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  1. Article: Where training is valued. Interview by Jennifer Taylor.

    Smallman, Ann / Smith, Valerie / Jopson, Nigel / Flynn, Sheila

    Nursing times

    2008  Volume 104, Issue 5, Page(s) 22–23

    MeSH term(s) Attitude of Health Personnel ; Education, Nursing, Continuing/organization & administration ; Humans ; Inservice Training/organization & administration ; Mandatory Programs/organization & administration ; Motivation ; Nursing Staff/education ; Nursing Staff/psychology ; Organizational Culture ; Organizational Policy ; Private Sector/organization & administration ; State Medicine/organization & administration ; Training Support/organization & administration ; United Kingdom
    Language English
    Publishing date 2008-02
    Publishing country England
    Document type Interview
    ZDB-ID 391202-4
    ISSN 0954-7762 ; 0029-6589
    ISSN 0954-7762 ; 0029-6589
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 428: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 17: Show issues

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  2. Article ; Online: Phenotype versus genotype to optimize cancer dosing in the clinical setting-focus on 5-fluorouracil and tyrosine kinase inhibitors.

    Martin, Jennifer H / Galettis, Peter / Flynn, Alex / Schneider, Jennifer

    Pharmacology research & perspectives

    2024  Volume 12, Issue 2, Page(s) e1182

    Abstract: Cancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival. Determining the optimal dose for each patient is difficult, with body-surface area used most ... ...

    Abstract Cancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival. Determining the optimal dose for each patient is difficult, with body-surface area used most commonly for chemotherapy and flat dosing for tyrosine kinase inhibitors, despite accumulating evidence of a wide range of exposures in individual patients with many receiving a suboptimal dose with these strategies. Therapeutic drug monitoring (measuring the drug concentration in a biological fluid, usually plasma) (TDM) is an accepted and well validated method to guide dose adjustments for individual patients to improve this. However, implementing TDM in routine care has been difficult outside a research context. The development of genotyping of various proteins involved in drug elimination and activity has gained prominence, with several but not all Guideline groups recommending dose reductions for particular variant genotypes. However, there is increasing concern that dosing recommendations are based on limited data sets and may lead to unnecessary underdosing and increased cancer mortality. This Review discusses the evidence surrounding genotyping and TDM to guide decisions around best practice.
    MeSH term(s) Humans ; Fluorouracil ; Tyrosine Kinase Inhibitors ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/chemically induced ; Phenotype ; Genotype
    Chemical Substances Fluorouracil (U3P01618RT) ; Tyrosine Kinase Inhibitors
    Language English
    Publishing date 2024-03-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2740389-0
    ISSN 2052-1707 ; 2052-1707
    ISSN (online) 2052-1707
    ISSN 2052-1707
    DOI 10.1002/prp2.1182
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  3. Article ; Online: Cip1 tunes cell cycle arrest duration upon calcineurin activation.

    Flynn, Mackenzie J / Benanti, Jennifer A

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 23, Page(s) e2202469119

    Abstract: Cells exposed to environmental stress arrest the cell cycle until they have adapted to their new environment. Cells adjust the length of the arrest for each unique stressor, but how they do this is not known. Here, we investigate the role of the stress- ... ...

    Abstract Cells exposed to environmental stress arrest the cell cycle until they have adapted to their new environment. Cells adjust the length of the arrest for each unique stressor, but how they do this is not known. Here, we investigate the role of the stress-activated phosphatase calcineurin (CN) in controlling cell cycle arrest in Saccharomyces cerevisiae. We find that CN controls arrest duration through activation of the G1 cyclin–dependent kinase inhibitor Cip1. Our results demonstrate that multiple stressors trigger a G1/S arrest through Hog1-dependent down-regulation of G1 cyclin transcription. When a stressor also activates CN, this arrest is lengthened as CN prolongs Hog1-dependent phosphorylation of Cip1. Cip1 plays no role in response to stressors that activate Hog1 but not CN. These findings illustrate how stress response pathways cooperate to tailor the stress response and suggest that Cip1 functions to prolong cell cycle arrest when a cell requires additional time for adaptation.
    MeSH term(s) Calcineurin/metabolism ; Cell Cycle/physiology ; Cell Cycle Checkpoints ; Cell Cycle Proteins/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Cell Cycle Proteins ; Cip1 protein, S cerevisiae ; Cyclin-Dependent Kinase Inhibitor p21 ; Saccharomyces cerevisiae Proteins ; Calcineurin (EC 3.1.3.16)
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2202469119
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Determining a Worldwide Prevalence of Oculocutaneous Albinism: A Systematic Review.

    Kromberg, Jennifer G R / Flynn, Kaitlyn A / Kerr, Robyn A

    Investigative ophthalmology & visual science

    2023  Volume 64, Issue 10, Page(s) 14

    Abstract: Purpose: The aim of this systematic review was to investigate the available data on the epidemiology of oculocutaneous albinism (OCA) around the world, and to determine whether a generalizable, worldwide prevalence figure could be proposed.: Methods: ...

