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Article ; Online: Evaluation of Organisational Structures of Self-help Groups in the Field of Paediatric Orthopaedics.

Peterlein, Christian-Dominik / Friedrich, Sinja / Daniel, Hanna / Malcherczyk, Dominik / Ruden, Janine / El Zayat, Bilal F

Zeitschrift fur Orthopadie und Unfallchirurgie

2018 Volume 157, Issue 1, Page(s) 54–58

Abstract: Background: There have been few publications on the organisational structures of self-help groups that handle orthopaedic disorders in children.: Material and methods: A standardised questionnaire was sent by post to the corresponding support groups. ...

Title translation	Evaluation der Organisationsstrukturen von Selbsthilfegruppen auf dem Gebiet der Kinderorthopädie.
Abstract	Background: There have been few publications on the organisational structures of self-help groups that handle orthopaedic disorders in children. Material and methods: A standardised questionnaire was sent by post to the corresponding support groups. The aim was to evaluate the self-help group's structure, use of social media and financial background. Results: Support groups for dwarfism, infantile cerebral palsy and Down syndrome responded and sent the questionnaire back to our department. Most self-help groups were incorporated societies and belonged to an umbrella organisation. The founding year was predominantly in the decade 1990 - 2000 (n = 15). The founders were predominantly parents (n = 28; 77.8%), concerned individuals (n = 11; 30.6%) and - in two cases - physicians (5.6%). 29 support groups (80.6%) received donations for financial support. The aims, activities, and manner of contact were presented in the home page (n = 35; 97.2%). Most self-help group focussing on paediatric orthopaedic disorders cooperate with physicians in different specialisations to obtain information and recommendations. Conclusions: The study presents the first information on self-help groups and documents the multidisciplinarity of paediatric orthopaedics. Close collaboration between paediatric orthopaedic surgeons and regional support groups might contribute to the reduction of uncertainty and fears and improve of medical provision.
MeSH term(s)	Cerebral Palsy/therapy ; Child ; Down Syndrome/therapy ; Humans ; Musculoskeletal Diseases/therapy ; Self-Help Groups/organization & administration ; Social Media
Language	German
Publishing date	2018-07-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2280747-0
ISSN	1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
ISSN (online)	1864-6743 ; 1438-941X
ISSN	1864-6697 ; 0044-3220
DOI	10.1055/a-0639-5795
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Complications after direct anterior versus Watson-Jones approach in total hip arthroplasty: results from a matched pair analysis on 1408 patients.

Klasan, Antonio / Neri, Thomas / Oberkircher, Ludwig / Malcherczyk, Dominik / Heyse, Thomas Jan / Bliemel, Christopher

BMC musculoskeletal disorders

2019 Volume 20, Issue 1, Page(s) 77

Abstract: Background: The direct anterior approach (DAA) has gained popularity in total hip arthroplasty (THA) over the past decade. A large number of studies have compared the DAA to other approaches with inclusion of a learning curve phase. The aim of this ... ...

Abstract	Background: The direct anterior approach (DAA) has gained popularity in total hip arthroplasty (THA) over the past decade. A large number of studies have compared the DAA to other approaches with inclusion of a learning curve phase. The aim of this study was to compare the complication rate and bleeding between the DAA and the anterolateral approach after the learning curve phase. Methods: For this retrospective, single-institutional study, propensity score matching was performed, from an initial cohort of 1408 patients receiving an elective THA. Two matching groups were created, comprising of 396 patients each. After matching, both groups were similar in age, gender, body mass index, anesthesiologist's score and surgeon's experience. Results: Average age in the matched groups was 68.7 ± 10.3 years. The total blood loss was similar in both groups, 450 vs 469 mL (p = 0.400), whereas the transfusion rate (14.1 vs 5.8%, p < 0.001) and the overall complication rate (17.6 vs 12.1%, p = 0.018) were lower in the DAA group. The overall fracture rate was comparable, 1.5 vs 1% (p = 0.376), as well as the early infection rate, 0.3 vs 1% (p = 0.162). The dislocation rate was significantly increased in the DAA group, 2.2 vs 0.5% (p = 0.032). Conclusions: The direct anterior approach has comparable short-term surgical complications with reduced transfusion and general complication rates. Level of evidence: Level III retrospective study.
MeSH term(s)	Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/methods ; Blood Loss, Surgical/prevention & control ; Blood Transfusion ; Female ; Germany ; Hip Joint/diagnostic imaging ; Hip Joint/physiopathology ; Hip Joint/surgery ; Humans ; Male ; Matched-Pair Analysis ; Middle Aged ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome
Language	English
Publishing date	2019-02-14
Publishing country	England
Document type	Comparative Study ; Journal Article
ISSN	1471-2474
ISSN (online)	1471-2474
DOI	10.1186/s12891-019-2463-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Concomitant glenohumeral pathologies in high-grade acromioclavicular separation (type III - V).

