim, Shahid / Bafail, Duaa Abdullah Omer / Aldawsari, Hibah Mubarak / Kotta, Sabna / Ilyas, U K

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1213052

    Abstract: Ocimum sanctum L. ...

    Abstract Ocimum sanctum L.
    Language English
    Publishing date 2023-10-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1213052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ADVANCES OF NON-IRON METAL NANOPARTICLES IN BIOMEDICINE.

    Anroop B Nair / Mohamed A Morsy / Pottathil Shinu / Sabna Kotta / Mithra Chandrasekaran / Abu Tahir

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    2021  Volume 24, Page(s) 41–61

    Abstract: Metal nanoparticles (MNPs) comprise of nanoparticles originating from metallic elements with additional properties inherent to metal ions. MNPs found applications in various field such as electronics, optics, mechanics, physics etc. There are many ... ...

    Abstract Metal nanoparticles (MNPs) comprise of nanoparticles originating from metallic elements with additional properties inherent to metal ions. MNPs found applications in various field such as electronics, optics, mechanics, physics etc. There are many reviews on iron MNPs for biomedical application. Hence, in this review, we focus on non-iron MNPs and their vivid biomedical applications. Here, we review the applications of non-iron MNPs in biomedicine such as drug delivery, gene delivery, anticancer activity, antimicrobial activity, tissue engineering, bioimaging, and photodynamic, and photothermal therapies.
    MeSH term(s) Animals ; Biomedical Research ; Humans ; Metal Nanoparticles/chemistry
    Language English
    Publishing date 2021-01-28
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 1422972-9
    ISSN 1482-1826 ; 1482-1826
    ISSN (online) 1482-1826
    ISSN 1482-1826
    DOI 10.18433/jpps31434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Amalgamation of solid dispersion and melt adsorption techniques for augmentation of oral bioavailability of novel anticoagulant rivaroxaban.

    Shah, Pranav J / Patel, Milan P / Shah, Jigar / Nair, Anroop B / Kotta, Sabna / Vyas, Bhavin

    Drug delivery and translational research

    2022  Volume 12, Issue 12, Page(s) 3029–3046

    Abstract: The objective of the present study was to evaluate the potential of solid dispersion adsorbate (SDA) to improve the solubility and bioavailability of rivaroxaban (RXN). SDA of RXN was developed by fusion method using PEG 4000 as carrier and Neusilin as ... ...

    Abstract The objective of the present study was to evaluate the potential of solid dispersion adsorbate (SDA) to improve the solubility and bioavailability of rivaroxaban (RXN). SDA of RXN was developed by fusion method using PEG 4000 as carrier and Neusilin as adsorbent. A 3
    MeSH term(s) Humans ; Biological Availability ; Rivaroxaban ; Adsorption ; Anticoagulants ; Caco-2 Cells ; Solubility ; Tablets/chemistry ; Calorimetry, Differential Scanning ; Excipients
    Chemical Substances Rivaroxaban (9NDF7JZ4M3) ; Anticoagulants ; Tablets ; Excipients
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-022-01168-9
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  4. Article: Progress in Polymeric Micelles for Drug Delivery Applications.

    Kotta, Sabna / Aldawsari, Hibah Mubarak / Badr-Eldin, Shaimaa M / Nair, Anroop B / Yt, Kamal

    Pharmaceutics

    2022  Volume 14, Issue 8

    Abstract: Polymeric micelles (PMs) have made significant progress in drug delivery applications. A robust core-shell structure, kinetic stability and the inherent ability to solubilize hydrophobic drugs are the highlights of PMs. This review presents the recent ... ...

    Abstract Polymeric micelles (PMs) have made significant progress in drug delivery applications. A robust core-shell structure, kinetic stability and the inherent ability to solubilize hydrophobic drugs are the highlights of PMs. This review presents the recent advances and understandings of PMs with a focus on the latest drug delivery applications. The types, methods of preparation and characterization of PMs are described along with their applications in oral, parenteral, transdermal, intranasal and other drug delivery systems. The applications of PMs for tumor-targeted delivery have been provided special attention. The safety, quality and stability of PMs in relation to drug delivery are also provided. In addition, advanced polymeric systems and special PMs are also reviewed. The in vitro and in vivo stability assessment of PMs and recent understandings in this area are provided. The patented PMs and clinical trials on PMs for drug delivery applications are considered indicators of their tremendous future applications. Overall, PMs can help overcome many unresolved issues in drug delivery.
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14081636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Three-Dimensional In Vitro Cell Culture Models for Efficient Drug Discovery: Progress So Far and Future Prospects.

    Badr-Eldin, Shaimaa M / Aldawsari, Hibah M / Kotta, Sabna / Deb, Pran Kishore / Venugopala, Katharigatta N

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 8

    Abstract: Despite tremendous advancements in technologies and resources, drug discovery still remains a tedious and expensive process. Though most cells are cultured using 2D monolayer cultures, due to lack of specificity, biochemical incompatibility, and cell-to- ... ...

