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  1. Article ; Online: The Immaculate Carbapenemase Study.

    Thomson, Kenneth S

    Journal of clinical microbiology

    2017  Volume 55, Issue 6, Page(s) 1608–1611

    Abstract: Carbapenemase-producing organisms, or CPOs, are Gram-negative pathogens that produce a transmissible carbapenemase and are typically resistant to most (sometimes all) antibiotics. We now face a global CPO pandemic of high mortality. In this issue of ... ...

    Abstract Carbapenemase-producing organisms, or CPOs, are Gram-negative pathogens that produce a transmissible carbapenemase and are typically resistant to most (sometimes all) antibiotics. We now face a global CPO pandemic of high mortality. In this issue of the
    MeSH term(s) Bacterial Proteins ; Enterobacteriaceae ; Enterobacteriaceae Infections ; Humans ; Imipenem ; beta-Lactamases
    Chemical Substances Bacterial Proteins ; Imipenem (71OTZ9ZE0A) ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2017-04-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00430-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Digital imaging for reading of direct rapid antibiotic susceptibility tests from positive blood cultures.

    Thomson, Gina K / Jamros, Kira / Snyder, James W / Thomson, Kenneth S

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2021  Volume 40, Issue 10, Page(s) 2105–2112

    Abstract: Delaying effective antibiotic therapy is a major cause of sepsis-associated mortality. The EUCAST rapid antibiotic susceptibility test (RAST) is performed from positive blood cultures to provide rapid results. Disc diffusion tests inoculated with ... ...

    Abstract Delaying effective antibiotic therapy is a major cause of sepsis-associated mortality. The EUCAST rapid antibiotic susceptibility test (RAST) is performed from positive blood cultures to provide rapid results. Disc diffusion tests inoculated with positive blood culture broth are read at 4, 6, and 8 h and interpreted against species and time-specific criteria. Potential problems are the possibility of missing specific reading times for tests and slower growth in incubators that are frequently opened. The current study aimed to assess if digital visualization by the BD Kiestra™ total laboratory automation system is suitable for reading RASTs by capturing images at the correct times and retaining them for review. Utilizing the Kiestra™ InoqulA, 100 μl of positive blood culture broth was lawn-inoculated onto Mueller-Hinton agar and incubated at 35 °C for automated digital zone measurement at 4, 6, and 8 h. Aliquots from 135 positive blood cultures were tested against EUCAST-recommended and other drugs and assessed for readability of digital images. Microdilution MICs were determined in parallel to RASTs. All isolates except 7/10 enterococci yielded images of suitable quality for zone measurement. Of the 641 digitally read tests for other organisms, 207 (32.3%) were readable in 4 h, 555 (86.6%) in 6 h, and 641 (100%) in 8 h. For tests included in EUCAST criteria, 92.1% provided categorical agreement with microdilution MICs. Digital image reading of RASTs is a potentially viable, inexpensive tool for providing rapid susceptibility results which can help reduce sepsis-associated mortality.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Automation/methods ; Bacteria/drug effects ; Bacteria/growth & development ; Bacterial Infections/microbiology ; Blood Culture ; Computers ; Humans ; Microbial Sensitivity Tests/instrumentation ; Microbial Sensitivity Tests/methods
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-04-25
    Publishing country Germany
    Document type Evaluation Study ; Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-021-04249-8
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    Zs.A 1732: Show issues Location:
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  3. Article ; Online: CPO Complete, a novel test for fast, accurate phenotypic detection and classification of carbapenemases.

    Thomson, Gina K / AbdelGhani, Sameh / Thomson, Kenneth S

    PloS one

    2019  Volume 14, Issue 12, Page(s) e0220586

    Abstract: Carbapenemase-producing organisms (CPOs) are Gram-negative bacteria that are typically resistant to most or all antibiotics and are responsible for a global pandemic of high mortality. Rapid, accurate detection of CPOs and the classification of their ... ...

