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Article: Acute Kidney Injury Following Naphthalene (Mothball) Poisoning.

Mathur, Piyush / Garg, Shalini

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2024 Volume 34, Issue 3, Page(s) 259–264

Abstract: Naphthalene is a widely available moth repellant in the Asian subcontinent. Toxicity can occur either accidentally or intentionally as a suicide attempt. An overdose can lead to a variety of clinical symptoms, including intravascular hemolysis, and can ... ...

Abstract	Naphthalene is a widely available moth repellant in the Asian subcontinent. Toxicity can occur either accidentally or intentionally as a suicide attempt. An overdose can lead to a variety of clinical symptoms, including intravascular hemolysis, and can sometimes lead to life-threatening clinical situations. A young male was admitted to our center with an alleged history of ingesting an unknown quantity of naphthalene balls (mothballs). He developed methemoglobinemia, intra-vascular hemolysis, anuria, and acute kidney injury (AKI), followed by cardiorespiratory arrest. He was treated successfully with intravenous methylene blue and dialysis. Naphthalene toxicity can lead to methemoglobinemia and intravascular hemolysis. This can result in AKI caused by pigment nephropathy.
MeSH term(s)	Humans ; Male ; Hemolysis ; Methemoglobinemia/chemically induced ; Methemoglobinemia/diagnosis ; Methemoglobinemia/therapy ; Methylene Blue ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Naphthalenes
Chemical Substances	Methylene Blue (T42P99266K) ; naphthalene (2166IN72UN) ; Naphthalenes
Language	English
Publishing date	2024-01-17
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.394000
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Article ; Online: Super-hydrophilic LaCoO

Rathore, Lokesh Kumar / Garg, Parul / Kumar, Piyush / Bera, Ashok

Nanoscale

2024 Volume 16, Issue 5, Page(s) 2599–2607

Abstract: Interfacial solar steam generation (ISSG) is emerging as a promising, environment-friendly solution for fulfilling freshwater and energy demands. However, a critical challenge for ISSG lies in the presence of harmful volatile organic compounds (VOCs) in ... ...

Abstract	Interfacial solar steam generation (ISSG) is emerging as a promising, environment-friendly solution for fulfilling freshwater and energy demands. However, a critical challenge for ISSG lies in the presence of harmful volatile organic compounds (VOCs) in the feedwater which are co-evaporated with water, leading to more enriched concentration in condensed water. Herein, lanthanum cobaltate-graphitic carbon nitride (LaCoO
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr04951e
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Article: Dosimetric Comparison of the Heart and Left Anterior Descending Artery in Patients With Left Breast Cancer Treated With Three-Dimensional Conformal and Intensity-Modulated Radiotherapy.

Garg, Ayush / Kumar, Piyush

Cureus

2022 Volume 14, Issue 1, Page(s) e21108

Abstract: Background Adjuvant radiotherapy plays an important role in the management of breast cancer, along with surgery and chemotherapy. However, postoperative radiotherapy poses an increased risk of radiation-induced heart diseases in patients with left-sided ... ...

Abstract	Background Adjuvant radiotherapy plays an important role in the management of breast cancer, along with surgery and chemotherapy. However, postoperative radiotherapy poses an increased risk of radiation-induced heart diseases in patients with left-sided breast cancer due to damage of the coronary arteries, which can cause myocardial fibrosis and coronary artery disease; however, there is a lack of sufficient evidence for it. Hence, the present study aimed to assess the dosimetric parameters of the heart and left anterior descending (LAD) coronary artery in patients with left breast cancer treated with three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT). Methodology This study included 20 patients with left-sided breast cancer treated between January and July 2019. Patients were equally divided into two groups as follows: group I included those treated with 3DCRT and group II included those treated with IMRT. Radiotherapy was administered to the chest wall and regional lymph nodes. The dose administered for the planning target volume was 50 Gy in 25 daily fractions over five weeks with 6 MV photons. Dosimetric parameters of planning tumor volume (PTV; V95%, V90%, Dmax, Dmin, Dmean, V53.5 Gy, conformity index, and homogeneity index) along with the heart (V5%, V30%, and Dmean) and LAD artery (mean and V25%) were evaluated. Dose-volume histograms were generated and compared. The LAD artery was contoured virtually retrospectively during the study to determine the dosimetric parameters; the dose to the LAD artery was not considered during planning. Results Dosimetric parameters of the PTV were similar for 3DCRT and IMRT; D95 (38.53 vs. 41.61 Gy), D90 (43.67 vs. 44.77 Gy), Dmean (48.3 vs. 48.72 Gy), conformity index (1.10 vs. 1.06), and homogeneity index (0.50 and 0.28) did not show a significant difference. The Dmean for the LAD artery was significantly higher than that for the heart on 3DCRT (23.66 Gy vs. 8.46 Gy; p < 0.0000) and IMRT (31.53 vs. 17.7 Gy; p < 0.0000). The V25 for the LAD artery was significantly higher than that for the heart on 3DCRT (40.27 vs. 14.13 Gy; p < 0.0024) and IMRT (66.21 vs. 27.74 Gy; p < 0.0002). Conclusions Radiation doses to the LAD artery and heart must be evaluated prior to radiotherapy in patients with left breast cancer. Long-term follow-up is needed to evaluate cardiac complications and their association with dosimetric parameters.
Language	English
Publishing date	2022-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.21108
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Article: Thyroid Autoimmunity in Vitiligo: A Case-Control Study.

