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  1. Article: Pseudomonas aeruginosa

    Li, Xuejie / Gu, Nixuan / Huang, Teng Yi / Zhong, Feifeng / Peng, Gongyong

    Frontiers in microbiology

    2023  Volume 13, Page(s) 1114199

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1114199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Intense pulsed light for inactivating planktonic and biofilm molds in food.

    Li, Xuejie / Gu, Nixuan / Ye, Yanrui / Lan, Haifeng / Peng, Fang / Peng, Gongyong

    Frontiers in microbiology

    2023  Volume 13, Page(s) 1104875

    Abstract: It has been reported that about a quarter of the world's agriculture products is unable to be consumed each year because of mold contamination, resulting in incalculable economic losses. Despite modern food technology and the various preservation ... ...

    Abstract It has been reported that about a quarter of the world's agriculture products is unable to be consumed each year because of mold contamination, resulting in incalculable economic losses. Despite modern food technology and the various preservation techniques available, the problem of mold contamination of food is still not adequately controlled. In this study, we simulated the biofilm formed by
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.1104875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Establishment and application of a rapid visual detection method for

    Chen, Moutong / Huang, Tengyi / Du, Min / Bai, Xiaoxi / Soteyome, Thanapop / Yuan, Lei / Bai, Caiying / Lan, Haifeng / Hong, Wei / Peng, Fang / Fu, Xin / Peng, Gongyong / Liu, Liyan / Kjellerup, Birthe V / Xu, Zhenbo

    Bioengineered

    2022  Volume 13, Issue 3, Page(s) 7860–7867

    Abstract: ... Listeria ... ...

    Abstract Listeria monocytogenes
    MeSH term(s) DNA Primers/genetics ; Food Microbiology ; Listeria monocytogenes/genetics ; Nucleic Acid Amplification Techniques/methods ; Polymerase Chain Reaction/methods ; Sensitivity and Specificity
    Chemical Substances DNA Primers
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2022.2044262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Correction to: Platelet-derived growth factor-BB induces pulmonary venous smooth muscle cells proliferation by upregulating calcium sensing receptor under hypoxic conditions.

    Liu, Rongmin / Xu, Juan / Jiang, Yongliang / Hong, Wei / Li, Shaoxing / Fu, Zhenli / Cao, Weitao / Li, Bing / Ran, Pixin / Peng, Gongyong

    Cytotechnology

    2021  Volume 73, Issue 6, Page(s) 841

    Abstract: This corrects the article DOI: 10.1007/s10616-021-00456-5.]. ...

    Abstract [This corrects the article DOI: 10.1007/s10616-021-00456-5.].
    Language English
    Publishing date 2021-09-18
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/s10616-021-00488-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2604: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Impaired exercise capacity in individuals with non-obstructive small airway dysfunction.

    Deng, Zhishan / Li, Xiaochen / Li, Chenglong / Zheng, Youlan / Wu, Fan / Wang, Zihui / Liu, Sha / Tian, Heshen / Zheng, Jinzhen / Peng, Jieqi / Huang, Peiyu / Yang, Huajing / Xiao, Shan / Wen, Xiang / Yang, Changli / Luo, Xiangwen / Peng, Gongyong / Li, Bing / Zhou, Yumin /
    Ran, Pixin

    Journal of thoracic disease

    2023  Volume 15, Issue 2, Page(s) 472–483

    Abstract: Background: Whether individuals with non-obstructive spirometry-defined small airway dysfunction (SAD) have impaired exercise capacity is unclear, particularly in never-smokers. This study clarifies the degree of impaired exercise capacity and its ... ...

    Abstract Background: Whether individuals with non-obstructive spirometry-defined small airway dysfunction (SAD) have impaired exercise capacity is unclear, particularly in never-smokers. This study clarifies the degree of impaired exercise capacity and its potential cause in individuals with non-obstructive SAD.
    Methods: This community-based, multiyear cross-sectional study analyzed data collected in Guangdong, China from 2012-2019 by the National Science and Technology Support Plan Program. Measurements of exercise capacity [peak work rate and peak oxygen uptake (
    Results: The risk of impaired exercise capacity was significantly higher in participants with non-obstructive SAD [
    Conclusions: Although not meeting the current criteria for chronic obstructive pulmonary disease, individuals with non-obstructive SAD have impaired exercise capacity that may be associated with ventilatory inefficiency regardless of smoking status.
    Language English
    Publishing date 2023-02-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-22-1328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades.

