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  1. Article ; Online: Dengue and chikungunya: future threats for Northern Europe?

    Laverdeur, Justine / Desmecht, Daniel / Hayette, Marie-Pierre / Darcis, Gilles

    Frontiers in epidemiology

    2024  Volume 4, Page(s) 1342723

    Abstract: Arthropod-borne viral diseases are likely to be affected by the consequences of climate change with an increase in their distribution and intensity. Among these infectious diseases, chikungunya and dengue viruses are two (re)emergent arboviruses ... ...

    Abstract Arthropod-borne viral diseases are likely to be affected by the consequences of climate change with an increase in their distribution and intensity. Among these infectious diseases, chikungunya and dengue viruses are two (re)emergent arboviruses transmitted by
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2674-1199
    ISSN (online) 2674-1199
    DOI 10.3389/fepid.2024.1342723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Persistent HIV-1 transcription during ART: time to reassess its significance?

    Fombellida-Lopez, Céline / Berkhout, Ben / Darcis, Gilles / Pasternak, Alexander O

    Current opinion in HIV and AIDS

    2024  Volume 19, Issue 3, Page(s) 124–132

    Abstract: Purpose of review: Despite suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and reignite viral replication if therapy is interrupted. Persistence of the viral reservoir in people with HIV-1 (PWH) is the main obstacle to an HIV-1 cure. ... ...

    Abstract Purpose of review: Despite suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and reignite viral replication if therapy is interrupted. Persistence of the viral reservoir in people with HIV-1 (PWH) is the main obstacle to an HIV-1 cure. The reservoirs are not transcriptionally silent, and viral transcripts can be detected in most ART-treated individuals. Here, we review the recent progress in the characterization of persistent HIV-1 transcription during ART.
    Recent findings: Evidence from several studies indicates that, although cell-associated unspliced (US) HIV-1 RNA is abundantly expressed in ART-treated PWH, intact full-length US transcripts are rare and most US RNA is derived from defective proviruses. The transcription- and translation-competent defective proviruses, previously considered irrelevant, are increasingly being linked to residual HIV-1 pathogenesis under suppressive ART. Recent data suggest a continuous crosstalk between the residual HIV-1 activity under ART and the immune system. Persistent HIV-1 transcription on ART, despite being mostly derived from defective proviruses, predicts viral rebound upon therapy interruption, suggesting its role as an indicator of the strength of the host antiviral immune response that is shaping the viral rebound.
    Summary: In light of the recent findings, the significance of persistent HIV-1 transcription during ART for the long-term health of PWH and the cure research should be reassessed.
    MeSH term(s) Humans ; HIV Infections/drug therapy ; HIV-1/genetics ; Anti-Retroviral Agents/therapeutic use ; Virus Replication ; Proviruses/genetics ; RNA, Viral/genetics ; CD4-Positive T-Lymphocytes ; Viral Load
    Chemical Substances Anti-Retroviral Agents ; RNA, Viral
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6812: Show issues Location:
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  3. Article: Risk Factors for Late HIV Presentation in Patients Treated at a Single Belgian Reference Centre from 2018 to 2022.

    Scaia, Damien / Fombellida, Karine / Maes, Nathalie / El Moussaoui, Majdouline / Darcis, Gilles

    Infectious disease reports

    2024  Volume 16, Issue 2, Page(s) 239–248

    Abstract: A late HIV diagnosis is associated with increased mortality and morbidity, increased healthcare costs and increased onward viral transmission. In this regard, we retrospectively analysed the characteristics of patients who presented for care at our ... ...

    Abstract A late HIV diagnosis is associated with increased mortality and morbidity, increased healthcare costs and increased onward viral transmission. In this regard, we retrospectively analysed the characteristics of patients who presented for care at our centre from January 2018 to December 2022 to assess the proportion of patients and factors associated with late HIV presentation. We collected data from the Liège University Hospital database, and we used binary logistic regression models to analyse the impact of individuals' characteristics on late presentation. Among 167 participants, 38.3% were late presenters (LPs) (presenting for care with a CD4
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr16020019
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  4. Article: Une cause émergente de fatigue et de douleurs chroniques : l’affection post-COVID-19 ou COVID long.

    El Moussaoui, Majdouline / Guiot, Julien / Frippiat, Frédéric / Darcis, Gilles

    Revue medicale de Liege

    2023  Volume 78, Issue 5-6, Page(s) 299–304

    Abstract: Some individuals who have been infected with SARS-CoV-2 can experience long-term effects from their infection, known as post-COVID conditions, post-acute sequelae of COVID-19 or long COVID. Different underlying mechanisms can lead to long COVID, none of ... ...

    Title translation An emerging cause of chronic fatigue and pain : post-COVID-19 condition or long COVID.
    Abstract Some individuals who have been infected with SARS-CoV-2 can experience long-term effects from their infection, known as post-COVID conditions, post-acute sequelae of COVID-19 or long COVID. Different underlying mechanisms can lead to long COVID, none of which are mutually exclusive. Lingering symptoms can persist years after SARS-CoV-2 infection, including fatigue, muscle weakness, tachycardia, dyspnea and various neurological symptoms. The symptomatology is partly similar to that reported by people with chronic fatigue syndrome and other unwell studied long-lasting diseases that may occur after other infections. People who have experienced more severe COVID-19 illness are at higher risk of developing long COVID, although anyone who was infected can experience post-COVID conditions. Importantly, unvaccinated individuals are more likely to develop long COVID. Here we review the current knowledge and discuss key findings regarding the epidemiology and physiopathology of long COVID. We briefly review current diagnostic and treatment options that remain so far largely insufficient.
    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; Fatigue Syndrome, Chronic/diagnosis ; Fatigue Syndrome, Chronic/epidemiology ; Fatigue Syndrome, Chronic/etiology ; COVID-19/complications ; SARS-CoV-2 ; Pain
    Language French
    Publishing date 2023-06-23
    Publishing country Belgium
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
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    Zs.A 597: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The Current Status of Latency Reversing Agents for HIV-1 Remission.

