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  1. Article ; Online: [How will the repeal of the special ordinances affect the occupational environment evaluation system?]

    Kumagai, Shinji

    Sangyo eiseigaku zasshi = Journal of occupational health

    2022  Volume 65, Issue 1, Page(s) 42–47

    MeSH term(s) Humans ; Smoking ; Restaurants
    Language Japanese
    Publishing date 2022-03-16
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1234922-7
    ISSN 1349-533X ; 1341-0725
    ISSN (online) 1349-533X
    ISSN 1341-0725
    DOI 10.1539/sangyoeisei.2022-004-W
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1162: Show issues Location:
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  2. Article ; Online: [Obstructive lung disease among workers exposed to diacetyl].

    Kumagai, Shinji / Mori, Ippei

    Sangyo eiseigaku zasshi = Journal of occupational health

    2021  Volume 64, Issue 4, Page(s) 211–220

    MeSH term(s) Air Pollutants, Occupational ; Diacetyl/analysis ; Diacetyl/toxicity ; Humans ; Lung Diseases, Obstructive ; Occupational Diseases/chemically induced ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis
    Chemical Substances Air Pollutants, Occupational ; Diacetyl (K324J5K4HM)
    Language Japanese
    Publishing date 2021-08-04
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1234922-7
    ISSN 1349-533X ; 1341-0725
    ISSN (online) 1349-533X
    ISSN 1341-0725
    DOI 10.1539/sangyoeisei.2021-025-W
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Knee joint synovial hemangioma treated with arthroscopic resection without hemarthrosis: A case report.

    Uemura, Ryota / Kumagai, Kosuke / Kubo, Mitsuhiko / Mimura, Tomohiro / Yayama, Takafumi / Imai, Shinji

    International journal of surgery case reports

    2024  Volume 116, Page(s) 109352

    Abstract: Introduction: Intra-articular synovial hemangioma of the knee is a relatively rare benign tumor that if left undiagnosed and treated may be followed by degenerative cartilaginous changes and osteoarthritis. However, the non-specific symptoms of synovial ...

    Abstract Introduction: Intra-articular synovial hemangioma of the knee is a relatively rare benign tumor that if left undiagnosed and treated may be followed by degenerative cartilaginous changes and osteoarthritis. However, the non-specific symptoms of synovial hemangiomas limit its early diagnosis. We report our encounter with synovial hemangioma of the knee in which the diagnosis was based on a > 20-year history of chronic pain without joint swelling or hematoma.
    Presentation of case: A 34-year-old man with a localized vascular malformation on the upper edge of the left patella presented with pain and a restricted range of motion. CT and MRI revealed a tumorous lesion at this location. Upon excision of the lesion, the patient's symptoms disappeared, with no recurrence at the 1-year follow-up.
    Discussion: Accurate diagnosis and appropriate early treatment are necessary for synovial hemangiomas to forestall articular cartilage degeneration due to recurrent intra-articular hemorrhages.
    Conclusion: Synovial hemangioma should be considered when a patient presents with recurrent knee pain, even in the absence of swelling or episodes of joint effusion.
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2024.109352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N'- methylguanidine-bridged nucleic acids.

    Yamaguchi, Takao / Horie, Naohiro / Aoyama, Hiroshi / Kumagai, Shinji / Obika, Satoshi

    Nucleic acids research

    2023  Volume 51, Issue 15, Page(s) 7749–7761

    Abstract: Antisense oligonucleotides (ASOs) are becoming a promising class of drugs for treating various diseases. Over the past few decades, many modified nucleic acids have been developed for application to ASOs, aiming to enhance their duplex-forming ability ... ...

    Abstract Antisense oligonucleotides (ASOs) are becoming a promising class of drugs for treating various diseases. Over the past few decades, many modified nucleic acids have been developed for application to ASOs, aiming to enhance their duplex-forming ability toward cognate mRNA and improve their stability against enzymatic degradations. Modulating the sugar conformation of nucleic acids by substituting an electron-withdrawing group at the 2'-position or incorporating a 2',4'-bridging structure is a common approach for enhancing duplex-forming ability. Here, we report on incorporating an N-tert-butylguanidinium group at the 2',4'-bridging structure, which greatly enhances duplex-forming ability because of its interactions with the minor groove. Our results indicated that hydrophobic substituents fitting the grooves of duplexes also have great potential to increase duplex-forming ability.
    MeSH term(s) Methylguanidine ; Nucleic Acid Conformation ; Oligonucleotides/chemistry ; Oligonucleotides/therapeutic use ; Oligonucleotides, Antisense/chemistry ; RNA, Messenger ; Guanidines/chemistry ; Guanidines/metabolism
    Chemical Substances Methylguanidine (5L0H5Q9VAG) ; Oligonucleotides ; Oligonucleotides, Antisense ; RNA, Messenger ; Guanidines
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1067: Show issues Location:
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  5. Article: [Cholangiocarcinoma among printing workers].

    Kumagai, Shinji

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 3, Page(s) 827–831

    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms/epidemiology ; Bile Duct Neoplasms/etiology ; Bile Ducts, Intrahepatic ; Child ; Child, Preschool ; Cholangiocarcinoma/epidemiology ; Cholangiocarcinoma/etiology ; Humans ; Infant ; Middle Aged ; Occupational Exposure ; Printing ; Young Adult
    Language Japanese
    Publishing date 2015-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 429: Show issues Location:
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  6. Article ; Online: [Epidemiological characteristic of occupational pneumatosis cystoides intestinalis].