    Wang, Haiyan / Yan, Yongyong / Pathak, Janak L / Hong, Wei / Zeng, Jing / Qian, Dongyang / Hao, Binwei / Li, Haiqing / Gu, Jinlan / Jaspers, Richard T / Wu, Gang / Shao, Ming / Peng, Gongyong / Lan, Haifeng

    Journal of cellular and molecular medicine

    2023  Volume 27, Issue 4, Page(s) 515–528

    Abstract: Due to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians. Quercetin, a bioflavonoid, has shown potent anti-inflammatory effects. However, its effect on preventing OA progression and the underlying mechanisms are ... ...

    Abstract Due to the lack of effective treatments, osteoarthritis (OA) remains a challenge for clinicians. Quercetin, a bioflavonoid, has shown potent anti-inflammatory effects. However, its effect on preventing OA progression and the underlying mechanisms are still unclear. In this study, Sprague-Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra-articular injection), and three quercetin-treated groups. Quercetin-treated groups were treated with intragastric quercetin once a day for 28 days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High-dose quercetin-group joints showed failure in OA progression. High-dose quercetin inhibited the OA-induced expression of MMP-3, MMP-13, ADAMTS4, and ADAMTS5 and promoted the OA-reduced expression of aggrecan and collagen II. Levels of most inflammatory cytokines and growth factors tested in synovial fluid and serum were upregulated in the OA group and these increases were reversed by high-dose quercetin. Similarly, subchondral trabecular bone was degraded in the OA group and this effect was reversed in the high-dose quercetin group. Our findings indicate that quercetin has a protective effect against OA development and progression possibly via maintaining the inflammatory cascade homeostasis. Therefore, quercetin could be a potential therapeutic agent to prevent OA progression in risk groups.
    MeSH term(s) Rats ; Animals ; Male ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Rats, Sprague-Dawley ; Disease Models, Animal ; Osteoarthritis/drug therapy ; Osteoarthritis/prevention & control ; Osteoarthritis/metabolism ; Cartilage/metabolism ; Cartilage, Articular/pathology
    Chemical Substances Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5752: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Platelet-derived growth factor-BB induces pulmonary venous smooth muscle cells proliferation by upregulating calcium sensing receptor under hypoxic conditions.

    Liu, Rongmin / Xu, Juan / Jiang, Yongliang / Hong, Wei / Li, Shaoxing / Fu, Zhenli / Cao, Weitao / Li, Bing / Ran, Pixin / Peng, Gongyong

    Cytotechnology

    2021  Volume 73, Issue 2, Page(s) 189–201

    Abstract: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling, which exists in both pulmonary arteries and pulmonary veins. Pulmonary vascular remodeling stems from excessive proliferation of pulmonary vascular myocytes. Platelet-derived ... ...

    Abstract Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling, which exists in both pulmonary arteries and pulmonary veins. Pulmonary vascular remodeling stems from excessive proliferation of pulmonary vascular myocytes. Platelet-derived growth factor-BB (PDGF-BB) is a vital vascular regulator whose level increases in PH human lungs. Although the mechanisms by which pulmonary arterial smooth muscle cells respond to PDGF-BB have been studied extensively, the effects of PDGF-BB on pulmonary venous smooth muscle cells (PVSMCs) remain unknown. We herein examined the involvement of calcium sensing receptor (CaSR) in PDGF-BB-induced PVSMCs proliferation under hypoxic conditions. In PVSMCs isolated from rat intrapulmonary veins, PDGF-BB increased the cell number and DNA synthesis under normoxic and hypoxic conditions, which was accompanied by upregulated CaSR expression. The influences of PDGF-BB on proliferation and CaSR expression in hypoxic PVSMCs were greater than that in normoxic PVSMCs. In hypoxic PVSMCs superfused with Ca
    Language English
    Publishing date 2021-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1035772-5
    ISSN 0920-9069
    ISSN 0920-9069
    DOI 10.1007/s10616-021-00456-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2604: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Regulatory network controls microbial biofilm development, with

    Xu, Zhenbo / Huang, Tengyi / Min, Du / Soteyome, Thanapop / Lan, Haifeng / Hong, Wei / Peng, Fang / Fu, Xin / Peng, Gongyong / Liu, Junyan / Kjellerup, Birthe V

    Bioengineered

    2021  Volume 13, Issue 1, Page(s) 253–267

    Abstract: Microorganisms mainly exist in the form of biofilm in nature. Biofilm can contaminate food and drinking water system, as well as cause chronic wound infections, thereby posing a potential threat to public health safety. In the last two decades, ... ...

    Abstract Microorganisms mainly exist in the form of biofilm in nature. Biofilm can contaminate food and drinking water system, as well as cause chronic wound infections, thereby posing a potential threat to public health safety. In the last two decades, researchers have made efforts to investigate the genetic contributors control different stages of biofilm development (adherence, initiation, maturation, and dispersal). As an opportunistic pathogen,
    MeSH term(s) Antifungal Agents/therapeutic use ; Biofilms/drug effects ; Biofilms/growth & development ; Candida albicans/physiology ; Candidiasis/drug therapy ; Candidiasis/metabolism ; Candidiasis/mortality ; Fungal Proteins/metabolism ; Humans
    Chemical Substances Antifungal Agents ; Fungal Proteins
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Video-Audio Media
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.1996747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension.

