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  1. Article: Citric Acid and Magnolol Ameliorate

    Ding, Xieying / Zhong, Xin / Yang, Yunqiao / Zhang, Geyin / Si, Hongbin

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 4

    Abstract: Clostridium ... ...

    Abstract Clostridium perfringens
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13040577
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  2. Article ; Online: Mitigation of the small-scale self-focusing effect by a rotating laser beam in a high-power laser.

    Nie, Hongbin / Wu, Shijiang / Zhong, Zheqiang / Zhang, Bin

    Applied optics

    2023  Volume 62, Issue 15, Page(s) 4115–4122

    Abstract: Intense lasers tend to produce nonlinear effects during propagating through the nonlinear media, which greatly limits the output power and beam quality of lasers. The approach against small-scale self-focusing (SSSF) of high-power lasers (HPLs) is ... ...

    Abstract Intense lasers tend to produce nonlinear effects during propagating through the nonlinear media, which greatly limits the output power and beam quality of lasers. The approach against small-scale self-focusing (SSSF) of high-power lasers (HPLs) is proposed by using rotating beams generated by the coherent superposition of two vortex beams with opposite topological charges and frequency shift. The propagation model of rotating beams in the nonlinear medium is established, and the SSSF effects of the non-rotating and rotating beams are numerically simulated and comparatively analyzed. The results show that, compared with the non-rotating beam, the rotating beam can contribute to the reduction of the breakup integral and mid-high frequency components of the HPLs.
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.489928
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  3. Article ; Online: A synergetic promotion of surface stability for high-voltage LiCoO

    Lin, Hongbin / Kang, Xiumei / Xu, Guigui / Chen, Yue / Zhong, Kehua / Zhang, Jian-Min / Huang, Zhigao

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 5, Page(s) 4174–4183

    Abstract: The utilization of high-voltage ... ...

    Abstract The utilization of high-voltage LiCoO
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04130a
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  4. Article ; Online: Degradation of Sulfamethoxazole by Manganese(IV) Oxide in the Presence of Humic Acid: Role of Stabilized Semiquinone Radicals.

    Zhong, Chen / Cao, Hongbin / Huang, Qingguo / Xie, Yongbing / Zhao, He

    Environmental science & technology

    2023  Volume 57, Issue 36, Page(s) 13625–13634

    Abstract: In this work, we demonstrate for the first time the abatement of sulfamethoxazole (SMX) induced by ... ...

    Abstract In this work, we demonstrate for the first time the abatement of sulfamethoxazole (SMX) induced by stabilized
    MeSH term(s) Sulfamethoxazole ; Humic Substances ; Manganese ; Oxides ; Manganese Compounds
    Chemical Substances Sulfamethoxazole (JE42381TNV) ; Humic Substances ; Manganese (42Z2K6ZL8P) ; Oxides ; semiquinone radicals (3225-29-4) ; Manganese Compounds
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c03698
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  5. Article ; Online: Ectopic expression of the Arabidopsis mutant L3 NB-LRR receptor gene in Nicotiana benthamiana cells leads to cell death.

    Huang, Jianzhong / Jia, Peng / Zhong, Xiaoju / Guan, Xiuying / Zhang, Hongbin / Gao, Zhiyong

    Gene

    2024  Volume 906, Page(s) 148256

    Abstract: Nucleotide-binding sites and leucine-rich repeat proteins (NLRs) act as critical intracellular immune receptors. Previous studies reported an Arabidopsis-resistant gene L3 (AT1G15890), which encoded a coiled-coil (CC) NLR that conferred cell death in ... ...

