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Article ; Online: Endothelial Basement Membrane Laminins as an Environmental Cue in Monocyte Differentiation to Macrophages.

Li, Lixia / Song, Jian / Chuquisana, Omar / Hannocks, Melanie-Jane / Loismann, Sophie / Vogl, Thomas / Roth, Johannes / Hallmann, Rupert / Sorokin, Lydia

Frontiers in immunology

2020 Volume 11, Page(s) 584229

Abstract: Monocyte differentiation to macrophages is triggered by migration across the endothelial barrier, which is constituted by both endothelial cells and their underlying basement membrane. We address here the role of the endothelial basement membrane ... ...

Abstract	Monocyte differentiation to macrophages is triggered by migration across the endothelial barrier, which is constituted by both endothelial cells and their underlying basement membrane. We address here the role of the endothelial basement membrane laminins (laminins 411 and 511) in this monocyte to macrophage switch. Chimeric mice carrying CX3CR1-GFP bone marrow were employed to track CCL2-induced monocyte extravasation in a cremaster muscle model using intravital microscopy, revealing faster extravasation in mice lacking endothelial laminin 511 (
MeSH term(s)	Animals ; Basement Membrane/metabolism ; Cell Adhesion/physiology ; Cell Differentiation/physiology ; Cell Movement/physiology ; Cells, Cultured ; Cues ; Endothelial Cells/metabolism ; Endothelium/metabolism ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Integrins/metabolism ; Laminin/metabolism ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Monocytes/metabolism
Chemical Substances	Integrins ; Laminin
Language	English
Publishing date	2020-10-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.584229
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Article ; Online: The role of basement membrane laminins in vascular function.

Hallmann, Rupert / Hannocks, Melanie-Jane / Song, Jian / Zhang, Xueli / Di Russo, Jacopo / Luik, Anna-Liisa / Burmeister, Miriam / Gerwien, Hanna / Sorokin, Lydia

The international journal of biochemistry & cell biology

2020 Volume 127, Page(s) 105823

Abstract: The extracellular matrix is an integral component of the vasculature, contributing to both developmental processes and structural and functional homeostasis. We describe here the types of extracellular matrices that occur in different blood vessel types, ...

Abstract	The extracellular matrix is an integral component of the vasculature, contributing to both developmental processes and structural and functional homeostasis. We describe here the types of extracellular matrices that occur in different blood vessel types, ranging from capillaries to veins, venules and arteries, and focus on the endothelial basement membranes and the laminin family of proteins. We summarize data on the molecular composition of endothelial basement membranes, the structure and in vivo expression patterns of the main endothelial laminin isoforms (laminins 411 and 511) and their, to date, deciphered functions in the vasculature. A significant portion of the review focuses on postcapillary venules and leukocyte extravasation and how the endothelial laminins affect adhesion and migration of different leukocyte types, but also how laminins affect endothelial barrier function by modulating expression and localization of endothelial cell-cell junction molecules, and how these effects differ in CNS versus non-CNS tissues. Comparisons are made to small artery dilation in response to shear flow, which has been shown to be dependent on endothelial laminins and junctional complexes. The data discussed support a central role for basement membrane laminins in different aspects of micro- and macro-vessel endothelial function, but also reveal that many open questions remain, including the contribution of perivascular cells which are either embedded or in direct contact with the endothelial cell basement membrane laminins.
MeSH term(s)	Animals ; Basement Membrane/metabolism ; Blood Vessels/cytology ; Blood Vessels/metabolism ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Extracellular Matrix/metabolism ; Humans ; Laminin/metabolism ; Leukocytes/metabolism ; Protein Isoforms
Chemical Substances	Laminin ; Protein Isoforms
Language	English
Publishing date	2020-08-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1228429-4
ISSN	1878-5875 ; 1357-2725
ISSN (online)	1878-5875
ISSN	1357-2725
DOI	10.1016/j.biocel.2020.105823
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Article: The role of basement membrane laminins in vascular function

