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Article ; Online: Closing the scissor-shaped curve: Strategies to promote gender equality in academia.

Joyce, Johanna A / Masina, Slavica / Michalik, Liliane / Pot, Caroline / Sempoux, Christine / Amati, Francesca

2024 Volume 187, Issue 6, Page(s) 1335–1342

Abstract: Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reaching leadership positions. This commentary discusses ... ...

Abstract	Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reaching leadership positions. This commentary discusses the "scissor-shaped curve" and examines effective strategies to fix it, including data-driven initiatives that we have implemented at our university.
MeSH term(s)	Humans ; Female ; Gender Equity ; Academia ; Leadership ; Universities
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2024.01.050
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Brain lipid metabolism: the emerging role of lipid droplets in glial cells.

Petrelli, Francesco / Knobloch, Marlen / Amati, Francesca

Current opinion in lipidology

2021 Volume 33, Issue 1, Page(s) 86–87

MeSH term(s)	Brain ; Humans ; Lipid Droplets/metabolism ; Lipid Metabolism ; Neuroglia
Language	English
Publishing date	2021-12-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1045394-5
ISSN	1473-6535 ; 0957-9672
ISSN (online)	1473-6535
ISSN	0957-9672
DOI	10.1097/MOL.0000000000000812
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Article ; Online: Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease.

Vancheri, Chiara / Morini, Elena / Prandi, Francesca Romana / Barillà, Francesco / Romeo, Francesco / Novelli, Giuseppe / Amati, Francesca

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Coronary heart disease (CHD), one of the leading causes of disability and death worldwide, is a multifactorial disease whose early diagnosis is demanding. Thus, biomarkers predicting the occurrence of this pathology are of great importance from a ... ...

Abstract	Coronary heart disease (CHD), one of the leading causes of disability and death worldwide, is a multifactorial disease whose early diagnosis is demanding. Thus, biomarkers predicting the occurrence of this pathology are of great importance from a clinical and therapeutic standpoint. By means of a pilot study on peripheral blood cells (PBMCs) of subjects with no coronary lesions (CTR; n = 2) and patients with stable CAD (CAD; n = 2), we revealed 61 differentially methylated regions (DMRs) (18 promoter regions, 24 genes and 19 CpG islands) and 14.997 differentially methylated single CpG sites (DMCs) in CAD patients. MiRNA-seq results displayed a peculiar miRNAs profile in CAD patients with 18 upregulated and 32 downregulated miRNAs (FC ≥ ±1.5, p ≤ 0.05). An integrated analysis of genome-wide DNA methylation and miRNA-seq results indicated a significant downregulation of hsa-miR-200c-3p (FCCAD = −2.97, p ≤ 0.05) associated to the hypermethylation of two sites (genomic coordinates: chr12:7073122-7073122 and chr12:7072599-7072599) located intragenic to the miR-200c/141 genomic locus (encoding hsa-miR-200c-3p) (p-value = 0.009) in CAD patients. We extended the hsa-miR-200c-3p expression study in a larger cohort (CAD = 72, CTR = 24), confirming its reduced expression level in CAD patients (FCCAD = −2; p = 0.02). However, when we analyzed the methylation status of the two CpG sites in the same cohort, we failed to identify significant differences. A ROC curve analysis showed good performance of hsa-miR-200c-3p expression level (AUC = 0.65; p = 0.02) in distinguishing CAD from CTR. Moreover, we found a significant positive correlation between hsa-miR-200c-3p expression and creatinine clearance (R2 = 0.212, p < 0.005, Pearson r = 0.461) in CAD patients. Finally, a phenotypic correlation performed in the CAD group revealed lower hsa-miR-200c-3p expression levels in CAD patients affected by dyslipidemia (+DLP, n = 58) (p < 0.01). These results indicate hsa-miR-200c-3p as potential epi-biomarker for the diagnosis and clinical progression of CAD and highlight the importance of deeper studies on the expression of this miRNA to understand its functional role in coronary artery disease development.
MeSH term(s)	Humans ; Coronary Artery Disease/genetics ; Down-Regulation/genetics ; Pilot Projects ; Gene Expression Profiling/methods ; MicroRNAs/metabolism ; Biomarkers ; Dyslipidemias
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021112
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Article ; Online: Association between metabolic syndrome, hypertension, and chronic depression

Pasquale Palmiero / Maria Maiello / Francesca Amati / Marco Matteo Ciccone / Timir Paul

Italian Journal of Medicine, Vol 17, Iss

a postmenopausal women prevention study

2023 Volume 1

Abstract: Background. Chronic depression (CD) is common among postmenopausal women and is associated with an increased risk of cardiovascular disease (CVD). The diagnosis of CD is a challenging problem in clinical practice which is vastly underdiagnosed. CD ... ...

