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  1. Article ; Online: Medicaid Value-Based Payments and Health Care Use for Patients With Mental Illness.

    Lewis, Ashley / Howland, Renata E / Horwitz, Leora I / Desai, Sunita M

    JAMA health forum

    2023  Volume 4, Issue 9, Page(s) e233197

    Abstract: Importance: Medicaid patients with mental illness comprise one of the most high-need and complex patient populations. Value-based reforms aim to improve care, but their efficacy in the Medicaid program is unclear.: Objective: To investigate if New ... ...

    Abstract Importance: Medicaid patients with mental illness comprise one of the most high-need and complex patient populations. Value-based reforms aim to improve care, but their efficacy in the Medicaid program is unclear.
    Objective: To investigate if New York state's Medicaid value-based payment reform was associated with improved utilization patterns for patients with mental illness.
    Design, setting, and participants: This retrospective cohort study used a difference-in-differences analysis to compare changes in utilization between Medicaid beneficiaries whose outpatient practices participated in value-based payment reform and beneficiaries whose practices did not participate from before (July 1, 2013-June 30, 2015) to after reform (July 1, 2015-June 30, 2019). Participants were Medicaid beneficiaries in New York state aged 18 to 64 years with major depression disorder, bipolar disorder, and/or schizophrenia. Data analysis was performed from April 2021 to July 2023.
    Exposure: Beneficiaries were exposed to value-based payment reforms if their attributed outpatient practice participated in value-based payment reform at baseline (July 1, 2015).
    Main outcomes and measures: Primary outcomes were the number of outpatient primary care visits and the number of behavioral health visits per year. Secondary outcomes were the number of mental health emergency department visits and hospitalizations per year.
    Results: The analytic population comprised 306 290 individuals with depression (67.4% female; mean [SD] age, 38.6 [11.9] years), 85 105 patients with bipolar disorder (59.6% female; mean [SD] age, 38.0 [11.6] years), and 71 299 patients with schizophrenia (45.1% female; mean [SD] age, 40.3 [12.2] years). After adjustment, analyses estimated a statistically significant, positive association between value-based payments and behavioral health visits for patients with depression (0.91 visits; 95% CI, 0.51-1.30) and bipolar disorder (1.01 visits; 95% CI, 0.22-1.79). There was no statistically significant changes to primary care visits for patients with depression and bipolar disorder, but value-based payments were associated with reductions in primary care visits for patients with schizophrenia (-1.31 visits; 95% CI, -2.51 to -0.12). In every diagnostic population, value-based payment was associated with significant reductions in mental health emergency department visits (population with depression: -0.01 visits [95% CI, -0.02 to -0.002]; population with bipolar disorder: -0.02 visits [95% CI, -0.05 to -0.001]; population with schizophrenia: -0.04 visits [95% CI, -0.07 to -0.01]).
    Conclusions and relevance: In this cohort study, Medicaid value-based payment reform was statistically significantly associated with an increase in behavioral health visits and a reduction in mental health emergency department visits for patients with mental illness. Medicaid value-based payment may be effective at altering health care utilization in patients with mental illness.
    MeSH term(s) United States ; Humans ; Female ; Adult ; Male ; Cohort Studies ; Medicaid ; Retrospective Studies ; Mental Disorders/epidemiology ; Mental Disorders/therapy ; Outpatients ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/therapy
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ISSN 2689-0186
    ISSN (online) 2689-0186
    DOI 10.1001/jamahealthforum.2023.3197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Suicidal ideation and intentional self-inflicted injury in autism spectrum disorder and intellectual disability: An examination of trends in youth emergency department visits in the United States from 2006 to 2014.

    Cervantes, Paige E / Brown, Derek S / Horwitz, Sarah M

    Autism : the international journal of research and practice

    2022  Volume 27, Issue 1, Page(s) 226–243

    Abstract: ... with intellectual disability than in youth without these diagnoses (i.e. the comparison group). This was true when examining ...