Markel, Jochen / Schwarting, Tim / Malcherczyk, Dominik / Peterlein, Christian-Dominik / Ruchholtz, Steffen / El-Zayat, Bilal Farouk

BMC musculoskeletal disorders

2017 Volume 18, Issue 1, Page(s) 439

Abstract: Background: Acromioclavicular joint (ACJ) dislocations are common injuries of the shoulder associated with physical activity. The diagnosis of concomitant injuries proves complicated due to the prominent clinical symptoms of acute ACJ dislocation. ... ...

Abstract	Background: Acromioclavicular joint (ACJ) dislocations are common injuries of the shoulder associated with physical activity. The diagnosis of concomitant injuries proves complicated due to the prominent clinical symptoms of acute ACJ dislocation. Because of increasing use of minimally invasive surgery techniques concomitant pathologies are diagnosed more often than with previous procedures. Methods: The aim of this study was to identify the incidence of concomitant intraarticular injuries in patients with high-grade acromioclavicular separation (Rockwood type III - V) as well as to reveal potential risk constellations. The concomitant pathologies were compiled during routine arthroscopically assisted treatment in altogether 163 patients (147 male; 16 female; mean age 36.8 years) with high-grade acromioclavicular separation (Rockwood type III: n = 60; Rockwood type IV: n = 6; Rockwood type V: n = 97). Results: Acromioclavicular separation occurred less often in women than men (1:9). In patients under 35, the most common cause for ACJ dislocation was sporting activity (37.4%). Rockwood type V was observed significantly more often than the other types with 57.5% (Rockwood type III = 36.8%, Rockwood type IV 3.7%). Concomitant pathologies were diagnosed in 39.3% of the patients with that number rising to as much as 57.3% in patients above 35 years. Most common associated injuries were rotator cuff injuries (32.3%), chondral defects (30.6%) and SLAP-lesions (22.6%). Of all patients, 8.6% needed additional reconstructive surgery. Conclusion: Glenohumeral injuries are a much more common epiphenomenon during acromioclavicular separation than previously ascertained. High risk group for accompanying injuries are patients above 35 years with preexisting degenerative disease. The increasing use of minimally invasive techniques allows for an easier diagnosis and simultaneous treatment of the additional pathologies.
MeSH term(s)	Acromioclavicular Joint/injuries ; Adult ; Female ; Germany/epidemiology ; Humans ; Male ; Retrospective Studies ; Shoulder Injuries/complications ; Shoulder Injuries/epidemiology ; Shoulder Injuries/surgery
Language	English
Publishing date	2017-11-10
Publishing country	England
Document type	Journal Article
ISSN	1471-2474
ISSN (online)	1471-2474
DOI	10.1186/s12891-017-1803-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Factors affecting blood loss and blood transfusion in patients with proximal humeral fractures.