Abstract	Background. Chronic depression (CD) is common among postmenopausal women and is associated with an increased risk of cardiovascular disease (CVD). The diagnosis of CD is a challenging problem in clinical practice which is vastly underdiagnosed. CD detection in postmenopausal women with metabolic syndrome (MetS) or hypertension is necessary for CVD prevention. Our study aims to assess the prevalence of CD in postmenopausal women and the relationship between CD and MetS or hypertension. Results. The rate of CD was significantly higher among postmenopausal women with MetS compared with the control group [18% versus 8%; Odds ratio (OR) 2.2, P<0.007]. The CD rate was significantly higher among women with MetS and hypertension (21% versus 8%; OR 2.7, P<0.0000). The rate of CD was similar between women with MetS and women with hypertension, 18% versus 21%; OR 0.8, P<0.44) and between women with metabolic cardiomyopathy and hypertensive cardiomyopathy (10% versus 8%; OR 1.1, P<0.65). Conclusions. There is a relationship between MetS and CD, which is stronger when compared to women with hypertension. There is a need to improve the diagnosis of CD in postmenopausal women with MetS or hypertension as unrecognized and untreated CD is associated with a poor outcome.
Keywords	Postmenopausal women ; metabolic syndrome ; hypertension ; depression ; cardiomyopathy ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
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Article ; Online: Relationship Between Lung Volumes and Heterogeneity in the Response to Elexacaftor/Tezacaftor/Ivacaftor in Patients With Cystic Fibrosis and Advanced Lung Disease.

Gramegna, Andrea / Alicandro, Gianfranco / Premuda, Chiara / Lucca, Francesca / Pinali, Lucia / Retucci, Mariangela / Vespro, Valentina / Andrisani, Maria Carmela / Carraffiello, Gianpaolo / Amati, Francesco / Volpi, Sonia / Aliberti, Stefano / Cipolli, Marco / Blasi, Francesco

Chest

2024

Abstract: Background: The effects of elexacaftor/tezacaftor/ivacaftor (ETI) on respiratory outcomes for people with cystic fibrosis (CF) were demonstrated by several clinical trials, mainly based on simple spirometry. However, gains in lung function may vary ... ...

Abstract	Background: The effects of elexacaftor/tezacaftor/ivacaftor (ETI) on respiratory outcomes for people with cystic fibrosis (CF) were demonstrated by several clinical trials, mainly based on simple spirometry. However, gains in lung function may vary greatly between patients, and predictors of FEV Research question: Which ventilatory parameters are involved in the heterogeneity of FEV Study design and methods: This was a multicenter, observational, prospective cohort study at two major CF centers in Italy. We enrolled 47 adults with CF and advanced lung disease (FEV Results: After 12 months of ETI treatment, there was a significant increase in FEV Interpretation: ETI was associated with improvements in both static and dynamic volumes in people with CF and advanced lung disease. Heterogeneity in FEV
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2024.03.033
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Zs.MO 349: Show issues

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Article ; Online: Treatable Traits in Systemic Sclerosis.

Amati, Francesco / Bongiovanni, Gabriele / Tonutti, Antonio / Motta, Francesca / Stainer, Anna / Mangiameli, Giuseppe / Aliberti, Stefano / Selmi, Carlo / De Santis, Maria

Clinical reviews in allergy & immunology

2023 Volume 65, Issue 2, Page(s) 251–276

Abstract: Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective tissue diseases, specifically characterized by vascular abnormalities and inflammatory and fibrotic involvement of the skin and internal organs resulting in high ... ...

