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  1. Article: Risk Score Prediction Model of Prognosis in GC Patients by Age and Gender Combined With m6A Modification Genes FTO and RBM15.

    Yue, Limin / Zhang, Rongguang / Chen, Shuaiyin / Duan, Guangcai

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 710708

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.710708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hand, Foot, and Mouth Disease Challenges and Its Antiviral Therapeutics

    Zijie Li / Wangquan Ji / Shuaiyin Chen / Guangcai Duan / Yuefei Jin

    Vaccines, Vol 11, Iss 571, p

    2023  Volume 571

    Abstract: Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [.] ...

    Abstract Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Hand, Foot, and Mouth Disease Challenges and Its Antiviral Therapeutics.

    Li, Zijie / Ji, Wangquan / Chen, Shuaiyin / Duan, Guangcai / Jin, Yuefei

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [ ... ]. ...

    Abstract Hand, Foot, and Mouth Disease (HFMD) is an infectious disease caused by enteroviruses (EVs) and is extremely contagious and prevalent among infants and children under 5 years old [...].
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Crystal structure of the ATPase domain of porcine circovirus type 2 Rep protein.

    Guan, Shuaiyin / Li, Zhen / Han, Yang / Tian, Ang / Zhou, Saisai / Chen, Huanchun / Peng, Guiqing / Song, Yunfeng

    The Journal of general virology

    2024  Volume 105, Issue 3

    Abstract: PCV2 belongs to the ... ...

    Abstract PCV2 belongs to the genus
    MeSH term(s) Swine ; Animals ; Circovirus/genetics ; Adenosine Triphosphatases/genetics ; Crystallography, X-Ray ; DNA Helicases/genetics ; DNA Replication
    Chemical Substances Adenosine Triphosphatases (EC 3.6.1.-) ; DNA Helicases (EC 3.6.4.-)
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001972
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  5. Article ; Online: Emerging concerns of blood-brain barrier dysfunction caused by neurotropic enteroviral infections.

    Han, Shujie / Ji, Wangquan / Duan, Guangcai / Chen, Shuaiyin / Yang, Haiyan / Jin, Yuefei

    Virology

    2024  Volume 591, Page(s) 109989

    Abstract: Enteroviruses (EVs), comprise a genus in the Picornaviridae family, which have been shown to be neurotropic and can cause various neurological disorders or long-term neurological condition, placing a huge burden on society and families. The blood-brain ... ...

    Abstract Enteroviruses (EVs), comprise a genus in the Picornaviridae family, which have been shown to be neurotropic and can cause various neurological disorders or long-term neurological condition, placing a huge burden on society and families. The blood-brain barrier (BBB) is a protective barrier that prevents dangerous substances from entering the central nervous system (CNS). Recently, numerous EVs have been demonstrated to have the ability to disrupt BBB, and further lead to severe neurological damage. However, the precise mechanisms of BBB disruption associated with these EVs remain largely unknown. In this Review, we focus on the molecular mechanisms of BBB dysfunction caused by EVs, emphasizing the invasiveness of enterovirus A71 (EVA71), which will provide a research direction for further treatment and prevention of CNS disorders.
    MeSH term(s) Humans ; Blood-Brain Barrier ; Enterovirus Infections ; Enterovirus/physiology ; Central Nervous System ; Biological Transport
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2024.109989
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  6. Article ; Online: A meta-analysis of immunogenicity and safety of two versus single-doses of influenza A (H1N1) vaccine in person living with HIV.

    Zhang, Teng / Geng, Juan / Du, Yazhe / Yang, Haiyan / Jin, Yuefei / Chen, Shuaiyin / Duan, Guangcai

    International journal of STD & AIDS

    2023  Volume 35, Issue 5, Page(s) 326–336

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; Adjuvants, Immunologic ; Antibodies, Viral ; Immunogenicity, Vaccine ; Influenza A Virus, H1N1 Subtype ; Influenza Vaccines/immunology ; Influenza, Human/prevention & control ; Vaccination ; HIV Infections
    Chemical Substances Adjuvants, Immunologic ; Antibodies, Viral ; Influenza Vaccines
    Language English
    Publishing date 2023-12-12
    Publishing country England
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624231220424
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  7. Article ; Online: Risk Score Prediction Model of Prognosis in GC Patients by Age and Gender Combined With m6A Modification Genes FTO and RBM15

    Limin Yue / Rongguang Zhang / Shuaiyin Chen / Guangcai Duan

    Frontiers in Cell and Developmental Biology, Vol

    2022  Volume 10

    Abstract: Background: Gastric cancer (GC) has a high mortality rate. N6-methyladenosine (m6A) is involved in the development of GC. Age and gender are associated with GC incidence and survival. This study aimed to explore the risk score prediction model of ... ...