Malcherczyk, Dominik / Klasan, Antonio / Ebbinghaus, Arne / Greene, Brandon / Bäumlein, Martin / Ruchholtz, Steffen / El-Zayat, Bilal F

Journal of shoulder and elbow surgery

2019 Volume 28, Issue 6, Page(s) e165–e174

Abstract: Background: The aim of this study was to determine the amount of blood loss and the rate of blood transfusion in patients receiving surgery for proximal humeral fractures depending on the treatment and fracture classification. Moreover, factors ... ...

Abstract	Background: The aim of this study was to determine the amount of blood loss and the rate of blood transfusion in patients receiving surgery for proximal humeral fractures depending on the treatment and fracture classification. Moreover, factors associated with blood loss and blood transfusion were analyzed. Methods: The study included 420 patients who had received surgery for proximal humeral fractures. Data from medical records were collected retrospectively. The calculated blood loss and the transfusion rate were analyzed depending on the type of surgery (plate fixation, arthroplasty, and others) or the fracture classification (2-, 3-, and 4-part fractures). The extent of blood loss and the need for transfusion were correlated with potential risk factors. A score to estimate the probability of blood transfusion was developed. Results: Average blood loss was 284 mL, and the transfusion rate was 14.5% for all proximal humeral fractures. Shoulder arthroplasty was associated with higher blood loss (353 mL, P < .01) and a higher blood transfusion rate (27.3%, P < .01) than plate fixation (263 mL and 10.9%, respectively). The fracture classification had no effect on either factor. Significant risk factors for blood loss were male sex, body mass index, surgery time, time until surgery, and vitamin K antagonists. Age, blood loss, American Society of Anesthesiologists score greater than 2, vitamin K antagonists, coronary artery disease (CAD), peripheral artery disease (PAD), and renal disease were associated with a higher transfusion rate. Conclusion: Blood loss could be affected by a shorter surgery time and by choosing an adequate time until surgery. The consideration of risk factors and the use of a transfusion risk score allow more elaborate ordering of cross-matched blood units and can decrease institutional costs.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Shoulder/statistics & numerical data ; Blood Loss, Surgical/statistics & numerical data ; Blood Transfusion/statistics & numerical data ; Bone Plates/statistics & numerical data ; Cohort Studies ; Databases, Factual ; Female ; Germany/epidemiology ; Humans ; Injury Severity Score ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Shoulder Fractures/epidemiology ; Shoulder Fractures/surgery
Language	English
Publishing date	2019-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2019.01.018
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Article: Evaluation of Organisational Structures of Self-help Groups in the Field of Paediatric Orthopaedics

Peterlein, Christian-Dominik / Friedrich, Sinja / Daniel, Hanna / Malcherczyk, Dominik / Ruden, Janine / El Zayat, Bilal F.

Zeitschrift für Orthopädie und Unfallchirurgie

2018 Volume 157, Issue 01, Page(s) 54–58

Abstract: Hintergrund: Studien über Selbsthilfegruppen zu Krankheitsbildern auf kinderorthopädischem Fachgebiet und deren Organisationsformen liegen im deutschsprachigen und internationalen Raum bisher noch nicht vor.: Material und Methoden: Mittels eines auf ... ...