    Abstract Lay abstract: Youth suicide is a major problem in the United States and globally, but little is known about suicide risk in autistic youth and youth with intellectual disability specifically. Using data from the National Emergency Department Sample, which is the largest database of emergency department visits in the United States, we found that emergency department visits with a suicidal ideation or intentional self-inflicted injury diagnosis were more common in autistic youth and youth with intellectual disability than in youth without these diagnoses (i.e. the comparison group). This was true when examining both suicidal ideation diagnoses and intentional self-inflicted injury diagnoses at emergency department visits. In addition, the number of emergency department visits with a suicidal ideation or intentional self-inflicted injury diagnosis increased more from 2006 to 2014 in autistic youth and youth with intellectual disability compared with the comparison group. We also found both similarities and differences when examining factors, such as age, sex, and co-occurring mental health conditions, related to emergency department visits with a suicidal ideation or intentional self-inflicted injury diagnosis across groups that may be helpful for understanding suicide risk. It is urgent that we improve our understanding, assessment, and treatment of suicidality and self-harm in these groups through more research and clinical efforts.
    MeSH term(s) Humans ; Adolescent ; United States/epidemiology ; Suicidal Ideation ; Autism Spectrum Disorder/epidemiology ; Intellectual Disability/epidemiology ; Self-Injurious Behavior/epidemiology ; Self-Injurious Behavior/psychology ; Emergency Service, Hospital
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1338513-6
    ISSN 1461-7005 ; 1362-3613
    ISSN (online) 1461-7005
    ISSN 1362-3613
    DOI 10.1177/13623613221091316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Use of Allogeneic Hematopoietic Stem Cell Transplantation in Primary Myelofibrosis.

    Wolfe, Heather R / Horwitz, Mitchell E / Rein, Lindsay A M

    Journal of personalized medicine

    2022  Volume 12, Issue 4

    Abstract: Primary myelofibrosis (PMF) is a BCR-ABL1 negative myeloproliferative neoplasm characterized by clonal proliferation of myeloid cells. This leads to reactive bone marrow fibrosis, ultimately resulting in progressive marrow failure, hepatosplenomegaly, ... ...

    Abstract Primary myelofibrosis (PMF) is a BCR-ABL1 negative myeloproliferative neoplasm characterized by clonal proliferation of myeloid cells. This leads to reactive bone marrow fibrosis, ultimately resulting in progressive marrow failure, hepatosplenomegaly, and extramedullary hematopoiesis. PMF is considered the most aggressive of the BCR-ABL1 negative myeloproliferative neoplasms with the least favorable prognosis. Constitutional symptoms are common, which can impact an individual's quality of life and leukemic transformation remains an important cause of death in PMF patients. The development of the Janus kinase 2 (JAK2) inhibitors have provided a good option for management of PMF-related symptoms. Unfortunately, these agents have not been shown to improve overall survival or significantly alter the course of disease. Allogenic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative treatment option in PMF. However, allo-HSCT is associated with significant treatment-related morbidity and mortality and has historically been reserved for younger, high-risk patients. This review examines patient, disease, and transplant-specific factors which may impact transplant-related outcomes in PMF. Through the vast improvements in donor selection, conditioning regimens, and post-transplant care, allo-HSCT may provide a safe and effective curative option for a broader range of PMF patients in the future.
    Language English
    Publishing date 2022-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12040571
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Association of Pediatric Emergency Medicine Physicians' Self-Identified Skills in Suicide Risk Assessment and Management With Training in Mental Health.

    Cervantes, Paige E / Tay, Ee Tein / Knapp, Katrina / Wiener, Ethan / Seag, Dana E M / Richards-Rachlin, Shira / Baroni, Argelinda / Horwitz, Sarah M

    Pediatric emergency care

    2023  Volume 39, Issue 8, Page(s) 595–599

    Abstract: Objective: Because changes to pediatric emergency medicine (PEM) education may help address barriers to youth suicide risk screening programs, this study aimed to understand the impact of formal training in areas that likely include suicide-related ... ...