Hallmann, Rupert / Hannocks, Melanie-Jane / Song, Jian / Zhang, Xueli / Di Russo, Jacopo / Luik, Anna-Liisa / Burmeister, Miriam / Gerwien, Hanna / Sorokin, Lydia

international journal of biochemistry & cell biology. 2020 Oct., v. 127

2020

Abstract	The extracellular matrix is an integral component of the vasculature, contributing to both developmental processes and structural and functional homeostasis. We describe here the types of extracellular matrices that occur in different blood vessel types, ranging from capillaries to veins, venules and arteries, and focus on the endothelial basement membranes and the laminin family of proteins. We summarize data on the molecular composition of endothelial basement membranes, the structure and in vivo expression patterns of the main endothelial laminin isoforms (laminins 411 and 511) and their, to date, deciphered functions in the vasculature. A significant portion of the review focuses on postcapillary venules and leukocyte extravasation and how the endothelial laminins affect adhesion and migration of different leukocyte types, but also how laminins affect endothelial barrier function by modulating expression and localization of endothelial cell-cell junction molecules, and how these effects differ in CNS versus non-CNS tissues. Comparisons are made to small artery dilation in response to shear flow, which has been shown to be dependent on endothelial laminins and junctional complexes. The data discussed support a central role for basement membrane laminins in different aspects of micro- and macro-vessel endothelial function, but also reveal that many open questions remain, including the contribution of perivascular cells which are either embedded or in direct contact with the endothelial cell basement membrane laminins.
Keywords	adhesion ; basement membrane ; direct contact ; endothelial cells ; extracellular matrix ; homeostasis ; laminin ; leukocytes
Language	English
Dates of publication	2020-10
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1228429-4
ISSN	1878-5875 ; 1357-2725
ISSN (online)	1878-5875
ISSN	1357-2725
DOI	10.1016/j.biocel.2020.105823
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Article ; Online: Vascular laminins in physiology and pathology.

Di Russo, Jacopo / Hannocks, Melanie-Jane / Luik, Anna-Liisa / Song, Jian / Zhang, Xueli / Yousif, Lema / Aspite, Gunita / Hallmann, Rupert / Sorokin, Lydia

Matrix biology : journal of the International Society for Matrix Biology

2017 Volume 57-58, Page(s) 140–148

Language	English
Publishing date	2017
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1183793-7
ISSN	1569-1802 ; 0945-053X
ISSN (online)	1569-1802
ISSN	0945-053X
DOI	10.1016/j.matbio.2016.06.008
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Zs.A 1694: Show issues

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Article ; Online: Signals of the Neuropilin-1-MET Axis and Cues of Mechanical Force Exertion Converge to Elicit Inflammatory Activation in Coherent Endothelial Cells.

Rezaei, Maryam / Martins Cavaco, Ana C / Seebach, Jochen / Niland, Stephan / Zimmermann, Jana / Hanschmann, Eva-Maria / Hallmann, Rupert / Schillers, Hermann / Eble, Johannes A

Journal of immunology (Baltimore, Md. : 1950)

2019 Volume 202, Issue 5, Page(s) 1559–1572

Abstract: The neuropilin-1 (NRP1)-MET signaling axis regulates the motility of individual endothelial cells (ECs). It is unknown how this signaling pathway affects the endothelial barrier in coherent ECs forming a tight monolayer. We hypothesized that it is ... ...