    Kumagai, Shinji

    Sangyo eiseigaku zasshi = Journal of occupational health

    2015  Volume 57, Issue 2, Page(s) 40–44

    MeSH term(s) Adult ; Aged ; Female ; Humans ; Japan/epidemiology ; Male ; Middle Aged ; Occupational Diseases/chemically induced ; Occupational Diseases/diagnosis ; Occupational Diseases/epidemiology ; Occupational Diseases/prevention & control ; Occupational Exposure/adverse effects ; Pneumatosis Cystoides Intestinalis/chemically induced ; Pneumatosis Cystoides Intestinalis/diagnosis ; Pneumatosis Cystoides Intestinalis/epidemiology ; Pneumatosis Cystoides Intestinalis/prevention & control ; Risk Factors ; Solvents/adverse effects ; Time Factors ; Trichloroethylene/adverse effects ; Young Adult
    Chemical Substances Solvents ; Trichloroethylene (290YE8AR51)
    Language Japanese
    Publishing date 2015
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1234922-7
    ISSN 1349-533X ; 1341-0725
    ISSN (online) 1349-533X
    ISSN 1341-0725
    DOI 10.1539/sangyoeisei.A14002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Zinc Acetate Hydrate Supplementation versus Polaprezinc Supplementation for Improving Hypozincemia in Hemodialysis Patients: A Randomized Clinical Trial.

    Kumagai, Etsuko / Furumachi, Kazuhiro / Kurihara, Akihiro / Hosokawa, Ken / Hosohata, Keiko / Takai, Shinji

    International journal of nephrology

    2023  Volume 2023, Page(s) 2403755

    Abstract: Zinc supplementation may ameliorate zinc deficiency in maintenance hemodialysis patients; however, no standard protocol has been established. This study aimed to investigate the effects of zinc acetate hydrate (ZAH) and polaprezinc (PPZ) as zinc ... ...

    Abstract Zinc supplementation may ameliorate zinc deficiency in maintenance hemodialysis patients; however, no standard protocol has been established. This study aimed to investigate the effects of zinc acetate hydrate (ZAH) and polaprezinc (PPZ) as zinc supplements in hemodialysis patients. We enrolled 75 hemodialysis patients with serum zinc levels <60
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573904-9
    ISSN 2090-2158 ; 2090-214X
    ISSN (online) 2090-2158
    ISSN 2090-214X
    DOI 10.1155/2023/2403755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Synthesis and properties of oligonucleotides modified with an

    Horie, Naohiro / Yamaguchi, Takao / Kumagai, Shinji / Obika, Satoshi

    Beilstein journal of organic chemistry

    2021  Volume 17, Page(s) 622–629

    Abstract: Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with ... ...

    Abstract Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an
    Language English
    Publishing date 2021-03-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.17.54
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Impact of System-Related Magnetic Resonance Imaging Geometric Distortion in Stereotactic Radiotherapy: A Case Report.

    Kumagai, Motoki / Kawamura, Mariko / Kato, Yutaka / Okudaira, Kuniyasu / Naganawa, Shinji

    Cureus

    2022  Volume 14, Issue 7, Page(s) e27269

    Abstract: Magnetic resonance imaging (MRI) is now essential in stereotactic radiotherapy (SRT) planning for brain tumors because of its excellence in soft-tissue contrast and high spatial resolution. However, MRI distortion is sometimes difficult to recognize, and ...

    Abstract Magnetic resonance imaging (MRI) is now essential in stereotactic radiotherapy (SRT) planning for brain tumors because of its excellence in soft-tissue contrast and high spatial resolution. However, MRI distortion is sometimes difficult to recognize, and it may cause large misalignments in radiotherapy planning. In this case report, we will show how much difference in the dose distribution of SRT can be made by using MRI without distortion correction.
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.27269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Cholangiocarcinoma among printing workers].

    Kumagai, Shinji

    Nihon rinsho. Japanese journal of clinical medicine

    2014  Volume 72, Issue 2, Page(s) 306–309

    Abstract: By June 2013, seventeen workers had suffered from intrahepatic or extrahepatic bile duct cancer (cholangiocarcinoma) in an offset proof-printing company in Osaka and nine of the workers had died. Ages at diagnosis were 25 to 45 years old. Known risk ... ...

    Abstract By June 2013, seventeen workers had suffered from intrahepatic or extrahepatic bile duct cancer (cholangiocarcinoma) in an offset proof-printing company in Osaka and nine of the workers had died. Ages at diagnosis were 25 to 45 years old. Known risk factors for cholangiocarcinoma were not found in the patients. All of the patients were exposed to 1,2-dichloropropane at high level for long-term and were diagnosed with cholangiocarcinoma 7 to 20 years after the first exposure. Twelve of the patients were also exposed to dichloromethane. The Japan Ministry of Health, Labour and Welfare recognized the cancer to be an occupational disease.
    MeSH term(s) Adult ; Bile Duct Neoplasms/etiology ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma/etiology ; Humans ; Middle Aged ; Occupational Diseases ; Printing
    Language Japanese
    Publishing date 2014-02
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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