    Rodari, Anthony / Darcis, Gilles / Van Lint, Carine M

    Annual review of virology

    2021  Volume 8, Issue 1, Page(s) 491–514

    Abstract: Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable HIV-1-infected ... ...

    Abstract Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable HIV-1-infected cellular reservoirs. These reservoirs are mainly composed of CD4
    MeSH term(s) CD4-Positive T-Lymphocytes ; HIV Infections/drug therapy ; HIV-1/physiology ; Humans ; Virus Activation ; Virus Latency
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2764224-0
    ISSN 2327-0578 ; 2327-056X
    ISSN (online) 2327-0578
    ISSN 2327-056X
    DOI 10.1146/annurev-virology-091919-103029
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  6. Article ; Online: Virus-Specific T-Cell Therapy for Viral Infections of the Central Nervous System: A Review.

    Lambert, Nicolas / El Moussaoui, Majdouline / Baron, Frédéric / Maquet, Pierre / Darcis, Gilles

    Viruses

    2023  Volume 15, Issue 7

    Abstract: Opportunistic viral infections of the central nervous system represent a significant cause of morbidity and mortality among an increasing number of immunocompromised patients. Since antiviral treatments are usually poorly effective, the prognosis ... ...

    Abstract Opportunistic viral infections of the central nervous system represent a significant cause of morbidity and mortality among an increasing number of immunocompromised patients. Since antiviral treatments are usually poorly effective, the prognosis generally relies on the ability to achieve timely immune reconstitution. Hence, strategies aimed at reinvigorating antiviral immune activity have recently emerged. Among these, virus-specific T-cells are increasingly perceived as a principled and valuable tool to treat opportunistic viral infections. Here we briefly discuss how to develop and select virus-specific T-cells, then review their main indications in central nervous system infections, including progressive multifocal leukoencephalopathy, CMV infection, and adenovirus infection. We also discuss their potential interest in the treatment of progressive multiple sclerosis, or EBV-associated central nervous system inflammatory disease. We finish with the key future milestones of this promising treatment strategy.
    MeSH term(s) Humans ; Central Nervous System ; Leukoencephalopathy, Progressive Multifocal ; Cytomegalovirus Infections ; Opportunistic Infections ; Central Nervous System Diseases/therapy ; Antiviral Agents/therapeutic use ; Cell- and Tissue-Based Therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15071510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Clinical Outcomes of Third-Generation Cephalosporin Definitive Therapy for Bloodstream Infections Due to Enterobacterales with Potential AmpC Induction: A Single-Center Retrospective Study.

    Vossius, Gilles / Meex, Cécile / Moerman, Filip / Thys, Marie / Ernst, Marie / Bourgeois, Marie-Eve / Wagner, Léa / Delahaye, Thibaut / Darcis, Gilles

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: The recommended therapy for severe infections caused by AmpC-inducible Enterobacterales (AmpC-E) typically involves cefepime or carbapenems. In an era of emerging resistance to these antimicrobials, we aim to assess the impact of third-generation ... ...

    Abstract The recommended therapy for severe infections caused by AmpC-inducible Enterobacterales (AmpC-E) typically involves cefepime or carbapenems. In an era of emerging resistance to these antimicrobials, we aim to assess the impact of third-generation cephalosporins (3GCs) vs. alternative antibiotics on clinical outcomes in bloodstream infections (BSIs) due to AmpC-E. We retrospectively included hospitalized adult patients with BSIs caused by 3GC-susceptible AmpC-E between 2012 and 2022, comparing the outcomes of 3GC and non-3GC definitive therapies. The primary outcome was overall treatment failure (OTF), encompassing 90-day all-cause mortality, 90-day reinfection, and 90-day readmission. Secondary outcomes comprised components of the OTF, in-hospital all-cause mortality, and length-of-stay. Within a total cohort of 353 patients, OTF occurred in 46.5% and 41.5% in the 3GC- and non-3GC-therapy groups, respectively (
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12091152
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  8. Article ; Online: Wild-type HIV infection despite PrEP: a lot to learn from a case report.

    Darcis, Gilles / Moutschen, Michel

    The lancet. HIV

    2018  Volume 5, Issue 1, Page(s) e10

    MeSH term(s) Anti-HIV Agents ; HIV Infections ; Humans ; Pre-Exposure Prophylaxis ; Tenofovir
    Chemical Substances Anti-HIV Agents ; Tenofovir (99YXE507IL)
    Language English
    Publishing date 2018
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(17)30212-6
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  9. Article ; Online: Human Immunodeficiency Virus Resistance to Dolutegravir: Are We Looking in the Wrong Place?

    Darcis, Gilles / Berkhout, Ben

    The Journal of infectious diseases

    2018  Volume 218, Issue 12, Page(s) 2020

    MeSH term(s) HIV Infections ; HIV-1 ; Heterocyclic Compounds, 3-Ring ; Humans
    Chemical Substances Heterocyclic Compounds, 3-Ring ; dolutegravir (DKO1W9H7M1)
    Language English
    Publishing date 2018-08-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiy474
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  10. Article ; Online: The Risk of Underestimating the Contribution of Children to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic.

    Darcis, Gilles / Meuris, Christelle / Kremer, Cécile / Faes, Christel / Hens, Niel

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 74, Issue 4, Page(s) 747

    MeSH term(s) COVID-19 ; Child ; Humans ; Middle East Respiratory Syndrome Coronavirus ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab571
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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