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  1. Article: Disseminated Tuberculosis Mimicking as Crohn's Disease in a Paediatric Patient.

    Feenstra, Elizabeth / Driesen, Yentl / Moes, Nicolette / Jouret, Nathalie / Vanden Driessche, Koen

    Case reports in infectious diseases

    2023  Volume 2023, Page(s) 7312630

    Abstract: Tuberculosis is an important infectious disease for children worldwide. The clinical presentation of tuberculosis in children is diverse and, depending on the affected organs, it is often accompanied with nonspecific symptoms that can mimic other ... ...

    Abstract Tuberculosis is an important infectious disease for children worldwide. The clinical presentation of tuberculosis in children is diverse and, depending on the affected organs, it is often accompanied with nonspecific symptoms that can mimic other diseases. In this report, we present a case of disseminated tuberculosis in an 11-year-old boy with intestinal followed by pulmonary involvement. The diagnosis was delayed for several weeks due to the clinical picture which was mimicking Crohn's disease, the known difficulties in diagnostic tests and the improvement on meropenem. This case demonstrates the importance of a detailed microscopic examination of gastrointestinal biopsies and the tuberculostatic effect of meropenem which physicians should be aware of.
    Language English
    Publishing date 2023-06-29
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2023/7312630
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  2. Article ; Online: Exposure to cough aerosols and development of pulmonary COVID-19.

    Vanden Driessche, Koen / Nestele, Jeremy / Grouwels, Jeroen / Duval, Els Lim

    Journal of breath research

    2020  Volume 14, Issue 4, Page(s) 41003

    Abstract: We hypothesized that most patients with severe pulmonary COVID-19 were exposed to cough aerosols. Among patients that were almost 100% certain which person infected them, only 14 out of 38 overall, and 9 out of 25 hospitalized patients requiring ... ...

    Abstract We hypothesized that most patients with severe pulmonary COVID-19 were exposed to cough aerosols. Among patients that were almost 100% certain which person infected them, only 14 out of 38 overall, and 9 out of 25 hospitalized patients requiring supplemental oxygen, were infected by someone who coughed, which did not support our hypothesis. Talking, especially with a loud voice, could be an alternative source generating SARS-CoV-2 aerosols. Further research is needed to determine how SARS-CoV-2 spreads. Avoiding to talk when you are not wearing your mask and not talking with a loud voice, 'voice etiquette', could be other public health interventions worthwhile exploring.
    MeSH term(s) Aerosols ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/etiology ; Cough/complications ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/etiology ; SARS-CoV-2
    Chemical Substances Aerosols
    Keywords covid19
    Language English
    Publishing date 2020-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/abb28c
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  3. Article ; Online: Exposure to cough aerosols and development of pulmonary COVID-19

    Vanden Driessche, Koen / Nestele, Jeremy / Grouwels, Jeroen / Duval, Els LIM

    Journal of Breath Research

    2020  Volume 14, Issue 4, Page(s) 41003

    Keywords Pulmonary and Respiratory Medicine ; covid19
    Publisher IOP Publishing
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/abb28c
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  4. Article ; Online: The burden and surveillance of RSV disease in young children in Belgium-expert opinion.

    Raes, Marc / Daelemans, Siel / Cornette, Luc / Moniotte, Stéphane / Proesmans, Marijke / Schaballie, Heidi / Frère, Julie / Vanden Driessche, Koen / Van Brusselen, Daan

    European journal of pediatrics

    2022  Volume 182, Issue 1, Page(s) 451–460

    Abstract: Infections with respiratory syncytial virus (RSV) can cause severe disease. In young children, RSV is the most common cause of lower respiratory tract illness and life-threatening infections most commonly occur in the first years of life. In adults, ... ...

