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  1. Book: Riboswitches as targets and tools

    Burke-Aguero, Donald H.

    (Methods in enzymology ; 550)

    2015  

    Author's details ed. by Donald H. Burke-Aguero
    Series title Methods in enzymology ; 550
    Collection
    Language English
    Size XIX, 423, [48] S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier, AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    Note Includes bibliographical references and indexes
    HBZ-ID HT018542993
    ISBN 978-0-12-801123-2 ; 0-12-801123-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 222 -550- verfügbar in Königswinter Königswinter

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  2. Book: Riboswitch discovery, structure and function

    Burke-Aguero, Donald H.

    (Methods in enzymology ; 549)

    2014  

    Author's details ed. by Donald H. Burke-Aguero
    Series title Methods in enzymology ; 549
    Collection
    Language English
    Size XXIII, 546, [24] S. : Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier, AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018578739
    ISBN 978-0-12-801122-5 ; 0-12-801122-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 222 -549- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Minimizing amplification bias during reverse transcription for in vitro selections.

    Lucas, Jordyn K / Gruenke, Paige R / Burke, Donald H

    RNA (New York, N.Y.)

    2023  Volume 29, Issue 8, Page(s) 1301–1315

    Abstract: ... ...

    Abstract S
    MeSH term(s) Reverse Transcription ; DNA, Complementary ; RNA-Directed DNA Polymerase/genetics ; RNA-Directed DNA Polymerase/metabolism ; Gene Library ; RNA, Viral ; Aptamers, Nucleotide/chemistry ; SELEX Aptamer Technique
    Chemical Substances DNA, Complementary ; RNA-Directed DNA Polymerase (EC 2.7.7.49) ; RNA, Viral ; Aptamers, Nucleotide
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.079650.123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4777: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Cancer immunomodulation using bispecific aptamers.

    Thomas, Brian J / Porciani, David / Burke, Donald H

    Molecular therapy. Nucleic acids

    2022  Volume 27, Page(s) 894–915

    Abstract: Evasion of immune destruction is a major hallmark of cancer. Recent US Food and Drug Administration (FDA) approvals of various immunomodulating therapies underline the important role that reprogramming the immune system can play in combating this disease. ...

    Abstract Evasion of immune destruction is a major hallmark of cancer. Recent US Food and Drug Administration (FDA) approvals of various immunomodulating therapies underline the important role that reprogramming the immune system can play in combating this disease. However, a wide range of side effects still limit the therapeutic potential of immunomodulators, suggesting a need for more precise reagents with negligible off-target and on-target/off-tumor effects. Aptamers are single-chained oligonucleotides that bind their targets with high specificity and affinity owing to their three-dimensional (3D) structures, and they are one potential way to address this need. In particular, bispecific aptamers (bsApts) have been shown to induce artificial immune synapses that promote T cell activation and subsequent tumor cell lysis in various
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2022.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exponential growth of drug overdose poisoning and opportunities for intervention.

    Jalal, Hawre / Burke, Donald S

    Addiction (Abingdon, England)

    2023  Volume 117, Issue 5, Page(s) 1200–1202

    MeSH term(s) Drug Overdose ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Language
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.15841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 551: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Development of Nanomaterial-Modified Impedimetric Aptasensor-A Single-Step Strategy for 3,4-Methylenedioxymethylamphetamine Detection.

    Soni, Shringika / Jain, Utkarsh / Burke, Donald H / Chauhan, Nidhi

    Biosensors

    2022  Volume 12, Issue 7

    Abstract: Developing rapid, sensitive detection methods for 3,4-Methylenedioxymethylamphetamine (MDMA) is crucial to reduce its current misuse in the world population. With that aim, we developed an aptamer-modified tin nanoparticle (SnNP)-based nanoarchitecture ... ...

    Abstract Developing rapid, sensitive detection methods for 3,4-Methylenedioxymethylamphetamine (MDMA) is crucial to reduce its current misuse in the world population. With that aim, we developed an aptamer-modified tin nanoparticle (SnNP)-based nanoarchitecture as an electrochemical sensor in this study. This platform exhibited a high electron transfer rate with enhanced conductivity arising from its large surface area in comparison to the bare electrode. This observation was explained by the 40-fold higher electroactive surface area of SnNPs@Au, which provided a large space for 1.0 μM
    MeSH term(s) Aptamers, Nucleotide/chemistry ; Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Gold/chemistry ; Limit of Detection ; Metal Nanoparticles/chemistry ; N-Methyl-3,4-methylenedioxyamphetamine ; Nanostructures
    Chemical Substances Aptamers, Nucleotide ; Gold (7440-57-5) ; N-Methyl-3,4-methylenedioxyamphetamine (KE1SEN21RM)
    Language English
    Publishing date 2022-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12070538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Valency and affinity control of aptamer-conjugated nanoparticles for selective cancer cell targeting.