Prashant, Praveen / Garg, Renu / Bansal, Piyush / Praveen, Sonia

Cureus

2023 Volume 15, Issue 1, Page(s) e34031

Abstract: Introduction There is scanty evidence regarding the role of autoimmunity in vitiligo, especially in the Asian population. Moreover, the existing studies reported conflicting results. This prompted the investigators to identify the association of thyroid ... ...

Abstract	Introduction There is scanty evidence regarding the role of autoimmunity in vitiligo, especially in the Asian population. Moreover, the existing studies reported conflicting results. This prompted the investigators to identify the association of thyroid autoimmunity with vitiligo by employing a case-control design in this setting. Methodology The present study was a hospital-based case-control study conducted in one of the tertiary care hospitals of North India. We recruited 30 subjects aged 16-60 years with vitiligo attending the skin and venereal diseases outpatient department. The subjects attending the general medicine outpatient department without having a diagnosis of vitiligo were considered for the control group. Thyroid hormones (FT3 and FT4), thyroid-stimulating hormones, anti-thyroid peroxidase (anti-TPO) antibodies, and anti-thyroglobulin (anti-TG) antibodies were the primary investigations performed among the study subjects. Results The mean age of the study subjects was 31.3 (SD: 13.3) years. Both the case and control groups were comparable based on selected socio-demographic variables (p > 0.05). There was a statistically significant difference in terms of mean anti-TPO and anti-TG values between the case and control groups in which subjects with vitiligo reported significantly higher values (p < 0.05). Conclusion Our study reported a significant elevation in the mean values of the thyroid antibodies (anti-TG and anti-TPO antibodies) in vitiligo subjects compared to control subjects in this setting. Hence, screening for autoimmune thyroid diseases among patients with vitiligo is suggested for the early detection and the initiation of appropriate intervention.
Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34031
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Book ; Online: TONE

Gupta, Srishti / Garg, Piyush Kumar / Dandapat, Sourav Kumar

A 3-Tiered ONtology for Emotion analysis

2024

Abstract: Emotions have played an important part in many sectors, including psychology, medicine, mental health, computer science, and so on, and categorizing them has proven extremely useful in separating one emotion from another. Emotions can be classified using ...

Abstract	Emotions have played an important part in many sectors, including psychology, medicine, mental health, computer science, and so on, and categorizing them has proven extremely useful in separating one emotion from another. Emotions can be classified using the following two methods: (1) The supervised method's efficiency is strongly dependent on the size and domain of the data collected. A categorization established using relevant data from one domain may not work well in another. (2) An unsupervised method that uses either domain expertise or a knowledge base of emotion types already exists. Though this second approach provides a suitable and generic categorization of emotions and is cost-effective, the literature doesn't possess a publicly available knowledge base that can be directly applied to any emotion categorization-related task. This pushes us to create a knowledge base that can be used for emotion classification across domains, and ontology is often used for this purpose. In this study, we provide TONE, an emotion-based ontology that effectively creates an emotional hierarchy based on Dr. Gerrod Parrot's group of emotions. In addition to ontology development, we introduce a semi-automated vocabulary construction process to generate a detailed collection of terms for emotions at each tier of the hierarchy. We also demonstrate automated methods for establishing three sorts of dependencies in order to develop linkages between different emotions. Our human and automatic evaluation results show the ontology's quality. Furthermore, we describe three distinct use cases that demonstrate the applicability of our ontology.
Keywords	Computer Science - Artificial Intelligence
Subject code	006
Publishing date	2024-01-10
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epidemiology of Panton Valentine Leukocidin in clinical Staphylococcus aureus isolates - A prospective study at a tertiary care centre in North India

Rani Jaiswal / Aditi Garg / Piyush Tripathi / Vimala Venkatesh

Clinical Epidemiology and Global Health, Vol 15, Iss , Pp 101006- (2022)

2022

Abstract: Background: Staphylococcus aureus is a cause of wide range of infections. The pathogenicity of Staphylococcus aureus is related to a number of virulence factors. Panton-Valentine Leukocidin (PVL), a cytolysin that has the ability of leukocyte destruction ...