Abstract	Hintergrund: Studien über Selbsthilfegruppen zu Krankheitsbildern auf kinderorthopädischem Fachgebiet und deren Organisationsformen liegen im deutschsprachigen und internationalen Raum bisher noch nicht vor. Material und Methoden: Mittels eines auf postalischem Weg verschickten, standardisierten Fragebogens wurden gezielt Organisationsstruktur, Kommunikationsplattformen und Art der Finanzierung von dem Anforderungsprofil entsprechenden Selbsthilfegruppen ermittelt. Ergebnisse: Die zahlenmäßig häufigsten Rückmeldungen kamen von Selbsthilfegruppen zum Krankheitsbild Kleinwuchs, infantile Zerebralparese und Trisomie 21. Die Mehrzahl der befragten Selbsthilfegruppen hatte den Status eines eingetragenen Vereins und war einem Dachverband angeschlossen. Das Gründungsjahr war primär in der Dekade 1990 – 2000 (n = 15); Gründer waren überwiegend Eltern (n = 28; 77,8%), Betroffene (n = 11; 30,6%) und nur in 2 Fällen (5,6%) Ärzte. 80,6% der ausgewerteten Selbsthilfegruppen (n = 29) finanzierte sich auch über Spenden. Die Darstellung der Ziele, der Aktivitäten und der Möglichkeit einer ersten Kontaktaufnahme erfolgt primär über die eigene Homepage (n = 35; 97,2%). Nicht wenige Selbsthilfegruppen zu kinderorthopädischen Grunderkrankungen arbeiten mit Ärzten unterschiedlicher Disziplinen zusammen und lassen sich von diesen beraten. Schlussfolgerung: Diese Studie liefert erste Daten über Organisationsstrukturen kinderorthopädischer Selbsthilfegruppen und verdeutlicht die Interdisziplinarität des Fachs Kinderorthopädie. Eine enge Zusammenarbeit zwischen Kinderorthopäden und lokalen Selbsthilfegruppen könnte helfen, Ängste und Unsicherheiten abzubauen und die Qualität der medizinischen Versorgung vor Ort zu verbessern. ; Background: There have been few publications on the organisational structures of self-help groups that handle orthopaedic disorders in children. Material and Methods: A standardised questionnaire was sent by post to the corresponding support groups. The aim was to evaluate the self-help groupʼs structure, use of social media and financial background. Results: Support groups for dwarfism, infantile cerebral palsy and Down syndrome responded and sent the questionnaire back to our department. Most self-help groups were incorporated societies and belonged to an umbrella organisation. The founding year was predominantly in the decade 1990 – 2000 (n = 15). The founders were predominantly parents (n = 28; 77.8%), concerned individuals (n = 11; 30.6%) and – in two cases – physicians (5.6%). 29 support groups (80.6%) received donations for financial support. The aims, activities, and manner of contact were presented in the home page (n = 35; 97.2%). Most self-help group focussing on paediatric orthopaedic disorders cooperate with physicians in different specialisations to obtain information and recommendations. Conclusions: The study presents the first information on self-help groups and documents the multidisciplinarity of paediatric orthopaedics. Close collaboration between paediatric orthopaedic surgeons and regional support groups might contribute to the reduction of uncertainty and fears and improve of medical provision.
Keywords	Kinderorthopädie ; Studie ; Selbsthilfegruppe ; Internet ; soziale Medien ; paediatric orthopaedics ; study ; self-help group ; internet ; social media
Language	English
Publishing date	2018-07-11
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2280747-0
ISSN	1864-6743 ; 1438-941X ; 1864-6697 ; 0044-3220
ISSN (online)	1864-6743 ; 1438-941X
ISSN	1864-6697 ; 0044-3220
DOI	10.1055/a-0639-5795
Database	Thieme publisher's database

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Article ; Online: Transfusions increase complications and infections after hip and knee arthroplasty: An analysis of 2760 cases.

Klasan, Antonio / Dworschak, Philipp / Heyse, Thomas J / Malcherczyk, Dominik / Peterlein, Christian D / Schüttler, Karl F / Lahner, Matthias / El-Zayat, Bilal Farouk

Technology and health care : official journal of the European Society for Engineering and Medicine

2018 Volume 26, Issue 5, Page(s) 825–832

Abstract: Background: Knee and hip replacement surgery are still the mainstay therapy for osteoarthritis. In spite of the improvement of techniques and implants, anemia is a relatively common complication, with transfusion rates of up to 23% in some centers.: ... ...