    Abstract Carbapenemase-producing organisms (CPOs) are Gram-negative bacteria that are typically resistant to most or all antibiotics and are responsible for a global pandemic of high mortality. Rapid, accurate detection of CPOs and the classification of their carbapenemases are valuable tools for reducing the mortality of the CPO-associated infections, preventing the spread of CPOs, and optimizing use of new β-lactamase inhibitor combinations such as ceftazidime/avibactam, meropenem/vaborbactam and imipenem/relebactam. The current study evaluated the performance of CPO Complete, a novel, manual, phenotypic carbapenemase detection and classification test. The test was evaluated for sensitivity and specificity against 262 CPO isolates of Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii and 67 non-CPO isolates. It was also evaluated for carbapenemase classification accuracy against 205 CPOs that produced a single carbapenemase class. The test exhibited 100% sensitivity 98.5% specificity for carbapenemase detection within 90 minutes and detected 74.1% of carbapenemases within 10 minutes. In the classification evaluation, 99.0% of carbapenemases were correctly classified for isolates that produced a single carbapenemase. The test is technically simple and has potential for adaptation to automated instruments. With lyophilized kit storage at temperatures up to 38°C, the CPO Complete test has the potential to provide rapid, accurate carbapenemase detection and classification in both limited resource and technologically advanced laboratories.
    MeSH term(s) Acinetobacter baumannii/drug effects ; Acinetobacter baumannii/enzymology ; Acinetobacter baumannii/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/classification ; Bacterial Proteins/metabolism ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/enzymology ; Enterobacteriaceae/isolation & purification ; Enzyme Assays ; Humans ; Microbial Sensitivity Tests/methods ; Phenotype ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/enzymology ; Pseudomonas aeruginosa/isolation & purification ; beta-Lactamases/classification ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2019-12-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0220586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Lowering of third generation cephalosporin breakpoints.

    Thomson, Kenneth S

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2013  Volume 57, Issue 11, Page(s) 1663–1664

    MeSH term(s) Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteria/drug effects ; Cephalosporins/pharmacokinetics ; Cephalosporins/pharmacology ; Cephalosporins/therapeutic use ; Drug Resistance, Bacterial ; Enterobacteriaceae Infections/drug therapy ; Humans ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Cephalosporins
    Language English
    Publishing date 2013-12
    Publishing country United States
    Document type Letter
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cit569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  5. Article ; Online: Detection of gram-negative β-lactamase producing pathogens in the clinical lab.

    Thomson, Kenneth S

    Current pharmaceutical design

    2013  Volume 19, Issue 2, Page(s) 250–256

    Abstract: Pathogens that produce extended spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases, and carbapenemases may appear falsely susceptible to β-lactam antibiotics in the laboratory. Infected patients may be treated with inappropriate ... ...

    Abstract Pathogens that produce extended spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases, and carbapenemases may appear falsely susceptible to β-lactam antibiotics in the laboratory. Infected patients may be treated with inappropriate antibiotics if laboratories do not perform accurate tests to detect these resistance mechanisms. Furthermore the resistant pathogens may spread undetected to amplify the therapeutic and infection control challenge. This review makes a case for why and how laboratories should perform tests to detect β-lactamase-mediated resistance in gram-negative pathogens.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Gram-Negative Bacteria/drug effects ; Gram-Negative Bacteria/enzymology ; Gram-Negative Bacteria/isolation & purification ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Microbial Sensitivity Tests/methods ; beta-Lactam Resistance ; beta-Lactamases/metabolism ; beta-Lactams/pharmacology
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2013
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Photochemical Mediated Ring Contraction of 4

    Broumidis, Emmanouil / Thomson, Christopher G / Gallagher, Brendan / Sotorríos, Lia / McKendrick, Kenneth G / Macgregor, Stuart A / Paterson, Martin J / Lovett, Janet E / Lloyd, Gareth O / Rosair, Georgina M / Kalogirou, Andreas S / Koutentis, Panayiotis A / Vilela, Filipe

    Organic letters

    2023  Volume 25, Issue 37, Page(s) 6907–6912

    Abstract: 1,2,6-Thiadiazines treated with visible light ... ...

    Abstract 1,2,6-Thiadiazines treated with visible light and
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c02673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Double-carbapenem therapy not proven to be more active than carbapenem monotherapy against KPC-positive Klebsiella pneumoniae.

    Thomson, Kenneth S

    Antimicrobial agents and chemotherapy

    2012  Volume 56, Issue 7, Page(s) 4037; author reply 4038

    MeSH term(s) Animals ; Bacterial Proteins/biosynthesis ; Carbapenems/pharmacology ; Female ; Klebsiella pneumoniae/drug effects ; beta-Lactamases/biosynthesis
    Chemical Substances Bacterial Proteins ; Carbapenems ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2012-06-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.06409-11
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    Zs.A 809: Show issues Location:
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    Einzelsignatur: Show issues

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  8. Article: Activity of Cefepime-Zidebactam against Multidrug-Resistant (MDR) Gram-Negative Pathogens.