    Abstract Infections with respiratory syncytial virus (RSV) can cause severe disease. In young children, RSV is the most common cause of lower respiratory tract illness and life-threatening infections most commonly occur in the first years of life. In adults, elderly and immunocompromised people are most vulnerable. Recently there has been an acceleration in the development of candidate RSV vaccines, monoclonal antibodies and therapeutics which are expected to become available in Europe within the next 2-10 years. Understanding the true burden of childhood RSV disease will become very important to support public health authorities and policy makers in the assessment of new therapeutic opportunities against RSV disease. A systematic literature search was performed to map local data on the burden of RSV disease and to evaluate available RSV surveillance systems. A group of 9 paediatric infectious diseases specialists participated in an expert panel. The purpose of this meeting was to evaluate and map the burden associated with RSV infection in children, including patient pathways and the epidemiological patterns of virus circulation in Belgium. Sources of information on the burden of RSV disease in Belgium are very limited. For the outpatient setting, it is estimated that 5-10% of young patients seen in primary care are referred to the hospital. Around 3500 children between 0 and 12 months of age are hospitalized for RSV-bronchiolitis every year and represent the majority of all hospitalizations. The current Belgian RSV surveillance system was evaluated and found to be insufficient. Knowledge gaps are highlighted and future perspectives and priorities offered.
    Conclusion: The Belgian population-based RSV surveillance should be improved, and a hospital-led reporting system should be put in place to enable the evaluation of the true burden of RSV disease in Belgium and to improve disease management in the future.
    What is known: • RSV bronchiolitis is a very important cause of infant hospitalization. • The burden of disease in the community is poorly studied and underestimated.
    What is new: • This expert opinion summarizes knowledge gaps and offers insights that allow improvement of local surveillance systems in order to establish a future-proof RSV surveillance system.
    MeSH term(s) Humans ; Infant ; Infant, Newborn ; Belgium/epidemiology ; Bronchiolitis/epidemiology ; Bronchiolitis/virology ; Hospitalization ; Population Surveillance ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human
    Language English
    Publishing date 2022-11-12
    Publishing country Germany
    Document type Journal Article ; Systematic Review
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-022-04698-z
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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.75: Show issues Location:
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  5. Article: Contribution of QuantiFERON-TB Gold-in-Tube to the Diagnosis of

    Debulpaep, Sara / Corbière, Véronique / Levy, Jack / Schelstraete, Petra / Vanden Driessche, Koen / Mascart, Françoise / Mouchet, Françoise

    Frontiers in pediatrics

    2019  Volume 7, Page(s) 291

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2019-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2019.00291
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  6. Article ; Online: Bilateral subacute lacrimal gland enlargement mimicking dacryoadenitis in a 7-year-old boy: a rare adverse effect of valproic acid (sodium valproate).

    Lyons, Christopher / Godoy, Flavia / Vanden Driessche, Koen

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2017  Volume 21, Issue 3, Page(s) 257–258

    Abstract: A healthy 7-year-old boy presented with bilateral symmetrical lacrimal gland enlargement; a week later salivary gland enlargement was also noted. Clinical investigations suggested no diagnosis, and surgical biopsy was considered. Valproic acid (sodium ... ...

    Abstract A healthy 7-year-old boy presented with bilateral symmetrical lacrimal gland enlargement; a week later salivary gland enlargement was also noted. Clinical investigations suggested no diagnosis, and surgical biopsy was considered. Valproic acid (sodium valproate), which he was taking for absence seizures, has been reported to cause salivary gland swelling in adults. Suspecting that a similar mechanism could be causal, the drug was discontinued. Complete resolution of the lacrimal and salivary gland enlargement rapidly ensued. This is the first report of lacrimal gland enlargement caused by valproic acid.
    MeSH term(s) Acute Disease ; Anticonvulsants/adverse effects ; Child ; Dacryocystitis/chemically induced ; Dacryocystitis/diagnosis ; Diagnosis, Differential ; Drug Substitution ; Ethosuximide/therapeutic use ; Humans ; Lacrimal Apparatus Diseases/chemically induced ; Lacrimal Apparatus Diseases/diagnosis ; Male ; Submandibular Gland Diseases/chemically induced ; Submandibular Gland Diseases/diagnosis ; Valproic Acid/adverse effects
    Chemical Substances Anticonvulsants ; Ethosuximide (5SEH9X1D1D) ; Valproic Acid (614OI1Z5WI)
    Language English
    Publishing date 2017-03-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2017.02.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5188: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Quantifying superspreading for COVID-19 using Poisson mixture distributions.