Abstract	Background: Knee and hip replacement surgery are still the mainstay therapy for osteoarthritis. In spite of the improvement of techniques and implants, anemia is a relatively common complication, with transfusion rates of up to 23% in some centers. Objective: The purpose of the study was to determine a correlation of transfusions to complications including infection since this topic is still being debated or even disputed in the literature. Methods: This is a level III, single center retrospective observational cohort study of 2760 unilateral primary knee and hip replacements. Preoperative assessment, the number of transfusions and the occurrence of complications were collected and the correlations were analyzed using analysis of variance and logistic regression. Results: Fifteen percent of all patients developed at least one complication. Transfusion rate was 9%. Risk factors for receiving a transfusion were female gender, hip replacement, American Society of Anesthesiologists' Score (ASA) > III, history of myocardial infarction, chronic cardiac disease, diabetes mellitus, chronic kidney disease, and length of surgery. The risk factors for developing a complication were: ASA score, presence of chronic renal insufficiency, and transfusion during hospital stay. Transfusion increases the risk of complications and infection rate. Complication rate with transfusion was 34.7% and without transfusion 13.2%. Infection rate without transfusion was 0.4% and with transfusion 2.82%. Conclusions: The complication rate is higher in transfused patients. The number of complications rises linearly with the number of transfusions. Infection rate is also higher after a transfusion. Efforts should be made to reduce the transfusion rate.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/methods ; Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/methods ; Blood Transfusion/statistics & numerical data ; Comorbidity ; Female ; Humans ; Length of Stay/statistics & numerical data ; Logistic Models ; Male ; Middle Aged ; Operative Time ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors ; Sex Factors ; Surgical Wound Infection/epidemiology
Language	English
Publishing date	2018-06-18
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	1159961-3
ISSN	1878-7401 ; 0928-7329
ISSN (online)	1878-7401
ISSN	0928-7329
DOI	10.3233/THC-181324
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Zs.A 3846: Show issues

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Article ; Online: Patient-specific instruments' routine use over conventional total knee arthroplasty remains inconclusive: Analysis of 961 cases.

Klasan, Antonio / Dworschak, Philipp / Heyse, Thomas J / Lahner, Matthias / Malcherczyk, Dominik / Efe, Turgay / El-Zayat, Bilal Farouk

Technology and health care : official journal of the European Society for Engineering and Medicine

2018 Volume 26, Issue 3, Page(s) 523–528

Abstract: Background: An increasing demand for total knee arthroplasty (TKA) has pushed innovations in the industry and created a promising new technique called patient specific instruments (PSI). Early reports had promising results such as reducing operative ... ...

Abstract	Background: An increasing demand for total knee arthroplasty (TKA) has pushed innovations in the industry and created a promising new technique called patient specific instruments (PSI). Early reports had promising results such as reducing operative time, cost, and improved alignment. More recent reports are conflicting. Objective: We aimed to evaluate bleeding, operative time, complication rates, and in-hospital stay. Methods: A monocentric retrospective analysis was performed on a total of 961 patients that met inclusion criteria. Four different TKA Systems, two of which were performed using conventional instrumentation (CI) (n= 768) and two with PSI (n= 193) were trialed under the same conditions by three senior surgeons. Operative time, complications, bleeding, range of motion, and length of stay were analyzed. Results: There was no difference in operative time (p= 0.991) and length of hospital stay (p= 0.371) between PSI and CI approaches. Complication rates were lower in the PSI group. CI patients showed less non-compensated blood loss (p< 0.001) but required more transfusions (5.8% vs. 1.5%, p= 0.014). Conclusions: There was no difference in duration of surgery, length of stay, and total blood loss when performing TKA with PSI or CI. There were fewer complications in the PSI group. It remains debatable whether these findings justify routine use of PSI in TKA.
MeSH term(s)	Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee/instrumentation ; Arthroplasty, Replacement, Knee/methods ; Blood Loss, Surgical ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Operative Time ; Osteoarthritis, Knee/surgery ; Postoperative Complications/epidemiology ; Range of Motion, Articular ; Retrospective Studies
Language	English
Publishing date	2018-03-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1159961-3
ISSN	1878-7401 ; 0928-7329
ISSN (online)	1878-7401
ISSN	0928-7329
DOI	10.3233/THC-171167
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3846: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The effect of ankle tape on joint position sense after local muscle fatigue: a randomized controlled trial.