Abstract	Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective tissue diseases, specifically characterized by vascular abnormalities and inflammatory and fibrotic involvement of the skin and internal organs resulting in high morbidity and mortality. The clinical phenotype of SSc is heterogeneous, and serum autoantibodies together with the extent of skin involvement have a predictive value in the risk stratification. Current recommendations include an organ-based management according to the predominant involvement with only limited individual factors included in the treatment algorithm. Similar to what has been proposed for other chronic diseases, we hypothesize that a "treatable trait" approach based on relevant phenotypes and endotypes could address the unmet needs in SSc stratification and treatment to maximize the outcomes. We provide herein a comprehensive review and a critical discussion of the literature regarding potential treatable traits in SSc, focusing on established and candidate biomarkers, with the purpose of setting the bases for a precision medicine-based approach. The discussion, structured based on the organ involvement, allows to conjugate the pathogenetic mechanisms of tissue injury with the proposed predictors, particularly autoantibodies and other serum biomarkers. Ultimately, we are convinced that precision medicine is the ideal guide to manage a complex condition such as SSc for which available treatments are largely unsatisfactory.
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1239045-8
ISSN	1559-0267 ; 1080-0549
ISSN (online)	1559-0267
ISSN	1080-0549
DOI	10.1007/s12016-023-08969-x
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Article ; Online: Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids.

Grepper, Dogan / Tabasso, Cassandra / Aguettaz, Axel K F / Martinotti, Adrien / Ebrahimi, Ammar / Lagarrigue, Sylviane / Amati, Francesca

Molecular metabolism

2023 Volume 68, Page(s) 101669

Abstract: Objective: Ectopic lipid accumulation is a hallmark of metabolic diseases, linking obesity to non-alcoholic fatty liver disease, insulin resistance and diabetes. The use of zebrafish as a model of obesity and diabetes is raising due to the conserved ... ...

Abstract	Objective: Ectopic lipid accumulation is a hallmark of metabolic diseases, linking obesity to non-alcoholic fatty liver disease, insulin resistance and diabetes. The use of zebrafish as a model of obesity and diabetes is raising due to the conserved properties of fat metabolism between humans and zebrafish, the homologous genes regulating lipid uptake and transport, the implementation of the '3R's principle and their cost-effectiveness. To date, a method allowing the conservation of lipid droplets (LDs) and organs in zebrafish larvae to image ectopic lipids is not available. Our objectives were to develop a novel methodology to quantitatively evaluate organ-specific LDs, in skeletal muscle and liver, in response to a nutritional perturbation. Methods: We developed a novel embedding and cryosectioning protocol allowing the conservation of LDs and organs in zebrafish larvae. To establish the quantitative measures, we used a three-arm parallel nutritional intervention design. Zebrafish larvae were fed a control diet containing 14% of nutritional fat or two high fat diets (HFDs) containing 25 and 36% of dietary fats. In muscle and liver, LDs were characterized using immunofluorescence confocal microscopy. In liver, intrahepatocellular lipids were discriminated from intrasinusoid lipids. To complete liver characteristics, fibrosis was identified with Masson's Trichrome staining. Finally, to confirm the conservation and effect of HFD, molecular players of fat metabolism were evaluated by RT-qPCR. Results: The cryosections obtained after setting up the embedding and cryopreservation method were of high quality, preserving tissue morphology and allowing the visualization of ectopic lipids. Both HFDs were obesogenic, without modifying larvae survival or development. Neutral lipid content increased with time and augmented dietary fat. Intramuscular LD volume density increased and was explained by an increase in LDs size but not in numbers. Intrahepatocellular LD volume density increased and was explained by an increased number of LDs, not by their increased size. Sinusoid area and lipid content were both increased. Hepatic fibrosis appeared with both HFDs. We observed alterations in the expression of genes associated with LD coating proteins, LD dynamics, lipogenesis, lipolysis and fatty acid oxidation. Conclusions: In this study, we propose a reproducible and fast method to image zebrafish larvae without losing LD quality and organ morphology. We demonstrate the impact of HFD on LD characteristics in liver and skeletal muscle accompanied by alterations of key players of fat metabolism. Our observations confirm the evolutionarily conserved mechanisms in lipid metabolism and reveal organ specific adaptations. The methodological advancements proposed in this work open the doors to study organelle adaptations in obesity and diabetes related research such as lipotoxicity, organelle contacts and specific lipid depositions.
MeSH term(s)	Animals ; Humans ; Diabetes Mellitus/metabolism ; Diet, High-Fat ; Dietary Fats/metabolism ; Liver/metabolism ; Muscle, Skeletal/metabolism ; Obesity/metabolism ; Zebrafish
Chemical Substances	Dietary Fats
Language	English
Publishing date	2023-01-12
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2023.101669
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Article: Exercise Testing in Individuals With Diabetes, Practical Considerations for Exercise Physiologists.

