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Book ; Online: Japan’s Peacekeeping at a Crossroads

Fujishige, Hiromi Nagata / Uesugi, Yuji / Honda, Tomoaki

Taking a Robust Stance or Remaining Hesitant?

(Sustainable Development Goals Series)

2022

Author's details	by Hiromi Nagata Fujishige, Yuji Uesugi, Tomoaki Honda
Series title	Sustainable Development Goals Series
Keywords	International relations ; Peace ; Asia—Politics and government ; Japan—History
Subject code	327.1
Language	English
Size	1 Online-Ressource (XXV, 236 p. 4 illus)
Edition	1st ed. 2022
Publisher	Springer International Publishing ; Imprint: Palgrave Macmillan
Publishing place	Cham
Document type	Book ; Online
HBZ-ID	HT021217123
ISBN	978-3-030-88509-0 ; 9783030885083 ; 9783030885106 ; 9783030885113 ; 3-030-88509-7 ; 3030885089 ; 3030885100 ; 3030885119
DOI	10.1007/978-3-030-88509-0
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Immunogenicity and protective efficacy of SARS-CoV-2 recombinant S-protein vaccine S-268019-b in cynomolgus monkeys.

Vaccine

2022 Volume 40, Issue 31, Page(s) 4231–4241

Abstract: The vaccine S-268019-b is a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S ... protein vaccine consisting of full-length recombinant SARS-CoV-2 S-protein (S-910823) as antigen, mixed ... with the squalene-based adjuvant A-910823. The current study evaluated the immunogenicity of S-268019-b using ...

Abstract	The vaccine S-268019-b is a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-protein vaccine consisting of full-length recombinant SARS-CoV-2 S-protein (S-910823) as antigen, mixed with the squalene-based adjuvant A-910823. The current study evaluated the immunogenicity of S-268019-b using various doses of S-910823 and its vaccine efficacy against SARS-CoV-2 challenge in cynomolgus monkeys. The different doses of S-910823 combined with A-910823 were intramuscularly administered twice at a 3-week interval. Two weeks after the second dosing, dose-dependent humoral immune responses were observed with neutralizing antibody titers being comparable to that of human convalescent plasma. Pseudoviruses harboring S proteins from Beta and Gamma SARS-CoV-2 variants displayed approximately 3- to 4-fold reduced sensitivity to neutralizing antibodies induced after two vaccine doses compared with that against ancestral viruses, whereas neutralizing antibody titers were reduced >14-fold against the Omicron variant. Cellular immunity was also induced with a relative Th1 polarized response. No adverse clinical signs or weight loss associated with the vaccine were observed, suggesting safety of the vaccine in cynomolgus monkeys. Immunization with 10 µg of S-910823 with A-910823 demonstrated protective efficacy against SARS-CoV-2 challenge according to genomic and subgenomic viral RNA transcript levels in nasopharyngeal, throat, and rectal swab specimens. Pathological analysis revealed no detectable vaccine-dependent enhancement of disease in the lungs of challenged vaccinated monkeys. The current findings provide fundamental information regarding vaccine doses for human trials and support the development of S-268019-b as a safe and effective vaccine for controlling the current pandemic, as well as general protection against SARS-CoV-2 moving forward.
MeSH term(s)	Animals ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19/therapy ; Immunization, Passive ; Immunogenicity, Vaccine ; Macaca fascicularis ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Viral Vaccines ; COVID-19 Serotherapy
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; Viral Vaccines ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-06-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.05.081
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Article ; Online: Author Correction: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice.

Homma, Tomoyuki / Nagata, Noriyo / Hashimoto, Masayuki / Iwata-Yoshikawa, Naoko / Seki, Naomi M / Shiwa-Sudo, Nozomi / Ainai, Akira / Dohi, Keiji / Nikaido, Eiji / Mukai, Akiko / Ukai, Yuuta / Nakagawa, Takayuki / Shimo, Yusuke / Maeda, Hiroki / Shirai, Seiki / Aoki, Miwa / Sonoyama, Takuhiro / Sato, Mamoru / Fumoto, Masataka /

Nagira, Morio / Nakata, Fumihisa / Hashiguchi, Takao / Suzuki, Tadaki / Omoto, Shinya / Hasegawa, Hideki

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2599

Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52772-3
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Article: Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates.