    Abstract Despite tremendous advancements in technologies and resources, drug discovery still remains a tedious and expensive process. Though most cells are cultured using 2D monolayer cultures, due to lack of specificity, biochemical incompatibility, and cell-to-cell/matrix communications, they often lag behind in the race of modern drug discovery. There exists compelling evidence that 3D cell culture models are quite promising and advantageous in mimicking in vivo conditions. It is anticipated that these 3D cell culture methods will bridge the translation of data from 2D cell culture to animal models. Although 3D technologies have been adopted widely these days, they still have certain challenges associated with them, such as the maintenance of a micro-tissue environment similar to in vivo models and a lack of reproducibility. However, newer 3D cell culture models are able to bypass these issues to a maximum extent. This review summarizes the basic principles of 3D cell culture approaches and emphasizes different 3D techniques such as hydrogels, spheroids, microfluidic devices, organoids, and 3D bioprinting methods. Besides the progress made so far in 3D cell culture systems, the article emphasizes the various challenges associated with these models and their potential role in drug repositioning, including perspectives from the COVID-19 pandemic.
    Language English
    Publishing date 2022-07-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15080926
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  6. Article: Development and evaluation of quercetin enriched bentonite-reinforced starch-gelatin based bioplastic with antimicrobial property.

    Mubarak Aldawsari, Hibah / Kotta, Sabna / Asfour, Hani Z / Vattamkandathil, Sajith / Abdelkhalek Elfaky, Mahmoud / Ashri, Lubna Y / Badr-Eldin, Shaimaa M

    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

    2023  Volume 31, Issue 12, Page(s) 101861

    Abstract: Nowadays novel bio-based materials have been widely employed in food and pharmaceutical industry because of their wide acceptability by the consumers rather than the synthetic materials nevertheless, they possess poor mechanical properties. Reinforcement ...

    Abstract Nowadays novel bio-based materials have been widely employed in food and pharmaceutical industry because of their wide acceptability by the consumers rather than the synthetic materials nevertheless, they possess poor mechanical properties. Reinforcement of biopolymers with intercalation of mineral clays can improve their physicochemical properties; so that such biocomposites possess superior barrier and mechanical properties as well as stability and drug loading efficacy. Thus, this research aimed at formulating quercetin loaded bentonite-reinforced starch-gelatin based novel bioplastic with diverse applicability. The methodology of the study included Box Behnken optimization as well as physical, structural, mechanical and antimicrobial properties evaluation of the proposed reinforced bioplastics. Amount of starch, bentonite and glycerin were the independent variables while the tensile strength, swelling index and elongation percentage were studied as dependent variables. The optimized bioplastic film showed excellent physicochemical and morphological characteristics and also for efficient percentage drug content. The antimicrobial activity showed the highest activity against Escherichia coli followed by Pseudomonas aeruginosa and Staphylococcus aureus. Scanning electron microscopy (SEM) revealed the non-homogenous nature of the film. Generally, the results revealed that quercetin loaded bentonite-reinforced starch-gelatin based could be used as ecological friendly active food packaging as well as pharmaceutical application with significant antimicrobial properties.
    Language English
    Publishing date 2023-11-02
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1378024-4
    ISSN 1319-0164
    ISSN 1319-0164
    DOI 10.1016/j.jsps.2023.101861
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4758: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Physical, Chemical, Barrier, and Antioxidant Properties of Pectin/Collagen Hydrogel-Based Films Enriched with

    Bhatia, Saurabh / Al-Harrasi, Ahmed / Alhadhrami, Aysha Salim / Shah, Yasir Abbas / Kotta, Sabna / Iqbal, Javed / Anwer, Md Khalid / Nair, Anjana Karunakaran / Koca, Esra / Aydemir, Levent Yurdaer

    Gels (Basel, Switzerland)

    2023  Volume 9, Issue 7

    Abstract: The essential oil extracted ... ...

    Abstract The essential oil extracted from
    Language English
    Publishing date 2023-06-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9070511
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  8. Article ; Online: Coconut oil-based resveratrol nanoemulsion: Optimization using response surface methodology, stability assessment and pharmacokinetic evaluation.

    Kotta, Sabna / Mubarak Aldawsari, Hibah / Badr-Eldin, Shaimaa M / Alhakamy, Nabil A / Md, Shadab

    Food chemistry

    2021  Volume 357, Page(s) 129721

    Abstract: Phytochemicals are widely studied for therapeutic applications and nanostructured delivery systems for phytochemicals are under spotlight. Resveratrol is a promising candidate for neurodegenerative disorders. In the present study, we aimed to formulate ... ...