Abstract	The neuropilin-1 (NRP1)-MET signaling axis regulates the motility of individual endothelial cells (ECs). It is unknown how this signaling pathway affects the endothelial barrier in coherent ECs forming a tight monolayer. We hypothesized that it is involved both in modulation of the endothelial barrier and in EC activation. To investigate the role of NRP1-MET signaling in inflammatory processes (e.g., systemic inflammatory response syndrome [SIRS] or snakebite-induced SIRS-like conditions), we employed the C-type lectin-related protein rhodocetin-αβ (RCαβ) as a specific trigger of this signal axis in ECs in vitro. In coherent HUVECs, RCαβ reinforced the actin cytoskeleton and increased cell stiffness, thus favoring vascular endothelial cadherin-mediated transmission of intercellular forces. Increased cell stiffness was associated with enhanced activation of RhoA and nuclear translocation of NF-κB. Simultaneously, RCαβ-triggered signaling via the NRP1-MET axis increased EC monolayer permeability, induced transcription of proinflammatory genes such as ICAM-1 and, consequently, leukocyte tethering. The RCαβ-induced transcriptome differed from that induced by hepatocyte growth factor, although in both cases the same tyrosine kinase, MET, was involved. This was due to RCαβ-mediated recruitment of the MET coreceptor NRP1 and additional Rho-mediated activation of the actomyosin system. RCαβ induced similar transcriptional and cellular changes if external shear forces were applied. These data highlight the modulatory role of NRP1 as MET coreceptor, and they explain how some snake venoms induce SIRS-like conditions. Additionally, this study demonstrates that inflammatory activation of coherent ECs is triggered by converging signals that are induced by NRP1-MET signaling and influenced by intercellular forces.
MeSH term(s)	Cells, Cultured ; Human Umbilical Vein Endothelial Cells/immunology ; Humans ; Inflammation/immunology ; Neuropilin-1/immunology ; Proto-Oncogene Proteins c-met/immunology ; Signal Transduction/immunology
Chemical Substances	Neuropilin-1 (144713-63-3) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
Language	English
Publishing date	2019-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1801346
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling.

Riese, Sebastian B / Kuehne, Christian / Tedder, Thomas F / Hallmann, Rupert / Hohenester, Erhard / Buscher, Konrad

Journal of immunology (Baltimore, Md. : 1950)

2014 Volume 192, Issue 4, Page(s) 1862–1869

Abstract: Selectins are a family of adhesion receptors designed for efficient leukocyte tethering to the endothelium under shear. As a key property to resist premature bond disruption, selectin adhesiveness is enhanced by tensile forces that promote the conversion ...

Abstract	Selectins are a family of adhesion receptors designed for efficient leukocyte tethering to the endothelium under shear. As a key property to resist premature bond disruption, selectin adhesiveness is enhanced by tensile forces that promote the conversion of a bent into an extended conformation of the N-terminal lectin and epidermal growth factor-like domains. Conformation-specific Abs have been invaluable in deciphering the activation mechanism of integrins, but similar reagents are not available for selectins. In this study, we show that the anti-human L-selectin mAbs DREG-55 and LAM1-5 but not DREG-56, DREG-200, or LAM1-1 heterotropically modulate adhesion presumably by stabilizing the extended receptor conformation. Force-free affinity assays, flow chamber, and microkinetic studies reveal a ligand-specific modulation of L-selectin affinity by DREG-55 mAb, resulting in a dramatic decrease of rolling velocity under flow. Furthermore, secondary tethering of polymorphonuclear cells was blocked by DREG-200 but significantly boosted by DREG-55 mAb. The results emphasize the need for a new classification for selectin Abs and introduce the new concept of heterotropic modulation of receptor function.
MeSH term(s)	Amino Acid Sequence ; Antibodies/immunology ; Antibodies, Monoclonal/immunology ; Cell Adhesion/immunology ; Cell Line ; Humans ; Jurkat Cells ; Leukocyte Rolling/immunology ; Neutrophils/immunology ; Selectins/immunology ; Selectins/metabolism ; Sequence Alignment
Chemical Substances	Antibodies ; Antibodies, Monoclonal ; Selectins
Language	English
Publishing date	2014-01-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1302147
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The regulation of immune cell trafficking by the extracellular matrix.

Hallmann, Rupert / Zhang, Xueli / Di Russo, Jacopo / Li, Lixia / Song, Jian / Hannocks, Melanie-Jane / Sorokin, Lydia

Current opinion in cell biology

2015 Volume 36, Page(s) 54–61

Abstract: The extracellular matrix (ECM) comes in different structural forms and biochemical compositions, which determine both its biophysical properties and its ability to convey specific signals to immune cells encountering or navigating through it. ... ...