Moliva, Juan I / Andrew, Shayne F / Flynn, Barbara J / Wagner, Danielle A / Foulds, Kathryn E / Gagne, Matthew / Flebbe, Dillon R / Lamb, Evan / Provost, Samantha / Marquez, Josue / Mychalowych, Anna / Lorag, Cynthia G / Honeycutt, Christopher Cole / Burnett, Matthew R / McCormick, Lauren / Henry, Amy R / Godbole, Sucheta / Davis-Gardner, Meredith E / Minai, Mahnaz /

Bock, Kevin W / Nagata, Bianca M / Todd, John-Paul M / McCarthy, Elizabeth / Dodson, Alan / Kouneski, Katelyn / Cook, Anthony / Pessaint, Laurent / Ry, Alex Van / Valentin, Daniel / Young, Steve / Littman, Yoav / Boon, Adrianus C M / Suthar, Mehul S / Lewis, Mark G / Andersen, Hanne / Alves, Derron A / Woodward, Ruth / Leuzzi, Adriano / Vitelli, Alessandra / Colloca, Stefano / Folgori, Antonella / Raggiolli, Angelo / Capone, Stefania / Nason, Martha C / Douek, Daniel C / Roederer, Mario / Seder, Robert A / Sullivan, Nancy J

bioRxiv : the preprint server for biology

2023

Abstract: ... protein (S-2P) in non-human primates provided protective immunity for over one year against the BA.5 ... variant of SARS-CoV-2. A prime-boost regimen using GRAd followed by adjuvanted S-2P (GRAd+S-2P ... accelerated viral clearance in both the lower and upper airways. GRAd delivered via aerosol (GRAd(AE)+S-2P ...

Abstract	SARS-CoV-2 continues to pose a global threat, and current vaccines, while effective against severe illness, fall short in preventing transmission. To address this challenge, there's a need for vaccines that induce mucosal immunity and can rapidly control the virus. In this study, we demonstrate that a single immunization with a novel gorilla adenovirus-based vaccine (GRAd) carrying the pre-fusion stabilized Spike protein (S-2P) in non-human primates provided protective immunity for over one year against the BA.5 variant of SARS-CoV-2. A prime-boost regimen using GRAd followed by adjuvanted S-2P (GRAd+S-2P) accelerated viral clearance in both the lower and upper airways. GRAd delivered via aerosol (GRAd(AE)+S-2P) modestly improved protection compared to its matched intramuscular regimen, but showed dramatically superior boosting by mRNA and, importantly, total virus clearance in the upper airway by day 4 post infection. GrAd vaccination regimens elicited robust and durable systemic and mucosal antibody responses to multiple SARS-CoV-2 variants, but only GRAd(AE)+S-2P generated long-lasting T cell responses in the lung. This research underscores the flexibility of the GRAd vaccine platform to provide durable immunity against SARS-CoV-2 in both the lower and upper airways.
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.11.22.567930
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Article ; Online: Immune response and protective efficacy of the SARS-CoV-2 recombinant spike protein vaccine S-268019-b in mice.

Nagira, Morio / Nakata, Fumihisa / Hashiguchi, Takao / Suzuki, Tadaki / Omoto, Shinya / Hasegawa, Hideki

Scientific reports

2022 Volume 12, Issue 1, Page(s) 20861

Abstract: ... This study evaluated the efficacy of the COVID-19 vaccine S-268019-b, which comprises the recombinant full ... length SARS-CoV-2 spike protein S-910823 (antigen) and A-910823 (adjuvant). In addition to eliciting ... both Th1-type and Th2-type cellular immune responses, two doses of S-910823 plus A-910823 induced anti ...

Abstract	Vaccines that efficiently target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease (COVID-19), are the best means for controlling viral spread. This study evaluated the efficacy of the COVID-19 vaccine S-268019-b, which comprises the recombinant full-length SARS-CoV-2 spike protein S-910823 (antigen) and A-910823 (adjuvant). In addition to eliciting both Th1-type and Th2-type cellular immune responses, two doses of S-910823 plus A-910823 induced anti-spike protein IgG antibodies and neutralizing antibodies against SARS-CoV-2. In a SARS-CoV-2 challenge test, S-910823 plus A-910823 mitigated SARS-CoV-2 infection-induced weight loss and death and inhibited viral replication in mouse lungs. S-910823 plus A-910823 promoted cytokine and chemokine at the injection site and immune cell accumulation in the draining lymph nodes. This led to the formation of germinal centers and the induction of memory B cells, antibody-secreting cells, and memory T cells. These findings provide fundamental property of S-268019-b, especially importance of A-910823 to elicit humoral and cellular immune responses.
MeSH term(s)	Mice ; Animals ; Humans ; Spike Glycoprotein, Coronavirus/genetics ; SARS-CoV-2 ; COVID-19 Vaccines ; COVID-19/prevention & control ; Vaccines ; Antibodies, Neutralizing ; Immunity
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Vaccines ; Vaccines ; Antibodies, Neutralizing
Language	English
Publishing date	2022-12-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-25418-5
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Article ; Online: Loneliness is associated with eating disorders among a national sample of U.S. college students during the COVID-19 pandemic.

