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  1. Article ; Online: Earth steward: Will Steffen's contributions to Earth System Science, governance and law.

    Boonstra, Wiebren Johannes / Kim, Rakhyun E / Kotzé, Louis J / Lim, Michelle / Magalhães, Paulo / Preston, Brian J / Rockström, Johan / Taylor, Prue

    Ambio

    2023  Volume 52, Issue 6, Page(s) 995–1003

    Language English
    Publishing date 2023-04-25
    Publishing country Sweden
    Document type Editorial
    ZDB-ID 120759-3
    ISSN 1654-7209 ; 0044-7447
    ISSN (online) 1654-7209
    ISSN 0044-7447
    DOI 10.1007/s13280-023-01867-8
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  2. Article ; Online: Attenuation of Excess TNF-α Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking.

    Louis, Taylor J / Qasem, Ahmad / Naser, Saleh A

    Frontiers in immunology

    2022  Volume 13, Page(s) 887830

    Abstract: TNFα converting enzyme (TACE) is a transmembrane metalloprotease that sheds an assortment of signaling receptors, cytokines, growth factors, and pro-inflammatory mediators. In Crohn's disease (CD), TACE activity is upregulated, resulting in a marked ... ...

    Abstract TNFα converting enzyme (TACE) is a transmembrane metalloprotease that sheds an assortment of signaling receptors, cytokines, growth factors, and pro-inflammatory mediators. In Crohn's disease (CD), TACE activity is upregulated, resulting in a marked increase of TNFα secretion and inflammation. Although treatment of CD with TNFα monoclonal antibodies is beneficial, many patients are at risk for acquiring opportunistic infections, and the treatment efficacy of TNFα monoclonal antibodies typically decreases over time. This study investigated an alternative approach for mitigating TNFα release by knocking down TACE membrane translocation in macrophages
    MeSH term(s) Animals ; Antibodies, Monoclonal ; Crohn Disease/metabolism ; Cytokines ; Gene Silencing ; Humans ; Immunosuppression Therapy ; Intracellular Signaling Peptides and Proteins/genetics ; Ligands ; Membrane Proteins/genetics ; Mycobacterium avium subsp. paratuberculosis ; RNA, Small Interfering ; Transforming Growth Factor beta/immunology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Antibodies, Monoclonal ; Cytokines ; Intracellular Signaling Peptides and Proteins ; Ligands ; Membrane Proteins ; RHBDF2 protein, human ; RNA, Small Interfering ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.887830
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  3. Article ; Online: Endoscopic 5-Aminolevulinic Acid-Induced Fluorescence-Guided Intraparenchymal Brain Tumor Resection-Can the Endoscope Detect More Fluorescence Than the Microscope?

    Ma, Ruichong / Livermore, Laurent J / Taylor, Louis / Laycock, Jake / Williams, Sarah / Ansorge, Olaf / Vallance, Claire / Plaha, Puneet

    World neurosurgery

    2024  

    Abstract: Objectives: Using a laboratory-based optical setup, we show that 5-aminolevulinic acid (5ALA) fluorescence is better detected using the endoscope than the microscope. Furthermore, we present our case series of fully endoscopic 5ALA-guided resection of ... ...

    Abstract Objectives: Using a laboratory-based optical setup, we show that 5-aminolevulinic acid (5ALA) fluorescence is better detected using the endoscope than the microscope. Furthermore, we present our case series of fully endoscopic 5ALA-guided resection of intraparenchymal tumors.
    Methods: A Zeiss Pentero microscope was compared with the Karl Storz Hopkins endoscope. The spectra and intensity of each blue light source were measured. Quantitative fluorescence detection thresholds were measured using a spectrometer. Subjective fluorescence detection thresholds were measured by 6 blinded neuro-oncology surgeons. Clinical data were prospectively collected for all consecutive cases of fully endoscopic 5ALA-guided resection of intraparenchymal tumors between 2012 and 2023.
    Results: The intensity of blue light on the sample was greater for the endoscope than the microscope at working distances less than 20 mm. The quantitative fluorescence detection thresholds were lower for the endoscope than the microscope at both 30-/10-mm working distances. Fluorescence detection threshold was 0.65%-0.80% relative 4-dicyanomethylene-2-methyl-6-p-dimethylaminostyryl-4H-pyranthe concentration (3.20 × 10
    Conclusions: The endoscope provides enhanced visualization/detection of 5ALA-induced fluorescence compared with the microscope. 5ALA endoscopic-assisted resection of intraparenchymal tumors is safe and feasible.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.03.067
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  4. Article ; Online: The enigmatic roles of Anelloviridae and Redondoviridae in humans.

    Taylor, Louis J / Keeler, Emma L / Bushman, Frederic D / Collman, Ronald G

    Current opinion in virology

    2022  Volume 55, Page(s) 101248

    Abstract: Anelloviridae and Redondoviridae are virus families with small, circular, single-stranded DNA genomes that are common components of the human virome. Despite their small genome size of less than 5000 bases, they are remarkably successful - anelloviruses ... ...

