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  1. Article ; Online: L

    Tian, Hua / Liu, Jingxin / Guo, Jianrong / Cao, Leigang / He, Junhui

    Talanta

    2022  Volume 242, Page(s) 123320

    Abstract: Developing non-noble metal, even metal-free chemical sensors for the detection of toxic heavy metal ions is significantly desirable for economically and environmentally sustainable application but has heretofore remained elusive. Herein, ... ...

    Abstract Developing non-noble metal, even metal-free chemical sensors for the detection of toxic heavy metal ions is significantly desirable for economically and environmentally sustainable application but has heretofore remained elusive. Herein, a
    MeSH term(s) Adsorption ; Colorimetry/methods ; Cysteine ; Graphite ; Hydrogen Peroxide ; Mercury ; Peroxidase ; Peroxidases
    Chemical Substances graphene oxide ; Graphite (7782-42-5) ; Hydrogen Peroxide (BBX060AN9V) ; Peroxidases (EC 1.11.1.-) ; Peroxidase (EC 1.11.1.7) ; Mercury (FXS1BY2PGL) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2022-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2022.123320
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  2. Article ; Online: L

    Zhang, Heng / Guo, Hongbo / Li, Shuangchen / Liu, Yanqiu / He, Xuelei / He, Xiaowei / Hou, Yuqing

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2021  Volume 2021, Page(s) 3640–3645

    Abstract: ... distribution. In this paper, we proposed L ...

    Abstract Fluorescent Molecular Tomography (FMT) is a highly sensitive and noninvasive imaging method that provides three-dimensional distribution of biomarkers by noninvasive detection of fluorescent marker probes. However, due to the light scattering effect and ill-posedness of inverse problems, it is challenging to develop an efficient construction method that can provide the exact location and morphology of the fluorescence distribution. In this paper, we proposed L
    MeSH term(s) Algorithms ; Animals ; Computer Simulation ; Image Processing, Computer-Assisted ; Mice ; Tomography ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC46164.2021.9630236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: L-GrAFT

    Li, Songming / Luo, Qijie / Chen, Shirui / Jia, Zehua / Wang, Tielong / Yu, Xinyu / Wang, Wenjing / YuyiZhang / Zhu, Jiaxing / Deng, Feiwen / Sun, Qiang / Guo, Zhiyong / He, Xiaoshun

    Journal of clinical and translational hepatology

    2023  Volume 12, Issue 1, Page(s) 62–69

    Abstract: ... the Liver Graft Assessment Following Transplantation (L-GrAFT) risk model in a Chinese cohort of 942 adult ... patients undergoing primary liver transplantation at three Chinese centers. L-GrAFT (L-GrAFT: Results: L ... GrAFT: Conclusions: The accuracy of L-GrAFT ...

    Abstract Background and aims: Increasing utilization of extended criteria donor leads to an increasing rate of early allograft failure after liver transplantation. However, consensus of definition of early allograft failure is lacking.
    Methods: A retrospective, multicenter study was performed to validate the Liver Graft Assessment Following Transplantation (L-GrAFT) risk model in a Chinese cohort of 942 adult patients undergoing primary liver transplantation at three Chinese centers. L-GrAFT (L-GrAFT
    Results: L-GrAFT
    Conclusions: The accuracy of L-GrAFT
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2023.00178
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  4. Article ; Online: Bipolar Membrane Electrodialysis for Direct Conversion of L-Ornithine Monohydrochloride to L-Ornithine.

    He, Jinfeng / Liu, Wenlong / Hao, Jianrong / Ma, Xixi / Zheng, Zhiyi / Fang, Yinghan / Liang, Yuxin / Tian, Zhihao / Sun, Li / Li, Chuanrun / Yan, Haiyang

    International journal of molecular sciences

    2023  Volume 24, Issue 17

    Abstract: In this study, bipolar membrane electrodialysis was proposed to directly convert L-ornithine ... monohydrochloride to L-ornithine. The stack configuration was optimized in the BP-A (BP, bipolar membrane; A, anion ...

