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  1. Article: Unraveling the mystery: congenital absence of the portal vein and its cardiac implications.

    Xu, Zhanwen / Yin, Xiaoping

    Revista espanola de enfermedades digestivas

    2024  

    Abstract: A 25-year-old male with tachycardia and right heart enlargement was diagnosed with atrial-ventricular nodal reentrant tachycardia (AVNRT) and successfully treated with radiofrequency ablation. Cardiac MRI confirmed right heart enlargement but ruled out ... ...

    Abstract A 25-year-old male with tachycardia and right heart enlargement was diagnosed with atrial-ventricular nodal reentrant tachycardia (AVNRT) and successfully treated with radiofrequency ablation. Cardiac MRI confirmed right heart enlargement but ruled out cardiomyopathy. Further imaging revealed a rare congenital absence of the portal vein (CAPV) with an associated portosystemic shunt. This case highlights the importance of considering CAPV in unexplained cardiac symptoms and structural heart changes.
    Language English
    Publishing date 2024-03-07
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2024.10323/2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 199: Show issues Location:
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  2. Article: Dynamics of

    Hu, Xuemin / Fu, Songping / Li, Yuxiang / Xu, Xiangming / Hu, Xiaoping

    Plant disease

    2023  Volume 107, Issue 10, Page(s) 3155–3163

    Abstract: Wheat stripe rust, caused ... ...

    Abstract Wheat stripe rust, caused by
    MeSH term(s) Plant Diseases ; Puccinia ; Basidiomycota/genetics ; China
    Language English
    Publishing date 2023-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-02-23-0237-RE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2043: Show issues

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  3. Article ; Online: Adaptive Fixed-Time Control for High-Order Stochastic Nonlinear Time-Delay Systems: An Improved Lyapunov-Krasovskii Function.

    Xu, Ke / Wang, Huanqing / Liu, Peter Xiaoping

    IEEE transactions on cybernetics

    2024  Volume 54, Issue 2, Page(s) 776–786

    Abstract: In this article, the adaptive tracking control problem is considered for high-order stochastic nonlinear time-delay systems in fixed-time. Being different from existing results, an improved Lyapunov-Krasovskii function is designed, which can not only ... ...

    Abstract In this article, the adaptive tracking control problem is considered for high-order stochastic nonlinear time-delay systems in fixed-time. Being different from existing results, an improved Lyapunov-Krasovskii function is designed, which can not only compensate for the time-delay term but also remove the obstacle from the high-order term. Due to the introduction of the Lyapunov-Krasovskii function into the total Lyapunov function, it makes it difficult to stabilize the controlled system within a fixed-time interval. L'Hopital's rule is used to determine the boundedness of the Lyapunov-Krasovskii function, and the fixed-time boundedness of the integral functions can be inferred. By utilizing the fixed-time Lyapunov stability theorem, it is proved that the controlled system is semi-globally practical fixed-time stable (SGPFS), all the closed-loop signals (CLSs) are bounded within the fixed-time interval, and the tracking error converges into a small region around zero. The validity of the designed scheme is substantiated via simulation results.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2023.3337792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Delayed cardiotoxicity following osimertinib therapy in non-small cell lung cancer: a unique case report.

    Xu, Zhanwen / Jia, Haiyan / Yin, Xiaoping

    Anti-cancer drugs

    2024  

    Abstract: This case report features a 62-year-old male with stage IB lung adenocarcinoma harboring an epidermal growth factor receptor exon 19 deletion, who underwent treatment with osimertinib following a left upper lobectomy and lymph node dissection. Despite a ... ...

    Abstract This case report features a 62-year-old male with stage IB lung adenocarcinoma harboring an epidermal growth factor receptor exon 19 deletion, who underwent treatment with osimertinib following a left upper lobectomy and lymph node dissection. Despite a history of smoking and well-managed type 2 diabetes, the patient developed heart failure 18 months post-initiation of osimertinib therapy, marking one of the latest occurrences of heart failure following osimertinib treatment documented in limited literature. Cardiac MRI revealed significant left ventricular enlargement, lateral wall myocardial thinning, and localized myocardial fibrosis without perfusion defects, a finding not previously reported in literature. This case underscores the severe and unusual cardiac effects of osimertinib in patients with latent risk factors, highlighting the importance of vigilant cardiac monitoring and a multidisciplinary management approach.
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000001595
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3125: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: An extensive calcified chronic subdural hematoma.