Abstract	Background: Staphylococcus aureus is a cause of wide range of infections. The pathogenicity of Staphylococcus aureus is related to a number of virulence factors. Panton-Valentine Leukocidin (PVL), a cytolysin that has the ability of leukocyte destruction and tissue necrosis is one such virulence factor determining the pathogenicity of Staphylococcus aureus infections. This study aims to know the distribution of pvl gene in various clinical specimens and associate pvl gene with antimicrobial resistance in Staphylococcus aureus, particularly MRSA. Methods: Consecutive clinical samples including pus, blood, respiratory samples and body fluids received in laboratory, during the study period, which gave growth of Staphylococcus aureus were included in the study. Further antibiotic sensitivity testing was done using CLSI guidelines. Detection of pvl gene was done by extraction of DNA using boiling method followed by conventional PCR. The amplified DNA was analysed by 264 nm wavelength UV transillumination via Gel Electrophoresis. Results: Out of 258 Staphylococcus aureus pvl gene was detected in 24.03%(62/258, p < 0.05). The distribution of PVL in Staphylococcus aureus isolates among various clinical samples was 29.9% in pus samples, 12% blood culture samples, 26.4% in respiratory samples. Only 1 of 5 body fluid Staphylococcus aureus isolate detected PVL. Out of 62 pvl gene positive isolates 79% of were MRSA and 20.9% were Methicillin sensitive. Conclusion: Association with pvl gene was significantly higher in skin and soft tissue infection but it also detected in blood stream infection and pneumonia, which indicate association of pvl gene with invasive infection.
Keywords	PVL ; Staphylococcus aureus ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Feasibility of Achieving Dose Constraints for Dysphagia Aspiration-Related Structures and Its Clinical Significance in Intensity-Modulated Radiotherapy Planning of Head and Neck Cancer.

Agarwal, Karishma / Kumar, Piyush / S, Navitha / Kumar, Pavan / Garg, Ayush / Nigam, Jitendra / N S, Silambarasan

Cureus

2024 Volume 16, Issue 2, Page(s) e53769

Abstract: Introduction Dysphagia is commonly seen in patients with head and neck cancers after undergoing chemoradiotherapy and is often under-reported and also not given clinical importance. The quality of life of the patients can be significantly improved if the ...

Abstract	Introduction Dysphagia is commonly seen in patients with head and neck cancers after undergoing chemoradiotherapy and is often under-reported and also not given clinical importance. The quality of life of the patients can be significantly improved if the required dose constraints to the dysphagia aspiration-related structures (DARS) are achieved. The present study was conducted in order to determine the feasibility of achieving the dose constraints to DARS between the standard intensity-modulated radiotherapy (st-IMRT) arm and the dysphagia-optimized IMRT (do-IMRT) arm. Material and methods Sixty patients with head and neck cancer were recruited and randomized into two groups: In one group called the st-IMRT, constraints were not given to DARS, and in the other group called the do-IMRT, constraints were given to DARS. Treatment was given in the form of chemoradiation with a dose of 70 Gy in 35 fractions by IMRT technique, over seven weeks, 2 Gy per fraction along with weekly concurrent Cisplatin (35 mg/m
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53769
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Book ; Online: PORTRAIT

Garg, Piyush Kumar / Chakraborty, Roshni / Dandapat, Sourav Kumar

a hybrid aPproach tO cReate extractive ground-TRuth summAry for dIsaster evenT

2023

Abstract: Disaster summarization approaches provide an overview of the important information posted during disaster events on social media platforms, such as, Twitter. However, the type of information posted significantly varies across disasters depending on ... ...