    Abstract In this study, bipolar membrane electrodialysis was proposed to directly convert L-ornithine monohydrochloride to L-ornithine. The stack configuration was optimized in the BP-A (BP, bipolar membrane; A, anion exchange membrane) configuration with the Cl
    MeSH term(s) Membranes ; Endoplasmic Reticulum ; Ornithine
    Chemical Substances Ornithine (E524N2IXA3)
    Language English
    Publishing date 2023-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241713174
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  5. Article ; Online: L-Theanine and Immunity: A Review.

    Chen, Shuna / Kang, Jiaxin / Zhu, Huanqing / Wang, Kaixi / Han, Ziyi / Wang, Leyu / Liu, Junsheng / Wu, Yuanyuan / He, Puming / Tu, Youying / Li, Bo

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 9

    Abstract: L-theanine (N-ethyl-γ-glutamine) is the main amino acid in tea leaves. It not only contributes ... activities, the immunomodulatory effects of L-theanine have received less attention. Clinical and epidemiological studies have ... shown that L-theanine reduces immunosuppression caused by strenuous exercise and prevents colds and ...

    Abstract L-theanine (N-ethyl-γ-glutamine) is the main amino acid in tea leaves. It not only contributes to tea flavor but also possesses several health benefits. Compared with its sedative and calming activities, the immunomodulatory effects of L-theanine have received less attention. Clinical and epidemiological studies have shown that L-theanine reduces immunosuppression caused by strenuous exercise and prevents colds and influenza by improving immunity. Numerous cell and animal studies have proven that theanine plays an immunoregulatory role in inflammation, nerve damage, the intestinal tract, and tumors by regulating γδT lymphocyte function, glutathione (GSH) synthesis, and the secretion of cytokines and neurotransmitters. In addition, theanine can be used as an immunomodulator in animal production. This article reviews the research progress of L-theanine on immunoregulation and related mechanisms, as well as its application in poultry and animal husbandry. It is hoped that this work will be beneficial to future related research.
    MeSH term(s) Animals ; Glutamates/chemistry ; Cytokines ; Immunity ; Tea/chemistry
    Chemical Substances theanine (8021PR16QO) ; Glutamates ; Cytokines ; Tea
    Language English
    Publishing date 2023-05-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28093846
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Equine enterocytes actively oxidize l-glutamine, but do not synthesize l-citrulline or l-arginine from l-glutamine or l-proline in vitro.

    Martinez, Rafael E / Leatherwood, Jessica L / Bradbery, Amanda N / Silvers, Brittany L / Fridley, Jennifer / Arnold, Carolyn E / Posey, Erin A / He, Wenliang / Bazer, Fuller W / Wu, Guoyao

    Journal of animal science

    2022  Volume 100, Issue 4

    Abstract: ... O2/5% CO2) Krebs bicarbonate buffer (pH 7.4) containing 5 mM D-glucose and 0 mM, 2-mM L-[U-14C ... glutamine, or 2 mM L-[U-14C]proline plus 2 mM L-glutamine. Concentrations of arginine, citrulline, and ...