    Woythe, Laura / Porciani, David / Harzing, Tessa / van Veen, Stijn / Burke, Donald H / Albertazzi, Lorenzo

    Journal of controlled release : official journal of the Controlled Release Society

    2023  Volume 355, Page(s) 228–237

    Abstract: Nanoparticles (NPs) are commonly functionalized using targeting ligands to drive their selective uptake in cells of interest. Typical target cell types are cancer cells, which often overexpress distinct surface receptors that can be exploited for NP ... ...

    Abstract Nanoparticles (NPs) are commonly functionalized using targeting ligands to drive their selective uptake in cells of interest. Typical target cell types are cancer cells, which often overexpress distinct surface receptors that can be exploited for NP therapeutics. However, these targeted receptors are also moderately expressed in healthy cells, leading to unwanted off-tumor toxicities. Multivalent interactions between NP ligands and cell receptors have been investigated to increase the targeting selectivity towards cancer cells due to their non-linear response to receptor density. However, to exploit the multivalent effect, multiple variables have to be considered such as NP valency, ligand affinity, and cell receptor density. Here, we synthesize a panel of aptamer-functionalized silica-supported lipid bilayers (SSLB) to study the effect of valency, aptamer affinity, and epidermal growth factor receptor (EGFR) density on targeting specificity and selectivity. We show that there is an evident interplay among those parameters that can be tuned to increase SSLB selectivity towards high-density EGFR cells and reduce accumulation at non-tumor tissues. Specifically, the combination of high-affinity aptamers and low valency SSLBs leads to increased high-EGFR cell selectivity. These insights provide a better understanding of the multivalent interactions of NPs with cells and bring the nanomedicine field a step closer to the rational design of cancer nanotherapeutics.
    MeSH term(s) Humans ; Nanoparticles ; ErbB Receptors ; Neoplasms/drug therapy ; Cell Line, Tumor
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2023-02-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2023.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Methods in Enzymology. Riboswitches as targets and tools. Preface.

    Burke-Aguero, Donald H

    Methods in enzymology

    2015  Volume 550, Page(s) xv–xix

    MeSH term(s) Biology/methods ; Enzymes
    Chemical Substances Enzymes
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Introductory Journal Article
    ISSN 1557-7988 ; 0076-6879
    ISSN (online) 1557-7988
    ISSN 0076-6879
    DOI 10.1016/S0076-6879(15)00012-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reply commentary by Jalal and Burke.

    Burke, Donald S / Jalal, Hawre

    The International journal on drug policy

    2022  Volume 104, Page(s) 103674

    Language English
    Publishing date 2022-04-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2010000-0
    ISSN 1873-4758 ; 0955-3959
    ISSN (online) 1873-4758
    ISSN 0955-3959
    DOI 10.1016/j.drugpo.2022.103674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Valency and affinity control of aptamer-conjugated nanoparticles for selective cancer cell targeting

    Woythe, Laura / Porciani, David / Harzing, Tessa / van Veen, Stijn / Burke, Donald H. / Albertazzi, Lorenzo

    Journal of Controlled Release. 2023 Mar., v. 355 p.228-237

    2023  

    Abstract: Nanoparticles (NPs) are commonly functionalized using targeting ligands to drive their selective uptake in cells of interest. Typical target cell types are cancer cells, which often overexpress distinct surface receptors that can be exploited for NP ... ...

    Abstract Nanoparticles (NPs) are commonly functionalized using targeting ligands to drive their selective uptake in cells of interest. Typical target cell types are cancer cells, which often overexpress distinct surface receptors that can be exploited for NP therapeutics. However, these targeted receptors are also moderately expressed in healthy cells, leading to unwanted off-tumor toxicities. Multivalent interactions between NP ligands and cell receptors have been investigated to increase the targeting selectivity towards cancer cells due to their non-linear response to receptor density. However, to exploit the multivalent effect, multiple variables have to be considered such as NP valency, ligand affinity, and cell receptor density. Here, we synthesize a panel of aptamer-functionalized silica-supported lipid bilayers (SSLB) to study the effect of valency, aptamer affinity, and epidermal growth factor receptor (EGFR) density on targeting specificity and selectivity. We show that there is an evident interplay among those parameters that can be tuned to increase SSLB selectivity towards high-density EGFR cells and reduce accumulation at non-tumor tissues. Specifically, the combination of high-affinity aptamers and low valency SSLBs leads to increased high-EGFR cell selectivity. These insights provide a better understanding of the multivalent interactions of NPs with cells and bring the nanomedicine field a step closer to the rational design of cancer nanotherapeutics.
    Keywords epidermal growth factor receptors ; ligands ; lipid bilayers ; nanomedicine ; nanoparticles ; neoplasm cells ; oligonucleotides ; therapeutics ; Tumor targeting ; Silica-supported lipid bilayers ; Multivalency ; Nanoparticle targeting ; Aptamer avidity and affinity
    Language English
    Dates of publication 2023-03
    Size p. 228-237.
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2023.01.008
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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