    Wang, Han / Xu, Xiaoping / Yi, Yong / Liu, Bing

    Asian journal of surgery

    2023  Volume 46, Issue 11, Page(s) 4766–4767

    MeSH term(s) Humans ; Hematoma, Subdural, Chronic ; Calcinosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.05.089
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  6. Article ; Online: Identification of a necroptosis-related gene signature for making clinical predictions of the survival of patients with lung adenocarcinoma

    Xiaoping Zhou / Ming Zhao / Yingzi Fan / Ying Xu

    PeerJ, Vol 12, p e

    2024  Volume 16616

    Abstract: Background Lung adenocarcinoma (LUAD) is a major pathological subtype of malignant lung cancer with a poor prognosis. Necroptosis is a caspase-independent programmed cell death mode that plays a pivotal role in cancer oncogenesis and metastasis. Here, we ...

    Abstract Background Lung adenocarcinoma (LUAD) is a major pathological subtype of malignant lung cancer with a poor prognosis. Necroptosis is a caspase-independent programmed cell death mode that plays a pivotal role in cancer oncogenesis and metastasis. Here, we explore the prognostic values of different necroptosis-related genes (NRGs) in LUAD. Methods mRNA expression data and related clinical information for LUAD samples were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. NRGs were identified using the GeneCards database. Least absolute shrinkage and selection operator Cox regression and multivariate Cox analysis were used to construct a prognostic risk model. Time-dependent receiver-operating characteristic curves and a nomogram were constructed to validate the predictive values of the prognostic signatures. A necroptosis-related protein–protein interaction network was visualised using the STRING database and Cytoscape software. Functional analyses, including Gene Ontology, Kyoto Encyclopaedia of Genes and Genomes pathway enrichment, gene set enrichment, and gene set variation analyses, were conducted to explore the underlying molecular mechanisms. Finally, the mRNA expression of the prognostic signatures in LUAD cell lines was assessed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. Results A prognostic model was established for eight NRGs (CALM1, DDX17, FPR1, OGT, PGLYRP1, PRDX1, TUFM, and CPSF3) based on TCGA-cohort data and validated with the GSE68465 cohort. Patients with low-risk scores had better survival outcomes than those with high-risk scores (p = 0.00013). The nomogram was used to predict the prognosis of patients with LUAD. The prediction curves for 1-, 3-, and 5-year OS showed good predictive performance and the accuracy of the nomograms increased over time. RT-qPCR results demonstrated that these eight genes, especially CALM1, PRDX1, and PGLYRP1, were differentially expressed in LUAD cells. Conclusion We constructed a reliable ...
    Keywords Lung adenocarcinoma ; NRGs ; Prognosis ; ROC ; Nomogram ; Overall survival ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Identification of a necroptosis-related gene signature for making clinical predictions of the survival of patients with lung adenocarcinoma.

    Zhou, Xiaoping / Zhao, Ming / Fan, Yingzi / Xu, Ying

    PeerJ

    2024  Volume 12, Page(s) e16616

    Abstract: Background: Lung adenocarcinoma (LUAD) is a major pathological subtype of malignant lung cancer with a poor prognosis. Necroptosis is a caspase-independent programmed cell death mode that plays a pivotal role in cancer oncogenesis and metastasis. Here, ... ...