    Abstract In livestock species, the enterocytes of the small intestine are responsible for the synthesis of citrulline and arginine from glutamine and proline. At present, little is known about de novo synthesis of citrulline and arginine in horses. To test the hypothesis that horses of different age groups can utilize glutamine and proline for the de novo synthesis of citrulline and arginine, jejunal enterocytes from 19 horses of three different age groups: neonates (n = 4; 7.54 ± 2.36 d of age), adults (n = 9; 6.4 ± 0.35 yr), and aged (n = 6; 22.9 ± 1.0 yr) with healthy gastrointestinal tracts were used in the present study. Enterocytes were isolated from the jejunum and incubated at 37 °C for 30 min in oxygenated (95% O2/5% CO2) Krebs bicarbonate buffer (pH 7.4) containing 5 mM D-glucose and 0 mM, 2-mM L-[U-14C]glutamine, or 2 mM L-[U-14C]proline plus 2 mM L-glutamine. Concentrations of arginine, citrulline, and ornithine in cells plus medium were determined using high-performance liquid chromatography. Results indicate that the rate of oxidation of glutamine to CO2 was high in enterocytes from neonatal horses, but low in cells from adult and aged horses. Enterocytes from all age groups of horses did not degrade proline into CO2. Regardless of age, equine enterocytes formed ornithine from glutamine and proline, but failed to convert ornithine into citrulline and arginine. Because arginine is an essential substrate for the synthesis of not only proteins, but also nitrogenous metabolites (e.g., nitric oxide, polyamines, and creatine), our novel findings have important implications for the nutrition, performance, and health of horses.
    MeSH term(s) Animals ; Arginine/metabolism ; Carbon Dioxide/metabolism ; Citrulline/metabolism ; Enterocytes ; Glutamine/metabolism ; Horses ; Ornithine/metabolism ; Proline/metabolism
    Chemical Substances Glutamine (0RH81L854J) ; Carbon Dioxide (142M471B3J) ; Citrulline (29VT07BGDA) ; Arginine (94ZLA3W45F) ; Proline (9DLQ4CIU6V) ; Ornithine (E524N2IXA3)
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390959-1
    ISSN 1525-3163 ; 0021-8812
    ISSN (online) 1525-3163
    ISSN 0021-8812
    DOI 10.1093/jas/skac077
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1312: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: DsbA-L: A Promising Therapeutic Target for Metabolic Diseases.

    Yang, Ming / Luo, Shilu / Yang, Jinfei / Chen, Wei / He, Liyu / Liu, Di / Wang, Xi / Xiao, Li / Sun, Lin

    Current medicinal chemistry

    2023  

    Abstract: ... for these diseases. DsbA-L is a protein that is widely expressed in many tissues and is closely related to metabolism ... Emerging evidence shows that DsbA-L plays an important role in antioxidative stress, promoting ... we reviewed the tissue expression patterns and regulatory factors of DsbA-L, summarized its biological ...

    Abstract The increasing incidence of metabolic diseases, including obesity and diabetes, is a serious social public problem. Therefore, there is an urgent need to find effective prevention and treatment measures for these diseases. DsbA-L is a protein that is widely expressed in many tissues and is closely related to metabolism. Emerging evidence shows that DsbA-L plays an important role in antioxidative stress, promoting the synthesis and secretion of adiponectin and maintaining mitochondrial homeostasis, and the abnormalities of these functions are also closely related to the occurrence and development of metabolic diseases. Here, we reviewed the tissue expression patterns and regulatory factors of DsbA-L, summarized its biological functions and the current research progress of DsbA-L in metabolic diseases, and found that DsbA-L may be a promising target for metabolic diseases.
    Language English
    Publishing date 2023-10-24
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0109298673252630231018044159
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Anti-inflammatory steroids from the stems of Solanum nigrum L.

    Deng, Junru / Wang, Lin / Jin, Qingyu / Zeng, Jia / Xu, Jingwen / He, Xiangjiu / Wang, Yihai

    Phytochemistry

    2023  Volume 210, Page(s) 113667

    Abstract: ... from the stems of Solanum nigrum L. (Solanaceae). Their structures were identified using a combination of 1D and ...

