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Article ; Online: A Quality Improvement Initiative to Transform Seasonal Immunization Processes Using Learning from the Coronavirus 2019 Pandemic.

Robinette, Eric D / Nelly, Pamela M / Engler, Laurie J / Bigham, Michael T

Pediatric quality & safety

2024 Volume 9, Issue 1, Page(s) e716

Abstract: Background: Surge demands for annual influenza vaccines challenge healthcare systems. Mass immunizations differ from the traditional care model. The coronavirus 2019 (COVID-19) pandemic challenged current care models with amplified demand and infection ... ...

Abstract	Background: Surge demands for annual influenza vaccines challenge healthcare systems. Mass immunizations differ from the traditional care model. The coronavirus 2019 (COVID-19) pandemic challenged current care models with amplified demand and infection risks while challenging the organization to create new and improve existing processes. Methods: Using the Model for Improvement, the team set out to (1) safely meet a surge in vaccination demand and (2) adopt pandemic-driven innovations into routine immunization practice. Results: This free-standing pediatric system delivered 87,000 COVID-19 vaccines (~1.3% state total). It administered over 50% of COVID-19 vaccines using new mass immunization processes, including 37,000 adult vaccines before pediatric authorization. In the 2021-2022 influenza season, it used the new or improved immunization processes to deliver 22% of influenza vaccines. Conclusions: Pandemic-driven adaptation for the COVID-19 vaccine substantially increased the efficiency of influenza vaccination processes but did not result in a clear increase in influenza vaccine administration rates.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ISSN	2472-0054
ISSN (online)	2472-0054
DOI	10.1097/pq9.0000000000000716
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Article ; Online: Uterine horn intussusception in immediate post-partum in a Pomeranian Spitz dog.

Mashhadi, Mehrdad / Ganjiani, Vahid / Bigham-Sadegh, Amin / Shafiee, Amir-Hossein

Veterinary medicine and science

2024 Volume 10, Issue 2, Page(s) e1375

Abstract: A 2-year-old Pomeranian-Spitz dog (5.8 kg) was admitted with symptoms of uterine prolapse and lethargy 1 day after whelping three puppies. The prolapsed uterus was corrected, but the next day, prolapse reoccurred. To fix the cervix to the abdominal wall, ...

Abstract	A 2-year-old Pomeranian-Spitz dog (5.8 kg) was admitted with symptoms of uterine prolapse and lethargy 1 day after whelping three puppies. The prolapsed uterus was corrected, but the next day, prolapse reoccurred. To fix the cervix to the abdominal wall, the dog underwent a surgery operation where intussusception in the left horn of the uterus was found. Ovariohysterectomy was performed as the treatment of choice. The diagnosis of intussusception is challenging, and exploratory laparotomy is the reliable diagnostic approach. Although uterine intussusception is rare, it should be one of the important considerations in dogs within the post-partum period.
MeSH term(s)	Female ; Dogs ; Animals ; Intussusception/diagnosis ; Intussusception/surgery ; Intussusception/veterinary ; Uterus/surgery ; Hysterectomy/veterinary ; Uterine Prolapse/surgery ; Uterine Prolapse/veterinary ; Postpartum Period ; Dog Diseases/diagnostic imaging ; Dog Diseases/surgery
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Case Reports
ZDB-ID	2819409-3
ISSN	2053-1095 ; 2053-1095
ISSN (online)	2053-1095
ISSN	2053-1095
DOI	10.1002/vms3.1375
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Article ; Online: The effects of allogeneic and xenogeneic lyophilized leukocyte-and platelet-rich fibrin on bone healing in rat.

Khanbazi, M H / Bigham-Sadegh, A / Oryan, A / Meimandi-Parizi, A / Jannesar, A M

Injury

2024 Volume 55, Issue 3, Page(s) 111396

Abstract: Background: Critical size defects are one of the challenges in the treatment of fractures in humans and animals. Blood products such as leukocyte-SAand platelet-rich fibrin (L-PRF) are one of the alternatives to bone autograft to solve this challenge. ... ...