    Abstract Nucleotide-binding sites and leucine-rich repeat proteins (NLRs) act as critical intracellular immune receptors. Previous studies reported an Arabidopsis-resistant gene L3 (AT1G15890), which encoded a coiled-coil (CC) NLR that conferred cell death in bacteria; however, its function in planta remains unclear. This study describes a comprehensive structure-function analysis of L3 in Nicotiana benthamiana. The results of the transient assay showed that the L3 CC domain is sufficient for cell-death induction. The first 140 amino acid segment constituted the minimal function region that could cause cell death. The YFP-labeled L3 CC domain was localized to the plasma membrane, which was considered crucial for the function and self-interaction of the L3 CC domain. The results of point mutations analysis showed that L3 CC domain function is affected by mutations in some specific residues, and loss-of-function mutations in the CC domain affected the function of full-length L3. These study results offered considerable evidence to understand the activation mechanism of L3.
    MeSH term(s) Arabidopsis/genetics ; Arabidopsis/metabolism ; Nicotiana/genetics ; Amino Acid Sequence ; Ectopic Gene Expression ; Carrier Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cell Death/genetics ; Plant Diseases/genetics ; Plant Proteins/metabolism
    Chemical Substances Carrier Proteins ; Arabidopsis Proteins ; Plant Proteins
    Language English
    Publishing date 2024-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2024.148256
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    Zs.A 1357: Show issues Location:
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  6. Article ; Online: Stratification of Health Professional Education and Its Funding Disparities: Evidence From China During the Period of 1998-2017.

    Gao, Wenjuan / Li, Wenzhuo / Zang, Yue / Zhong, Yuxin / Wu, Hongbin

    Frontiers in public health

    2022  Volume 9, Page(s) 800163

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) China ; Education, Professional ; Health Personnel ; Humans ; Schools, Medical ; Universities
    Language English
    Publishing date 2022-01-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2021.800163
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  7. Article: TiO

    Chen, Zhanjun / Wang, Tao / Yang, Xianglin / Peng, Yangxi / Zhong, Hongbin / Hu, Chuanyue

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 5

    Abstract: The thermal stability of the polyethylene (PE) separator is of utmost importance for the safety of lithium-ion batteries. Although the surface coating of PE separator with oxide nanoparticles can improve thermal stability, some serious problems still ... ...

    Abstract The thermal stability of the polyethylene (PE) separator is of utmost importance for the safety of lithium-ion batteries. Although the surface coating of PE separator with oxide nanoparticles can improve thermal stability, some serious problems still exist, such as micropore blockage, easy detaching, and introduction of excessive inert substances, which negatively affects the power density, energy density, and safety performance of the battery. In this paper, TiO
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16052049
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  8. Article ; Online: Optimal vitamin D supplement dosage for improving insulin resistance in children and adolescents with overweight/obesity: a systematic review and network meta-analysis.

    Zhu, Linlian / Li, Shan / Zhong, Lijuan / Xu, Shiping / Zhu, Hongbin

    European journal of nutrition

    2023  Volume 63, Issue 3, Page(s) 763–775

    Abstract: Purpose: We conducted a network meta-analysis which aims to evaluate the comparative efficacy of different supplementation dosages of vitamin D on cardiometabolic and bone-metabolic indicators as well as insulin resistance in children and adolescents ... ...

    Abstract Purpose: We conducted a network meta-analysis which aims to evaluate the comparative efficacy of different supplementation dosages of vitamin D on cardiometabolic and bone-metabolic indicators as well as insulin resistance in children and adolescents with overweight/obesity.
    Methods: Eligible studies published before December 10, 2022 were retrieved from PubMed, EMBASE, Cochrane Library, and Web of Science. Mean difference and 95% confidence interval (CI) were used to express pooled estimates. Network meta-analysis of multiple doses, including low (< 1000 IU/day, LDS), medium (1000-2000 IU/day, MDS), high (2000-4000 IU/day, HDS), and extremely high (> 4000 IU/day, EHDS) dosage strategy, was conducted using STATA/MP 14.0.
    Results: Our network meta-analysis of 15 RCTs suggested that, compared with placebo and LDS, EHDS was increased 25-(OH)-D, with a pooled MD of 8.65 (95% CI 4.72-12.58) and 7.66 (95% CI 0.91-14.41), respectively. Meanwhile, EHDS also decreased ho meostasis model assessment-insulin resistance (HOMA-IR) (MD: - 0.74; 95% CI: - 1.45 to - 0.04) and C-reactive protein (CRP) (MD: - 18.99; 95% CI - 21.60 to - 16.38), and EHDS was also better than LDS (MD: - 18.47; 95% CI - 20.66 to - 16.28) and MDS (MD: - 19.69; 95% CI - 22.17 to - 17.21) in decreasing CRP. Ranking probability suggested that EHDS ranked best for increasing 25-(OH)-D, and decreasing HOMA-IR and CRP, with a probability of 86.1%, 83.1%, and 76.6%, respectively.
    Conclusions: The results of our network meta-analysis suggest that EHDS may be the best strategy for vitamin D supplementation to reduce inflammatory responses as well as improve insulin resistance in children and adolescents with overweight/obesity.
    Prospero registration number: CRD42023387775.
    MeSH term(s) Child ; Humans ; Adolescent ; Insulin Resistance/physiology ; Overweight/drug therapy ; Network Meta-Analysis ; Vitamin D ; Obesity/drug therapy ; Dietary Supplements ; C-Reactive Protein
    Chemical Substances Vitamin D (1406-16-2) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2023-12-30
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-023-03301-x
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    Ue I Zs.262: Show issues Location:
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  9. Article ; Online: Do you need sharpened details? Asking MMDC-Net: Multi-layer multi-scale dilated convolution network for retinal vessel segmentation.

