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  1. Article ; Online: A

    de Bruijn, Suzanne E / Smits, Jeroen J / Liu, Chang / Lanting, Cornelis P / Beynon, Andy J / Blankevoort, Joëlle / Oostrik, Jaap / Koole, Wouter / de Vrieze, Erik / Cremers, Cor W R J / Cremers, Frans P M / Roosing, Susanne / Yntema, Helger G / Kunst, Henricus P M / Zhao, Bo / Pennings, Ronald J E / Kremer, Hannie

    Journal of medical genetics

    2020  

    Abstract: Background: Hearing loss is one of the most prevalent disabilities worldwide, and has a significant impact on quality of life. The adult-onset type of the condition is highly heritable but the genetic causes are largely unknown, which is in contrast to ... ...

    Abstract Background: Hearing loss is one of the most prevalent disabilities worldwide, and has a significant impact on quality of life. The adult-onset type of the condition is highly heritable but the genetic causes are largely unknown, which is in contrast to childhood-onset hearing loss.
    Methods: Family and cohort studies included exome sequencing and characterisation of the hearing phenotype. Ex vivo protein expression addressed the functional effect of a DNA variant.
    Results: An in-frame deletion of 12 nucleotides in
    Conclusion: Collectively, the presented data demonstrate that an inherited form of adult-onset hearing loss is relatively common, with potentially thousands of individuals at risk in the Netherlands and beyond, which makes it an attractive target for developing a (genetic) therapy.
    Language English
    Publishing date 2020-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmedgenet-2020-106863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 177: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Book ; Online ; E-Book: Clinical guide to exposure therapy

    Smits, Jasper A. J.

    beyond phobias

    2022  

    Author's details Jasper A. J. Smits [and four others]
    Keywords Phobias/Treatment ; Exposure therapy ; Teràpia d'exposició ; Fòbies ; Terapèutica
    Subject code 616.85223
    Language English
    Size 1 online resource (358 pages)
    Publisher Springer International Publishing
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-04927-6 ; 9783031049262 ; 978-3-031-04927-9 ; 3031049268
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: The Visual Memory of Protest

    Rigney, Ann / Smits, Thomas

    (Protest and Social Movements)

    2023  

    Series title Protest and Social Movements
    Keywords Social & cultural history ; Sociology ; Media studies ; activism, protest, cultural memory, visual representation
    Language English
    Size 1 electronic resource (233 pages)
    Publisher Amsterdam University Press
    Publishing place Amsterdam
    Document type Book ; Online
    Note English
    HBZ-ID HT030381762
    ISBN 9789463723275 ; 9463723277
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Radioembolization Working in Synergy with Chemotherapy in NET, but can Dosimetry Bring us Even Further?

    Smits, Maarten / Braat, Arthur

    Cardiovascular and interventional radiology

    2024  Volume 47, Issue 4, Page(s) 529–530

    MeSH term(s) Humans ; Radiometry ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/drug therapy ; Yttrium Radioisotopes/therapeutic use ; Embolization, Therapeutic
    Chemical Substances Yttrium Radioisotopes
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-024-03678-0
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  5. Article: Quantitative Adherence Level Evaluation Among Long-Term Antiretroviral Therapy Patients in Latvia.

    Gavrilova, Anna / Zolovs, Maksims / Urtāne, Inga / Šmits, Dins

    Patient preference and adherence

    2023  Volume 17, Page(s) 3147–3154

    Abstract: Introduction: The global prevalence of human immunodeficiency virus (HIV) remains substantial, particularly in regions with limited resources, despite the progress in scientific knowledge and the accessibility of antiretroviral therapy (ART). ART is the ...

    Abstract Introduction: The global prevalence of human immunodeficiency virus (HIV) remains substantial, particularly in regions with limited resources, despite the progress in scientific knowledge and the accessibility of antiretroviral therapy (ART). ART is the cornerstone of HIV treatment. Ensuring proper adherence to medication therapy is essential for effective HIV infection control. Meanwhile, Latvia reported one of the highest rates of HIV infections among EU countries.
    Purpose: This study aimed to assess adherence levels to ART among long-term users by utilizing the National Health Service prescription electronic database records. It is essential to determine whether non-adherence is a problem at the state level.
    Patients and methods: This retrospective study was conducted utilizing the Latvian National Health Service's reimbursed prescription database, covering the period from January 2017 to December 2018. The analysis included ART prescriptions. Medication adherence was assessed using a Proportion of Days Covered (PDC) calculation. The adherence rates were categorized into three groups: (1) < 80% (non-adherence), (2) 80% to 90% (suboptimal adherence), and (3) > 90% (optimal adherence) groups.
    Results: A total of 25,892 ARV medicines prescription records for 1471 patients were analysed. The adherence level of long-term ART was 38.3%. Of all patients, only 37 (2.5%) had achieved an optimal and 25 (1.7%) suboptimal adherence level. Meanwhile, the remaining patients (95.8%) were identified as non-adherent to therapy. It has been determined that 96.1% (n=1414) of patients experienced a time gap of more than 90 days between their prescriptions at least once. On average, each patient had 3.5 of these gaps, with a maximum of 7 times.
    Conclusion: Medication adherence level to ART is low in Latvia. Less than 3% of patients achieved optimal adherence levels with a PDC higher than 90%. These results are concerning. Further studies and interventions must be conducted to enhance adherence levels.
    Language English
    Publishing date 2023-12-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2455848-5
    ISSN 1177-889X
    ISSN 1177-889X
    DOI 10.2147/PPA.S437611
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  6. Article ; Online: De overgang.