    Abstract Anelloviridae and Redondoviridae are virus families with small, circular, single-stranded DNA genomes that are common components of the human virome. Despite their small genome size of less than 5000 bases, they are remarkably successful - anelloviruses colonize over 90% of adult humans, while the recently discovered redondoviruses have been found at up to 80% prevalence in some populations. Anelloviruses are present in blood and many organs, while redondoviruses are found mainly in the ororespiratory tract. Despite their high prevalence, little is known about their biology or pathogenic potential. In this review, we discuss anelloviruses and redondoviruses and explore their enigmatic roles in human health and disease.
    MeSH term(s) Adult ; Anelloviridae/genetics ; Humans
    Language English
    Publishing date 2022-07-20
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2611378-8
    ISSN 1879-6265 ; 1879-6257
    ISSN (online) 1879-6265
    ISSN 1879-6257
    DOI 10.1016/j.coviro.2022.101248
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  5. Article ; Online: Assessment of Executive Function in Infants and Toddlers: A Potential Role of the Bayley-4.

    Aylward, Glen P / Taylor, H Gerry / Anderson, Peter J / Vannier, Louis Charles

    Journal of developmental and behavioral pediatrics : JDBP

    2022  Volume 43, Issue 7, Page(s) e431–e441

    Abstract: Objective: The development of executive function (EF) in infants and toddlers has received increased interest by clinicians and researchers. Higher rates of deficits in EF have been reported in at-risk groups of infants such as those born extremely ... ...

    Abstract Objective: The development of executive function (EF) in infants and toddlers has received increased interest by clinicians and researchers. Higher rates of deficits in EF have been reported in at-risk groups of infants such as those born extremely preterm. These deficits play an important role in the etiology of early neurodevelopmental problems and are predictive of subsequent nonoptimal educational outcomes. In this study, the Bayley-4 is used to follow the developmental course of EF and to determine whether EF is a unitary concept or can be parsed into discrete components over the first 42 months.
    Method: All 81 cognitive items from the Bayley-4 normative sample of 1700 infants and toddlers were classified a priori into 6 EFs, and then, 5 age groups derived from Bayley-4 start points were factor analyzed to determine at what age EFs emerge and to address the controversy of whether the factor structure of the cognitive items for each of 5 age groups reflect a single factor or multiple factors.
    Results: Bayley-4 items form 1 to 5 EF factors for each age group, accounting for 59% to 74% of the variance. There is a developmental progression in EF as well. The results indicate EF constructs can be identified early.
    Conclusion: Executive function tasks in infants and toddlers are interrelated with task content either remaining the same or changing with advancing age (i.e., content that is homotypic or heterotypic, respectively). EFs measured by Bayley-4 items are useful clinically and become more complex with increasing age, corresponding to more advanced brain development and integration. The findings have the potential of providing additional information in the assessment of infants at risk such as those born preterm.
    MeSH term(s) Child Development ; Child, Preschool ; Executive Function ; Humans ; Infant ; Infant, Newborn
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603379-9
    ISSN 1536-7312 ; 0196-206X
    ISSN (online) 1536-7312
    ISSN 0196-206X
    DOI 10.1097/DBP.0000000000001072
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1582: Show issues Location:
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  6. Article: Extra-Pulmonary Complications in SARS-CoV-2 Infection: A Comprehensive Multi Organ-System Review.

    Louis, Taylor J / Qasem, Ahmad / Abdelli, Latifa S / Naser, Saleh A

    Microorganisms

    2022  Volume 10, Issue 1

    Abstract: Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is typically presented with acute symptoms affecting upper and lower respiratory systems. As the current pandemic progresses, COVID-19 ... ...

    Abstract Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is typically presented with acute symptoms affecting upper and lower respiratory systems. As the current pandemic progresses, COVID-19 patients are experiencing a series of nonspecific or atypical extra-pulmonary complications such as systemic inflammation, hypercoagulability state, and dysregulation of the renin-angiotensin-aldosterone system (RAAS). These manifestations often delay testing, diagnosis, and the urge to seek effective treatment. Although the pathophysiology of these complications is not clearly understood, the incidence of COVID-19 increases with age and the presence of pre-existing conditions. This review article outlines the pathophysiology and clinical impact of SARS-CoV-2 infection on extra-pulmonary systems. Understanding the broad spectrum of atypical extra-pulmonary manifestations of COVID-19 should increase disease surveillance, restrict transmission, and most importantly prevent multiple organ-system complications.
    Language English
    Publishing date 2022-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10010153
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  7. Article ; Online: Efficacy and safety of using auditory-motor entrainment to improve walking after stroke: a multi-site randomized controlled trial of InTandem

    Awad, Louis N / Jayaraman, Arun / Nolan, Karen J / Lewek, Michael D / Bonato, Paolo / Newman, Mark / Putrino, David / Raghavan, Preeti / Pohlig, Ryan T / Harris, Brian A / Parker, Danielle A / Taylor, Sabrina R

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1081

    Abstract: Walking slowly after stroke reduces health and quality of life. This multi-site, prospective, interventional, 2-arm randomized controlled trial (NCT04121754) evaluated the safety and efficacy of an autonomous neurorehabilitation system ( ... ...