    Kremer, Cécile / Torneri, Andrea / Boesmans, Sien / Meuwissen, Hanne / Verdonschot, Selina / Vanden Driessche, Koen / Althaus, Christian L / Faes, Christel / Hens, Niel

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 14107

    Abstract: The number of secondary cases, i.e. the number of new infections generated by an infectious individual, is an important parameter for the control of infectious diseases. When individual variation in disease transmission is present, like for COVID-19, the ...

    Abstract The number of secondary cases, i.e. the number of new infections generated by an infectious individual, is an important parameter for the control of infectious diseases. When individual variation in disease transmission is present, like for COVID-19, the distribution of the number of secondary cases is skewed and often modeled using a negative binomial distribution. However, this may not always be the best distribution to describe the underlying transmission process. We propose the use of three other offspring distributions to quantify heterogeneity in transmission, and we assess the possible bias in estimates of the mean and variance of this distribution when the data generating distribution is different from the one used for inference. We also analyze COVID-19 data from Hong Kong, India, and Rwanda, and quantify the proportion of cases responsible for 80% of transmission, [Formula: see text], while acknowledging the variation arising from the assumed offspring distribution. In a simulation study, we find that variance estimates may be biased when there is a substantial amount of heterogeneity, and that selection of the most accurate distribution from a set of distributions is important. In addition we find that the number of secondary cases for two of the three COVID-19 datasets is better described by a Poisson-lognormal distribution.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/transmission ; COVID-19/virology ; Computer Simulation ; Hong Kong/epidemiology ; Humans ; India/epidemiology ; Infectious Disease Transmission, Vertical/statistics & numerical data ; Poisson Distribution ; Rwanda/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-93578-x
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  8. Article ; Online: Exposure to cough aerosols and development of pulmonary COVID-19

    Driessche, Koen Vanden / Nestele, Jeremy / Grouwels, Jeroen / Duval, Els L.I.M.

    Abstract: Half a year after the emergence of COVID-19, research is still going on to gain insight in the importance of different SARS-CoV-2 transmission routes and their impact on the clinical picture of COVID-19. Our findings suggest that coughing is not as ... ...

    Abstract Half a year after the emergence of COVID-19, research is still going on to gain insight in the importance of different SARS-CoV-2 transmission routes and their impact on the clinical picture of COVID-19. Our findings suggest that coughing is not as important for transmission as initially anticipated and we discuss the potentially important role for loud conversation as a driver for transmission.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20121004
    DOI 10.1101/2020.06.03.20121004
    Database COVID19

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  9. Article ; Online: Face masks in the post-COVID-19 era: a silver lining for the damaged tuberculosis public health response?

    Vanden Driessche, Koen / Mahlobo, Precious Z / Venter, Rouxjeane / Caldwell, Judy / Jennings, Karen / Diacon, Andreas H / Cotton, Mark F / de Groot, Ronald / Hens, Niel / Marx, Florian M / Warren, Robin M / Mishra, Hridesh / Theron, Grant

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 4, Page(s) 340–342

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19/virology ; Communicable Disease Control/instrumentation ; Communicable Disease Control/standards ; Health Policy ; Humans ; Masks/standards ; Mycobacterium tuberculosis/pathogenicity ; SARS-CoV-2/pathogenicity ; Social Stigma ; Tuberculosis/microbiology ; Tuberculosis/mortality ; Tuberculosis/prevention & control ; Tuberculosis/transmission
    Language English
    Publishing date 2021-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00020-5
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  10. Article ; Online: Exposure to cough aerosols and development of pulmonary COVID-19

    Vanden Driessche, Koen / Nestele, Jeremy / Grouwels, Jeroen / Duval, Els L.I.M.

    medRxiv

    Abstract: Half a year after the emergence of COVID-19, research is still going on to gain insight in the importance of different SARS-CoV-2 transmission routes and their impact on the clinical picture of COVID-19. Our findings suggest that coughing is not as ... ...

    Abstract Half a year after the emergence of COVID-19, research is still going on to gain insight in the importance of different SARS-CoV-2 transmission routes and their impact on the clinical picture of COVID-19. Our findings suggest that coughing is not as important for transmission as initially anticipated and we discuss the potentially important role for loud conversation as a driver for transmission.
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.06.03.20121004
    Database COVID19

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