Abstract	Background: Critical size defects are one of the challenges in the treatment of fractures in humans and animals. Blood products such as leukocyte-SAand platelet-rich fibrin (L-PRF) are one of the alternatives to bone autograft to solve this challenge. This study aims to evaluate the effects of allogeneic and xenogeneic lyophilized L-PRF on bone healing in a critical defect of radius bone in rat. Methods: A defect with a diameter of 5 mm was created in the radius bone of 60 rats in four groups. The defect was left empty in the untreated group, and it was filled with autogenous bone graft, allogeneic, and xenogeneic lyophilized L-PRF, respectively, in the other three groups. Radiographic evaluation was done every two weeks, and histopathological evaluation in the 14th, 28th, and 56th days after surgery. Results: The radiographic scores of allogeneic and xenogeneic lyophilized l-PRF groups were significantly higher than the untreated group in all times (P<0.05). In connection with histopathological Emery's scoring system, the score of allogeneic lyophilized L-PRF was significantly higher than the untreated group (P<0.05) in the 14th and 28th days after surgery. The score of the xenogeneic lyophilized L-PRF group was also higher than the untreated group, but the difference was not significant (P>0.05). The allogeneic and xenogeneic lyophilized L-PRF scores were significantly higher than the untreated group (P < 0.05) on the 56th day. Conclusion: The results of the present study showed that the allogeneic and xenogeneic lyophilized L-PRF can improve bone healing in the critical radius bone defect in rat model of study.
MeSH term(s)	Humans ; Rats ; Animals ; Platelet-Rich Fibrin ; Bone Regeneration ; Leukocytes ; Fractures, Bone ; Hematopoietic Stem Cell Transplantation
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2024.111396
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Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Improving Accuracy of Medication Reconciliation for Hospitalized Children: A Quality Project.

Gunkelman, Samantha M / Jamerino-Thrush, Jennifer / Genet, Katherine / Blackford, Martha / Jones, Kerwyn / Bigham, Michael T

Hospital pediatrics

2024 Volume 14, Issue 4, Page(s) 300–307

Abstract: Background and objectives: Medication reconciliation is a complex, but necessary, process to prevent patient harm from medication discrepancies. Locally, the steps of medication reconciliation are completed consistently; however, medication errors still ...

Abstract	Background and objectives: Medication reconciliation is a complex, but necessary, process to prevent patient harm from medication discrepancies. Locally, the steps of medication reconciliation are completed consistently; however, medication errors still occur, which suggest process inaccuracies. We focused on removal of unnecessary medications as a proxy for accuracy. The primary aim was to increase the percentage of patients admitted to the pediatric hospital medicine service with at least 1 medication removed from the home medication list by 10% during the hospital stay by June of 2022. Methods: Using the Model for Improvement, a multidisciplinary team was formed at a children's hospital, a survey was completed, and multiple Plan-Do-Study-Act cycles were done focusing on: 1. simplifying electronic health record processes by making it easier to remove medications; 2. continuous resident education about the electronic health record processes to improve efficiency and address knowledge gaps; and 3. auditing charts and real-time feedback. Data were monitored with statistical process control charts. Results: The project exceeded the goal, improving from 35% to 48% of patients having at least 1 medication removed from their home medication list. Improvement has sustained for 12 months. Conclusions: The combination of interventions including simplifying workflow, improving education, and enhancing accountability resulted in more patients with medications removed from their home medication list.
MeSH term(s)	Child ; Humans ; Medication Reconciliation ; Child, Hospitalized ; Medication Errors/prevention & control ; Patient Admission ; Hospitalization
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2154-1671
ISSN (online)	2154-1671
DOI	10.1542/hpeds.2023-007396
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Article: Gender, Socioeconomic Status, Race, and Ethnic Disparities in Bystander Cardiopulmonary Resuscitation and Education-A Scoping Review.

Blewer, Audrey L / Bigham, Blair L / Kaplan, Samantha / Del Rios, Marina / Leary, Marion

Healthcare (Basel, Switzerland)

2024 Volume 12, Issue 4

Abstract: Background: Social determinants are associated with survival from out-of-hospital sudden cardiac arrest (SCA). Because prompt delivery of bystander CPR (B-CPR) doubles survival and B-CPR rates are low, we sought to assess whether gender, socioeconomic ... ...

Abstract	Background: Social determinants are associated with survival from out-of-hospital sudden cardiac arrest (SCA). Because prompt delivery of bystander CPR (B-CPR) doubles survival and B-CPR rates are low, we sought to assess whether gender, socioeconomic status (SES), race, and ethnicity are associated with lower rates of B-CPR and CPR training. Methods: This scoping review was conducted as part of the continuous evidence evaluation process for the 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care as part of the Resuscitation Education Science section. We searched PubMed and excluded citations that were abstracts only, letters or editorials, and pediatric studies. Results: We reviewed 762 manuscripts and identified 24 as relevant; 4 explored gender disparities; 12 explored SES; 11 explored race and ethnicity; and 3 had overlapping themes, all of which examined B-CPR or CPR training. Females were less likely to receive B-CPR than males in public locations. Observed gender disparities in B-CPR may be associated with individuals fearing accusations of inappropriate touching or injuring female victims. Studies demonstrated that low-SES neighborhoods were associated with lower rates of B-CPR and CPR training. In the US, predominantly Black and Hispanic neighborhoods were associated with lower rates of B-CPR and CPR training. Language barriers were associated with lack of CPR training. Conclusion: Gender, SES, race, and ethnicity impact receiving B-CPR and obtaining CPR training. The impact of this is that these populations are less likely to receive B-CPR, which decreases their odds of surviving SCA. These health disparities must be addressed. Our work can inform future research, education, and public health initiatives to promote equity in B-CPR knowledge and provision. As an immediate next step, organizations that develop and deliver CPR curricula to potential bystanders should engage affected communities to determine how best to improve training and delivery of B-CPR.
Language	English
Publishing date	2024-02-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare12040456
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Article ; Online: Severity of Illness Scoring for Pediatric Interfacility Transport: A North American Survey.