Jahjah, Akram / Seidenspinner, Dietmar / Schüttler, Karl / Klasan, Antonio / Heyse, Thomas J / Malcherczyk, Dominik / El-Zayat, Bilal Farouk

BMC musculoskeletal disorders

2018 Volume 19, Issue 1, Page(s) 8

Abstract: Background: Ankle tape is widely used by athletes to prevent ankle sprain. Although there is growing evidence that ankle tape improve joint position sense, but yet it is not clear even if tape improve joint position sense after muscle fatigue, because ... ...

Abstract	Background: Ankle tape is widely used by athletes to prevent ankle sprain. Although there is growing evidence that ankle tape improve joint position sense, but yet it is not clear even if tape improve joint position sense after muscle fatigue, because fatigue impair joint position sense and raise the risk of ankle sprain. The aim of this study is to examine the effect of ankle tape on joint position sense after local muscle fatigue. Method: This trial is a randomized controlled trial. 34 healthy subjects participated in this trial. Subjects were randomized distributed into two groups: with tape and without tape. Active and passive absolute error and variable error mean values for two target positions of the ankle joint (15° inversions and inversion minus 5°) before and after fatigue protocol consisted of 30 consecutive maximal concentric/concentric contractions of the ankle evertors and invertors. In this trail joint position sense for all subjects was assessed using The Biodex System isokinetic dynamometer 3, this system is used also for fatigue protocol. Results: For the variable error (VE), significant mean effect was found for active joint position sense in 15° of inversion after muscle fatigue (P < 0, 05). It was a significant decrease in the work in the last third of inversion detected (P < 0, 05). There was no significant main effect found for fatigue index of eversion. Conclusion: Ankle tape can improve joint position sense at the fatigue session when joint position sense becomes worse. As a result, ankle tape may be useful to prevent ankle sprain during playing sports. We suggest athletes and individuals at risk of ankle sprain to apply taping before high-load activity. Trial registration: The study was retrospectively registered on the ISRCTN registry with study ID ISRCTN30042335 on 12th December 2017.
MeSH term(s)	Adult ; Ankle Injuries/physiopathology ; Ankle Injuries/prevention & control ; Ankle Joint/physiology ; Athletic Tape/utilization ; Female ; Humans ; Male ; Muscle Fatigue/physiology ; Proprioception/physiology ; Treatment Outcome
Language	English
Publishing date	2018-01-09
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ISSN	1471-2474
ISSN (online)	1471-2474
DOI	10.1186/s12891-017-1909-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Expression of MMP-9 decreases metastatic potential of Chondrosarcoma: an immunohistochemical study.

Malcherczyk, Dominik / Heyse, Thomas J / El-Zayat, Bilal F / Kunzke, Vanessa / Moll, Roland / Fuchs-Winkelmann, Susanne / Paletta, Jürgen R J

BMC musculoskeletal disorders

2018 Volume 19, Issue 1, Page(s) 9

Abstract: Background: Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that will allow for a more accurate ... ...