    Abstract Sixteen previously undescribed steroidal sapogenins along with two known ones were isolated from the stems of Solanum nigrum L. (Solanaceae). Their structures were identified using a combination of 1D and 2D NMR, HR-ESI-MS spectroscopy, the Mosher method, and X-ray diffraction analysis. Compounds 1-8 have an unusual F ring and 9-12 have a derived A ring, both of which are rare skeletons found in natural products. The biological evaluation showed that the isolated steroids exhibited inhibition of nitric oxide in the LPS-induced RAW 264.7 macrophages with IC
    MeSH term(s) Animals ; Mice ; Solanum nigrum/chemistry ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/metabolism ; Macrophages/metabolism ; NF-kappa B/metabolism ; Steroids/chemistry ; Lipopolysaccharides/pharmacology ; Nitric Oxide ; Nitric Oxide Synthase Type II/metabolism ; RAW 264.7 Cells
    Chemical Substances Anti-Inflammatory Agents ; NF-kappa B ; Steroids ; Lipopolysaccharides ; Nitric Oxide (31C4KY9ESH) ; Nitric Oxide Synthase Type II (EC 1.14.13.39)
    Language English
    Publishing date 2023-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2023.113667
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    In stock of ZB MED Bonn / Germany

    Z 1586: Show issues
    Z 8.5: Show issues

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  9. Article ; Online: Robust transformed l

    Yuan, Yating / Yi, Huangjian / Kang, Dizhen / Yu, Jingjing / Guo, Hongbo / He, Xuelei / He, Xiaowei

    Computer methods and programs in biomedicine

    2023  Volume 234, Page(s) 107503

    Abstract: ... However, traditional algorithms that use the squared l: Methods: In this study, we propose a novel robust ... transformed l: Results: Various numerical simulations and in vivo bead-implanted mouse experiments were ...

    Abstract Background and objective: Fluorescence molecular tomography (FMT) is a non-invasive molecular imaging modality that can be used to observe the three-dimensional distribution of fluorescent probes in vivo. FMT is a promising imaging technique in clinical and preclinical research that has attracted significant attention. Numerous regularization based reconstruction algorithms have been proposed. However, traditional algorithms that use the squared l
    Methods: In this study, we propose a novel robust transformed l
    Results: Various numerical simulations and in vivo bead-implanted mouse experiments were conducted to verify the performance of the proposed method. The experimental results show that the DCATL1 algorithm is more robust than the state-of-the-art approaches and achieves better source localization and morphology recovery.
    Conclusions: The in vivo experiments showed that DCATL1 can be used to visualize the distribution of fluorescent probes inside biological tissues and promote preclinical application in small animals, demonstrating the feasibility and effectiveness of the proposed method.
    MeSH term(s) Animals ; Mice ; Fluorescence ; Fluorescent Dyes ; Tomography/methods ; Algorithms ; Phantoms, Imaging ; Image Processing, Computer-Assisted/methods
    Chemical Substances Fluorescent Dyes
    Language English
    Publishing date 2023-03-22
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632564-6
    ISSN 1872-7565 ; 0169-2607
    ISSN (online) 1872-7565
    ISSN 0169-2607
    DOI 10.1016/j.cmpb.2023.107503
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 521: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Structural Basis of the Inhibition of L-Methionine γ-Lyase from

    Bu, Tingting / Lan, Jing / Jo, Inseong / Zhang, Jie / Bai, Xue / He, Shanru / Jin, Xiaoling / Wang, Lulu / Jin, Yu / Jin, Xiaoyu / Zhang, Liying / Piao, Hailong / Ha, Nam-Chul / Quan, Chunshan / Nam, Ki Hyun / Xu, Yongbin

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Fusobacterium ... ...

    Abstract Fusobacterium nucleatum
    MeSH term(s) Fusobacterium nucleatum/metabolism ; Molecular Docking Simulation ; Hydrogen Sulfide/pharmacology ; Hydrogen Sulfide/metabolism ; Carbon-Sulfur Lyases/genetics ; Carbon-Sulfur Lyases/metabolism
    Chemical Substances L-methionine gamma-lyase (EC 4.4.1.11) ; Hydrogen Sulfide (YY9FVM7NSN) ; Carbon-Sulfur Lyases (EC 4.4.-)
    Language English
    Publishing date 2023-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021651
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