    Abstract Purpose: The aim of this systematic review was to investigate the available data on the epidemiology of oculocutaneous albinism (OCA) around the world, and to determine whether a generalizable, worldwide prevalence figure could be proposed.
    Methods: Extensive literature search strategies were conducted, interrogating PubMed, Scopus, and Web of Science, to locate relevant literature. Ultimately 34 studies reporting original data were included for analysis.
    Results: Findings showed that most data were outdated, and only 6 of 34 articles (18%) were published after 2010. There were few good studies with sound methodology and large, clearly defined population samples. Only a small proportion of countries worldwide (26/193 [13%]) have produced prevalence figures for OCA. By continent, African studies were disproportionately represented (15/34 [44%]). The highest prevalence rates (range, 1 in 22 to 1 in 1300; mean, 1 in 464) were reported in population isolates. The mean prevalence from four African countries was 1 in 4264 (range, 1 in 1755 to 1 in 7900). Prevalence for three countries in Europe (mean, 1 in 12,000; range, 1 in 10,000 to 1 in 15,000) may be underestimated, as the phenotype, in fair-skinned populations, may be missed or misdiagnosed as ocular albinism or isolated visual impairment. Population rates may vary depending on local cultural factors (e.g., consanguineous matings) and may change over time.
    Conclusions: The prevalence of OCA varies widely between continents and population groups, and it is often influenced by local factors. It was not possible, therefore, to determine a single, generalizable worldwide prevalence rate for OCA, although continental rates for Africa and Europe are useful.
    MeSH term(s) Humans ; Mutation ; Prevalence ; Albinism, Oculocutaneous/epidemiology ; Albinism, Oculocutaneous/diagnosis ; Phenotype ; Albinism, Ocular/epidemiology ; Albinism, Ocular/genetics
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.64.10.14
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 45: Show issues Location:
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  5. Article: Paclitaxel and Therapeutic Drug Monitoring with Microsampling in Clinical Practice.

    Radovanovic, Mirjana / Galettis, Peter / Flynn, Alex / Martin, Jennifer H / Schneider, Jennifer J

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 17, Issue 1

    Abstract: Paclitaxel is an anticancer agent efficacious in various tumors. There is large interindividual variability in drug plasma concentrations resulting in a wide variability in observed toxicity in patients. Studies have shown the time the concentration of ... ...

    Abstract Paclitaxel is an anticancer agent efficacious in various tumors. There is large interindividual variability in drug plasma concentrations resulting in a wide variability in observed toxicity in patients. Studies have shown the time the concentration of paclitaxel exceeds 0.05 µM is a predictive parameter of toxicity, making dose individualization potentially useful in reducing the adverse effects. To determine paclitaxel drug concentration, a venous blood sample collected 24 h following the end of infusion is required, often inconvenient for patients. Alternatively, using a microsampling device for self-sampling would facilitate paclitaxel monitoring regardless of the patient's location. We investigated the feasibility of collecting venous and capillary samples (using a Mitra
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010063
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  6. Article ; Online: Artificial intelligence-driven approach for patient-focused drug development.

    Karmalkar, Prathamesh / Gurulingappa, Harsha / Spies, Erica / Flynn, Jennifer A

    Frontiers in artificial intelligence

    2023  Volume 6, Page(s) 1237124

    Abstract: Patients' increasing digital participation provides an opportunity to pursue patient-centric research and drug development by understanding their needs. Social media has proven to be one of the most useful data sources when it comes to understanding a ... ...

    Abstract Patients' increasing digital participation provides an opportunity to pursue patient-centric research and drug development by understanding their needs. Social media has proven to be one of the most useful data sources when it comes to understanding a company's potential audience to drive more targeted impact. Navigating through an ocean of information is a tedious task where techniques such as artificial intelligence and text analytics have proven effective in identifying relevant posts for healthcare business questions. Here, we present an enterprise-ready, scalable solution demonstrating the feasibility and utility of social media-based patient experience data for use in research and development through capturing and assessing patient experiences and expectations on disease, treatment options, and unmet needs while creating a playbook for roll-out to other indications and therapeutic areas.
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2624-8212
    ISSN (online) 2624-8212
    DOI 10.3389/frai.2023.1237124
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  7. Article ; Online: Rural health and rural industries: Opportunities for partnership and action.

    Scott, Kenneth A / Elliott, K C / Lincoln, Jennifer / Flynn, Michael A / Hill, Ryan / Hall, Diane M

    The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association

    2023  Volume 40, Issue 2, Page(s) 401–405

    MeSH term(s) Humans ; Rural Health ; Rural Health Services ; Community-Based Participatory Research ; Rural Population
    Language English
    Publishing date 2023-09-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 639160-6
    ISSN 1748-0361 ; 0890-765X
    ISSN (online) 1748-0361
    ISSN 0890-765X
    DOI 10.1111/jrh.12791
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    Zs.B 3102: Show issues Location:
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  8. Article: Calcineurin promotes adaptation to chronic stress through two distinct mechanisms.