    Hong, Wei / Mo, Qiudi / Wang, Luyao / Peng, Fang / Zhou, Yuming / Zou, Weifeng / Sun, Ruiting / Liang, Chunxiao / Zheng, Mengning / Li, Haiqing / Zhao, Dongxing / Gao, Mi / Pu, Jinding / Li, Bing / Ran, Pixin / Peng, Gongyong

    Bioengineered

    2021  Volume 12, Issue 1, Page(s) 5173–5183

    Abstract: The gut microbiota is widely considered to be involved in several diseases, including atherosclerosis, obesity, chronic obstructive pulmonary disease (COPD) and pulmonary arterial hypertension (PAH). This study aimed to determine if changes in the gut ... ...

    Abstract The gut microbiota is widely considered to be involved in several diseases, including atherosclerosis, obesity, chronic obstructive pulmonary disease (COPD) and pulmonary arterial hypertension (PAH). This study aimed to determine if changes in the gut microbiome and metabolome play a major role in the early pathogenesis of PAH. Male Wistar rats were injected with monocrotaline (MCT) (55 mg/kg) at day 1 and injected with calcium-sensing receptor (CaSR) antagonist NPS2143 (4.5 mg/kg/d) from days 1 to 21. Fecal samples were obtained. The gut microbiota and metabolome were analyzed by 16S rRNA gene sequencing and mass spectrometry-based analysis to investigate the effect of PAH in this rat model. MCT injection had a marked effect on the composition of the gut microbiota. This finding was further confirmed by metabolomic analysis with identification of several metabolites relevant to the gut microflora. However, NPS2143 partially abrogated this intestinal flora disorder and reversed fecal metabolite abnormalities. In conclusion, our study shows correlations between changes in the gut microbiome and the metabolome in PAH, which are affected by NPS2143.
    MeSH term(s) Animals ; Calcium/metabolism ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/genetics ; Gastrointestinal Microbiome/physiology ; Male ; Metabolome/drug effects ; Metabolome/genetics ; Metabolome/physiology ; Monocrotaline/adverse effects ; Naphthalenes/metabolism ; Naphthalenes/pharmacology ; Pulmonary Arterial Hypertension/chemically induced ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/metabolism ; Pulmonary Arterial Hypertension/physiopathology ; Rats ; Rats, Wistar ; Receptors, Calcium-Sensing/metabolism
    Chemical Substances N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine ; Naphthalenes ; Receptors, Calcium-Sensing ; Monocrotaline (73077K8HYV) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.1952365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis.

    Lan, Haifeng / Hong, Wei / Qian, Dongyang / Peng, Fang / Li, Haiqing / Liang, Chunxiao / Du, Min / Gu, Jinlan / Mai, Junxuan / Bai, Bo / Peng, Gongyong

    Bioengineered

    2021  Volume 12, Issue 1, Page(s) 6240–6250

    Abstract: Although the mechanism of osteoarthritis (OA) has been widely studied and the use of quercetin for OA therapy is well documented, the relevant characteristics of the microbiome and metabolism remain unclear. This study reports changes in the gut ... ...

    Abstract Although the mechanism of osteoarthritis (OA) has been widely studied and the use of quercetin for OA therapy is well documented, the relevant characteristics of the microbiome and metabolism remain unclear. This study reports changes in the gut microbiota and metabolism during quercetin therapy for OA in a rat model and provides an integrative analysis of the biomechanism. In this study, the rats were categorized into 3 different groups: the OA model, quercetin treatment, and control groups. The OA rats was conducted using a monoiodoacetate (MIA) injection protocol. The rats in the quercetin group received daily intragastric administration of quercetin from day 1 to day 28. Stool samples were collected, and DNA was extracted. We used an integrated approach that combined the sequencing of whole 16S rRNA, short-chain fatty acid (SCFA) measurements and metabolomics analysis by mass spectrometry (MS) to characterize the functional impact of quercetin on the gut microbiota and metabolism in a rat model of OA. The use of quercetin partially abrogated intestinal flora disorder and reversed fecal metabolite abnormalities. Compared with the control rats, the OA rats showed differences at both the class level (
    MeSH term(s) Animals ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/genetics ; Metabolome/drug effects ; Osteoarthritis/metabolism ; Osteoarthritis/microbiology ; Quercetin/pharmacology ; Rats
    Chemical Substances Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2021-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.1969194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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