    Zhong, Xiang / Zhang, Hongbin / Li, Guangli / Ji, Donghong

    Computers in biology and medicine

    2022  Volume 150, Page(s) 106198

    Abstract: Convolutional neural networks (CNN), especially numerous U-shaped models, have achieved great progress in retinal vessel segmentation. However, a great quantity of global information in fundus images has not been fully explored. And the class imbalance ... ...

    Abstract Convolutional neural networks (CNN), especially numerous U-shaped models, have achieved great progress in retinal vessel segmentation. However, a great quantity of global information in fundus images has not been fully explored. And the class imbalance problem of background and blood vessels is still serious. To alleviate these issues, we design a novel multi-layer multi-scale dilated convolution network (MMDC-Net) based on U-Net. We propose an MMDC module to capture sufficient global information under diverse receptive fields through a cascaded mode. Then, we place a new multi-layer fusion (MLF) module behind the decoder, which can not only fuse complementary features but filter noisy information. This enables MMDC-Net to capture the blood vessel details after continuous up-sampling. Finally, we employ a recall loss to resolve the class imbalance problem. Extensive experiments have been done on diverse fundus color image datasets, including STARE, CHASEDB1, DRIVE, and HRF. HRF has a large resolution of 3504 × 2336 whereas others have a small resolution of slightly more than 512 × 512. Qualitative and quantitative results verify the superiority of MMDC-Net. Notably, satisfactory accuracy and sensitivity are acquired by our model. Hence, some key blood vessel details are sharpened. In addition, a large number of further validations and discussions prove the effectiveness and generalization of the proposed MMDC-Net.
    MeSH term(s) Retinal Vessels/diagnostic imaging ; Fundus Oculi ; Neural Networks, Computer ; Image Processing, Computer-Assisted ; Algorithms
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2022.106198
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    Zs.A 653: Show issues Location:
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  10. Article ; Online: Azobenzene-Based Linker Strategy for Selective Activation of Antibody-Drug Conjugates.

    Xiao, Dian / Liu, Lianqi / Xie, Fei / Dong, Jingwen / Wang, Yanming / Xu, Xin / Zhong, Wu / Deng, Hongbin / Zhou, Xinbo / Li, Song

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 16, Page(s) e202310318

    Abstract: Existing antibody-drug conjugate (ADC) linkers, whether cleavable or non-cleavable, are designed to release highly toxic payloads or payload derivatives upon internalisation of the ADCs into cells. However, clinical studies have shown that only <1 % of ... ...

    Abstract Existing antibody-drug conjugate (ADC) linkers, whether cleavable or non-cleavable, are designed to release highly toxic payloads or payload derivatives upon internalisation of the ADCs into cells. However, clinical studies have shown that only <1 % of the dosed ADCs accumulate in tumour cells. The remaining >99 % of ADCs are nonspecifically distributed in healthy tissue cells, thus inevitably leading to off-target toxicity. Herein, we describe an intelligent tumour-specific linker strategy to address these limitations. A tumour-specific linker is constructed by introducing a hypoxia-activated azobenzene group as a toxicity controller. We show that this azobenzene-based linker is non-cleavable in healthy tissues (O
    MeSH term(s) Humans ; Antineoplastic Agents/pharmacology ; Immunoconjugates ; Azo Compounds ; Neoplasms ; Cell Line, Tumor ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents ; Immunoconjugates ; azobenzene (F0U1H6UG5C) ; Azo Compounds
    Language English
    Publishing date 2024-03-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202310318
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