    Thomson, Kenneth S / AbdelGhani, Sameh / Snyder, James W / Thomson, Gina K

    Antibiotics (Basel, Switzerland)

    2019  Volume 8, Issue 1

    Abstract: This study compared the activity of cefepime + zidebactam (FEP-ZID) and selected currently available antibacterial agents against a panel of multidrug-resistant (MDR) clinical isolates chosen to provide an extreme challenge for antibacterial activity. ... ...

    Abstract This study compared the activity of cefepime + zidebactam (FEP-ZID) and selected currently available antibacterial agents against a panel of multidrug-resistant (MDR) clinical isolates chosen to provide an extreme challenge for antibacterial activity. FEP⁻ZID had a very broad and potent in vitro spectrum of activity, and was highly active against many MDR isolates of
    Language English
    Publishing date 2019-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics8010032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Utility of the Validated Intraoperative Bleeding Scale in Thoracolumbar Spine Surgery: A Single-Center Prospective Study.

    Smith, Ryan A / Pease, Tyler J / Chiu, Anthony K / Shear, Brian M / Sahlani, Mario N / Ratanpal, Amit S / Ye, Ivan B / Thomson, Alexandra E / Bivona, Louis J / Jauregui, Julio J / Crandall, Kenneth M / Sansur, Charles A / Cavanaugh, Daniel L / Koh, Eugene Y / Ludwig, Steven C

    Global spine journal

    2024  , Page(s) 21925682241228219

    Abstract: Study design: Prospective, single-center study.: Objective: To evaluate the clinical relevance of the validated intraoperative bleeding severity scale (VIBe) in thoracolumbar spine surgery.: Methods: Adult patients aged 18 through 88 undergoing ... ...

    Abstract Study design: Prospective, single-center study.
    Objective: To evaluate the clinical relevance of the validated intraoperative bleeding severity scale (VIBe) in thoracolumbar spine surgery.
    Methods: Adult patients aged 18 through 88 undergoing elective decompression, instrumentation, and fusion of the thoracolumbar spine were prospectively enrolled after informed consent was provided and written consent was obtained. Validated intraoperative bleeding severity scores were recorded intraoperatively. Univariate analysis consisted of Student T-tests, Pearson's χ
    Results: A total of N = 121 patients were enrolled and included in the analysis. After adjusting for confounders, VIBe scores were correlated with an increased likelihood of intraoperative blood transfusion (β = 2.46,
    Conclusion: The VIBe scale is associated with perioperative transfusion rates and EBL in patients undergoing thoracolumbar spine surgery. Overall, the VIBe scale has clinically relevant meaning in spine surgery, and shows potential utility in clinical research.
    Level of evidence: Level II.
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2648287-3
    ISSN 2192-5690 ; 2192-5682
    ISSN (online) 2192-5690
    ISSN 2192-5682
    DOI 10.1177/21925682241228219
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  10. Article ; Online: CPO Complete, a novel test for fast, accurate phenotypic detection and classification of carbapenemases.

    Gina K Thomson / Sameh AbdelGhani / Kenneth S Thomson

    PLoS ONE, Vol 14, Iss 12, p e

    2019  Volume 0220586

    Abstract: Carbapenemase-producing organisms (CPOs) are Gram-negative bacteria that are typically resistant to most or all antibiotics and are responsible for a global pandemic of high mortality. Rapid, accurate detection of CPOs and the classification of their ... ...

    Abstract Carbapenemase-producing organisms (CPOs) are Gram-negative bacteria that are typically resistant to most or all antibiotics and are responsible for a global pandemic of high mortality. Rapid, accurate detection of CPOs and the classification of their carbapenemases are valuable tools for reducing the mortality of the CPO-associated infections, preventing the spread of CPOs, and optimizing use of new β-lactamase inhibitor combinations such as ceftazidime/avibactam, meropenem/vaborbactam and imipenem/relebactam. The current study evaluated the performance of CPO Complete, a novel, manual, phenotypic carbapenemase detection and classification test. The test was evaluated for sensitivity and specificity against 262 CPO isolates of Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii and 67 non-CPO isolates. It was also evaluated for carbapenemase classification accuracy against 205 CPOs that produced a single carbapenemase class. The test exhibited 100% sensitivity 98.5% specificity for carbapenemase detection within 90 minutes and detected 74.1% of carbapenemases within 10 minutes. In the classification evaluation, 99.0% of carbapenemases were correctly classified for isolates that produced a single carbapenemase. The test is technically simple and has potential for adaptation to automated instruments. With lyophilized kit storage at temperatures up to 38°C, the CPO Complete test has the potential to provide rapid, accurate carbapenemase detection and classification in both limited resource and technologically advanced laboratories.
    Keywords Medicine ; R ; Science ; Q
    Subject code 621
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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