    Abstract Phytochemicals are widely studied for therapeutic applications and nanostructured delivery systems for phytochemicals are under spotlight. Resveratrol is a promising candidate for neurodegenerative disorders. In the present study, we aimed to formulate nanoemulsion of resveratrol by ultrasonication process using response surface methodology. The effect of both formulation and ultrasonication process factors were studied for the nanoemulsification process using coconut oil, Pluronic-P107, and Cremophor EL. The time, intensity, and power of ultrasonication were selected as process factors. The globule size, PDI, and zeta potential were the responses selected. The concentrations of oil and surfactant and the intensity were found to significantly influence the globule size. The concentration of resveratrol in the optimized nanoemulsion formulation was 2.6442 mg/ml. The in vitro drug release in pH 6.8 phosphate buffer as well as in vitro permeation study on goat nasal mucosa proved the superiority of the nanoemulsion formulation. On intranasal administration in the rat at a resveratrol dose of 2 mg/kg, the brain targeting efficacy of the nanoemulsion formulation was high. Overall, this research provides the benefit of intake of resveratrol containing fruits and, its incorporation into nanoemulsions system could be a promising alternative for the management of Alzheimer's disease.
    Language English
    Publishing date 2021-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2021.129721
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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  9. Article ; Online: Thermosensitive Hydrogels Loaded with Resveratrol Nanoemulsion: Formulation Optimization by Central Composite Design and Evaluation in MCF-7 Human Breast Cancer Cell Lines.

    Kotta, Sabna / Aldawsari, Hibah Mubarak / Badr-Eldin, Shaimaa M / Nair, Anroop B / Kaleem, Mohammed / Dalhat, Mahmood Hassan

    Gels (Basel, Switzerland)

    2022  Volume 8, Issue 7

    Abstract: The second most common cause of mortality among women is breast cancer. A variety of natural compounds have been demonstrated to be beneficial in the management of various malignancies. Resveratrol is a promising anticancer polyphenolic compound found in ...

    Abstract The second most common cause of mortality among women is breast cancer. A variety of natural compounds have been demonstrated to be beneficial in the management of various malignancies. Resveratrol is a promising anticancer polyphenolic compound found in grapes, berries, etc. Nevertheless, its low solubility, and hence its low bioavailability, restrict its therapeutic potential. Therefore, in our study, we developed a thermosensitive hydrogel formulation loaded with resveratrol nanoemulsion to enhance its bioavailability. Initially, resveratrol nanoemulsions were formulated and optimized utilizing a central composite-face-centered design. The independent variables for optimization were surfactant level, homogenization speed, and time, while the size and zeta potential were the dependent variables. The optimized nanoemulsion formulation was converted into a sensitive hydrogel using poloxamer 407. Rheological studies proved the formation of gel consistency at physiological temperature. Drug loading efficiency and in vitro drug release from gels were also analyzed. The drug release mechanisms from the gels were assessed using various mathematical models. The effect of the optimized thermosensitive resveratrol nanoemulsion hydrogel on the viability of human breast cancer cells was tested using MCF-7 cancer cell lines. The globule size of the selected formulation was 111.54 ± 4.16 nm, with a zeta potential of 40.96 ± 3.1 mV. Within 6 h, the in vitro release profile demonstrated a release rate of 80%. According to cell line studies, the produced hydrogel of resveratrol nanoemulsion was cytotoxic to breast cancer cells. Overall, the results proved the developed nanoemulsion-loaded thermosensitive hydrogel is a promising platform for the effective delivery of resveratrol for the management of breast cancer.
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels8070450
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  10. Article ; Online: 3D Printing in medicine

    Abdul Aleem Mohammed / Mohammed S. Algahtani / Mohammad Zaki Ahmad / Javed Ahmad / Sabna Kotta

    Annals of 3D Printed Medicine, Vol 4, Iss , Pp 100037- (2021)

    Technology overview and drug delivery applications

    2021  

    Abstract: The concept of tailored medicine for individual patients have been around for a while but recently earned much attention. Great interest is given to 3D printing technology due to its immense application potential in the pharmaceutical industry and other ... ...

    Abstract The concept of tailored medicine for individual patients have been around for a while but recently earned much attention. Great interest is given to 3D printing technology due to its immense application potential in the pharmaceutical industry and other health care sectors. 3D printing technology involves Layer-by-layer fabrication of 3Dgra objects from digital designs. This review gives a detailed yet much-focused discussion about 3D printing technology, the outline of 3D printing-based drug delivery technology its application in the pharmaceutical product development process. Based on the method of material layering, 3D printers are generally inkjet, extrusion, or laser-based systems. This review discusses the different types of 3D printers and their applications in different areas of drug delivery. A selection of recent researches carried out in the field of pharmaceutical 3D printing for drug delivery applications is also included. In addition to the promising opportunities, the review discusses the technical and regulatory challenges that slow down the implementation of such technology in the pharmaceutical and health care sector and the suggested measures to overcome such challenges.
    Keywords 3D printing ; Layer-by-layer ; Pharmaceuticals ; Personalized medicine ; Customized dose ; Drug delivery ; Medical technology ; R855-855.5
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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