    Abstract Background: Lung adenocarcinoma (LUAD) is a major pathological subtype of malignant lung cancer with a poor prognosis. Necroptosis is a caspase-independent programmed cell death mode that plays a pivotal role in cancer oncogenesis and metastasis. Here, we explore the prognostic values of different necroptosis-related genes (NRGs) in LUAD.
    Methods: mRNA expression data and related clinical information for LUAD samples were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. NRGs were identified using the GeneCards database. Least absolute shrinkage and selection operator Cox regression and multivariate Cox analysis were used to construct a prognostic risk model. Time-dependent receiver-operating characteristic curves and a nomogram were constructed to validate the predictive values of the prognostic signatures. A necroptosis-related protein-protein interaction network was visualised using the STRING database and Cytoscape software. Functional analyses, including Gene Ontology, Kyoto Encyclopaedia of Genes and Genomes pathway enrichment, gene set enrichment, and gene set variation analyses, were conducted to explore the underlying molecular mechanisms. Finally, the mRNA expression of the prognostic signatures in LUAD cell lines was assessed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis.
    Results: A prognostic model was established for eight NRGs (CALM1, DDX17, FPR1, OGT, PGLYRP1, PRDX1, TUFM, and CPSF3
    Conclusion: We constructed a reliable eight-NRG signature that provides new insights for guiding clinical practice in the prognosis and treatment of LUAD.
    MeSH term(s) Humans ; Necroptosis/genetics ; Adenocarcinoma of Lung/genetics ; Lung Neoplasms/genetics ; Patients ; Calmodulin ; RNA, Messenger/genetics
    Chemical Substances Calmodulin ; RNA, Messenger
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine γ-lyase expression in a rat model of intracerebral hemorrhage.

    Liang, Tianyu / Xu, Sen / Liu, Renyang / Xia, Xiaoping

    Aging

    2024  Volume 16

    Abstract: Background: Intracerebral hemorrhage (ICH) comprises primary and secondary injuries, the latter of which induces increased inflammation and apoptosis and is more severe. Activating transcription factor 6 (ATF6) is a type-II transmembrane protein in the ... ...

    Abstract Background: Intracerebral hemorrhage (ICH) comprises primary and secondary injuries, the latter of which induces increased inflammation and apoptosis and is more severe. Activating transcription factor 6 (ATF6) is a type-II transmembrane protein in the endoplasmic reticulum (ER). ATF6 target genes could improve ER homeostasis, which contributes to cryoprotection. Hence, we predict that ATF6 will have a protective effect on brain tissue after ICH.
    Method: The ICH rat model was generated through autologous blood injection into the right basal ganglia, the expression of ATF6 after ICH was determined by WB and IF. The expression of ATF6 was effectively controlled by means of intervention, and a series of measures was used to detect cell death, neuroinflammation, brain edema, blood-brain barrier and other indicators after ICH. Finally, the effects on long-term neural function of rats were measured by behavioral means.
    Result: ATF6 was significantly increased in the ICH-induced brain tissues. Further, ATF6 was found to modulate the expression of cystathionine γ-lyase (CTH) after ICH. Upregulation of ATF6 attenuated neuronal apoptosis and inflammation in ICH rats, along with mitigation of ICH-induced brain edema, blood-brain barrier deterioration, and cognitive behavior defects. Conversely, ATF6 genetic knockdown induced effects counter to those aforementioned.
    Conclusions: This study thereby emphasizes the crucial role of ATF6 in secondary brain injury in response to ICH, indicating that ATF6 upregulation may potentially ameliorate ICH-induced secondary brain injury. Consequently, ATF6 could serve as a promising therapeutic target to alleviate clinical ICH-induced secondary brain injuries.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Liquid-Fermentation Formulation of

    Gao, Yuhan / Li, Xiaomin / Xu, Hui / Sun, Huijuan / Zhang, Junli / Wu, Xiaoping / Fu, Junsheng

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 8

    Abstract: Sanghuangporus ... ...

    Abstract Sanghuangporus sanghuang
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13081190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The efficacy and safety of sacubitril/valsartan compared with ACEI/ARB in the treatment of heart failure following acute myocardial infarction: a systematic review and meta-analysis of randomized controlled trials.

    Gao, Jinquan / Zhang, Xin / Xu, Mengzhuo / Deng, Shisu / Chen, Xiaoping

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1237210

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1237210
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