Abstract	The extracellular matrix (ECM) comes in different structural forms and biochemical compositions, which determine both its biophysical properties and its ability to convey specific signals to immune cells encountering or navigating through it. Traditionally, the role of the individual ECM molecules on cell migration has been investigated independent of considerations such as the tension/mechanical strength constituted by the ECM. However, more recently, this aspect has attracted considerable attention and data suggest that rigidity and molecular signals derived from the ECM define the mode of cell migration. We here review the different types of ECM encountered by migrating immune cells in vivo, as well as current information on how both molecular components of the ECM and their supramolecular structure can impact on modes of immune cell migration.
MeSH term(s)	Animals ; Basement Membrane/metabolism ; Cell Movement ; Extracellular Matrix/metabolism ; Immune System
Language	English
Publishing date	2015-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1026381-0
ISSN	1879-0410 ; 0955-0674
ISSN (online)	1879-0410
ISSN	0955-0674
DOI	10.1016/j.ceb.2015.06.006
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Zs.A 2963: Show issues

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Article ; Online: Endothelial basement membrane laminin 511 is essential for shear stress response.

Di Russo, Jacopo / Luik, Anna-Liisa / Yousif, Lema / Budny, Sigmund / Oberleithner, Hans / Hofschröer, Verena / Klingauf, Juergen / van Bavel, Ed / Bakker, Erik Ntp / Hellstrand, Per / Bhattachariya, Anirban / Albinsson, Sebastian / Pincet, Frederic / Hallmann, Rupert / Sorokin, Lydia M

The EMBO journal

2017 Volume 36, Issue 10, Page(s) 1464

Language	English
Publishing date	2017-05-15
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.15252/embj.201797000
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Article ; Online: Role of the extracellular matrix in lymphocyte migration.

Korpos, Eva / Wu, Chuan / Song, Jian / Hallmann, Rupert / Sorokin, Lydia

Cell and tissue research

2010 Volume 339, Issue 1, Page(s) 47–57

Abstract: The extracellular matrix (ECM) exists in various biochemical and structural forms that can act either as a barrier to migrating leukocytes, in the case of basement membranes, or provide a physical scaffold supporting or guiding migration (interstitial ... ...

Abstract	The extracellular matrix (ECM) exists in various biochemical and structural forms that can act either as a barrier to migrating leukocytes, in the case of basement membranes, or provide a physical scaffold supporting or guiding migration (interstitial matrix). This review focuses on basement membranes and our current knowledge of the way that leukocytes transmigrate this protein barrier, with emphasis on T lymphocytes. Recent data suggest that the classical concept of cell-matrix adhesion requires revision with respect to leukocyte-ECM interactions. Whereas specific receptors may be required for leukocyte recognition of ECM molecules or three-dimensional structural domains, the role of adhesion in migration as perceived from the traditional studies of adherent cell-ECM interactions is less clear. Further, the indirect effects of ECM such as the binding and presentation of cytokines or chemotactic factors may more profoundly influence the directed migration of normally non-adherent leukocytes than the migration of adherent cells such as epithelial cells or fibroblasts. Proteases (in particular matrix metalloproteinases) released at sites of inflammation can selectively process ECM, cell surface molecules or soluble factors, which may result in the release of bioactive fragments that can function as chemoattractants for different leukocyte subsets or may modulate the activity/function of resident mesenchymal and immune cells. Current findings suggest that different leukocyte types employ different mechanisms to migrate across or through the ECM; this might be determined by the composition and organization of the ECM itself.
MeSH term(s)	Animals ; Basement Membrane/metabolism ; Basement Membrane/pathology ; Cell Adhesion ; Cell Movement ; Cytokines/metabolism ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Matrix Metalloproteinases/metabolism ; T-Lymphocytes/metabolism
Chemical Substances	Cytokines ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2010-01
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	125067-x
ISSN	1432-0878 ; 0302-766X
ISSN (online)	1432-0878
ISSN	0302-766X
DOI	10.1007/s00441-009-0853-3
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Book ; Thesis: Die Entwicklung des Blutgefässsystems in der Flügelanlage von Gallus gallus

Hallmann, Rupert

histolog. u. biochem. Unters. zur lokalen Wachstumsinhibition

1988

Language	Undetermined
Size	93 S, Ill., graph. Darst, 21 cm
Document type	Book ; Thesis
Thesis / German Habilitation thesis	@Tübingen, Univ., Diss. : 1988
Database	Former special subject collection: coastal and deep sea fishing

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