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Article ; Online: Re: positive surgical margins in robot-assisted partial nephrectomy: a multi-institutional analysis of oncologic outcomes (leave no tumor behind): A. Khalifeh, J. H. Kaouk, S. Bhayani, C. Rogers, m. Stifelman, Y. S. Tanagho, R. Kumar, M. A. Gorin, G. Sivarajan, D. Samarasekera and M. E. Allaf J Urol 2013;190:1674-1679.

Goldfarb, Robert / Adejoro, Oluwakayode / Lane, Brian / Kim, Simon P / Weight, Christopher

2014 Volume 192, Issue 1, Page(s) 278–279

MeSH term(s)	Female ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Nephrectomy/methods ; Robotics
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2013.12.055
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Zs.MO 331: Show issues

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Article ; Online: Multiscale engineered human skeletal muscles with perfusable vasculature and microvascular network recapitulating the fluid compartments.

Kim, Hyeonyu / Osaki, Tatsuya / Kamm, Roger D / Asada, H Harry

Biofabrication

2022 Volume 15, Issue 1

Abstract: Creating a vasculature in engineered human skeletal muscle tissues (ehSMTs) enables us to create thick tissues, increase cell survival in implantation, provide models of blood-organ barriers for drug testing, and enhance muscle differentiation through ... ...

Abstract	Creating a vasculature in engineered human skeletal muscle tissues (ehSMTs) enables us to create thick tissues, increase cell survival in implantation, provide models of blood-organ barriers for drug testing, and enhance muscle differentiation through paracrine signaling. Here, contractile ehSMTs with a central perfusable vascular channel and microvascular networks growing from this central vasculature into the surrounding skeletal muscle tissue were newly demonstrated. Because coculturing muscle cells and endothelial cells requires incompatible media, we recapitulated thein vivoextracellular fluid compartments between blood plasma and interstitial fluid by creating anin vitroperfusable vasculature running through skeletal muscle tissue with a physiologic cell density. By using this model, we constructed large vascularized ehSMTs and showed the potential to be utilized for drug testing platforms. Also, we found that coculturing with two separate media from an early stage of muscle differentiation led to increased contractile force, thicker myotubes, and improved muscle differentiation.
MeSH term(s)	Humans ; Tissue Engineering ; Endothelial Cells/physiology ; Neovascularization, Physiologic ; Microvessels ; Muscle, Skeletal/physiology
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2500944-8
ISSN	1758-5090 ; 1758-5082
ISSN (online)	1758-5090
ISSN	1758-5082
DOI	10.1088/1758-5090/ac933d
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Article ; Online: Tri-culture of spatially organizing human skeletal muscle cells, endothelial cells, and fibroblasts enhances contractile force and vascular perfusion of skeletal muscle tissues.

Kim, Hyeonyu / Osaki, Tatsuya / Kamm, Roger D / Asada, H Harry

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2022 Volume 36, Issue 8, Page(s) e22453

Abstract: Constructing engineered human skeletal muscle tissues that resemble the function and microstructure of human skeletal muscles is key to utilizing them in a variety of applications such as drug development, disease modeling, regenerative medicine, and ... ...

Abstract	Constructing engineered human skeletal muscle tissues that resemble the function and microstructure of human skeletal muscles is key to utilizing them in a variety of applications such as drug development, disease modeling, regenerative medicine, and engineering biological machines. However, current in vitro skeletal muscle tissues are far inferior to native muscles in terms of contractile function and lack essential cues for muscle functions, particularly heterotypic cell-cell interactions between myoblasts, endothelial cells, and fibroblasts. Here, we develop an engineered muscle tissue with a coaxial three-layered tubular structure composed of an inner endothelial cell layer, an endomysium-like layer with fibroblasts in the middle, and an outer skeletal muscle cell layer, similar to the architecture of native skeletal muscles. Engineered skeletal muscle tissues with three spatially organized cell types produced thicker myotubes and lowered Young's modulus through extracellular matrix remodeling, resulting in 43% stronger contractile force. Furthermore, we demonstrated that fibroblasts localized in the endomysium layer induced angiogenic sprouting of endothelial cells into the muscle layer more effectively than fibroblasts homogeneously distributed in the muscle layer. This layered tri-culture system enables a structured spatial configuration of the three main cell types of skeletal muscle and promotes desired paracrine signaling, resulting in improved angiogenesis and increased contractile force. This research offers new insights to efficiently obtain new human skeletal muscle models, transplantable tissues, and actuators for biological machines.
MeSH term(s)	Endothelial Cells ; Fibroblasts ; Humans ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism ; Perfusion ; Tissue Engineering/methods
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202200500R
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Article ; Online: Employment conditions and mental health of overseas female migrant domestic workers in Hong Kong: a parallel mediation analysis.