Mansoor, Maha / Hansen, Gregory / Bigham, Michael / Holt, Tanya

Pediatric emergency care

2022 Volume 38, Issue 7, Page(s) e1362–e1364

Abstract: Objective: Severity of illness scoring during pediatric critical care transport may provide objective data to determine illness trajectory and disposition and contribute to quality assurance data for pediatric transport programs. The objective of this ... ...

Abstract	Objective: Severity of illness scoring during pediatric critical care transport may provide objective data to determine illness trajectory and disposition and contribute to quality assurance data for pediatric transport programs. The objective of this study was to ascertain the breadth of severity of illness scoring tool application among North American pediatric critical care transport teams. Methods: A cross-sectional quantitative survey using REDCap was distributed to 137 North American pediatric transport programs. Baseline team characteristics were established along with questions related to severity of illness tool application.Descriptive statistics were used for analysis. Results: There were 55 responses (40%), and of those, 13 (24%) use a severity of illness scoring tool within their practice. A variety of tools were used including: Transport Risk Index of Physiologic Stability, Children's Hospital Medical Center Cincinnati, Canadian Triage and Acuity Score, Transport Risk Assessment in Pediatrics, Pediatric Early Warning Scores, Levels of Acuity, Transport Pediatric Early Warning Scores, and an unspecified tool. The timing of scoring, team personnel who applied the score, and the frequency of analysis varied between transport programs. Conclusions: Severity of illness scoring is not consistently performed by pediatric interfacility transport programs in North America. Among the programs that use a scoring tool, there is variability in its application. There is no universally accepted or performed severity of illness scoring tool for pediatric interfacility transport.Future research to validate and standardize a pediatric transport severity of illness scoring tool for North America is necessary.
MeSH term(s)	Canada ; Child ; Cross-Sectional Studies ; Humans ; Severity of Illness Index ; Surveys and Questionnaires ; Triage
Language	English
Publishing date	2022-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002628
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Zs.A 2083: Show issues

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Article ; Online: A route toward fabrication of 3D printed bone scaffolds based on poly(vinyl alcohol)-chitosan/bioactive glass by sol-gel chemistry.

Biglari, Leila / Naghdi, Mina / Poursamar, S Ali / Nilforoushan, Mohammad Reza / Bigham, Ashkan / Rafienia, Mohammad

International journal of biological macromolecules

2023 Volume 258, Issue Pt 1, Page(s) 128716

Abstract: Among different methods for the fabrication of bone scaffolds, 3D printing has created great advances in tissue engineering and regenerative medicine owing to its ability to make objects mimicking native tissues. Thanks to its abundant availability, ... ...

Abstract	Among different methods for the fabrication of bone scaffolds, 3D printing has created great advances in tissue engineering and regenerative medicine owing to its ability to make objects mimicking native tissues. Thanks to its abundant availability, structural features, and favorable biological properties, chitosan (CS) hydrogel was selected to be used for preparation of the bone scaffolds. However, the 3D printing of CS-based hydrogels is still under early exploration. Knowing the fact that natural polymers are not so competent at holding large amounts of water, poly(vinyl alcohol) as the second polymer was employed. The novelty of the present research lies in the concept of employing sol-gel chemistry in order to attain proper viscosity and rheological behavior to give self-standing filaments of the polymer blends. Employing sol-gel reaction in the preparation of the hybrid hydrogels had the advantage of endowing shape fidelity to the polymer blend without any solidifying in the needle. The obtained organic-inorganic hybrids were directly printed and subsequently cross-linked. The best performance in terms of mechanical strength, cell viability, and bio-mineralization was observed for the 50:50 ratio. The in vitro cell culture and the bioactivity results showed that the printed scaffolds with this method have great potential in bone tissue engineering. Further, this method could be expandable to print other hydrogels with diverse applications such as implantable devices, soft robotics, etc.
MeSH term(s)	Chitosan/chemistry ; Tissue Scaffolds/chemistry ; Polyvinyl Alcohol ; Tissue Engineering/methods ; Polymers ; Hydrogels/chemistry ; Ethanol ; Printing, Three-Dimensional
Chemical Substances	Chitosan (9012-76-4) ; Polyvinyl Alcohol (9002-89-5) ; Polymers ; Hydrogels ; Ethanol (3K9958V90M)
Language	English
Publishing date	2023-12-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.128716
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Zs.B 2374: Show issues

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Article ; Online: The effect of olibanum on the rats with memory deficit induced by scopolamine.