Abstract	Background: Chondrosarcoma is the second most common primary malignant bone tumor. Because of their heterogeneity, with differences in invasive and metastatic behavior, it is important to identify biological markers that will allow for a more accurate estimation of prognosis in patients with these tumors. Matrix metalloproteinases (MMP) play a crucial role in tumor progression, invasion and metastasis. The mechanism of tumor progression dependent of MMPs is complex and influences malignant transformation, angiogenesis and tumor growth at the primary and metastatic sites. The purpose of this study was to investigate immunohistochemicaly the influence of MMP-1, MMP-3, MMP-9 and MMP-13 expression on prognostic parameter in chondrosarcoma. Methods: We investigated tissue samples of 28 patients with chondrosarcoma. Immunohistochemical staining to evaluate the expression of MMP-1, MMP-3, MMP-9 and MMP-13 was performed. Subsequently, the expression level was correlated with metastatic potential, histological grading and overall survival in patients with this neoplasm. Results: In consideration of semi quantitative scoring 64% of chondrosarcoma were scored as positive for MMP-1, 46% for MMP-3, 61% for MMP-9. The specimens had shown no expression of MMP-13. High expression of MMP-9 was associated with better histological differentiation, decreased metastatic potential and favourable overall survival. No correlation was found for expression of MMP-1, MMP-3 or MMP-13. Conclusions: MMP-1, MMP-3 and MMP-9 are expressed in chondrosarcoma. Our findings suggest that the expression of MMP-9 is associated with clinical outcome parameters in chondrosarcoma.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/biosynthesis ; Biomarkers, Tumor/genetics ; Bone Neoplasms/diagnosis ; Bone Neoplasms/enzymology ; Bone Neoplasms/mortality ; Chondrosarcoma/diagnosis ; Chondrosarcoma/enzymology ; Chondrosarcoma/mortality ; Female ; Follow-Up Studies ; Gene Expression Regulation, Enzymologic ; Humans ; Immunohistochemistry ; Male ; Matrix Metalloproteinase 9/analysis ; Matrix Metalloproteinase 9/biosynthesis ; Matrix Metalloproteinase 9/genetics ; Middle Aged ; Young Adult
Chemical Substances	Biomarkers, Tumor ; MMP9 protein, human (EC 3.4.24.35) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2018-01-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2474
ISSN (online)	1471-2474
DOI	10.1186/s12891-017-1920-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differences in total blood loss and transfusion rate between different indications for shoulder arthroplasty.

Malcherczyk, Dominik / Hack, Juliane / Klasan, Antonio / Abdelmoula, Asma / Heyse, Thomas J / Greene, Brandon / El-Zayat, Bilal F

International orthopaedics

2018 Volume 43, Issue 3, Page(s) 653–658

Abstract: Purpose: In this study, the total blood loss, transfusion rate and number of transfused blood units in patients with different indications for shoulder arthroplasty: primary, fracture and secondary were compared. Risk factors for bleeding and ... ...

Abstract	Purpose: In this study, the total blood loss, transfusion rate and number of transfused blood units in patients with different indications for shoulder arthroplasty: primary, fracture and secondary were compared. Risk factors for bleeding and transfusion were analysed. Methods: Medical records and the database of the institution's blood bank from 527 patients that received shoulder arthroplasty were analysed retrospectively. This study included 419 patients that were divided in three different groups: primary (n = 278), fracture (n = 110) and secondary (following prior osteosynthesis; n = 31) shoulder arthroplasty. The demographic and clinical data were collected. The total blood loss (TBL) was calculated and transfusions recorded. Results: The transfusion rate and mean amount of transfused blood units (BU) were higher in fracture (32.7% and 0.69BU, p < 0.01) and secondary arthroplasty (35.5% and 0.97BU, p < 0.01) than in primary arthroplasty (12.6% and 0.28BU). The overall transfusion rate was 19.6% at a mean TBL of 370 ml. However, patients with primary arthroplasty experienced significantly higher total blood loss than those after fracture arthroplasty (p < 0.01). Longer surgery time and male sex are significant risk factors for elevated blood loss. The pre-operative use of vitamin K antagonist, cemented arthroplasty, high BMI, coronary heart disease and ASA score > 2 are relevant risk factors for blood transfusion. Conclusion: The most important susceptible factor that affects the TBL is the surgery time. Transfusion rates are higher in patients with fracture arthroplasty than after primary arthroplasty.
MeSH term(s)	Aged ; Arthroplasty, Replacement, Shoulder/adverse effects ; Blood Loss, Surgical ; Blood Transfusion ; Female ; Humans ; Joint Diseases/surgery ; Male ; Middle Aged ; Postoperative Hemorrhage ; Retrospective Studies ; Risk Factors ; Shoulder Joint/surgery
Language	English
Publishing date	2018-08-03
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-018-4047-z
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