Sumerlin, Timothy S / Kim, Jean H / Hui, Alvin Yik-Kiu / Chan, Dicken / Liao, Tim / Padmadas, Sabu / Fong, Eric / Chung, Roger Y

International journal for equity in health

2024 Volume 23, Issue 1, Page(s) 8

Abstract: Background: Female migrant domestic workers (MDW), approximately 8.5 million globally, often live in their employer's home under vulnerable conditions. In Hong Kong, MDWs currently comprise 5% of the population. This study was conducted to assess the ... ...

Abstract	Background: Female migrant domestic workers (MDW), approximately 8.5 million globally, often live in their employer's home under vulnerable conditions. In Hong Kong, MDWs currently comprise 5% of the population. This study was conducted to assess the association between employment conditions and mental health, and the mediating roles stress and job satisfaction have, among female MDWs in Hong Kong. Methods: Participants completed an online cross-sectional survey. A total of 1,965 survey were collected between August 2020 and August 2021. Questions in the survey were related to MDWs background information, employment conditions, stress, job satisfaction, and two mental health outcomes: anxiety and depression. An employment conditions score was created to assess the cumulative effect poor employment conditions had on mental health. A multicategorical parallel mediation analysis was used to assess the direct effect employment conditions have on mental health and the indirect effects through stress and job satisfaction. Results: Overall, 17.7% of MDWs were reported to be suffering from anxiety and 30.8% from depression. An increase in poor employment conditions was statistically associated with an increase in both outcomes, while stress levels and job satisfaction mediated this association. Conclusions: The findings call for increased scrutiny of employment conditions and mental well-being of MDWs.
MeSH term(s)	Humans ; Female ; Hong Kong/epidemiology ; Mental Health ; Transients and Migrants ; Cross-Sectional Studies ; Mediation Analysis ; Employment/psychology
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2092056-8
ISSN	1475-9276 ; 1475-9276
ISSN (online)	1475-9276
ISSN	1475-9276
DOI	10.1186/s12939-024-02098-3
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Article ; Online: Educational strategies to foster bedside teaching.

Kim, Roger H / Mellinger, John D

Surgery

2019 Volume 167, Issue 3, Page(s) 532–534

Abstract: Owing to increasing external pressures on both faculty and learners, the practice of bedside teaching is declining. The objective of this paper is to provide an overview of educational strategies to foster bedside teaching in the current clinical ... ...

Abstract	Owing to increasing external pressures on both faculty and learners, the practice of bedside teaching is declining. The objective of this paper is to provide an overview of educational strategies to foster bedside teaching in the current clinical practice environment for surgical educators. General strategies include building a culture within the program that promotes the atmosphere of a learning community, and providing scaffolding for trainees that fosters gradual progression to autonomous practice. Specific techniques for bedside teaching include CAMEO, the "one-minute preceptor", and mini-presentations or peer-teaching. The intentional and proactive implementation of these strategies alongside others can assist educators in capturing the "redeemable moments" that occur in the course of routine clinical care at the patient's bedside.
MeSH term(s)	Educational Measurement/methods ; Faculty ; Humans ; Internship and Residency/methods ; Learning ; Peer Group ; Specialties, Surgical/education ; Teaching
Language	English
Publishing date	2019-07-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2019.06.007
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Article ; Online: Determinants of COVID-19 Vaccine Uptake among Female Foreign Domestic Workers in Hong Kong: A Cross-Sectional Quantitative Survey.

Sumerlin, Timothy S / Kim, Jean H / Wang, Zixin / Hui, Alvin Yik-Kiu / Chung, Roger Y

International journal of environmental research and public health

2022 Volume 19, Issue 10

Abstract: Globally, minority groups and non-citizens may not be sufficiently included in the COVID-19 vaccine coverage. This study seeks to understand determinants of vaccine uptake among female foreign domestic workers (FDWs) in Hong Kong. We conducted a cross- ... ...

Abstract	Globally, minority groups and non-citizens may not be sufficiently included in the COVID-19 vaccine coverage. This study seeks to understand determinants of vaccine uptake among female foreign domestic workers (FDWs) in Hong Kong. We conducted a cross-sectional study of female FDWs (
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Cross-Sectional Studies ; Female ; Hong Kong/epidemiology ; Humans ; Influenza Vaccines
Chemical Substances	COVID-19 Vaccines ; Influenza Vaccines
Language	English
Publishing date	2022-05-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19105945
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Article ; Online: An Exploratory, Randomized, Double-Blind Clinical Trial of Dipraglurant for Blepharospasm.

Kilic-Berkmen, Gamze / Kim, Hodam / Chen, Dongdong / Yeo, Cameron I / Dinasarapu, Ashok R / Scorr, Laura M / Yeo, Woon-Hong / Peterson, David A / Williams, Hilde / Ruby, April / Mills, Roger / Jinnah, H A

Movement disorders : official journal of the Movement Disorder Society

2024 Volume 39, Issue 4, Page(s) 738–745

Abstract: Background: Blepharospasm is treated with botulinum toxin, but obtaining satisfactory results is sometimes challenging.: Objective: The aim is to conduct an exploratory trial of oral dipraglurant for blepharospasm.: Methods: This study was an ... ...