    Janssen, C A H / Smits, Anneloes A L

    Nederlands tijdschrift voor geneeskunde

    2024  Volume 167

    Abstract: In this educative article 10 medical questions related to the menopausal transition are answered. The questions are related to etiology, symptomatology, lab investigation, sexuality, need for contraception, hormonal and non-hormonal treatments and their ... ...

    Title translation Menopausal transition.
    Abstract In this educative article 10 medical questions related to the menopausal transition are answered. The questions are related to etiology, symptomatology, lab investigation, sexuality, need for contraception, hormonal and non-hormonal treatments and their risks and benefits. The purpose of this article is to assist the healthcare practitioner to understand the impact of the menopausal transition, to recognize the symptoms and to understand the risks and benefits of treatment. As women on average work and live longer, they are on average 30 percent of their lives postmenopausal. Attention should be paid to quality of life not only during menopausal transition, but also thereafter, with special awareness of the long term sequelae on women's health.
    MeSH term(s) Humans ; Female ; Quality of Life ; Menopause ; Contraception ; Disease Progression ; Educational Status
    Language Dutch
    Publishing date 2024-01-17
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  7. Article ; Online: Re: Longitudinal Fluctuations in Treatment Response After OnabotulinumToxinA and Sacral Neuromodulation for Refractory Urgency Incontinence.

    Smits, Martijn A C / Heesakkers, John P F A

    European urology

    2024  

    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2024.01.027
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  8. Article ; Online: Multimodal Techniques to Study Tumor Growth, Basement Membrane Breaching, and Invasion in 3D Matrices.

    Smits, Daan / Khalil, Antoine A

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2608, Page(s) 281–303

    Abstract: Cancer-derived organoids and three-dimensional (3D) extracellular matrix (ECM) are taking center stage as in vitro models to study neoplastic cell behavior, since they recapitulate the heterogeneous cellular composition of tumors and their extracellular ... ...

    Abstract Cancer-derived organoids and three-dimensional (3D) extracellular matrix (ECM) are taking center stage as in vitro models to study neoplastic cell behavior, since they recapitulate the heterogeneous cellular composition of tumors and their extracellular environment. In combination with imaging and molecular/biochemical techniques, 3D organoid models have contributed substantially to our knowledge about the cellular and molecular mechanisms that regulate the growth of tumors and invasion into the surrounding tissue. We here outline a set of protocols that describe culturing of cancer-derived organoids in 3D matrices and various strategies that allow modeling of tumor growth, tumor cell penetration into basement membranes, and invasion into Collagen I-rich ECM. Furthermore, we specify protocols for subsequent handling of organoids cultured in 3D ECM for confocal microscopy and analysis of gene expression at the protein and mRNA level. Although we here use breast cancer-derived organoids, these protocols can be directly applied or adapted for organoids derived from other cancer types or healthy tissues. Thus, in addition to investigating cell behavior of multiple cancer types, the combination of protocols described here may be used to study processes such as cell differentiation and migration during homeostasis and normal development.
    MeSH term(s) Humans ; Female ; Extracellular Matrix/metabolism ; Collagen Type I/metabolism ; Breast Neoplasms/pathology ; Basement Membrane ; Organoids
    Chemical Substances Collagen Type I
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2887-4_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dynamic-susceptibility-contrast perfusion-weighted-imaging (DSC-PWI) in brain tumors: a brief up-to-date overview for clinical neuroradiologists.

    Pons-Escoda, Albert / Smits, Marion

    European radiology

    2023  Volume 33, Issue 11, Page(s) 8026–8030

    MeSH term(s) Humans ; Magnetic Resonance Angiography/methods ; Brain Neoplasms/diagnostic imaging ; Perfusion ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2023-05-13
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-09729-3
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  10. Article: Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on "De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling".

    Allegaert, Karel / Smits, Anne / Annaert, Pieter

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: This commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data ... ...

    Abstract This commentary further reflects on the paper of De Sutter et al. on predicting volume of distribution in neonates, and the performance of physiologically based pharmacokinetic models We hereby stressed the add on value to collaborate on real world data to further close this knowledge gap. We illustrated this by weight distribution characteristics in breastfed (physiology) and in asphyxiated (pathophysiology), with additional reflection on their kidney and liver function.
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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