    Flynn, Mackenzie J / Harper, Nicholas W / Li, Rui / Zhu, Lihua Julie / Lee, Michael J / Benanti, Jennifer A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Adaptation to environmental stress requires coordination between stress-defense programs and cell cycle progression. The immediate response to many stressors has been well characterized, but how cells survive in challenging environments long-term is ... ...

    Abstract Adaptation to environmental stress requires coordination between stress-defense programs and cell cycle progression. The immediate response to many stressors has been well characterized, but how cells survive in challenging environments long-term is unknown. Here, we investigate the role of the stress-activated phosphatase calcineurin (CN) in adaptation to chronic CaCl
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.19.585797
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  9. Article ; Online: Artificial intelligence-driven approach for patient-focused drug development

    Prathamesh Karmalkar / Harsha Gurulingappa / Erica Spies / Jennifer A. Flynn

    Frontiers in Artificial Intelligence, Vol

    2023  Volume 6

    Abstract: Patients' increasing digital participation provides an opportunity to pursue patient-centric research and drug development by understanding their needs. Social media has proven to be one of the most useful data sources when it comes to understanding a ... ...

    Abstract Patients' increasing digital participation provides an opportunity to pursue patient-centric research and drug development by understanding their needs. Social media has proven to be one of the most useful data sources when it comes to understanding a company's potential audience to drive more targeted impact. Navigating through an ocean of information is a tedious task where techniques such as artificial intelligence and text analytics have proven effective in identifying relevant posts for healthcare business questions. Here, we present an enterprise-ready, scalable solution demonstrating the feasibility and utility of social media-based patient experience data for use in research and development through capturing and assessing patient experiences and expectations on disease, treatment options, and unmet needs while creating a playbook for roll-out to other indications and therapeutic areas.
    Keywords patient-focused drug development ; artificial intelligence ; patient experience ; text analytics ; unmet needs ; natural language processing ; Electronic computers. Computer science ; QA75.5-76.95
    Subject code 401
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Reported xylazine exposure highly associated with overdose outcomes in a rapid community assessment among people who inject drugs in Baltimore.

    German, Danielle / Genberg, Becky / Sugarman, Olivia / Saloner, Brendon / Sawyer, Anne / Glick, Jennifer L / Gribbin, Molly / Flynn, Colin

    Harm reduction journal

    2024  Volume 21, Issue 1, Page(s) 18

    Abstract: Background: Addressing xylazine harms are now a critical harm reduction priority, but relatively little epidemiological information exists to determine prevalence, magnitude, and correlates of xylazine use or related outcomes.: Methods: We conducted ... ...

    Abstract Background: Addressing xylazine harms are now a critical harm reduction priority, but relatively little epidemiological information exists to determine prevalence, magnitude, and correlates of xylazine use or related outcomes.
    Methods: We conducted a rapid behavioral survey among people who inject drugs (n = 96) in Baltimore November-December 2022. Using a novel indicator of self-reported presumed xylazine effects, we examined prevalence and sociodemographic correlates of past year presumed xylazine effects and association with overdose and wound-related outcomes. Chi-square and descriptive statistics were used to examine bivariate associations overall and separately for those who reported xylazine by name and by reported fentanyl use frequency.
    Results: Almost two-thirds (61.5%) reported experiencing xylazine effects. There were no differences by socio-demographics, but xylazine effects were more commonly reported among those who reported injecting alone (66% vs 38%%, p < 0.007) and daily fentanyl use (47% vs 24% p < 0.003). Those reporting xylazine exposure was three times as likely to report overdose (32% vs 11%, p < 0.03) and twice as likely to have used naloxone (78% vs 46%, p < 0.003). They also more commonly reported knowing someone who died of an overdose (92% vs 76%, p < 0.09) and to report an abscess requiring medical attention (36% vs 19%, p < 0.80). These associations were higher among respondents who specifically named xylazine and those who used fentanyl more frequently, but fentanyl frequency did not fully explain the heightened associations with xylazine effects.
    Conclusions: This study provides insight into the scope of xylazine exposure and associated health concerns among community-based PWID and suggests measures that may be instrumental for urgently needed research.
    MeSH term(s) Humans ; Xylazine ; Baltimore/epidemiology ; Drug Users ; Drug Overdose ; Fentanyl
    Chemical Substances Xylazine (2KFG9TP5V8) ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2146691-9
    ISSN 1477-7517 ; 1477-7517
    ISSN (online) 1477-7517
    ISSN 1477-7517
    DOI 10.1186/s12954-024-00940-z
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