Kazemi, Sara / Marefati, Narges / Beheshti, Farimah / Salmani, Hossein / Bigham, Maryam / Hosseini, Mahmoud

Central nervous system agents in medicinal chemistry

2023

Abstract: Background: Oxidative stress is an important contributor to Alzheimer's disease. Olibanum has therapeutic effects on various diseases. The effect of Olibanum on memory deficit induced by scopolamine (Sco) was challenged.: Methods: Four groups were ... ...

Abstract	Background: Oxidative stress is an important contributor to Alzheimer's disease. Olibanum has therapeutic effects on various diseases. The effect of Olibanum on memory deficit induced by scopolamine (Sco) was challenged. Methods: Four groups were considered as (1) control (2) Sco, (3-4) Sco - Olib 100 and 200 mg/kg. Treatment by Olib or vehicle was done for two weeks. The third week was accompanied by the Morris water maze (MWM) and passive avoidance (PA) with Sco injection. On the last day, the brain and hippocampus were used for evaluation of the malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and a total thiol group. Results: Sco increased the traveled time and distance to reach the hidden platform during five days of learning (p<0.01 - p<0.001) whereas it decreased the traveled time and distance (p<0.05- p<0.01) in the target area during the probe test of MWM. Sco also decreased delay time in the PA test (P<0.05 - P<0.001). Sco also decreased CAT, SOD, and thiol, whereas it, increased MDA in both the cortex and hippocampus (p<0.01 - p<0.001). Olib attenuated the impaired performance of the rats induced by Sco in MWM and PA tests. Olib reversed the increasing effects of Sco on MDA in both cortex and hippocampus and also reversed the attenuating effects of Sco on CAT, SOD, and thiol. Conclusion: Olib had an inhibitory effect on memory deficit induced by Sco probably through its anti-oxidant property.
Language	English
Publishing date	2023-09-01
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2227560-5
ISSN	1875-6166 ; 1871-5249
ISSN (online)	1875-6166
ISSN	1871-5249
DOI	10.2174/1871524923666230901142436
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Zs.A 5594: Show issues

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Article ; Online: Preventing Firearm-Related Death and Injury: A Call to Action for Wisconsin Health Systems and the Wisconsin Hospital Association.

Stiles, Melissa / Hargarten, Stephen / Lauby, Mary / Peterson, Nan / Bigham, James

WMJ : official publication of the State Medical Society of Wisconsin

2022 Volume 121, Issue 2, Page(s) 74–76

MeSH term(s)	Firearms ; Hospitals ; Humans ; United States ; Violence ; Wisconsin/epidemiology
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Editorial
ZDB-ID	441051-8
ISSN	2379-3961 ; 0043-6542 ; 1098-1861
ISSN (online)	2379-3961
ISSN	0043-6542 ; 1098-1861
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Article: Surgical management of an aspirated bone in a Shih Tzu terrier dog: a case report.

Ganjiani, Vahid / Bigham-Sadegh, Amin / Meimandi-Parizi, Abdolhamid / Nouroozi, Mohsen / Sarikhani, Dariush / Afraz, Parisa

Veterinary research forum : an international quarterly journal

2023 Volume 14, Issue 11, Page(s) 631–633

Abstract: Foreign bodies in the respiratory tract (trachea/bronchus) are very rare conditions; therefore, it is not on top of the list of differential diagnoses in patients with chronic or severe cough, but its occurrence should not be considered unexpected. A 2- ... ...

Abstract	Foreign bodies in the respiratory tract (trachea/bronchus) are very rare conditions; therefore, it is not on top of the list of differential diagnoses in patients with chronic or severe cough, but its occurrence should not be considered unexpected. A 2-year-old male Shih Tzu terrier mix dog (9.20 kg) with a history of dyspnea for 6 days was referred to the Veterinary Teaching Hospital of Shiraz University, Shiraz, Iran. In the clinical examination, respiratory distress and pain during palpation of the neck area were observed. Radiology indicated a triangular radiopaque object (bone) in the trachea of the animal. The size of the foreign body, the weakness of the grasping forceps of the device, and the edges of the bone being stuck in the trachea caused tracheoscopy failure after 30 min of trying. Surgical procedure (tracheotomy) was effective to remove the foreign body using Noyes alligator tissue forceps. Aspirated foreign body is not a common condition. In the case of early recognition and immediate treatment of the aspirated foreign body, the prognosis is usually good.
Language	English
Publishing date	2023-11-15
Publishing country	Iran
Document type	Case Reports
ISSN	2008-8140
ISSN	2008-8140
DOI	10.30466/vrf.2023.2001992.3876
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