Abstract	Background: Blepharospasm is treated with botulinum toxin, but obtaining satisfactory results is sometimes challenging. Objective: The aim is to conduct an exploratory trial of oral dipraglurant for blepharospasm. Methods: This study was an exploratory, phase 2a, randomized, double-blind, placebo-controlled trial of 15 participants who were assigned to receive a placebo or dipraglurant (50 or 100 mg) and assessed over 2 days, 1 and 2 hours following dosing. Outcome measures included multiple scales rated by clinicians or participants, digital video, and a wearable sensor. Results: Dipraglurant was well tolerated, with no obvious impact on any of the measurement outcomes. Power analyses suggested fewer subjects would be required for studies using a within-subject versus independent group design, especially for certain measures. Some outcome measures appeared more suitable than others. Conclusion: Although dipraglurant appeared well tolerated, it did not produce a trend for clinical benefit. The results provide valuable information for planning further trials in blepharospasm. © 2024 International Parkinson and Movement Disorder Society.
MeSH term(s)	Humans ; Blepharospasm/drug therapy ; Double-Blind Method ; Male ; Female ; Middle Aged ; Aged ; Treatment Outcome
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Clinical Trial, Phase II
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29734
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Article ; Online: A computational modeling of invadopodia protrusion into an extracellular matrix fiber network.

Kim, Min-Cheol / Li, Ran / Abeyaratne, Rohan / Kamm, Roger D / Asada, H Harry

Scientific reports

2022 Volume 12, Issue 1, Page(s) 1231

Abstract: Invadopodia are dynamic actin-rich membrane protrusions that have been implicated in cancer cell invasion and metastasis. In addition, invasiveness of cancer cells is strongly correlated with invadopodia formation, which are observed during extravasation ...

Abstract	Invadopodia are dynamic actin-rich membrane protrusions that have been implicated in cancer cell invasion and metastasis. In addition, invasiveness of cancer cells is strongly correlated with invadopodia formation, which are observed during extravasation and colonization of metastatic cancer cells at secondary sites. However, quantitative understanding of the interaction of invadopodia with extracellular matrix (ECM) is lacking, and how invadopodia protrusion speed is associated with the frequency of protrusion-retraction cycles remains unknown. Here, we present a computational framework for the characterization of invadopodia protrusions which allows two way interactions between intracellular branched actin network and ECM fibers network. We have applied this approach to predicting the invasiveness of cancer cells by computationally knocking out actin-crosslinking molecules, such as α-actinin, filamin and fascin. The resulting simulations reveal distinct invadopodia dynamics with cycles of protrusion and retraction. Specifically, we found that (1) increasing accumulation of MT1-MMP at tips of invadopodia as the duration of protrusive phase is increased, and (2) the movement of nucleus toward the leading edge of the cell becomes unstable as duration of the retractile phase (or myosin turnover time) is longer than 1 min.
MeSH term(s)	Cell Movement ; Extracellular Matrix ; Humans ; Microfilament Proteins/physiology ; Models, Biological ; Neoplasm Invasiveness ; Neoplasms ; Podosomes/physiology
Chemical Substances	Microfilament Proteins
Language	English
Publishing date	2022-01-24
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-05224-9
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Article ; Online: A computational modeling of invadopodia protrusion into an extracellular matrix fiber network

Min-Cheol Kim / Ran Li / Rohan Abeyaratne / Roger D. Kamm / H. Harry Asada

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 19

Abstract: Abstract Invadopodia are dynamic actin-rich membrane protrusions that have been implicated in cancer cell invasion and metastasis. In addition, invasiveness of cancer cells is strongly correlated with invadopodia formation, which are observed during ... ...

Abstract	Abstract Invadopodia are dynamic actin-rich membrane protrusions that have been implicated in cancer cell invasion and metastasis. In addition, invasiveness of cancer cells is strongly correlated with invadopodia formation, which are observed during extravasation and colonization of metastatic cancer cells at secondary sites. However, quantitative understanding of the interaction of invadopodia with extracellular matrix (ECM) is lacking, and how invadopodia protrusion speed is associated with the frequency of protrusion-retraction cycles remains unknown. Here, we present a computational framework for the characterization of invadopodia protrusions which allows two way interactions between intracellular branched actin network and ECM fibers network. We have applied this approach to predicting the invasiveness of cancer cells by computationally knocking out actin-crosslinking molecules, such as α-actinin, filamin and fascin. The resulting simulations reveal distinct invadopodia dynamics with cycles of protrusion and retraction. Specifically, we found that (1) increasing accumulation of MT1-MMP at tips of invadopodia as the duration of protrusive phase is increased, and (2) the movement of nucleus toward the leading edge of the cell becomes unstable as duration of the retractile phase (or myosin turnover time) is longer than 1 min.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Epithelial sheath neuroma: A case series.

Flora, Akshay / Kim, Roger H / Lara Rivero, Alexis D / Carr, Urszula / Isaacs, Frank

JAAD case reports

2020 Volume 6, Issue 3, Page(s) 240–242

Language	English
Publishing date	2020-02-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2020.01.018
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