Kosinski, Christophe / Besson, Cyril / Amati, Francesca

Frontiers in physiology

2019 Volume 10, Page(s) 1257

Abstract: Exercise and sports activities are crucial for individuals with diabetes. Diabetic patients are often referred to sports clinics for cardiopulmonary exercise testing to evaluate physical capacity, exercise-related symptoms, or to obtain medical clearance. ...

Abstract	Exercise and sports activities are crucial for individuals with diabetes. Diabetic patients are often referred to sports clinics for cardiopulmonary exercise testing to evaluate physical capacity, exercise-related symptoms, or to obtain medical clearance. While there is an abundance of literature on cardiopulmonary testing, practical recommendations for exercise physiologists and sports clinic specialists performing exercise testing for this specific population are lacking. The goal of this report is to provide a practical framework to understand, prepare, and perform exercise testing in patients with diabetes, maximizing exercise physiology outcomes, diagnostic value, and ensuring safety.
Language	English
Publishing date	2019-09-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2019.01257
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Article ; Online: Two

Vancheri, Chiara / Morini, Elena / Prandi, Francesca Romana / Alkhoury, Elie / Celotto, Roberto / Romeo, Francesco / Novelli, Giuseppe / Amati, Francesca

Genes

2021 Volume 12, Issue 6

Abstract: Primary prevention is crucial for coronary heart disease (CAD) and the identification of new reliable biomarkers might help risk stratification or predict adverse coronary events. Alternative splicing (AS) is a less investigated genetic factors ... ...

Abstract	Primary prevention is crucial for coronary heart disease (CAD) and the identification of new reliable biomarkers might help risk stratification or predict adverse coronary events. Alternative splicing (AS) is a less investigated genetic factors implicated in CAD etiology. We performed an RNA-seq study on PBMCs from CAD patients and control subjects (CTR) and observed 113 differentially regulated AS events (24 up and 89 downregulated) in 86 genes. The
Language	English
Publishing date	2021-06-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12060939
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Article ; Online: Reassessing the Role of Diacylglycerols in Insulin Resistance.

Jayasinghe, Sisitha U / Tankeu, Aurel T / Amati, Francesca

Trends in endocrinology and metabolism: TEM

2019 Volume 30, Issue 9, Page(s) 618–635

Abstract: Skeletal muscle (SM) insulin resistance (IR) plays an important role in the burden of obesity, particularly because it leads to glucose intolerance and type 2 diabetes. Among the mechanisms thought to link IR to obesity is the accumulation, in muscle ... ...

Abstract	Skeletal muscle (SM) insulin resistance (IR) plays an important role in the burden of obesity, particularly because it leads to glucose intolerance and type 2 diabetes. Among the mechanisms thought to link IR to obesity is the accumulation, in muscle cells, of different lipid metabolites. Diacylglycerols (DAGs) are subject of particular attention due to reported interactions with the insulin signaling cascade. Given that SM accounts for the majority of insulin-stimulated glucose uptake, this review integrates recent observational and mechanistic works with the sole focus on questioning the role of DAGs in SM IR. Particular attention is given to the subcellular distributions and specific structures of DAGs, highlighting future research directions towards reaching a consensus on the mechanistic role played by DAGs.
MeSH term(s)	Animals ; Diglycerides/metabolism ; Humans ; Insulin Resistance/physiology ; Lipid Metabolism/physiology ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology
Chemical Substances	Diglycerides
Language	English
Publishing date	2019-07-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2019.06.005
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