    Abstract Background: Gastric cancer (GC) has a high mortality rate. N6-methyladenosine (m6A) is involved in the development of GC. Age and gender are associated with GC incidence and survival. This study aimed to explore the risk score prediction model of prognosis in GC patients by age and gender combined with m6A modification genes.Methods: Data on m6A modification gene expression and clinical information downloaded from the Cancer Genome Atlas (TCGA) database were used to construct the risk score prediction model. Cox and least absolute shrinkage and selection operator (LASSO) regression were performed to identify clinical characteristics and m6A modification genes associated with prognosis. A risk score prediction model was established based on multivariate Cox regression analysis. The Gene Expression Omnibus (GEO) database was used to validate this model.Results: Most of the m6A modification genes were upregulated in GC tumor tissues compared with that in normal tissues and were correlated with clinical characteristics including grade, stage status, and T status. The risk score prediction model was established based on age, gender, FTO, and RBM15. GC patients were divided into high- or low-risk groups based on the median risk score. Patients with a high risk score had poor prognosis. Multivariate Cox regression indicated that risk score was an independent prognostic factor for GC patients. The data from GSE84437 verified the predictive value of this model.Conclusion: The risk score prediction model based on age and gender combined with m6A modification genes FTO and RBM15 was an independent prognostic factor for GC patients.
    Keywords gastric cancer ; N6-methyladenosine ; prognostic factor ; FTO ; RBM15 ; Biology (General) ; QH301-705.5
    Subject code 616 ; 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Elevated Creatine Kinase-MB Is an Independent Risk Factor for Mortality of COVID-19: Based on Adjusted Data.

    Hu, Quanman / Cheng, Cheng / Li, Yang / Duan, Guangcai / Chen, Shuaiyin

    Archives of Iranian medicine

    2022  Volume 25, Issue 2, Page(s) 124–125

    MeSH term(s) Biomarkers/metabolism ; COVID-19/enzymology ; Creatine Kinase, MB Form/metabolism ; Humans ; Risk Factors
    Chemical Substances Biomarkers ; Creatine Kinase, MB Form (EC 2.7.3.2)
    Language English
    Publishing date 2022-02-01
    Publishing country Iran
    Document type Journal Article ; Comment
    ZDB-ID 2204979-4
    ISSN 1735-3947 ; 1029-2977
    ISSN (online) 1735-3947
    ISSN 1029-2977
    DOI 10.34172/aim.2022.20
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    Zs.A 6228: Show issues Location:
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  9. Article ; Online: Relationship between Helicobacter pylori and Incident Hypertension as well as Blood Pressure: A Systematic Review and Meta-Analysis.

    Yue, Limin / Zhang, Rongguang / Chen, Shuaiyin / Duan, Guangcai

    Digestive diseases (Basel, Switzerland)

    2022  Volume 41, Issue 1, Page(s) 124–137

    Abstract: Background: Helicobacter pylori (H. pylori) may be a risk factor for hypertension, but the reported studies have given conflicting results. This study aimed to explore the association between H. pylori infection and hypertension risk and blood pressure.! ...

    Abstract Background: Helicobacter pylori (H. pylori) may be a risk factor for hypertension, but the reported studies have given conflicting results. This study aimed to explore the association between H. pylori infection and hypertension risk and blood pressure.
    Method: PubMed, Embase, Web of Science, CNKI, Weipu, and Wanfang databases were searched for articles published up to June 2, 2021. Dual-selection and data abstraction were conducted. Random-effect models were used to measure pooled estimates. All data were analyzed with Stata 14.0 SE (StataCorp, College Station, TX, USA).
    Results: A total of 55 studies with 198,750 individuals were included in the meta-analysis. Among them, 33 studies reported the relationship between H. pylori infection and the risk of hypertension, and 25 studies reported the association of H. pylori infection with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Three studies reported both of the above. Meta-analysis showed that H. pylori infection increased the risk of hypertension by 32% (odd ratio: 1.32, 95% CI: 1.15-1.52). Compared with non-H. pylori-infection individuals, the subjects with H. pylori infection had elevated levels of SBP (WMD: 1.86, 95% CI: 1.21-2.50) and DBP (WMD: 1.12, 95% CI: 0.81-1.43).
    Conclusion: This meta-analysis suggested that H. pylori infection increased the risk of hypertension. This may provide a new strategy for hypertension prevention. However, the association between H. pylori infection and hypertension needs to be confirmed in further prospective cohort studies.
    MeSH term(s) Humans ; Helicobacter pylori/physiology ; Blood Pressure ; Prospective Studies ; Risk Factors ; Helicobacter Infections/complications ; Hypertension/complications
    Language English
    Publishing date 2022-04-04
    Publishing country Switzerland
    Document type Systematic Review ; Meta-Analysis
    ZDB-ID 632798-9
    ISSN 1421-9875 ; 0257-2753
    ISSN (online) 1421-9875
    ISSN 0257-2753
    DOI 10.1159/000524078
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  10. Article ; Online: Latest Advances in the Application of Humanized Mouse Model for Staphylococcus aureus.

    Zheng, Ping / Liu, Fang / Long, Jinzhao / Jin, Yuefei / Chen, Shuaiyin / Duan, Guangcai / Yang, Haiyan

    The Journal of infectious diseases

    2023  Volume 228, Issue 6, Page(s) 800–809

    Abstract: Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia, sepsis, and septicemia. The mouse models have greatly facilitated the ... ...

    Abstract Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia, sepsis, and septicemia. The mouse models have greatly facilitated the development of S. aureus studies. However, due to the substantial differences in immune system between mice and humans, the conventional mouse studies are not predictive of success in humans, in which case humanized mice may overcome this limitation to some extent. Humanized mice can be used to study the human-specific virulence factors produced by S. aureus and the mechanisms by which S. aureus interacts with humans. This review outlined the latest advances in humanized mouse models used in S. aureus studies.
    MeSH term(s) Mice ; Humans ; Animals ; Staphylococcus aureus ; Staphylococcal Infections ; Osteomyelitis ; Virulence Factors ; Sepsis ; Disease Models, Animal
    Chemical Substances Virulence Factors
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad253
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