    Abstract Objective: Because changes to pediatric emergency medicine (PEM) education may help address barriers to youth suicide risk screening programs, this study aimed to understand the impact of formal training in areas that likely include suicide-related practices, developmental-behavioral pediatrics (DBP) and adolescent medicine (AM), on PEM physician-perceived level of training, attitudes, and confidence assessing and managing youth suicide risk.
    Methods: Twenty-seven PEM attendings and trainees completed an online survey and were divided into 2 groups: those who had completed DBP and AM rotations (DBP/AM+; n = 20) and those who had not completed either rotation (DBP/AM-; n = 7). We compared perceived level of training, attitudes, and confidence in assessing and managing suicide risk across groups. We also examined the relationship between perceived level of training and confidence. Finally, we conducted exploratory analyses to evaluate the effect of an additional formal rotation in child psychiatry.
    Results: The DBP/AM+ and DBP/AM- groups did not differ on perceived level of training or on attitudes and confidence in suicide risk assessment or management. Perceived level of training in assessment and management predicted confidence in both assessing and managing suicide risk. Additional training in child psychiatry was not associated with increased perceived level of training or confidence.
    Conclusions: The DBP and AM rotations were not associated with higher perceived levels of suicide risk training or greater confidence; however, perceived level of training predicted physician confidence, suggesting continued efforts to enhance formal PEM education in mental health would be beneficial.
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000002999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Directing the migration of serum-free,

    Parwani, Kiran K / Branella, Gianna M / Burnham, Rebecca E / Burnham, Andre J / Bustamante, Austre Y Schiaffino / Foppiani, Elisabetta Manuela / Knight, Kristopher A / Petrich, Brian G / Horwitz, Edwin M / Doering, Christopher B / Spencer, H Trent

    Frontiers in immunology

    2024  Volume 15, Page(s) 1331322

    Abstract: Vγ9Vδ2 T cells represent a promising cancer therapy platform because the implementation of allogenic, off-the-shelf product candidates is possible. However, intravenous administration of human Vγ9Vδ2 T cells manufactured under good manufacturing practice ...

    Abstract Vγ9Vδ2 T cells represent a promising cancer therapy platform because the implementation of allogenic, off-the-shelf product candidates is possible. However, intravenous administration of human Vγ9Vδ2 T cells manufactured under good manufacturing practice (GMP)-compliant, serum-free conditions are not tested easily in most mouse models, mainly because they lack the ability to migrate from the blood to tissues or tumors. We demonstrate that these T cells do not migrate from the circulation to the mouse bone marrow (BM), the site of many malignancies. Thus, there is a need to better characterize human γδ T-cell migration
    MeSH term(s) Humans ; Mice ; Animals ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Busulfan ; Chemokines ; Neuroblastoma ; Receptors, Chemokine
    Chemical Substances Receptors, Antigen, T-Cell, gamma-delta ; Busulfan (G1LN9045DK) ; Chemokines ; Receptors, Chemokine
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1331322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Use of Allogeneic Hematopoietic Stem Cell Transplantation in Primary Myelofibrosis

    Heather R. Wolfe / Mitchell E. Horwitz / Lindsay A. M. Rein

    Journal of Personalized Medicine, Vol 12, Iss 571, p

    2022  Volume 571

    Abstract: Primary myelofibrosis (PMF) is a BCR-ABL1 negative myeloproliferative neoplasm characterized by clonal proliferation of myeloid cells. This leads to reactive bone marrow fibrosis, ultimately resulting in progressive marrow failure, hepatosplenomegaly, ... ...