Abstract	Disaster summarization approaches provide an overview of the important information posted during disaster events on social media platforms, such as, Twitter. However, the type of information posted significantly varies across disasters depending on several factors like the location, type, severity, etc. Verification of the effectiveness of disaster summarization approaches still suffer due to the lack of availability of good spectrum of datasets along with the ground-truth summary. Existing approaches for ground-truth summary generation (ground-truth for extractive summarization) relies on the wisdom and intuition of the annotators. Annotators are provided with a complete set of input tweets from which a subset of tweets is selected by the annotators for the summary. This process requires immense human effort and significant time. Additionally, this intuition-based selection of the tweets might lead to a high variance in summaries generated across annotators. Therefore, to handle these challenges, we propose a hybrid (semi-automated) approach (PORTRAIT) where we partly automate the ground-truth summary generation procedure. This approach reduces the effort and time of the annotators while ensuring the quality of the created ground-truth summary. We validate the effectiveness of PORTRAIT on 5 disaster events through quantitative and qualitative comparisons of ground-truth summaries generated by existing intuitive approaches, a semi-automated approach, and PORTRAIT. We prepare and release the ground-truth summaries for 5 disaster events which consist of both natural and man-made disaster events belonging to 4 different countries. Finally, we provide a study about the performance of various state-of-the-art summarization approaches on the ground-truth summaries generated by PORTRAIT using ROUGE-N F1-scores.
Keywords	Computer Science - Computation and Language ; Computer Science - Social and Information Networks
Subject code	410 ; 710
Publishing date	2023-05-19
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Simultaneous transcatheter dual valve replacement (mitral and tricuspid valves): a case report.

Garg, Piyush / Chouhan, Nagendra / Wander, Gagandeep S / Chandra, Praveen / Kashyap, Rahul

European heart journal. Case reports

2023 Volume 7, Issue 8, Page(s) ytad344

Abstract: Background: Structural valve dysfunction in bioprosthetic heart valves necessitates redo replacement procedure that are associated with high mortality and morbidity. The transcatheter valve-in-valve (VIV) approach has emerged as a preferred option for ... ...

Abstract	Background: Structural valve dysfunction in bioprosthetic heart valves necessitates redo replacement procedure that are associated with high mortality and morbidity. The transcatheter valve-in-valve (VIV) approach has emerged as a preferred option for patients requiring redo procedures due to structural valve degeneration. We report from India the first case of the simultaneous transcatheter dual VIV implantation (mitral valve and tricuspid valves) in a high-surgical-risk patient. Case summary: A 57-year-old female was presented with a history of rheumatic heart disease, post-mitral valve as well as tricuspid valve replacement (perimount 33 mm) 11 years back. Bioprosthetic heart valve was chosen probably due to limited life expectancy and compliance issues with monitoring of international normalised ratio (INR). She now presented with progressive dyspnoea, oedema, and palpitations (New York Heart Association Class III) for the last 6 months. The patient was scheduled for transcatheter dual valve replacement simultaneously. The procedure was successful with a favourable outcome, short hospital stays, and early recovery. Discussion: This is the first case of simultaneous transcatheter dual valve replacement reported from India, which is fluoroscopically guided and supported by TEE. It is a valuable and considerable option for patients with failing bioprosthesis valves who are at increased peri-operative risk.
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad344
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Article: A Rapid Screening Platform for Simultaneous Evaluation of Biodegradation and Therapeutic Release of an Ocular Hydrogel.

Ho, Brandon / Phan, Chau-Minh / Garg, Piyush / Shokrollahi, Parvin / Jones, Lyndon

Pharmaceutics

2023 Volume 15, Issue 11

Abstract: This study attempts to address the challenge of accurately measuring the degradation of biodegradable hydrogels, which are frequently employed in drug delivery for controlled and sustained release. The traditional method utilizes a mass-loss approach, ... ...

Abstract	This study attempts to address the challenge of accurately measuring the degradation of biodegradable hydrogels, which are frequently employed in drug delivery for controlled and sustained release. The traditional method utilizes a mass-loss approach, which is cumbersome and time consuming. The aim of this study was to develop an innovative screening platform using a millifluidic device coupled with automated image analysis to measure the degradation of Gelatin methacrylate (GelMA) and the subsequent release of an entrapped wetting agent, polyvinyl alcohol (PVA). Gel samples were placed within circular wells on a custom millifluidic chip and stained with a red dye for enhanced visualization. A camera module captured time-lapse images of the gels throughout their degradation. An image-analysis algorithm was used to translate the image data into degradation rates. Simultaneously, the eluate from the chip was collected to quantify the amount of GelMA degraded and PVA released at various time points. The visual method was validated by comparing it with the mass-loss approach (R = 0.91), as well as the amount of GelMA eluted (R = 0.97). The degradation of the GelMA gels was also facilitated with matrix metalloproteinases 9. Notably, as the gels degraded, there was an increase in the amount of PVA released. Overall, these results support the use of the screening platform to assess hydrogel degradation and the subsequent release of entrapped therapeutic compounds.
Language	English
Publishing date	2023-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15112625
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