    Abstract Walking slowly after stroke reduces health and quality of life. This multi-site, prospective, interventional, 2-arm randomized controlled trial (NCT04121754) evaluated the safety and efficacy of an autonomous neurorehabilitation system (InTandem
    MeSH term(s) Humans ; Stroke Rehabilitation ; Quality of Life ; Prospective Studies ; Walking ; Stroke/therapy ; Stroke/complications
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44791-5
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  8. Article ; Online: Origins of US Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training.

    Johnson, David K / DeTolla, Louis J / Houghton, Paul W / Clarke, George L / Taylor, James F / Whitney, Robert A

    Journal of the American Association for Laboratory Animal Science : JAALAS

    2023  Volume 62, Issue 4, Page(s) 288–290

    Abstract: The US Government Principles for the use of animals in research are a landmark statement of ethical values and guidance for the biomedical research community. However, when The Principles were introduced, a context was not provided for their source or ... ...

    Abstract The US Government Principles for the use of animals in research are a landmark statement of ethical values and guidance for the biomedical research community. However, when The Principles were introduced, a context was not provided for their source or foundation. The US Government Principles were formulated with input from the Council of Europe, World Health Organization, and US Interagency Research Animal Committee. The Principles continue to provide an ethical foundation for the biomedical research community.
    MeSH term(s) Animals ; Government ; Biomedical Research ; Vertebrates
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article
    ISSN 2769-6677
    ISSN (online) 2769-6677
    DOI 10.30802/AALAS-JAALAS-22-000118
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  9. Article: Immune Literacy: a Call to Action for a System-Level Change.

    Mixter, Philip F / Kleinschmit, Adam J / Lal, Archana / Vanniasinkam, Thiru / Condry, Danielle L J / Taylor, Rebekah T / Justement, Louis B / Pandey, Sumali

    Journal of microbiology & biology education

    2023  Volume 24, Issue 1

    Abstract: Immune literacy-the ability to hear, learn, read, write, explain, and discuss immunological content with varied audiences-has become critically important in recent years. Yet, with its complex terminology and discipline-specific concepts, educating ... ...

    Abstract Immune literacy-the ability to hear, learn, read, write, explain, and discuss immunological content with varied audiences-has become critically important in recent years. Yet, with its complex terminology and discipline-specific concepts, educating individuals about the immune system and its role in health and disease may seem daunting. Here, we reflect on how to demystify the discipline and increase its accessibility for a broader audience. To address this, a working group of immunology educators from diverse institutions associated with the research coordination network, ImmunoReach, convened virtually. As a result of these discussions, we request a call to action for a system-level change and present a set of practical recommendations that novice and experienced educators from diverse institutions, professional societies, and policymakers may adopt to foster immune literacy in their classrooms and communities.
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ISSN 1935-7877
    ISSN 1935-7877
    DOI 10.1128/jmbe.00203-22
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  10. Article ; Online: grabseqs: simple downloading of reads and metadata from multiple next-generation sequencing data repositories.

    Taylor, Louis J / Abbas, Arwa / Bushman, Frederic D

    Bioinformatics (Oxford, England)

    2020  Volume 36, Issue 11, Page(s) 3607–3609

    Abstract: Summary: High-throughput sequencing is a powerful technique for addressing biological questions. Grabseqs streamlines access to publicly available metagenomic data by providing a single, easy-to-use interface to download data and metadata from multiple ... ...

    Abstract Summary: High-throughput sequencing is a powerful technique for addressing biological questions. Grabseqs streamlines access to publicly available metagenomic data by providing a single, easy-to-use interface to download data and metadata from multiple repositories, including the Sequence Read Archive, the Metagenomics Rapid Annotation through Subsystems Technology server and iMicrobe. Users can download data and metadata in a standardized format from any number of samples or projects from a given repository with a single grabseqs command.
    Availability and implementation: Grabseqs is an open-source tool implemented in Python and licensed under the MIT license. The source code is freely available at https://github.com/louiejtaylor/grabseqs, the Python Package Index and Anaconda Cloud repository.
    Contact: bushman@pennmedicine.upenn.edu.
    Supplementary information: Supplementary data are available at Bioinformatics online.
    MeSH term(s) High-Throughput Nucleotide Sequencing ; Metadata ; Metagenome ; Metagenomics ; Software
    Language English
    Publishing date 2020-03-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btaa167
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