Ganson, Kyle T / Cuccolo, Kelly / Nagata, Jason M

Journal of American college health : J of ACH

2023 , Page(s) 1–5

Abstract: ... among a national sample of U.S. college students during COVID-19.: Participants: Cross-sectional data ...

Abstract	Objective: To identify the association between loneliness and eating disorder symptomatology among a national sample of U.S. college students during COVID-19. Participants: Cross-sectional data from the 2020-2021 Healthy Minds Study ( Methods: Loneliness was measured using the UCLA 3-item Loneliness Scale and eating disorder symptomology was measured using the SCOFF questionnaire. Multiple modified Poisson regression analyses were conducted, adjusting for confounding variables. Results: Greater loneliness was associated with both a positive eating disorder screen (risk ratio [RR] 1.09, 95% confidence interval [CI] 1.09-1.10) and greater number of eating disorder symptoms (RR 1.07, 95% CI 1.06-1.08). Gender modified this relationship, and men who endorsed greater loneliness had higher risk of eating disorder symptomatology compared to women. Conclusions: Loneliness during the COVID-19 pandemic was associated with a greater risk of eating disorder symptomatology among college students. Findings underscore the need for social support and eating disorders programming on college campuses.
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	604907-2
ISSN	1940-3208 ; 0744-8481
ISSN (online)	1940-3208
ISSN	0744-8481
DOI	10.1080/07448481.2023.2232872
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Zs.A 427: Show issues

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Article ; Online: Lactobacillus pentosus strain S-PT84 improves steatohepatitis by maintaining gut permeability.

Sakai, Yuriko / Arie, Hideyuki / Ni, Yinhua / Zhuge, Fen / Xu, Liang / Chen, Guanliang / Nagata, Naoto / Suzuki, Takuya / Kaneko, Shuichi / Ota, Tsuguhito / Nagashimada, Mayumi

The Journal of endocrinology

2020 Volume 247, Issue 2, Page(s) 169–181

Abstract: ... The Lactobacillus pentosus strain S-PT84 activates helper T cells and natural killer/natural killer T cells ... In this study, we examined the effect of S-PT84 on NASH progression induced by high-cholesterol/high-fat diet ... a normal chow or CL diet with or without 1 × 1010 S-PT84 for 22 weeks. S-PT84 administration improved ...

Abstract	Intestinal mucosal barrier dysfunction is closely related to the pathogenesis of nonalcoholic steatohepatitis (NASH). Gut immunity has been recently demonstrated to regulate gut barrier function. The Lactobacillus pentosus strain S-PT84 activates helper T cells and natural killer/natural killer T cells. In this study, we examined the effect of S-PT84 on NASH progression induced by high-cholesterol/high-fat diet (CL), focusing on the immune responses involved in gut barrier function. C57BL/6 mice were fed a normal chow or CL diet with or without 1 × 1010 S-PT84 for 22 weeks. S-PT84 administration improved hepatic steatosis by decreasing triglyceride and free fatty acid levels by 34% and 37%, respectively. Furthermore, S-PT84 inhibited the development of hepatic inflammation and fibrosis, suppressed F4/80+ macrophage/Kupffer cell infiltration, and reduced liver hydroxyproline content. Administration of S-PT84 alleviated hyperinsulinemia and enhanced hepatic insulin signalling. Compared with mice fed CL diet, mice fed CL+S-PT84 had 71% more CD11c-CD206+ M2 macrophages, resulting in a significantly decreased M1/M2 macrophage ratio in the liver. Moreover, S-PT84 inhibited the CL diet-mediated increase in intestinal permeability. Additionally, S-PT84 reduced the recruitment of interleukin-17-producing T cells and increased the levels of intestinal tight junction proteins, including zonula occludens-1, occludin, claudin-3, and claudin-7. In conclusion, our findings suggest that S-PT84 attenuates diet-induced insulin resistance and subsequent NASH development by maintaining gut permeability. Thus, S-PT84 represents a feasible approach to prevent the development of NASH.
MeSH term(s)	Animals ; Gastrointestinal Microbiome/physiology ; Inflammation/microbiology ; Inflammation/therapy ; Interleukin-17/metabolism ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Lactobacillus pentosus/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/microbiology ; Non-alcoholic Fatty Liver Disease/therapy
Chemical Substances	Interleukin-17
Language	English
Publishing date	2020-10-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3028-4
ISSN	1479-6805 ; 0022-0795
ISSN (online)	1479-6805
ISSN	0022-0795
DOI	10.1530/JOE-20-0105
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Article ; Online: Cyberbullying and Sleep Disturbance Among Early Adolescents in the U.S.

Nagata, Jason M / Yang, Joanne H / Singh, Gurbinder / Kiss, Orsolya / Ganson, Kyle T / Testa, Alexander / Jackson, Dylan B / Baker, Fiona C

Academic pediatrics

2022 Volume 23, Issue 6, Page(s) 1220–1225

Abstract: Objective: To determine the association between cyberbullying (victimization and perpetration) and sleep disturbance among a demographically diverse sample of 10-14-year-old early adolescents.: Methods: We analyzed cross-sectional data from the ... ...