    Abstract Primary myelofibrosis (PMF) is a BCR-ABL1 negative myeloproliferative neoplasm characterized by clonal proliferation of myeloid cells. This leads to reactive bone marrow fibrosis, ultimately resulting in progressive marrow failure, hepatosplenomegaly, and extramedullary hematopoiesis. PMF is considered the most aggressive of the BCR-ABL1 negative myeloproliferative neoplasms with the least favorable prognosis. Constitutional symptoms are common, which can impact an individual’s quality of life and leukemic transformation remains an important cause of death in PMF patients. The development of the Janus kinase 2 (JAK2) inhibitors have provided a good option for management of PMF-related symptoms. Unfortunately, these agents have not been shown to improve overall survival or significantly alter the course of disease. Allogenic hematopoietic stem cell transplantation (allo-HSCT) remains the only curative treatment option in PMF. However, allo-HSCT is associated with significant treatment-related morbidity and mortality and has historically been reserved for younger, high-risk patients. This review examines patient, disease, and transplant-specific factors which may impact transplant-related outcomes in PMF. Through the vast improvements in donor selection, conditioning regimens, and post-transplant care, allo-HSCT may provide a safe and effective curative option for a broader range of PMF patients in the future.
    Keywords primary myelofibrosis ; myeloproliferative neoplasms ; hematopoietic stem cell transplantation ; conditioning regimens ; donor selection ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Leveraging Natural Killer Cell Innate Immunity against Hematologic Malignancies

    Chenyu Lin / Mitchell E. Horwitz / Lindsay A. M. Rein

    International Journal of Molecular Sciences, Vol 24, Iss 1, p

    From Stem Cell Transplant to Adoptive Transfer and Beyond

    2022  Volume 204

    Abstract: Numerous recent advancements in T-cell based immunotherapies have revolutionized the treatment of hematologic malignancies. In the race towards the first approved allogeneic cellular therapy product, there is growing interest in utilizing natural killer ( ...

    Abstract Numerous recent advancements in T-cell based immunotherapies have revolutionized the treatment of hematologic malignancies. In the race towards the first approved allogeneic cellular therapy product, there is growing interest in utilizing natural killer (NK) cells as a platform for off-the-shelf cellular therapies due to their scalable manufacturing potential, potent anti-tumor efficacy, and superior safety profile. Allogeneic NK cell therapies are now being actively explored in the setting of hematopoietic stem cell transplantation and adoptive transfer. Increasingly sophisticated gene editing techniques have permitted the engineering of chimeric antigen receptors, ectopic cytokine expression, and tumor recognition signals to improve the overall cytotoxicity of NK cell therapies. Furthermore, the enhancement of antibody-dependent cellular cytotoxicity has been achieved through the use of NK cell engagers and combination regimens with monoclonal antibodies that act synergistically with CD16-expressing NK cells. Finally, a greater understanding of NK cell biology and the mechanisms of resistance have allowed the preclinical development of NK checkpoint blockade and methods to modulate the tumor microenvironment, which have been evaluated in early phase trials. This review will discuss the recent clinical advancements in NK cell therapies in hematologic malignancies as well as promising avenues of future research.
    Keywords natural killer cells ; stem cell transplantation ; adoptive transfer ; chimeric antigen receptor ; bispecific antibodies ; cytokines ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Somatic mutations in FAS pathway increase hemophagocytic lymphohistiocytosis risk in T- and/or NK-cell lymphoma patients.

    Liu, Ying / Sardana, Rohan / Nemirovsky, David / Frosina, Denise / Jungbluth, Achim / Johnson, William T / Vardhana, Santosha A / Arcila, Maria E / Horwitz, Steven M / Derkach, Andriy / Dogan, Ahmet / Xiao, Wenbin

    Blood advances

    2024  

    Abstract: While significant progress has been made in understanding the genetic basis of primary hemophagocytic lymphohistiocytosis (HLH), the pathogenesis of secondary HLH, the more prevalent form, remains unclear. Among the various conditions giving rise to ... ...