Abstract	Objective: To determine the association between cyberbullying (victimization and perpetration) and sleep disturbance among a demographically diverse sample of 10-14-year-old early adolescents. Methods: We analyzed cross-sectional data from the Adolescent Brain Cognitive Development (ABCD) Study (Year 2, 2018-2020) of early adolescents (10-14 years) in the US. Modified Poisson regression analyses examined the association between cyberbullying and self-reported and caregiver-reported sleep disturbance measures. Results: In a sample of 9,443 adolescents (mean age 12.0 years, 47.9% female, 47.8% white), 5.1% reported cyberbullying victimization, and 0.5% reported cyberbullying perpetration in the past 12 months. Cyberbullying victimization in the past 12 months was associated with adolescent-reported trouble falling/staying asleep (risk ratio [RR] 1.87, 95% confidence interval [CI] 1.57, 2.21) and caregiver-reported overall sleep disturbance of the adolescent (RR: 1.16 95% CI 1.00, 1.33), in models adjusting for sociodemographic factors and screen time. Cyberbullying perpetration in the past 12 months was associated with trouble falling/staying asleep (RR 1.95, 95% CI 1.21, 3.15) and caregiver-reported overall sleep disturbance of the adolescent (RR: 1.49, 95% CI 1.00, 2.22). Conclusions: Cyberbullying victimization and perpetration are associated with sleep disturbance in early adolescence. Digital media education and counseling for adolescents, parents, teachers, and clinicians could focus on guidance to prevent cyberbullying and support healthy sleep behavior for early adolescents.
MeSH term(s)	Humans ; Adolescent ; Female ; Child ; Male ; Cyberbullying/psychology ; Cross-Sectional Studies ; Internet ; Bullying ; Crime Victims/psychology ; Sleep Wake Disorders/epidemiology ; Sleep
Language	English
Publishing date	2022-12-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2483385-X
ISSN	1876-2867 ; 1876-2859
ISSN (online)	1876-2867
ISSN	1876-2859
DOI	10.1016/j.acap.2022.12.007
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Article: Lower daily steps among U.S. adolescents during the COVID-19 pandemic: Objective findings from the Adolescent Brain Cognitive Development Study.

Nagata, Jason M / Yu, Jiayue / Dooley, Erin E / Baker, Fiona C / Alsamman, Sana / Wing, David / Ganson, Kyle T / Pettee Gabriel, Kelley

Preventive medicine reports

2022 Volume 31, Page(s) 102095

Language	English
Publishing date	2022-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2022.102095
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Article ; Online: Screen time and suicidal behaviors among U.S. children 9-11 years old: A prospective cohort study.

Chu, Jonathan / Ganson, Kyle T / Baker, Fiona C / Testa, Alexander / Jackson, Dylan B / Murray, Stuart B / Nagata, Jason M

Preventive medicine

2023 Volume 169, Page(s) 107452

Abstract: ... behaviors two-years later in a national (U.S.) cohort of 9-11-year-old-children. We analyzed prospective ...

Abstract	Suicide is a leading cause of death among adolescents. Emerging literature has described relationships between excessive screen time and suicidal behaviors, though findings have been mixed. The objective of this study is to determine the prospective associations between screen time and suicidal behaviors two-years later in a national (U.S.) cohort of 9-11-year-old-children. We analyzed prospective cohort data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 11,633). Logistic regression analyses were estimated to determine the associations between baseline self-reported screen time (exposure) and suicidal behaviors (outcome) based on the Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS-5) at two-year-follow-up. Participants reported an average of 4.0 h of total screen time per day at baseline. At two-year-follow-up, 1.38% of the sample reported at least one suicidal behavior. Each additional hour of total screen time was prospectively associated with 1.09 higher odds of suicidal behaviors at 2-year-follow-up (95% CI 1.03-1.14), after adjusting for covariates. For specific screen time modalities, each additional hour of texting (aOR 1.36, 95% CI 1.06-1.74), video chatting (aOR 1.30, 95% CI 1.03-1.65), watching videos (aOR 1.21, 95% CI 1.04-1.39), and playing video games (aOR 1.18, 95% CI 1.01-1.38) was associated with higher odds of subsequent suicidal behaviors. Higher screen time is associated with higher odds of reporting suicidal behaviors at two-year-follow-up. Future research should seek to identify how specific screen time experiences may influence suicidal behaviors.
MeSH term(s)	Adolescent ; Humans ; Child ; Suicidal Ideation ; Suicide, Attempted/psychology ; Screen Time ; Prospective Studies ; Risk Factors
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2023.107452
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