    Abstract While significant progress has been made in understanding the genetic basis of primary hemophagocytic lymphohistiocytosis (HLH), the pathogenesis of secondary HLH, the more prevalent form, remains unclear. Among the various conditions giving rise to secondary HLH, HLH in lymphoma patients (HLH-L) accounts for a substantial proportion. In this study, we investigated the role of somatic mutations in the pathogenesis of HLH-L in a cohort of patients with T- and/or NK-cell lymphoma. We identified a 3-time higher frequency of mutations in FAS pathway in patients with HLH-L. Patients harbouring these mutations had a 5-time increased HLH-L risk. These mutations were independently associated with inferior outcome. Hence, our study demonstrates the association between somatic mutations in FAS pathway and HLH-L. Further studies are warranted on the mechanistic role of these mutations in HLH-L.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Assessing and Managing Suicide Risk in Autistic Youth: Findings from a Clinician Survey in a Pediatric Psychiatric Emergency Setting.

    Cervantes, Paige E / Li, Annie / Sullivan, Katherine A / Seag, Dana E M / Baroni, Argelinda / Horwitz, Sarah M

    Journal of autism and developmental disorders

    2022  Volume 53, Issue 5, Page(s) 1755–1763

    Abstract: Suicidal thoughts and behaviors (STB) and emergency department (ED) utilization are prevalent in autistic youth. The current study surveyed clinicians in a pediatric psychiatric ED to examine differences in attitudes on suicide-related care for autistic ... ...

    Abstract Suicidal thoughts and behaviors (STB) and emergency department (ED) utilization are prevalent in autistic youth. The current study surveyed clinicians in a pediatric psychiatric ED to examine differences in attitudes on suicide-related care for autistic and non-autistic patient populations. While clinicians rated addressing STB in ASD as important and adaptations to care as necessary, less than half identified ASD as a suicide risk factor and confidence ratings were significantly lower for autistic patients. Previous ASD training predicted confidence and accounted for approximately 25% of the variance in confidence scores. Findings highlight the urgency to develop and disseminate ED clinician training, and address the lack of validated assessment tools, adapted suicide prevention practices, and evidence-based treatments for STB in autistic youth.
    MeSH term(s) Child ; Humans ; Adolescent ; Autism Spectrum Disorder/psychology ; Suicide ; Suicidal Ideation ; Suicide Prevention ; Autistic Disorder/diagnosis ; Autistic Disorder/therapy ; Autistic Disorder/psychology ; Emergency Service, Hospital
    Language English
    Publishing date 2022-02-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391999-7
    ISSN 1573-3432 ; 0162-3257
    ISSN (online) 1573-3432
    ISSN 0162-3257
    DOI 10.1007/s10803-022-05448-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Barriers to Universal Suicide Risk Screening for Youth in the Emergency Department.

    Seag, Dana E M / Cervantes, Paige E / Baroni, Argelinda / Gerson, Ruth / Knapp, Katrina / Tay, Ee Tein / Wiener, Ethan / Horwitz, Sarah McCue

    Pediatric emergency care

    2022  Volume 38, Issue 2, Page(s) e1009–e1013

    Abstract: Objective: Given the increasing rates of youth suicide, it is important to understand the barriers to suicide screening in emergency departments. This review describes the current literature, identifies gaps in existing research, and suggests ... ...

    Abstract Objective: Given the increasing rates of youth suicide, it is important to understand the barriers to suicide screening in emergency departments. This review describes the current literature, identifies gaps in existing research, and suggests recommendations for future research.
    Methods: A search of PubMed, MEDLINE, CINAHL, PsycInfo, and Web of Science was conducted. Data extraction included study/sample characteristics and barrier information categorized based on the Exploration, Preparation, Implementation, Sustainment model.
    Results: All studies focused on inner context barriers of implementation and usually examined individuals' attitudes toward screening. No study looked at administrative, policy, or financing issues.
    Conclusions: The lack of prospective, systematic studies on barriers and the focus on individual adopter attitudes reveal a significant gap in understanding the challenges to implementation of universal youth suicide risk screening in emergency departments.
    MeSH term(s) Adolescent ; Emergency Service, Hospital ; Humans ; Mass Screening ; Suicide Prevention
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000002506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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